2022
Child Neurology: Functional Reorganization Mediating Supplementary Motor Area Syndrome Recovery in Agenesis of the Corpus Callosum
Obaid S, Qureshi HM, Aljishi A, Shaikh N, Kundishora AJ, Bronen RA, DiLuna M, Damisah E. Child Neurology: Functional Reorganization Mediating Supplementary Motor Area Syndrome Recovery in Agenesis of the Corpus Callosum. Neurology 2022, 99: 161-165. PMID: 35618432, PMCID: PMC9421776, DOI: 10.1212/wnl.0000000000200772.Peer-Reviewed Case Reports and Technical NotesConceptsSMA syndromeFunctional recoveryCorpus callosumSupplementary motor area syndromeCorpus callosal fibersLow-grade gliomasMedial premotor cortexFunctional neuroimaging featuresSurgical resectionClinical presentationHealthy hemisphereTranscallosal fibersAcallosal patientsNeuroimaging featuresPreoperative fMRIParacentral lobuleLeft toePremotor cortexCallosal fibersPatientsSyndromeComplete ACCExact mechanismAgenesisCallosum
2018
Presurgical language fMRI: Technical practices in epilepsy surgical planning
Benjamin CFA, Dhingra I, Li AX, Blumenfeld H, Alkawadri R, Bickel S, Helmstaedter C, Meletti S, Bronen RA, Warfield SK, Peters JM, Reutens D, Połczyńska MM, Hirsch LJ, Spencer DD. Presurgical language fMRI: Technical practices in epilepsy surgical planning. Human Brain Mapping 2018, 39: 4032-4042. PMID: 29962111, PMCID: PMC6175127, DOI: 10.1002/hbm.24229.Peer-Reviewed Original ResearchConceptsLanguage functional MRIFunctional MRISurgical planningEpilepsy surgical planningEpilepsy surgical programsGeneral linear modelingBlood flowClinical practicePatient careSurgical programsRoutine useMarked heterogeneityClinical applicationVerbal fluencyData highlightFMRI dataMost programsPatientsWidespread useEpilepsyIndividualsMRICare
2008
Imaging Approaches to the Epileptic Patient
Bronen R, Bagley L. Imaging Approaches to the Epileptic Patient. 2008, 83-91. DOI: 10.1007/978-88-470-0840-3_14.Peer-Reviewed Educational Materials
2006
Volumetry of amygdala and hippocampus and memory performance in Alzheimer's disease
Basso M, Yang J, Warren L, MacAvoy MG, Varma P, Bronen RA, van Dyck CH. Volumetry of amygdala and hippocampus and memory performance in Alzheimer's disease. Psychiatry Research 2006, 146: 251-261. PMID: 16524704, DOI: 10.1016/j.pscychresns.2006.01.007.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingAD patientsAmygdaloid volumesAlzheimer's diseaseHealthy controlsHippocampal volumeAlzheimer's Disease Assessment Scale-CognitionMedial temporal lobe atrophyTemporal lobe atrophyOlder healthy subjectsADAS-Cog subscaleHealthy control samplesLobe atrophyAD groupHealthy subjectsAnalysis of covarianceMRI studiesProdromal stagePatientsResonance imagingMildest symptomsNeuropsychological assessmentNeuropsychological performanceHippocampusDisease
2005
Apolipoprotein E epsilon4 is associated with atrophy of the amygdala in Alzheimer's disease
Basso M, Gelernter J, Yang J, MacAvoy MG, Varma P, Bronen RA, van Dyck CH. Apolipoprotein E epsilon4 is associated with atrophy of the amygdala in Alzheimer's disease. Neurobiology Of Aging 2005, 27: 1416-1424. PMID: 16182410, DOI: 10.1016/j.neurobiolaging.2005.08.002.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseAD patientsAPOE epsilon4AD groupImportant genetic risk factorApolipoprotein E epsilon4Regional brain atrophyAPOE epsilon4 alleleElderly control subjectsNormal elderly control subjectsGenetic risk factorsAmygdaloid volumesBrain atrophyControl subjectsEpsilon4 carriersRisk factorsEpsilon4 alleleHippocampal volumeEpsilon4 doseAnalysis of covarianceDisease severityPatientsEpsilon4AmygdalaAtrophy
2000
MR Imaging and Histologic Features of Subinsular Bright Spots on T2-weighted MR Images: Virchow-Robin Spaces of the Extreme Capsule and Insular Cortex
Song C, Kim J, Kier E, Bronen R. MR Imaging and Histologic Features of Subinsular Bright Spots on T2-weighted MR Images: Virchow-Robin Spaces of the Extreme Capsule and Insular Cortex. Radiology 2000, 214: 671-677. PMID: 10715028, DOI: 10.1148/radiology.214.3.r00mr17671.Peer-Reviewed Original ResearchConceptsInsular cortexExtreme capsuleMR imagingControl subjectsBrain specimensPerivascular spacesFormalin-fixed brain specimensFluid-attenuated inversion recovery sequencesVirchow-Robin spacesT2-weighted magnetic resonance imagesCoronal T2-weighted imagesT2-weighted imagesCoronal MR imagesHigh signal intensityT2-weighted MR imagesInversion recovery sequenceHistologic featuresHistologic findingsCerebrospinal fluidMR imagesPatientsWhite matterPathologic conditionsGross anatomic inspectionMagnetic resonance images
1997
Postoperative changes in the brain: MR imaging findings in patients without neoplasms.
Sato N, Bronen R, Sze G, Kawamura Y, Coughlin W, Putman C, Spencer D. Postoperative changes in the brain: MR imaging findings in patients without neoplasms. Radiology 1997, 204: 839-46. PMID: 9280269, DOI: 10.1148/radiology.204.3.9280269.Peer-Reviewed Original ResearchConceptsPostoperative MR imagesPostoperative changesDural enhancementEnhancement patternThin linear enhancementContrast enhancement patternMagnetic resonance imagingMR imagesSurgical marginsTemporal lobectomyNeoplastic changesExtraaxial fluidIntracranial airContrast material-enhanced MR imagesDay 5Day 51Day 30Resonance imagingSurgeryBrainPatientsTime courseContrast enhancementLinear enhancementDaysA systematic approach for interpreting MR images of the seizure patient.
Bronen RA, Fulbright RK, Kim JH, Spencer SS, Spencer DD. A systematic approach for interpreting MR images of the seizure patient. American Journal Of Roentgenology 1997, 169: 241-7. PMID: 9207533, DOI: 10.2214/ajr.169.1.9207533.Peer-Reviewed Original ResearchConceptsSubtle cortical abnormalitiesFalse-negative diagnosesHippocampal sclerosisAbnormal findingsEpileptogenic lesionsCortical thickeningSeizure patientsCortical abnormalitiesLateral ventriclePeriventricular regionEpilepsy patientsMR findingsHigh indexMorphologic abnormalitiesPeriventricular heterotopiaDual abnormalitiesGray matterDevelopmental anomaliesAbnormalitiesMR scansCortical processesMass effectHead rotationPatientsHippocampusPositron Emission Tomography Measurement of Cerebral Metabolic Correlates of Tryptophan Depletion—Induced Depressive Relapse
Bremner JD, Innis RB, Salomon RM, Staib LH, Ng CK, Miller HL, Bronen RA, Krystal JH, Duncan J, Rich D, Price LH, Malison R, Dey H, Soufer R, Charney DS. Positron Emission Tomography Measurement of Cerebral Metabolic Correlates of Tryptophan Depletion—Induced Depressive Relapse. JAMA Psychiatry 1997, 54: 364-374. PMID: 9107153, DOI: 10.1001/archpsyc.1997.01830160092012.Peer-Reviewed Original ResearchConceptsCerebral metabolic correlatesDepressive relapseBrain metabolismMajor depressionMiddle frontal gyrusOrbitofrontal cortexTryptophan depletionMetabolic correlatesPositron emission tomography scanningFrontal gyrusRelapse-prone patientsPathogenesis of depressionPositron emission tomography (PET) measurementsSerotonin reuptake inhibitorsSymptoms of patientsPositron emission tomographySingle photon emissionSpecific brain regionsDorsolateral prefrontal cortexReuptake inhibitorsPlasma tryptophanLimbic regionsCaudate nucleusDepressive symptomsPatientsPositron Emission Tomography Measurement of Cerebral Metabolic Correlates of Yohimbine Administration in Combat-Related Posttraumatic Stress Disorder
Bremner JD, Innis RB, Ng CK, Staib LH, Salomon RM, Bronen RA, Duncan J, Southwick SM, Krystal JH, Rich D, Zubal G, Dey H, Soufer R, Charney DS. Positron Emission Tomography Measurement of Cerebral Metabolic Correlates of Yohimbine Administration in Combat-Related Posttraumatic Stress Disorder. JAMA Psychiatry 1997, 54: 246-254. PMID: 9075465, DOI: 10.1001/archpsyc.1997.01830150070011.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderAdministration of yohimbineNorepinephrine releaseHealthy subjectsHealthy age-matched control subjectsAge-matched control subjectsStress disorderDouble-blind fashionPositron emission tomography (PET) measurementsBrain metabolic responsesCerebral metabolic correlatesBrain norepinephrine releaseSymptoms of anxietyPositron emission tomographyBrain metabolismControl subjectsYohimbine administrationPreclinical studiesMetabolic correlatesCaudate nucleusPatientsYohimbineVietnam combat veteransEmission tomographyOrbitofrontal cortexMagnetic resonance imaging-based measurement of hippocampal volume in posttraumatic stress disorder related to childhood physical and sexual abuse—a preliminary report
Bremner J, Randall P, Vermetten E, Staib L, Bronen R, Mazure C, Capelli S, McCarthy G, Innis R, Charney D. Magnetic resonance imaging-based measurement of hippocampal volume in posttraumatic stress disorder related to childhood physical and sexual abuse—a preliminary report. Biological Psychiatry 1997, 41: 23-32. PMID: 8988792, PMCID: PMC3229101, DOI: 10.1016/s0006-3223(96)00162-x.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderLeft hippocampal volumeHippocampal volumeChildhood abuseAdult survivorsSmaller left hippocampal volumeAbuse-related posttraumatic stress disorderStress disorderSmaller hippocampal volumesCombat-related posttraumatic stress disorderMagnetic resonance imagingShort-term memoryHealthy subjectsYears of educationAlcohol abuseMagnetic resonance imaging-based measurementsComparison subjectsPTSD patientsImaging-based measurementsResonance imagingPatientsSexual abusePreliminary reportSurvivorsComparison regionEconomic impact of replacing CT with MR imaging for refractory epilepsy
Bronen R, Fulbright R, Spencer S, Spencer D, Kim J, Lange R. Economic impact of replacing CT with MR imaging for refractory epilepsy. Magnetic Resonance Imaging 1997, 15: 857-862. PMID: 9309616, DOI: 10.1016/s0730-725x(97)00047-7.Peer-Reviewed Original ResearchConceptsPreoperative evaluationRefractory epilepsyPositive imaging findingsRefractory epilepsy patientsPositive magnetic resonanceMagnetic resonanceIntracranial electroencephalogram monitoringSurgical ameliorationNormal CTImaging findingsPreoperative localizationIntractable epilepsyVascular lesionsEpileptogenic zoneElectroencephalogram monitoringPreoperative CTEpilepsy patientsPatientsMR imagingEpilepsyCTVascular substratesHealth costsLesionsSurgeryFocal cortical dysplasia of Taylor, balloon cell subtype: MR differentiation from low-grade tumors.
Bronen RA, Vives KP, Kim JH, Fulbright RK, Spencer SS, Spencer DD. Focal cortical dysplasia of Taylor, balloon cell subtype: MR differentiation from low-grade tumors. American Journal Of Neuroradiology 1997, 18: 1141-51. PMID: 9194442, PMCID: PMC8337292.Peer-Reviewed Original ResearchConceptsFocal cortical dysplasiaLow-grade tumorsCortical dysplasiaMR findingsLobe locationLow-grade glial neoplasmTemporal lobe locationSubcortical white matterFrontal lobe locationSurgical resectionCortical thickeningClinical variablesIntractable epilepsyGlial neoplasmsHyperintense signalLateral ventricleMR featuresWhite matterNeoplastic tissueCell subtypesDysplasiaPatientsMR variablesNeoplasmsSurgical planning
1996
Medial temporal lobe epilepsy without hippocampal atrophy
King D, Spencer S, Bouthillier A, Kim J, de Lanerolle N, Bronen R, McCarthy G, Luby M, Spencer D. Medial temporal lobe epilepsy without hippocampal atrophy. Epilepsy Research 1996, 9: 291-297. DOI: 10.1016/s0896-6974(96)00039-4.Peer-Reviewed Original ResearchMedial temporal lobe epilepsyHippocampal atrophyTemporal lobe epilepsyHippocampal sclerosisTemporal lobectomyLobe epilepsyMagnetic resonance imaging (MRI) volumetric studiesPresence of HADuration of epilepsyAnteromedial temporal lobectomyQuantitative cell countsPathologic evidenceSurgical outcomesClinical syndromeSeizure onsetPatientsCell countEpilepsyDepth EEGLonger durationAtrophyIncidenceVolumetric studiesInsufficient localizationOutcomesComparison of technetium-99m-HMPAO and technetium-99m-ECD cerebral SPECT images in Alzheimer's disease.
van Dyck CH, Lin CH, Smith EO, Wisniewski G, Cellar J, Robinson R, Narayan M, Bennett A, Delaney RC, Bronen RA, Hoffer PB. Comparison of technetium-99m-HMPAO and technetium-99m-ECD cerebral SPECT images in Alzheimer's disease. Journal Of Nuclear Medicine 1996, 37: 1749-55. PMID: 8917168.Peer-Reviewed Original ResearchConceptsControl subjectsAD patientsAlzheimer's diseaseAge-matched control subjectsBrain structuresBrain perfusion agentHigh diagnostic accuracyTechnetium-99mCysteinate dimerHealthy subjectsPatientsDiagnostic groupsPerfusion agentDiagnostic accuracyDiseaseSignificant differencesDiagnostic toolSPECT imagesSubjectsPurported advantagesCharacteristic analysisSignificant interactionCerebral imagesAnalysis of varianceCount densityRefractory epilepsy: comparison of MR imaging, CT, and histopathologic findings in 117 patients.
Bronen RA, Fulbright RK, Spencer DD, Spencer SS, Kim JH, Lange RC, Sutilla C. Refractory epilepsy: comparison of MR imaging, CT, and histopathologic findings in 117 patients. Radiology 1996, 201: 97-105. PMID: 8816528, DOI: 10.1148/radiology.201.1.8816528.Peer-Reviewed Original Research
1995
MRI-based measurement of hippocampal volume in patients with combat- related posttraumatic stress disorder
Bremner J, Randall P, Scott T, Bronen R, Seibyl J, Southwick S, Delaney R, McCarthy G, Charney D, Innis R. MRI-based measurement of hippocampal volume in patients with combat- related posttraumatic stress disorder. American Journal Of Psychiatry 1995, 152: 973-981. PMID: 7793467, PMCID: PMC3233767, DOI: 10.1176/ajp.152.7.973.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderCombat-related posttraumatic stress disorderSmaller right hippocampal volumeRight hippocampal volumeVerbal memoryHippocampal volumeStress disorderPTSD patientsShort-term verbal memoryShort-term memoryWechsler Memory ScaleComparison subjectsVietnam combat veteransMemory ScaleCombat veteransYears of educationMagnetic resonance imagingBrain regionsMemoryBrain structuresFunctional deficitsNeurotoxic effectsPsychiatric disordersAlcohol abusePatientsIs there any role for gadopentetate dimeglumine administration when searching for mesial temporal sclerosis in patients with seizures?
Bronen R. Is there any role for gadopentetate dimeglumine administration when searching for mesial temporal sclerosis in patients with seizures? American Journal Of Roentgenology 1995, 164: 503. PMID: 7839999, DOI: 10.2214/ajr.164.2.7839999.Commentaries, Editorials and LettersRegional distribution of MR findings in hippocampal sclerosis.
Bronen RA, Fulbright RK, Kim JH, Spencer SS, Spencer DD, al-Rodhan NR. Regional distribution of MR findings in hippocampal sclerosis. American Journal Of Neuroradiology 1995, 16: 1193-200. PMID: 7677010, PMCID: PMC8337833.Peer-Reviewed Original ResearchConceptsHippocampal sclerosisHippocampal bodyHippocampal headMR findingsHippocampal tailMR abnormalitiesLimbic structuresAbnormal MR findingsConsecutive patientsIpsilateral hippocampusMost patientsSignal changesSeizure generatorPathologic analysisHyperintense signalRegional atrophyEntire hippocampusPatientsSclerosisHippocampusAmygdalaAtrophyMR changesMR scansWidespread involvement
1994
CT-Guided Percutaneous Insertion of Interstitial Radiotherapy Catheters in Head and Neck Tumors
Bronen R, Lee G, Son Y, Healy G, Meli J, Sasaki C. CT-Guided Percutaneous Insertion of Interstitial Radiotherapy Catheters in Head and Neck Tumors. Journal Of Computer Assisted Tomography 1994, 18: 163. PMID: 8282876, DOI: 10.1097/00004728-199401000-00039.Peer-Reviewed Original ResearchConceptsNeck tumorsPercutaneous insertionRadiation therapyDetailed anatomical localizationPalliative radiation therapyTherapy catheterInterstitial radiation therapyPrecise percutaneous placementInoperable headTumor sizePercutaneous placementCT guidanceSurgical placementAnatomical localizationCatheterTumorsPatientsVascular structuresTherapyCTHeadPainPlacement