2017
Randomized, Controlled Trial of TRC101 to Increase Serum Bicarbonate in Patients with CKD
Bushinsky DA, Hostetter T, Klaerner G, Stasiv Y, Lockey C, McNulty S, Lee A, Parsell D, Mathur V, Li E, Buysse J, Alpern R. Randomized, Controlled Trial of TRC101 to Increase Serum Bicarbonate in Patients with CKD. Clinical Journal Of The American Society Of Nephrology 2017, 13: 26-35. PMID: 29102959, PMCID: PMC5753317, DOI: 10.2215/cjn.07300717.Peer-Reviewed Original ResearchConceptsSerum bicarbonateEnd of treatmentMetabolic acidosisTreatment groupsBaseline serum bicarbonateMean baseline eGFRMEq/LSignificant adverse effectsBaseline eGFRGastrointestinal eventsAdverse eventsFirst doseControlled TrialsHeart failurePatientsCKDBaseline levelsMean increaseAbstractTextUnit studiesAcidosisAdverse effectsPlaceboTreatmentDays
2011
Defining hypercalciuria in nephrolithiasis
Pak CY, Sakhaee K, Moe OW, Poindexter J, Adams-Huet B, Pearle MS, Zerwekh JE, Preminger GM, Wills MR, Breslau NA, Bartter FC, Brater DC, Heller HJ, Odvina CV, Wabner CL, Fordtran JS, Oh M, Garg A, Harvey JA, Alpern RJ, Snyder WH, Peters PC. Defining hypercalciuria in nephrolithiasis. Kidney International 2011, 80: 777-782. PMID: 21775970, PMCID: PMC4354881, DOI: 10.1038/ki.2011.227.Peer-Reviewed Original ResearchConceptsAbsorptive hypercalciuria type IUrinary calcium excretionMean urinary calciumCalcium excretionUrinary calciumStone formersUpper normal limitKidney stone formersType IOptimal cutoff pointNon-stone formersCharacteristic curve analysisAbsorptive hypercalciuriaRetrospective studyNormal limitsDietary variablesHypercalciuriaCutoff pointDietary influencesNormal individualsPatientsCurve analysisExcretionConstant dietDiet
1997
Metabolic alkalosis.
Palmer BF, Alpern RJ. Metabolic alkalosis. Journal Of The American Society Of Nephrology 1997, 8: 1462-9. PMID: 9294840, DOI: 10.1681/asn.v891462.Peer-Reviewed Original ResearchThe clinical spectrum of chronic metabolic acidosis: Homeostatic mechanisms produce significant morbidity
Alpern R, Sakhaee K. The clinical spectrum of chronic metabolic acidosis: Homeostatic mechanisms produce significant morbidity. American Journal Of Kidney Diseases 1997, 29: 291-302. PMID: 9016905, DOI: 10.1016/s0272-6386(97)90045-7.Peer-Reviewed Original ResearchConceptsChronic metabolic acidosisMetabolic acidosisHomeostatic responseSerum HCO3Acid loadBody's homeostatic responseHomeostatic mechanismsMuscle protein breakdownNormal homeostatic mechanismsSignificant morbidityClinical spectrumMeat ingestionBone demineralizationRenal growthClinical conditionsPathologic processesPathologic consequencesAcidosisProtein breakdownBloodResponseMorbidityPatientsNephrolithiasisIngestion
1993
The renal proximal tubule renin-angiotensin system.
Moe O, Alpern R, Henrich W. The renal proximal tubule renin-angiotensin system. Seminars In Nephrology 1993, 13: 552-7. PMID: 8278688.Peer-Reviewed Original ResearchConceptsProximal tubule renin-angiotensin systemProximal tubulesRenin-angiotensin systemAutosomal dominant polycystic kidney diseaseDominant polycystic kidney diseasePolycystic kidney diseaseEssential hypertensionKidney diseasePathogenetic roleRenal vasculatureJG cellsCyst growthMammalian proximal tubuleHypertensionReninTubulesComplete RASPatientsDiseaseAutocrineParacrineRAVasculature