Altered response to antidepressant treatment in FoxG1 heterozygous knockout mice
Kinsler R, Taylor MM, Flores NM, Leffert JJ, Beech RD. Altered response to antidepressant treatment in FoxG1 heterozygous knockout mice. Synapse 2009, 64: 169-171. PMID: 19852072, PMCID: PMC2789865, DOI: 10.1002/syn.20737.Peer-Reviewed Original ResearchConceptsAdult hippocampal neurogenesisTail suspension testDifferent rodent modelsHeterozygous knockout miceForkhead box protein G1Heterozygous null miceRole of Foxg1Phosphatidyl inositol 3 kinaseContextual fear learningMechanism of actionAntidepressant actionHippocampal neurogenesisNeurogenic propertiesSwim testMood disordersRodent modelsSuspension testAntidepressantsKnockout miceLittermate controlsBehavioral abnormalitiesNull miceNormal levelsFOXG1 geneAltered response