Featured Publications
Noise Reduction in the Simplified Reference Tissue Model for Neuroreceptor Functional Imaging
Wu Y, Carson RE. Noise Reduction in the Simplified Reference Tissue Model for Neuroreceptor Functional Imaging. Cerebrovascular And Brain Metabolism Reviews 2002, 22: 1440-1452. PMID: 12468889, DOI: 10.1097/01.wcb.0000033967.83623.34.Peer-Reviewed Original Research
2019
Quantification of PET infusion studies without true equilibrium: A tissue clearance correction
Hillmer AT, Carson RE. Quantification of PET infusion studies without true equilibrium: A tissue clearance correction. Cerebrovascular And Brain Metabolism Reviews 2019, 40: 860-874. PMID: 31088233, PMCID: PMC7168787, DOI: 10.1177/0271678x19850000.Peer-Reviewed Original Research
2017
Quantitative PET Imaging in Drug Development: Estimation of Target Occupancy
Naganawa M, Gallezot JD, Rossano S, Carson RE. Quantitative PET Imaging in Drug Development: Estimation of Target Occupancy. Bulletin Of Mathematical Biology 2017, 81: 3508-3541. PMID: 29230702, DOI: 10.1007/s11538-017-0374-2.Peer-Reviewed Original Research
2016
Imaging of cerebral α4β2* nicotinic acetylcholine receptors with (−)-[18F]Flubatine PET: Implementation of bolus plus constant infusion and sensitivity to acetylcholine in human brain
Hillmer AT, Esterlis I, Gallezot JD, Bois F, Zheng MQ, Nabulsi N, Lin SF, Papke RL, Huang Y, Sabri O, Carson RE, Cosgrove KP. Imaging of cerebral α4β2* nicotinic acetylcholine receptors with (−)-[18F]Flubatine PET: Implementation of bolus plus constant infusion and sensitivity to acetylcholine in human brain. NeuroImage 2016, 141: 71-80. PMID: 27426839, PMCID: PMC5026941, DOI: 10.1016/j.neuroimage.2016.07.026.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcholineAdultBenzamidesBrainBridged Bicyclo Compounds, HeterocyclicComputer SimulationHumansImage Interpretation, Computer-AssistedInfusions, IntraventricularMetabolic Clearance RateMiddle AgedModels, NeurologicalMolecular ImagingNeurotransmitter AgentsPositron-Emission TomographyRadiopharmaceuticalsReceptors, NicotinicReproducibility of ResultsSensitivity and SpecificityTissue DistributionYoung AdultConceptsGray matter regionsFirst-in-Human Assessment of the Novel PDE2A PET Radiotracer 18F-PF-05270430
Naganawa M, Waterhouse RN, Nabulsi N, Lin SF, Labaree D, Ropchan J, Tarabar S, DeMartinis N, Ogden A, Banerjee A, Huang Y, Carson RE. First-in-Human Assessment of the Novel PDE2A PET Radiotracer 18F-PF-05270430. Journal Of Nuclear Medicine 2016, 57: 1388-1395. PMID: 27103022, PMCID: PMC5093918, DOI: 10.2967/jnumed.115.166850.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAzabicyclo CompoundsAzetidinesBrainComputer SimulationCyclic Nucleotide Phosphodiesterases, Type 2Feasibility StudiesFemaleHumansIsotope LabelingMacaca mulattaMaleMetabolic Clearance RateModels, BiologicalMolecular ImagingOrgan SpecificityPilot ProjectsPositron-Emission TomographyRadiopharmaceuticalsReproducibility of ResultsSensitivity and SpecificityTissue DistributionConceptsTest-retest variabilityHuman studiesPET ligandWhite matterNeocortical regionsMultilinear analysis 1MSv/MBqHealthy male subjectsDetectable pharmacologic effectsAppropriate tracer kinetic modelsTest-retest protocolAdverse eventsBrain uptakePharmacologic effectsRegional time-activity curvesTarget doseTime-activity curvesTracer uptakeMale subjectsWhole brainBrain regionsEffective doseCritical organsPET radiotracersNonhuman primates
2014
Evaluation of bias and variance in low-count OSEM list mode reconstruction
Jian Y, Planeta B, Carson RE. Evaluation of bias and variance in low-count OSEM list mode reconstruction. Physics In Medicine And Biology 2014, 60: 15-29. PMID: 25479254, PMCID: PMC4823773, DOI: 10.1088/0031-9155/60/1/15.Peer-Reviewed Original Research
1998
Assessment of Dynamic Neurotransmitter Changes With Bolus or Infusion Delivery of Neuroreceptor Ligands
Endres C, Carson R. Assessment of Dynamic Neurotransmitter Changes With Bolus or Infusion Delivery of Neuroreceptor Ligands. Cerebrovascular And Brain Metabolism Reviews 1998, 18: 1196-1210. PMID: 9809509, DOI: 10.1097/00004647-199811000-00006.Peer-Reviewed Original ResearchBrainCarbon RadioisotopesComputer SimulationDopamineDopamine AntagonistsFlumazenilHumansInfusions, ParenteralInjectionsKineticsMicrodialysisModels, NeurologicalNaltrexoneNarcotic AntagonistsRacloprideRadioligand AssayReceptors, DopamineSalicylamidesSensitivity and SpecificityTomography, Emission-Computed
1997
Multimodality Bayesian algorithm for image reconstruction in positron emission tomography: a tissue composition model
Sastry S, Carson RE. Multimodality Bayesian algorithm for image reconstruction in positron emission tomography: a tissue composition model. IEEE Transactions On Medical Imaging 1997, 16: 750-761. PMID: 9533576, DOI: 10.1109/42.650872.Peer-Reviewed Original Research