Featured Publications
Comparison of Bolus and Infusion Methods for Receptor Quantitation: Application to [18F]Cyclofoxy and Positron Emission Tomography
Carson R, Channing M, Blasberg R, Dunn B, Cohen R, Rice K, Herscovitch P. Comparison of Bolus and Infusion Methods for Receptor Quantitation: Application to [18F]Cyclofoxy and Positron Emission Tomography. Cerebrovascular And Brain Metabolism Reviews 1993, 13: 24-42. PMID: 8380178, DOI: 10.1038/jcbfm.1993.6.Peer-Reviewed Original Research
2018
Evaluation of Pancreatic VMAT2 Binding with Active and Inactive Enantiomers of [18F]FP-DTBZ in Healthy Subjects and Patients with Type 1 Diabetes
Naganawa M, Lim K, Nabulsi NB, Lin SF, Labaree D, Ropchan J, Herold KC, Huang Y, Harris P, Ichise M, Cline GW, Carson RE. Evaluation of Pancreatic VMAT2 Binding with Active and Inactive Enantiomers of [18F]FP-DTBZ in Healthy Subjects and Patients with Type 1 Diabetes. Molecular Imaging And Biology 2018, 20: 835-845. PMID: 29468404, PMCID: PMC6533199, DOI: 10.1007/s11307-018-1170-6.Peer-Reviewed Original ResearchConceptsVesicular monoamine transporter type 2Non-displaceable uptakeHealthy controlsSUV ratioType 1 diabetes mellitus groupInactive enantiomerDiabetes mellitus groupBeta-cell massFirst human studyGroup differencesPositron emission tomography (PET) radiotracerTransporter type 2Mellitus groupVT valuesSignificant group differencesT1DM patientsRenal cortexHealthy subjectsPurposePrevious studiesHuman studiesUptake valueType 2Separate daysDistribution volumeReference SUV
1998
Assessment of Dynamic Neurotransmitter Changes With Bolus or Infusion Delivery of Neuroreceptor Ligands
Endres C, Carson R. Assessment of Dynamic Neurotransmitter Changes With Bolus or Infusion Delivery of Neuroreceptor Ligands. Cerebrovascular And Brain Metabolism Reviews 1998, 18: 1196-1210. PMID: 9809509, DOI: 10.1097/00004647-199811000-00006.Peer-Reviewed Original ResearchBrainCarbon RadioisotopesComputer SimulationDopamineDopamine AntagonistsFlumazenilHumansInfusions, ParenteralInjectionsKineticsMicrodialysisModels, NeurologicalNaltrexoneNarcotic AntagonistsRacloprideRadioligand AssayReceptors, DopamineSalicylamidesSensitivity and SpecificityTomography, Emission-Computed