2024
Deleting the mitochondrial respiration negative regulator MCJ enhances the efficacy of CD8+ T cell adoptive therapies in pre-clinical studies
Wu M, Valenca-Pereira F, Cendali F, Giddings E, Pham-Danis C, Yarnell M, Novak A, Brunetti T, Thompson S, Henao-Mejia J, Flavell R, D’Alessandro A, Kohler M, Rincon M. Deleting the mitochondrial respiration negative regulator MCJ enhances the efficacy of CD8+ T cell adoptive therapies in pre-clinical studies. Nature Communications 2024, 15: 4444. PMID: 38789421, PMCID: PMC11126743, DOI: 10.1038/s41467-024-48653-y.Peer-Reviewed Original ResearchConceptsMethylation-controlled J proteinCAR-T cellsEfficacy of adoptive T cell therapyCD8+ CAR T cellsAdoptive T cell therapyT-cell therapyCD8 cellsT cellsOvalbumin (OVA)-specific CD8T cell adoptive therapyCD8+ T cellsMelanoma tumors in vivoFunction of T cellsAdoptive cellular therapyMurine B-cell leukemiaPromote T cell functionB-cell leukemiaT cell functionTumors in vivoPre-clinical studiesAnti-tumor activityIn vivo efficacyAdoptive therapyPotential therapeutic strategyEndogenous negative regulator
2022
Mouse pulmonary interstitial macrophages mediate the pro-tumorigenic effects of IL-9
Fu Y, Pajulas A, Wang J, Zhou B, Cannon A, Cheung CCL, Zhang J, Zhou H, Fisher AJ, Omstead DT, Khan S, Han L, Renauld JC, Paczesny S, Gao H, Liu Y, Yang L, Tighe RM, Licona-Limón P, Flavell RA, Takatsuka S, Kitamura D, Sun J, Bilgicer B, Sears CR, Yang K, Kaplan MH. Mouse pulmonary interstitial macrophages mediate the pro-tumorigenic effects of IL-9. Nature Communications 2022, 13: 3811. PMID: 35778404, PMCID: PMC9249769, DOI: 10.1038/s41467-022-31596-7.Peer-Reviewed Original ResearchConceptsLung tumor growthIL-9Tumor growthAdoptive cell transfer therapyPulmonary interstitial macrophagesPotent anti-tumor activityLung cancer patientsCell transfer therapyLung tumor modelLung cancer therapyMultiple mouse modelsPotential therapeutic targetIL-9 signalingAnti-tumor activityPro-tumorigenic effectsAdoptive transferMacrophage axisPoor outcomePoor prognosisCancer patientsLung cancerArginase-1Interstitial macrophagesIL-9RInterstitial macrophage population