2011
Response: validity of evidence demonstrating efficacy of extracorporeal photochemotherapy
Berger C, Lewis J, Girardi M, Tigelaar R, Edelson R. Response: validity of evidence demonstrating efficacy of extracorporeal photochemotherapy. Blood 2011, 117: 367. PMID: 21212292, PMCID: PMC3037285, DOI: 10.1182/blood-2010-11-317107.Peer-Reviewed Original Research
2009
Skin immune surveillance by T cells—A new order?
Strid J, Tigelaar RE, Hayday AC. Skin immune surveillance by T cells—A new order? Seminars In Immunology 2009, 21: 110-120. PMID: 19369094, DOI: 10.1016/j.smim.2009.03.002.Peer-Reviewed Original ResearchConceptsImmune surveillanceAdaptive immune surveillanceStress-induced antigensSystemic immune cellsSkin immune surveillanceLocal lymphocytesOrgan dysfunctionDendritic cellsImmune cellsT cellsEpithelial cellsTissue integrityCellsSurveillanceBody surfaceImmunopathologyImmunoregulationDysfunctionLymphocytesInfectionAntigenImmunoprotectionStress response
2008
Development of Immunogenic Tumor-Loaded Dendritic Cells Through Physical Perturbation and Apoptotic Cell Loading
Shen X, Berger CL, Tigelaar R, Edelson RL. Development of Immunogenic Tumor-Loaded Dendritic Cells Through Physical Perturbation and Apoptotic Cell Loading. Immunological Investigations 2008, 37: 798-821. PMID: 18991097, DOI: 10.1080/08820130802403358.Peer-Reviewed Original ResearchMeSH KeywordsAntigen PresentationAntigens, CDAntigens, NeoplasmApoptosisB7-1 AntigenCancer VaccinesCD8-Positive T-LymphocytesCell DifferentiationCell Line, TumorCytotoxicity, ImmunologicDendritic CellsHumansImmunoglobulinsLymphocyte ActivationLymphoma, T-CellMechanotransduction, CellularMembrane GlycoproteinsMonocytesPerforinReceptors, CCR7Silicon DioxideConceptsT cellsDendritic cellsAllogeneic T cell proliferationCD8 T cellsLevels of perforinChemokine receptor CCR7T cell proliferationApoptotic tumor cellsUniverse of antigensDC vaccinesImmunogenic tumorsImmature DCsReceptor CCR7TNF-alphaPassage of leukocytesIFN-gammaHuman monocytesMonocytesTumor cellsPotent inductionCell apoptosisPhenotypic conversionCell proliferationApoptotic cellsCells induces
2005
The Integration of Conventional and Unconventional T Cells that Characterizes Cell‐Mediated Responses
Pennington D, Vermijlen D, Wise E, Clarke S, Tigelaar R, Hayday A. The Integration of Conventional and Unconventional T Cells that Characterizes Cell‐Mediated Responses. Advances In Immunology 2005, 87: 27-59. PMID: 16102571, DOI: 10.1016/s0065-2776(05)87002-6.Peer-Reviewed Original ResearchConceptsUnconventional T cellsGene expression analysisConventional T cellsExtensive gene expression analysisT cellsExpression analysisRegulatory functionsCell-mediated immune responsesCell-mediated responsesT cell activityAntigen-specific responsesCellsInflammatory diseasesImmune responseImmunopathology
2001
Regulation of Cutaneous Malignancy by γδ T Cells
Girardi M, Oppenheim D, Steele C, Lewis J, Glusac E, Filler R, Hobby P, Sutton B, Tigelaar R, Hayday A. Regulation of Cutaneous Malignancy by γδ T Cells. Science 2001, 294: 605-609. PMID: 11567106, DOI: 10.1126/science.1063916.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsCarcinogensCell LineCytotoxicity, ImmunologicDimerizationEpidermisEpithelial CellsHistocompatibility Antigens Class IHumansImmunologic SurveillanceLigandsMembrane ProteinsMiceMice, Inbred C57BLMinor Histocompatibility AntigensMolecular Sequence DataNK Cell Lectin-Like Receptor Subfamily KProtein ConformationProtein FoldingReceptors, Antigen, T-Cell, alpha-betaReceptors, Antigen, T-Cell, gamma-deltaReceptors, ImmunologicReceptors, Natural Killer CellRecombinant Fusion ProteinsReverse Transcriptase Polymerase Chain ReactionSkin NeoplasmsT-Lymphocyte SubsetsConceptsT cellsGammadelta cellsLocal T cellsNatural killer cellsΓδ T cellsGammadelta T cellsCytolytic T cellsSkin carcinoma cellsNKG2D engagementMultiple regimensKiller cellsCutaneous malignanciesCutaneous carcinogenesisEpithelial malignanciesRAE-1Human MICAMalignancyCarcinoma cellsSkin cellsCellsNKG2DRegimensMiceEpitheliumCarcinogenesisInduction of human tumor‐loaded dendritic cells
Berger C, Xu A, Hanlon D, Lee C, Schechner J, Glusac E, Christensen I, Snyder E, Holloway V, Tigelaar R, Edelson R. Induction of human tumor‐loaded dendritic cells. International Journal Of Cancer 2001, 91: 438-447. PMID: 11251964, DOI: 10.1002/1097-0215(200002)9999:9999<::aid-ijc1073>3.0.co;2-r.Peer-Reviewed Original ResearchMeSH KeywordsAntigens, CDApoptosisCD36 AntigensCell DifferentiationCell DivisionCell SurvivalCells, CulturedCytokinesCytoplasmDendritic CellsDose-Response Relationship, DrugFlow CytometryHumansImmunoglobulinsImmunohistochemistryImmunophenotypingImmunotherapyLeukapheresisLeukocytesLymphocytesMajor Histocompatibility ComplexMembrane GlycoproteinsMonocytesPhagocytosisPhenotypeTime FactorsT-LymphocytesConceptsExtracorporeal photopheresisDistinctive antigensTumor-loaded dendritic cellsStandard extracorporeal photopheresisMHC class II moleculesImproved cancer immunotherapyDendritic cell differentiationAnti-cancer vaccinesMalignant T cellsClass II moleculesTransition of monocytesDC vaccinesMalignant cell apoptosisDendritic cellsImmature DCsCancer immunotherapyCD83 expressionT cellsExogenous cytokinesSignificant proliferationCell apoptosisVaccineMembrane CD36Cell differentiationCells
1999
Stevens-Johnson syndrome limited to multiple sites of radiation therapy in a patient receiving phenobarbital
Duncan K, Tigelaar R, Bolognia J. Stevens-Johnson syndrome limited to multiple sites of radiation therapy in a patient receiving phenobarbital. Journal Of The American Academy Of Dermatology 1999, 40: 493-496. PMID: 10071329, DOI: 10.1016/s0190-9622(99)70508-6.Peer-Reviewed Case Reports and Technical NotesConceptsStevens-Johnson syndromeRadiation therapyAtypical erythema multiformeSevere cutaneous eruptionsSite of radiationToxic epidermal necrolysisEpidermal necrolysisCutaneous eruptionErythema multiformeAdverse reactionsTherapySyndromePhenobarbitalMultiple sitesNecrolysisMedicationsSecond casePatientsPhenytoinMultiforme
1995
Malignant and Normal T Cells Show Random Use of T-Cell Receptor ∝ Chain Variable Regions in Patients with Cutaneous T-Cell Lymphoma
Longley J, Tyrrell L, Lu S, Farrell J, Ding T, Yan S, Sallee D, Heald P, Berger C, Tigelaar R, Edelson R. Malignant and Normal T Cells Show Random Use of T-Cell Receptor ∝ Chain Variable Regions in Patients with Cutaneous T-Cell Lymphoma. Journal Of Investigative Dermatology 1995, 105: 62-64. PMID: 7615977, DOI: 10.1111/1523-1747.ep12312571.Peer-Reviewed Original ResearchConceptsCutaneous T-cell lymphomaT-cell lymphomaT cell receptorMalignant cellsRegion usagePathogenesis of CTCLNormal peripheral blood lymphocytesV region usagePeripheral blood lymphocytesNormal T cellsTCR V regionsMature T lymphocytesBeta-chain transcriptsBeta usageChain transcriptsOligoclonal patternAlpha usePeripheral bloodLeukemic patientsPolymerase chain reactionBlood lymphocytesChronic stimulationMalignant lymphocytesT cellsT lymphocytesTargetoid hemangioma associated with pregnancy and the menstrual cycle
Morganroth G, Tigelaar R, Longley B, Luck L, Leffell D. Targetoid hemangioma associated with pregnancy and the menstrual cycle. Journal Of The American Academy Of Dermatology 1995, 32: 282-284. PMID: 7829718, DOI: 10.1016/0190-9622(95)90149-3.Peer-Reviewed Case Reports and Technical Notes
1994
Superantigenic Staphylococcal Exotoxins Induce T-Cell Proliferation in the Presence of Langerhans Cells or Class II–Bearing Keratinocytes and Stimulate Keratinocytes to Produce T-Cell–Activating Cytokines
Tokura Y, Yagi J, O'Malley J, Lewis J, Takigawa M, Edelson R, Tigelaar R. Superantigenic Staphylococcal Exotoxins Induce T-Cell Proliferation in the Presence of Langerhans Cells or Class II–Bearing Keratinocytes and Stimulate Keratinocytes to Produce T-Cell–Activating Cytokines. Journal Of Investigative Dermatology 1994, 102: 31-38. PMID: 8288908, DOI: 10.1111/1523-1747.ep12371727.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, BacterialCell DivisionCells, CulturedCytokinesEnterotoxinsEnzyme-Linked Immunosorbent AssayEpidermal CellsEpidermisExfoliatinsFemaleHistocompatibility Antigens Class IIHumansInterferon-gammaInterleukin-1KeratinocytesLangerhans CellsLymphocyte ActivationMiceMice, Inbred BALB CMice, Inbred CBASpleenStaphylococcus aureusSuperantigensThymus GlandT-LymphocytesTumor Necrosis Factor-alphaConceptsStaphylococcal enterotoxin BT cell responsesLangerhans cellsT cellsExfoliative toxinAccessory cellsEnterotoxin BTumor necrosisT-cell receptor V beta gene segmentsT cell-activating cytokinesMajor histocompatibility complex (MHC) class II moleculesSuperantigen staphylococcal enterotoxin BMajor histocompatibility complex classMurine epidermal Langerhans cellsT-cell proliferative activityEpidermal Langerhans cellsSplenic T cellsT cell proliferationMurine splenic T cellsHistocompatibility complex classClass II moleculesEnzyme-linked immunosorbentBeta gene segmentsImmunostimulatory moleculesImmunomodulatory cytokines
1993
Skin-Selective Lymphocyte Homing Mechanisms in the Pathogenesis of Leukemic Cutaneous T-Cell Lymphoma
Heald P, Yan S, Edelson R, Tigelaar R, Picker L. Skin-Selective Lymphocyte Homing Mechanisms in the Pathogenesis of Leukemic Cutaneous T-Cell Lymphoma. Journal Of Investigative Dermatology 1993, 101: 222-226. PMID: 7688404, DOI: 10.1111/1523-1747.ep12364814.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAntigens, Differentiation, T-LymphocyteAntigens, NeoplasmCell Adhesion MoleculesEpitopesE-SelectinHumansLeukemia-Lymphoma, Adult T-CellLeukocyte Common AntigensLymphoma, T-Cell, CutaneousMembrane GlycoproteinsReceptors, Antigen, T-CellReceptors, Lymphocyte HomingSkin NeoplasmsT-LymphocytesConceptsCutaneous T-cell lymphomaT-cell lymphomaCutaneous lymphocyte antigenLymphocyte antigenT cellsErythrodermic cutaneous T-cell lymphomaLeukemic cutaneous T-cell lymphomaCutaneous T-cell lymphoma patientsSkin-associated lymphoid tissueT-cell lymphoma patientsTwo-color flow cytometryCutaneous host defenseT cells trafficMemory T cellsT cell subsetsCell surface phenotypeErythrodermic patientsLymphoma patientsPatient groupInflamed skinLymphoid tissueHoming receptorMalignant cloneLymphomaMalignant cellsIdiopathic CD4+ lymphocyte deficiency. Report of an unusual case associated with atopic dermatitis and allergic contact dermatitis and review of the literature.
Goodrich A, Tigelaar R, Watsky K, Heald P. Idiopathic CD4+ lymphocyte deficiency. Report of an unusual case associated with atopic dermatitis and allergic contact dermatitis and review of the literature. JAMA Dermatology 1993, 129: 876-8. PMID: 8100699, DOI: 10.1001/archderm.129.7.876.Peer-Reviewed Case Reports and Technical NotesConceptsIdiopathic CD4Allergic contact dermatitisLymphocyte deficiencyCutaneous manifestationsAtopic dermatitisOpportunistic infectionsContact dermatitisHuman immunodeficiency virus (HIV) infectionAcute opportunistic infectionsNew cutaneous manifestationImmunodeficiency virus infectionT-cell depletionUnique clinical presentationLymphocyte countClinical presentationCutaneous featuresSerologic evidenceClinical spectrumContact urticariaMinimal symptomsRisk factorsVirus infectionCD4Unusual caseDermatitis
1992
T Lymphocytes Bearing Gamma-Delta Antigen Receptors in Skin
Modlin R, Lewis J, Uyemura K, Tigelaar R. T Lymphocytes Bearing Gamma-Delta Antigen Receptors in Skin. Chemical Immunology And Allergy 1992, 53: 61-74. PMID: 1534236, DOI: 10.1159/000319103.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
1991
Adhesion Molecules CD11a, CD18, and ICAM-1 on Human Epidermal Langerhans Cells Serve a Functional Role in the Activation of Alloreactive T Cells
Simon J, Cruz P, Tigelaar R, Sontheimer R, Bergstresser P. Adhesion Molecules CD11a, CD18, and ICAM-1 on Human Epidermal Langerhans Cells Serve a Functional Role in the Activation of Alloreactive T Cells. Journal Of Investigative Dermatology 1991, 96: 148-151. PMID: 1670950, DOI: 10.1111/1523-1747.ep12515946.Peer-Reviewed Original ResearchConceptsPeripheral blood mononuclear leukocytesAdhesion molecules CD11aAlloreactive T cellsAntigen-presenting cellsLangerhans cellsT cellsICAM-1T cell activationAdhesion moleculesAccessory signalsAllogeneic peripheral blood mononuclear leukocytesHuman epidermal Langerhans cellsBlood mononuclear leukocytesEpidermal Langerhans cellsEpidermal cellsAdhesion molecule expressionTwo-color immunofluorescenceDependent T-cell activationRelevant adhesion moleculesEfficient T cell activationAllostimulatory capacityHuman epidermal cellsLC stimulationMolecule expressionMononuclear leukocytes
1990
TCR γ/δ+ Dendritic Epidermal T Cells as Constituents of Skin-Associated Lymphoid Tissue
Tigelaar R, Lewis J, Bergstresser P. TCR γ/δ+ Dendritic Epidermal T Cells as Constituents of Skin-Associated Lymphoid Tissue. Journal Of Investigative Dermatology 1990, 94: s58-s63. PMID: 1972173, DOI: 10.1111/1523-1747.ep12875138.Peer-Reviewed Original ResearchConceptsDendritic epidermal T cellsGamma/delta cellsT cell antigen receptorEpidermal T cellsT cellsCD4-CD8Alpha/beta T cell antigen receptorGamma/delta typeSkin-Associated Lymphoid TissueBone marrow-derived cellsGamma/delta populationsClass II MHC moleculesDelta cellsMarrow-derived cellsTCR junctional regionsEarly fetal thymocytesMHC-like moleculesLangerhans cellsLymphoid tissueTCR heterogeneityNormal miceMHC moleculesThy-1Fetal thymocytesMHC type
1988
Effect of Keratinocyte Cytokines on Thy‐1+ Dendritic Epidermal Cells
TIGELAAR R, NIXON‐FULTON J, TAKASHIMA A, KUZIEL W, TAKIJIRI C, LEWIS J, TUCKER P, BERGSTRESSER P. Effect of Keratinocyte Cytokines on Thy‐1+ Dendritic Epidermal Cells. Annals Of The New York Academy Of Sciences 1988, 548: 271-282. PMID: 2470301, DOI: 10.1111/j.1749-6632.1988.tb18815.x.Peer-Reviewed Original Research
1987
Hyperkeratotic Papules on the Hands and Feet
Blum S, Cruz P, Siegel D, Tigelaar R. Hyperkeratotic Papules on the Hands and Feet. JAMA Dermatology 1987, 123: 1225-1226. DOI: 10.1001/archderm.1987.01660330136027.Peer-Reviewed Case Reports and Technical NotesConceptsIntravenous drug abusersParkland Memorial HospitalPunch biopsy specimenIdiopathic cardiomyopathyPhysical examinationPrescription medicationsBiopsy specimenMemorial HospitalDermatology consultationHyperkeratotic papulesSimilar lesionsLateral aspectDorsal aspectDrug abusersPapulesEarly childhoodBlack womenFinger jointsFamily membersFootNumerous roundMedicationsPatientsCardiomyopathyHospital
1986
Ataxia‐telangiectasia Associated with Sarcoidosis
Fleck R, Myers L, Wasserman R, Tigelaar R, Freeman R. Ataxia‐telangiectasia Associated with Sarcoidosis. Pediatric Dermatology 1986, 3: 339-343. PMID: 3774655, DOI: 10.1111/j.1525-1470.1986.tb00537.x.Peer-Reviewed Case Reports and Technical Notes
1985
Lymphocyte Traffic and the Skin
Tigelaar R. Lymphocyte Traffic and the Skin. Dermatologic Clinics 1985, 3: 569-585. PMID: 3916171, DOI: 10.1016/s0733-8635(18)30857-x.Peer-Reviewed Original ResearchConceptsPeripheral lymph nodesLymph nodesLymphocyte migrationEndothelial cellsLymphoid organsImmunologic influenceMesenteric lymph nodesMovement of lymphocytesLymphocyte membrane receptorsDifferent organ sitesSpecialized endothelial cellsNonlymphoid organsLymphocyte trafficImmunologic defenseT cellsGastrointestinal tractOrgan sitesBlast transformationMajor subsetSkinLymphocytesCommon determinantsOrgansMembrane receptorsCellsConjugated avidin binds to mast cell granules.
Tharp M, Seelig L, Tigelaar R, Bergstresser P. Conjugated avidin binds to mast cell granules. Journal Of Histochemistry & Cytochemistry 1985, 33: 27-32. PMID: 2578142, DOI: 10.1177/33.1.2578142.Peer-Reviewed Original Research