1992
Peptidergic Neurons and Vasoactive Intestinal Peptide Modulate Experimental Delayed‐Type Hypersensitivity Reactionsa
GIROLOMONI G, TIGELAAR R. Peptidergic Neurons and Vasoactive Intestinal Peptide Modulate Experimental Delayed‐Type Hypersensitivity Reactionsa. Annals Of The New York Academy Of Sciences 1992, 650: 9-12. PMID: 1605501, DOI: 10.1111/j.1749-6632.1992.tb49087.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCapsaicinDermatitis, ContactHypersensitivity, DelayedMiceMice, Inbred BALB CNeuroimmunomodulationNeuropeptidesVasoactive Intestinal PeptideT Lymphocytes Bearing Gamma-Delta Antigen Receptors in Skin
Modlin R, Lewis J, Uyemura K, Tigelaar R. T Lymphocytes Bearing Gamma-Delta Antigen Receptors in Skin. Chemical Immunology And Allergy 1992, 53: 61-74. PMID: 1534236, DOI: 10.1159/000319103.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
1990
Capsaicin-sensitive primary sensory neurons are potent modulators of murine delayed-type hypersensitivity reactions.
Girolomoni G, Tigelaar R. Capsaicin-sensitive primary sensory neurons are potent modulators of murine delayed-type hypersensitivity reactions. The Journal Of Immunology 1990, 145: 1105-12. PMID: 2380551, DOI: 10.4049/jimmunol.145.4.1105.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCapsaicinDermatitis, ContactFemaleHypersensitivity, DelayedLymph NodesMast CellsMiceMice, Inbred BALB CNeurons, AfferentNeuropeptidesPainConceptsDelayed-type hypersensitivity reactionPrimary sensory neuronsHypersensitivity reactionsSensory neuronsCapsaicin-sensitive primary sensory neuronsBALB/c miceCapsaicin-pretreated miceEffector T cellsContact sensitivity reactionAdoptive transfer experimentsCutaneous inflammatory reactionsTopical capsaicinCapsaicin pretreatmentNeurogenic inflammationC miceNeuropeptide releaseHistologic studyInflammatory reactionT cellsPeptidergic neuronsIrritant reactionsSensitivity reactionsSuch neuronsCapsaicinPotent modulatorRoles of CD4+ and CD8+ T cells in murine contact sensitivity revealed by in vivo monoclonal antibody depletion.
Gocinski B, Tigelaar R. Roles of CD4+ and CD8+ T cells in murine contact sensitivity revealed by in vivo monoclonal antibody depletion. The Journal Of Immunology 1990, 144: 4121-8. PMID: 1971294, DOI: 10.4049/jimmunol.144.11.4121.Peer-Reviewed Original ResearchConceptsEffector cellsVivo depletionBALB/c miceEffector roleCS effector cellsMonoclonal antibody depletionMurine contact sensitivityDepletion of CD4Depletion of CD8Contact sensitivity responseRole of CD4Activity of CD8Delayed-type hypersensitivityT cell subsetsCutaneous hypersensitivity responseT-cell phenotypeImportant effector roleSubsequent flow cytometric analysisFlow cytometric analysisEnhanced earImmune lymphResidual CD4Adoptive transferSuppressor cellsDistinct CD4Langerhans cells that migrate to skin after intravenous infusion regulate the induction of contact hypersensitivity.
Cruz P, Tigelaar R, Bergstresser P. Langerhans cells that migrate to skin after intravenous infusion regulate the induction of contact hypersensitivity. The Journal Of Immunology 1990, 144: 2486-92. PMID: 1969448, DOI: 10.4049/jimmunol.144.7.2486.Peer-Reviewed Original ResearchConceptsLow-dose UVB radiationContact hypersensitivityLangerhans cellsIntravenous infusionLow-dose ultraviolet B (UVB) radiationExposure of LCThy-1UVB radiationSuppressor signalsMesenteric lymph nodesLow-dose UVBEffector signalsSkin graft experimentsLC migrationImmunologic targetsLymph nodesAllogeneic transferCH responsesLymphoid tissueImmune responseSyngeneic miceImmunization modelImmunogenic propertiesInfusionUltraviolet B radiationUVB Radiation and DNFB Skin Painting Induce Suppressor Cells Universally in Mice
Glass M, Bergstresser P, Tigelaar R, Streilein J. UVB Radiation and DNFB Skin Painting Induce Suppressor Cells Universally in Mice. Journal Of Investigative Dermatology 1990, 94: 273-278. PMID: 1689757, DOI: 10.1111/1523-1747.ep12874117.Peer-Reviewed Original ResearchConceptsSuppressor T cellsStrains of miceContact hypersensitivityLangerhans cellsT cellsSuppressor cellsHapten-specific suppressor T cellsInduction of CHSUVB-susceptible strainsT suppressor cellsTreatment of miceAntigen-presenting cellsEpidermal Langerhans cellsEffects of UVBEffector mechanismsMurine skinMiceUVBUVB radiationSkinInductionDinitrofluorobenzeneCellsUVRApparent effect
1989
Disparate Effects of In Vitro Low-Dose UVB Irradiation on Intravenous Immunization with Purified Epidermal Cell Subpopulations for the Induction of Contact Hypersensitivity
Cruz P, Nixon-Fulton J, Tigelaar R, Bergstresser P. Disparate Effects of In Vitro Low-Dose UVB Irradiation on Intravenous Immunization with Purified Epidermal Cell Subpopulations for the Induction of Contact Hypersensitivity. Journal Of Investigative Dermatology 1989, 92: 160-165. PMID: 2918229, DOI: 10.1111/1523-1747.ep12276682.Peer-Reviewed Original ResearchConceptsIntravenous immunizationCH responsesLow-dose UVB irradiationUVB irradiationLow-dose UVB radiationC3H/HeJ miceLow-dose ultraviolet B irradiationModel of immunosuppressionAntigen-presenting functionContact hypersensitivity reactionCapacity of ECUltraviolet B irradiationContact hypersensitivityEffects of UVBSubsequent immunizationHypersensitivity reactionsHeJ miceLeft earEpidermal cell subpopulationsSyngeneic miceRight earPanel of miceDay 14Day 0Abdominal skin
1986
Induction and regulation of contact hypersensitivity by resident, bone marrow-derived, dendritic epidermal cells: Langerhans cells and Thy-1+ epidermal cells.
Sullivan S, Bergstresser P, Tigelaar R, Streilein J. Induction and regulation of contact hypersensitivity by resident, bone marrow-derived, dendritic epidermal cells: Langerhans cells and Thy-1+ epidermal cells. The Journal Of Immunology 1986, 137: 2460-7. PMID: 2876041, DOI: 10.4049/jimmunol.137.8.2460.Peer-Reviewed Original ResearchConceptsContact hypersensitivityBone marrow-derived populationLangerhans cellsThy-1Epicutaneous applicationInduction of CHSRegulation of CHSDendritic epidermal cellsRoute of immunizationEpidermal Langerhans cellsSpecific unresponsivenessAntigenic encounterCH responsesImmunogenic signalsSyngeneic miceImmunogenic capacityAntigenic signalIntact skinMouse skinCellular elementsEpidermal cellsHypersensitivityMiceCell typesInduction
1983
Analysis of the mechanism of unresponsiveness produced by haptens painted on skin exposed to low dose ultraviolet radiation.
Elmets C, Bergstresser P, Tigelaar R, Wood P, Streilein J. Analysis of the mechanism of unresponsiveness produced by haptens painted on skin exposed to low dose ultraviolet radiation. Journal Of Experimental Medicine 1983, 158: 781-794. PMID: 6193234, PMCID: PMC2187099, DOI: 10.1084/jem.158.3.781.Peer-Reviewed Original ResearchConceptsTolerogenic signalsLow-dose ultraviolet B (UVB) radiationLow-dose ultraviolet radiationAntigen-presenting potentialAntigen-specific unresponsivenessResident Langerhans cellsMechanism of unresponsivenessSuppressor cellsContact hypersensitivityLyt-1Effector stageLangerhans cellsSystemic administrationT cellsLocal applicationUltraviolet B radiationInduction phaseB radiationUnresponsivenessSkinUltraviolet radiationCellsTolerogenDNFBHypersensitivityContact hypersensitivity reactions to dinitrofluorobenzene mediated by monoclonal IgE anti-DNP antibodies.
Ray M, Tharp M, Sullivan T, Tigelaar R. Contact hypersensitivity reactions to dinitrofluorobenzene mediated by monoclonal IgE anti-DNP antibodies. The Journal Of Immunology 1983, 131: 1096-102. PMID: 6193174, DOI: 10.4049/jimmunol.131.3.1096.Peer-Reviewed Original ResearchConceptsContact hypersensitivity reactionHypersensitivity reactionsDNFB challengeUnsensitized controlsAntigen challengeReactive haptenMonoclonal IgE anti-DNP antibodyIgE anti-DNP antibodyIgE anti-hapten antibodyBALB/c miceAllergic contact dermatitis reactionsBiphasic patternIgE-sensitized miceEars of miceCutaneous hypersensitivity reactionsCutaneous hypersensitivity responseCutaneous inflammatory reactionsContact dermatitis reactionsFailure of miceAnti-hapten antibodiesAnti-DNP antibodiesEar challengeEar swellingHypersensitivity responseIgE antibodies
1982
Oral ingestion of epicutaneously applied hapten in mice may unwittingly induce down-regulation of contact hypersensitivity.
Tigelaar R, Bergstresser P, Lonsberry L, Elmets C, Wood P, Streilen J. Oral ingestion of epicutaneously applied hapten in mice may unwittingly induce down-regulation of contact hypersensitivity. The Journal Of Immunology 1982, 129: 1898-904. PMID: 6749982, DOI: 10.4049/jimmunol.129.5.1898.Peer-Reviewed Original Research