2013
Chapter 38 Pathophysiology of Sodium Retention and Wastage
Palmer B, Alpern R, Seldin D. Chapter 38 Pathophysiology of Sodium Retention and Wastage. 2013, 1283-1317. DOI: 10.1016/b978-0-12-381462-3.00038-0.Peer-Reviewed Original Research
2011
Defining hypercalciuria in nephrolithiasis
Pak CY, Sakhaee K, Moe OW, Poindexter J, Adams-Huet B, Pearle MS, Zerwekh JE, Preminger GM, Wills MR, Breslau NA, Bartter FC, Brater DC, Heller HJ, Odvina CV, Wabner CL, Fordtran JS, Oh M, Garg A, Harvey JA, Alpern RJ, Snyder WH, Peters PC. Defining hypercalciuria in nephrolithiasis. Kidney International 2011, 80: 777-782. PMID: 21775970, PMCID: PMC4354881, DOI: 10.1038/ki.2011.227.Peer-Reviewed Original ResearchConceptsAbsorptive hypercalciuria type IUrinary calcium excretionMean urinary calciumCalcium excretionUrinary calciumStone formersUpper normal limitKidney stone formersType IOptimal cutoff pointNon-stone formersCharacteristic curve analysisAbsorptive hypercalciuriaRetrospective studyNormal limitsDietary variablesHypercalciuriaCutoff pointDietary influencesNormal individualsPatientsCurve analysisExcretionConstant dietDiet
2001
Endothelin-1/endothelin-B receptor–mediated increases in NHE3 activity in chronic metabolic acidosis
Laghmani K, Preisig P, Moe O, Yanagisawa M, Alpern R. Endothelin-1/endothelin-B receptor–mediated increases in NHE3 activity in chronic metabolic acidosis. Journal Of Clinical Investigation 2001, 107: 1563-1569. PMID: 11413164, PMCID: PMC200190, DOI: 10.1172/jci11234.Peer-Reviewed Original ResearchMeSH KeywordsAcidosisAmmoniaAnimalsBicarbonatesChronic DiseaseCitric AcidCulture TechniquesEndothelin-1EndothelinsKidney Tubules, ProximalMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicProtein PrecursorsReceptor, Endothelin BReceptors, EndothelinRNA, MessengerSodiumSodium-Hydrogen Exchanger 3Sodium-Hydrogen ExchangersConceptsTg/tgAcid ingestionTitratable acid excretionMetabolic acidosisNHE3 activityAcid excretionReceptor-deficient miceEndothelin B receptorET-1 expressionChronic metabolic acidosisProximal tubule suspensionsAmmonium excretionM endothelinNa/H antiporterC57BL/6 miceApical membrane NHE3Renal epithelial cellsCultured renal epithelial cellsEndothelin-1/Tubule suspensionsMRNA expressionControl dietMiceExcretionEpithelial cells
2000
Endocrine Control of Acid‐Base Balance
Alpern R. Endocrine Control of Acid‐Base Balance. 2000, 570-603. DOI: 10.1002/cphy.cp070315.Peer-Reviewed Original ResearchAtrial natriuretic factorRenal acid excretionRenal acid-base regulationAcid-base balanceUrinary bufferParathyroid hormoneAngiotensin IINatriuretic factorGlomerular filtrationAcid excretionThyroid hormonesSteroid hormonesEndocrine controlHormonePeptide hormonesCatecholaminesSignaling intermediatesAdrenergic catecholaminesAcid-base regulationEndothelinMineralocorticoidsGlucocorticoidsExcretionInsulinRenal citrate metabolism and urinary citrate excretion in the infant rat
Melnick J, Preisig P, Alpern R, Baum M. Renal citrate metabolism and urinary citrate excretion in the infant rat. Kidney International 2000, 57: 891-897. PMID: 10720942, PMCID: PMC4089854, DOI: 10.1046/j.1523-1755.2000.057003891.x.Peer-Reviewed Original ResearchConceptsUrinary citrate excretionHigher urinary citrateCitrate excretionInfant ratsAdult ratsUrinary citrateRenal citrate metabolismMitochondrial aconitase activityCreatinine ratioCitrate metabolismRenal excretionSame prevalenceRenal stonesTwofold higher concentrationLower plasmaATP citrate lyase activityProximal tubulesHigher plasmaMetabolic cagesRat kidneyRatsAdult levelsInfantsMaturational differencesExcretion
1995
Chronic regulation of the proximal tubular Na/H antiporter: From HCO3 to SRC
Alpern R, Moe O, Preisig P. Chronic regulation of the proximal tubular Na/H antiporter: From HCO3 to SRC. Kidney International 1995, 48: 1386-1396. PMID: 8544394, DOI: 10.1038/ki.1995.427.Peer-Reviewed Original ResearchConceptsNa/H antiporterChronic regulationH secretionProximal tubulesH antiporterNaCl absorptionProximal tubular acidificationMajor siteNa/K pumpCitrate reabsorptionBasolateral membraneTubular acidificationAcute regulationLuminal membraneK pumpExcretionReabsorptionSecretionPivotal roleVacuolar H-ATPaseH-ATPaseTubules
1992
Citraturic Response to Oral Citric Acid Load
Sakhaee K, Alpern R, Poindexter J, Pak C. Citraturic Response to Oral Citric Acid Load. Journal Of Urology 1992, 147: 975-976. PMID: 1552616, DOI: 10.1016/s0022-5347(17)37437-2.Peer-Reviewed Original ResearchConceptsAcid loadCitraturic responseUrinary citrateCarbon dioxide pressureSingle oral loadUrinary citrate excretionSingle oral doseSerum citrate concentrationAcid-base balanceCitraturic effectsOral loadVenous pHOral doseSerum electrolytesUrinary pHCitrate excretionNormal subjectsAlkali loadPotassium citrateSignificant differencesHoursTotal carbon dioxideCitrateExcretionCitrate concentration
1991
Chronic K depletion stimulates rat renal brush-border membrane Na-citrate cotransporter
Levi M, McDonald LA, Preisig PA, Alpern RJ. Chronic K depletion stimulates rat renal brush-border membrane Na-citrate cotransporter. American Journal Of Physiology 1991, 261: f767-f773. PMID: 1683169, DOI: 10.1152/ajprenal.1991.261.5.f767.Peer-Reviewed Original ResearchContrasting Effects of Various Potassium Salts on Renal Citrate Excretion*
SAKHAEE K, ALPERN R, JACOBSON H, PAK C. Contrasting Effects of Various Potassium Salts on Renal Citrate Excretion*. The Journal Of Clinical Endocrinology & Metabolism 1991, 72: 396-400. PMID: 1899422, DOI: 10.1210/jcem-72-2-396.Peer-Reviewed Original ResearchConceptsCitrate clearanceAcid-base statusUrinary citratePotassium citrateRenal citrate excretionMeq/dayPotassium citrate treatmentWeeks of treatmentNet acid excretionCitraturic responseUrinary ammoniumOral administrationCitrate excretionAcid excretionPotassium chlorideUrinary bicarbonateCitrate treatmentAlkali loadPotassium bicarbonateClearanceML/minExcretionDaysTreatmentTitratable acid