Featured Publications
Comparison of Bolus and Infusion Methods for Receptor Quantitation: Application to [18F]Cyclofoxy and Positron Emission Tomography
Carson R, Channing M, Blasberg R, Dunn B, Cohen R, Rice K, Herscovitch P. Comparison of Bolus and Infusion Methods for Receptor Quantitation: Application to [18F]Cyclofoxy and Positron Emission Tomography. Cerebrovascular And Brain Metabolism Reviews 1993, 13: 24-42. PMID: 8380178, DOI: 10.1038/jcbfm.1993.6.Peer-Reviewed Original Research
2023
Markerless head motion tracking and event-by-event correction in brain PET
Zeng T, Lu Y, Jiang W, Zheng J, Zhang J, Gravel P, Wan Q, Fontaine K, Mulnix T, Jiang Y, Yang Z, Revilla E, Naganawa M, Toyonaga T, Henry S, Zhang X, Cao T, Hu L, Carson R. Markerless head motion tracking and event-by-event correction in brain PET. Physics In Medicine And Biology 2023, 68: 245019. PMID: 37983915, PMCID: PMC10713921, DOI: 10.1088/1361-6560/ad0e37.Peer-Reviewed Original ResearchConceptsPoint source studyHead motion correctionSmaller residual displacementMotion correctionIterative closest point (ICP) registration algorithmHead motion trackingSpatial resolutionResidual displacementData-driven evaluation methodHigh spatial resolutionLow noiseMotion trackingStereovision cameraMotion tracking deviceStructured lightEvent correctionBrain positron emission tomography (PET) imagingTracking deviceReconstruction resultsHMT methodPoint cloudsNegative biasReference cloudUMTEvaluation method
2020
Data-Driven Motion Detection and Event-by-Event Correction for Brain PET: Comparison with Vicra
Lu Y, Naganawa M, Toyonaga T, Gallezot JD, Fontaine K, Ren S, Revilla EM, Mulnix T, Carson RE. Data-Driven Motion Detection and Event-by-Event Correction for Brain PET: Comparison with Vicra. Journal Of Nuclear Medicine 2020, 61: 1397-1403. PMID: 32005770, PMCID: PMC7456171, DOI: 10.2967/jnumed.119.235515.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsBrainHumansImage Processing, Computer-AssistedMovementPositron-Emission TomographyConceptsData-driven algorithmMotion correction methodMotion tracking informationHead motionCentroid of distributionMotion-compensated reconstructionLarge head motionsMotion correction frameworkUser-defined thresholdPET raw dataDynamic datasetsTracking informationImage registrationMotion detectionRaw dataSuch time pointsImage qualityBetter performanceMotion correctionAlgorithmLine of responseCorrection frameworkBrain PET studiesCentral coordinatesTracer kinetic modeling
2019
Assessment of a white matter reference region for 11C-UCB-J PET quantification
Rossano S, Toyonaga T, Finnema SJ, Naganawa M, Lu Y, Nabulsi N, Ropchan J, De Bruyn S, Otoul C, Stockis A, Nicolas JM, Martin P, Mercier J, Huang Y, Maguire RP, Carson RE. Assessment of a white matter reference region for 11C-UCB-J PET quantification. Cerebrovascular And Brain Metabolism Reviews 2019, 40: 1890-1901. PMID: 31570041, PMCID: PMC7446568, DOI: 10.1177/0271678x19879230.Peer-Reviewed Original ResearchEvent-by-event non-rigid data-driven PET respiratory motion correction methods: comparison of principal component analysis and centroid of distribution
Ren S, Lu Y, Bertolli O, Thielemans K, Carson RE. Event-by-event non-rigid data-driven PET respiratory motion correction methods: comparison of principal component analysis and centroid of distribution. Physics In Medicine And Biology 2019, 64: 165014. PMID: 30822762, DOI: 10.1088/1361-6560/ab0bc9.Peer-Reviewed Original ResearchData-driven voluntary body motion detection and non-rigid event-by-event correction for static and dynamic PET
Lu Y, Gallezot JD, Naganawa M, Ren S, Fontaine K, Wu J, Onofrey JA, Toyonaga T, Boutagy N, Mulnix T, Panin VY, Casey ME, Carson RE, Liu C. Data-driven voluntary body motion detection and non-rigid event-by-event correction for static and dynamic PET. Physics In Medicine And Biology 2019, 64: 065002. PMID: 30695768, DOI: 10.1088/1361-6560/ab02c2.Peer-Reviewed Original Research
2017
Cardiac‐gated parametric images from 82Rb PET from dynamic frames and direct 4D reconstruction
Germino M, Carson RE. Cardiac‐gated parametric images from 82Rb PET from dynamic frames and direct 4D reconstruction. Medical Physics 2017, 45: 639-654. PMID: 29205378, PMCID: PMC5807225, DOI: 10.1002/mp.12710.Peer-Reviewed Original ResearchDirect reconstruction of parametric images for brain PET with event-by-event motion correction: evaluation in two tracers across count levels
Germino M, Gallezot JD, Yan J, Carson RE. Direct reconstruction of parametric images for brain PET with event-by-event motion correction: evaluation in two tracers across count levels. Physics In Medicine And Biology 2017, 62: 5344-5364. PMID: 28504644, PMCID: PMC5783541, DOI: 10.1088/1361-6560/aa731f.Peer-Reviewed Original ResearchData-driven event-by-event respiratory motion correction using TOF PET list-mode centroid of distribution
Ren S, Jin X, Chan C, Jian Y, Mulnix T, Liu C, Carson RE. Data-driven event-by-event respiratory motion correction using TOF PET list-mode centroid of distribution. Physics In Medicine And Biology 2017, 62: 4741-4755. PMID: 28520558, PMCID: PMC6048592, DOI: 10.1088/1361-6560/aa700c.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsHumansImage Processing, Computer-AssistedMovementPositron-Emission TomographyRespirationConceptsData-driven eventsRespiratory motion correctionSignificant image quality improvementMotion correctionEvent respiratory motion correctionExternal motion tracking systemPET list-mode dataRespiratory motionMotion tracking systemImage quality improvementMotion correction techniqueReconstruction frameworkMotion correction methodDistribution algorithmMotion-induced blurList-mode dataTracking systemFurther processingGated reconstructionsImage noiseRespiratory gating techniqueHuman scansRadioactive eventsContrast recoveryAnzai
2015
Measurement of Bmax and Kd with the Glycine Transporter 1 Radiotracer 18F-MK6577 using a Novel Multi-Infusion Paradigm
Xia Y, Zheng MQ, Holden D, Lin SF, Kapinos M, Ropchan J, Gallezot JD, Huang Y, Carson RE. Measurement of Bmax and Kd with the Glycine Transporter 1 Radiotracer 18F-MK6577 using a Novel Multi-Infusion Paradigm. Cerebrovascular And Brain Metabolism Reviews 2015, 35: 2001-2009. PMID: 26198176, PMCID: PMC4671121, DOI: 10.1038/jcbfm.2015.163.Peer-Reviewed Original ResearchConceptsGlycine transporter-1 inhibitorNew positron emission tomography radiotracerPositron emission tomography (PET) radiotracerPotential therapeutic agentNondisplaceable distribution volumeNMDA receptorsVivo affinityBaboon brainDistribution volumeBmax valuesTomography radiotracerTherapeutic agentsVivo KDBrainRank orderUnlabeled compoundsRadiotracerKdBrainstem
2014
Applications of the line-of-response probability density function resolution model in PET list mode reconstruction
Jian Y, Yao R, Mulnix T, Jin X, Carson RE. Applications of the line-of-response probability density function resolution model in PET list mode reconstruction. Physics In Medicine And Biology 2014, 60: 253-278. PMID: 25490063, PMCID: PMC4820078, DOI: 10.1088/0031-9155/60/1/253.Peer-Reviewed Original ResearchEvaluation of bias and variance in low-count OSEM list mode reconstruction
Jian Y, Planeta B, Carson RE. Evaluation of bias and variance in low-count OSEM list mode reconstruction. Physics In Medicine And Biology 2014, 60: 15-29. PMID: 25479254, PMCID: PMC4823773, DOI: 10.1088/0031-9155/60/1/15.Peer-Reviewed Original Research
2012
Direct 4-D PET List Mode Parametric Reconstruction with a Novel EM Algorithm
Yan J, Planeta-Wilson B, Carson RE. Direct 4-D PET List Mode Parametric Reconstruction with a Novel EM Algorithm. IEEE Transactions On Medical Imaging 2012, 31: 2213-2223. PMID: 22929383, PMCID: PMC3660152, DOI: 10.1109/tmi.2012.2212451.Peer-Reviewed Original Research
2000
Performance characteristics of the 3-D OSEM algorithm in the reconstruction of small animal PET images
Yao R, Seidel J, Johnson CA, Daube-Witherspoon ME, Green MV, Carson RE. Performance characteristics of the 3-D OSEM algorithm in the reconstruction of small animal PET images. IEEE Transactions On Medical Imaging 2000, 19: 798-804. PMID: 11055803, DOI: 10.1109/42.876305.Peer-Reviewed Original Research
1997
Multimodality Bayesian algorithm for image reconstruction in positron emission tomography: a tissue composition model
Sastry S, Carson RE. Multimodality Bayesian algorithm for image reconstruction in positron emission tomography: a tissue composition model. IEEE Transactions On Medical Imaging 1997, 16: 750-761. PMID: 9533576, DOI: 10.1109/42.650872.Peer-Reviewed Original Research