2005
The Integration of Conventional and Unconventional T Cells that Characterizes Cell‐Mediated Responses
Pennington D, Vermijlen D, Wise E, Clarke S, Tigelaar R, Hayday A. The Integration of Conventional and Unconventional T Cells that Characterizes Cell‐Mediated Responses. Advances In Immunology 2005, 87: 27-59. PMID: 16102571, DOI: 10.1016/s0065-2776(05)87002-6.Peer-Reviewed Original ResearchConceptsUnconventional T cellsGene expression analysisConventional T cellsExtensive gene expression analysisT cellsExpression analysisRegulatory functionsCell-mediated immune responsesCell-mediated responsesT cell activityAntigen-specific responsesCellsInflammatory diseasesImmune responseImmunopathology
1993
THE TREATMENT OF MASTOCYTOMA CELLS WITH 8‐METHOXYPSORALEN AND LONG‐WAVELENGTH ULTRAVIOLET RADIATION ENHANCES CELLULAR IMMUNOGENICITY: PRELIMINARY RESULTS
Gasparro F, Malane M, Maxwell V, Tigelaar R. THE TREATMENT OF MASTOCYTOMA CELLS WITH 8‐METHOXYPSORALEN AND LONG‐WAVELENGTH ULTRAVIOLET RADIATION ENHANCES CELLULAR IMMUNOGENICITY: PRELIMINARY RESULTS. Photochemistry And Photobiology 1993, 58: 682-688. PMID: 8284324, DOI: 10.1111/j.1751-1097.1993.tb04952.x.Peer-Reviewed Original ResearchConceptsCutaneous T-cell lymphomaLong-wavelength ultraviolet radiationT-cell lymphomaMurine immune systemP1 cellsNew surface antigensCellular immunogenicityImmunized miceUVA photochemotherapyImmunosuppressed miceImmune cellsDBA/2 miceCell lymphomaSurface antigenImmune systemSignificant protectionPilot studyMiceImmunogenicityMastocytoma cellsN-methyl-N'UVA treatmentUltraviolet radiationTreatmentAntigen
1990
Roles of CD4+ and CD8+ T cells in murine contact sensitivity revealed by in vivo monoclonal antibody depletion.
Gocinski B, Tigelaar R. Roles of CD4+ and CD8+ T cells in murine contact sensitivity revealed by in vivo monoclonal antibody depletion. The Journal Of Immunology 1990, 144: 4121-8. PMID: 1971294, DOI: 10.4049/jimmunol.144.11.4121.Peer-Reviewed Original ResearchConceptsEffector cellsVivo depletionBALB/c miceEffector roleCS effector cellsMonoclonal antibody depletionMurine contact sensitivityDepletion of CD4Depletion of CD8Contact sensitivity responseRole of CD4Activity of CD8Delayed-type hypersensitivityT cell subsetsCutaneous hypersensitivity responseT-cell phenotypeImportant effector roleSubsequent flow cytometric analysisFlow cytometric analysisEnhanced earImmune lymphResidual CD4Adoptive transferSuppressor cellsDistinct CD4Langerhans cells that migrate to skin after intravenous infusion regulate the induction of contact hypersensitivity.
Cruz P, Tigelaar R, Bergstresser P. Langerhans cells that migrate to skin after intravenous infusion regulate the induction of contact hypersensitivity. The Journal Of Immunology 1990, 144: 2486-92. PMID: 1969448, DOI: 10.4049/jimmunol.144.7.2486.Peer-Reviewed Original ResearchConceptsLow-dose UVB radiationContact hypersensitivityLangerhans cellsIntravenous infusionLow-dose ultraviolet B (UVB) radiationExposure of LCThy-1UVB radiationSuppressor signalsMesenteric lymph nodesLow-dose UVBEffector signalsSkin graft experimentsLC migrationImmunologic targetsLymph nodesAllogeneic transferCH responsesLymphoid tissueImmune responseSyngeneic miceImmunization modelImmunogenic propertiesInfusionUltraviolet B radiation
1973
Graft-vs-host reactivity of mouse thymocytes: effect of cortisone pretreatment of donors.
Tigelaar R, Asofsky R. Graft-vs-host reactivity of mouse thymocytes: effect of cortisone pretreatment of donors. The Journal Of Immunology 1973, 110: 567-74. PMID: 4405321, DOI: 10.4049/jimmunol.110.2.567.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCortisoneGraft vs Host ReactionImmunity, CellularLymph NodesMiceMice, Inbred BALB COrgan SizeRadiation ChimeraSpleenT-LymphocytesConceptsSpleen weightNormal thymocytesPeripheral lymph node cellsCell-mediated immune reactionsBALB/c miceLymph node cellsThymus-derived cellsCortisone-resistant thymocytesLymphoid cell populationsCortisone pretreatmentGVH reactivityHost reactivityC miceNode cellsNormal donorsImmune reactionsThymus cellsCortisone acetateCumulative mortalityThymocytesMortalityUnique populationCell populationsMouse thymocytesDistinct cell types