2008
Maintenance treatment with buprenorphine and naltrexone for heroin dependence in Malaysia: a randomised, double-blind, placebo-controlled trial
Schottenfeld RS, Chawarski MC, Mazlan M. Maintenance treatment with buprenorphine and naltrexone for heroin dependence in Malaysia: a randomised, double-blind, placebo-controlled trial. The Lancet 2008, 371: 2192-2200. PMID: 18586174, PMCID: PMC4041792, DOI: 10.1016/s0140-6736(08)60954-x.Peer-Reviewed Original ResearchConceptsFirst heroin useHIV risk behaviorsHeroin dependenceHeroin useHeroin relapseMaintenance treatmentHeroin abstinenceDrug counsellingComputer-generated randomisation sequenceRisk behaviorsEffective public health approachConsecutive daysInterim safety analysisOutpatient research clinicPlacebo-controlled trialEfficacy of naltrexoneHeroin-dependent patientsMonths of enrollmentPrevention of relapseWorldwide health priorityPublic health approachRandomisation sequencePrimary outcomeHIV transmissionHIV risk
2005
Methadone Versus Buprenorphine With Contingency Management or Performance Feedback for Cocaine and Opioid Dependence
Schottenfeld RS, Chawarski MC, Pakes JR, Pantalon MV, Carroll KM, Kosten TR. Methadone Versus Buprenorphine With Contingency Management or Performance Feedback for Cocaine and Opioid Dependence. American Journal Of Psychiatry 2005, 162: 340-349. PMID: 15677600, DOI: 10.1176/appi.ajp.162.2.340.Peer-Reviewed Original ResearchConceptsCo-occurring cocaineDrug-free testOpioid dependenceMaintenance treatmentContingency managementOpioid agonist maintenance treatmentAgonist maintenance treatmentDaily sublingual buprenorphineEffects of buprenorphinePrimary outcome measureMixed-model repeated-measures analysisDouble-blind designUrine test resultsNarcotic treatment programsVoucher valueRepeated-measures analysisSublingual buprenorphineTreatment guidelinesIllicit opioidsUrine testsTreatment outcomesOutcome measuresSustained abstinenceWeek 13Buprenorphine