2023
The Impact of Rapid Drug Susceptibility Tests on Gonorrhea Burden and the Life Span of Antibiotic Treatments: A Modeling Study Among Men Who Have Sex With Men in the United States
Yaesoubi R, Xi Q, Hsu K, Gift T, St. Cyr S, Rönn M, Salomon J, Grad Y. The Impact of Rapid Drug Susceptibility Tests on Gonorrhea Burden and the Life Span of Antibiotic Treatments: A Modeling Study Among Men Who Have Sex With Men in the United States. American Journal Of Epidemiology 2023, 193: 17-25. PMID: 37625444, PMCID: PMC10773484, DOI: 10.1093/aje/kwad175.Peer-Reviewed Original ResearchConceptsRapid drug susceptibility testDrug susceptibility testGonorrhea casesSusceptibility testsFirst-line treatmentBurden of gonorrheaGonococcal infectionGonorrhoea transmissionAntibiotic treatmentPatient outcomesIndividualized treatmentLife spanDrug susceptibilityCare testRapid pointEffective life spanAntibiotic resistanceAntibioticsTest specificityGonorrheaMenCiprofloxacinTreatmentCorrect ascertainmentLong-term impactResistance-minimising strategies for introducing a novel antibiotic for gonorrhoea treatment: a mathematical modelling study
Reichert E, Yaesoubi R, Rönn M, Gift T, Salomon J, Grad Y. Resistance-minimising strategies for introducing a novel antibiotic for gonorrhoea treatment: a mathematical modelling study. The Lancet Microbe 2023, 4: e781-e789. PMID: 37619582, PMCID: PMC10865326, DOI: 10.1016/s2666-5247(23)00145-3.Peer-Reviewed Original ResearchConceptsPrevalence of resistancePrimary outcomeGonococcal infectionGonorrhea treatmentCombination therapyAntibiotic resistanceResistance emergenceNew antibioticsNew drugsUrgent public health concernCombination therapy strategiesSexual activity groupsPopulation-level prevalencePublic health concernSecondary outcomesAnnual incidenceGonorrhoea transmissionCurrent therapiesMSM populationUS CentersMathematical modelling studyCurrent drugsUS populationNeisseria gonorrhoeaeInfectious diseasesCT With CTA Versus MRI in Patients Presenting to the Emergency Department With Dizziness: Analysis Using Propensity Score Matching.
Tu L, Navaratnam D, Melnick E, Forman H, Venkatesh A, Malhotra A, Yaesoubi R, Sureshanand S, Sheth K, Mahajan A. CT With CTA Versus MRI in Patients Presenting to the Emergency Department With Dizziness: Analysis Using Propensity Score Matching. American Journal Of Roentgenology 2023, 221: 836-845. PMID: 37404082, DOI: 10.2214/ajr.23.29617.Peer-Reviewed Original ResearchConceptsSecondary stroke prevention medicationsStroke prevention medicationsEmergency departmentPrevention medicationsEchocardiography evaluationPosterior circulation strokeProportion of patientsGroup of patientsPhysical examination findingsNeuroimaging resultsUse of MRIReview of systemsGreater frequencyPropensity-score matchingExamination findingsRetrospective studyED readmissionMedical historyHead CTClinical impactMRI examinationsBrain MRINeck CTADizzinessPatientsCost-Effectiveness and Long-Term Savings of the Bright Bodies Intervention for Childhood Obesity
Pryor S, Savoye M, Nowicka P, Price G, Sharifi M, Yaesoubi R. Cost-Effectiveness and Long-Term Savings of the Bright Bodies Intervention for Childhood Obesity. Value In Health 2023, 26: 1183-1191. PMID: 36967028, PMCID: PMC10518029, DOI: 10.1016/j.jval.2023.03.006.Peer-Reviewed Original ResearchConceptsBody mass indexClinical controlMedical Expenditure Panel Survey dataClinical weight managementHealth system perspectivePrevention growth chartsParticipants' body mass indexFamily-based interventionsMass indexChildhood obesityBMI trajectoriesWeight managementHealthcare costsPrimary analysisGrowth chartsObesityTrial dataDisease controlMedical expendituresBright bodiesHealthcare expendituresIncremental costIntervention costsBody interventionsChildrenClinical criteria to exclude acute vascular pathology on CT angiogram in patients with dizziness
Tu L, Malhotra A, Venkatesh A, Taylor R, Sheth K, Yaesoubi R, Forman H, Sureshanand S, Navaratnam D. Clinical criteria to exclude acute vascular pathology on CT angiogram in patients with dizziness. PLOS ONE 2023, 18: e0280752. PMID: 36893103, PMCID: PMC9997874, DOI: 10.1371/journal.pone.0280752.Peer-Reviewed Original ResearchConceptsAcute vascular pathologyEmergency departmentVascular pathologyNegative predictive valueDizzy patientsStroke codeCTA headPredictive valueAdult ED encountersTransient ischemic attackHalf of patientsLong-term smokersLarge vessel occlusionCoronary artery diseasePast medical historySeparate validation cohortCross-sectional analysisIschemic attackAnalysis cohortArterial dissectionArtery diseaseClinical factorsED encountersMedication useChief complaintCost-effectiveness analysis of typhoid conjugate vaccines in an outbreak setting: a modeling study
Phillips M, Antillon M, Bilcke J, Bar-Zeev N, Limani F, Debellut F, Pecenka C, Neuzil K, Gordon M, Thindwa D, Paltiel A, Yaesoubi R, Pitzer V. Cost-effectiveness analysis of typhoid conjugate vaccines in an outbreak setting: a modeling study. BMC Infectious Diseases 2023, 23: 143. PMID: 36890448, PMCID: PMC9993384, DOI: 10.1186/s12879-023-08105-2.Peer-Reviewed Original ResearchConceptsTyphoid Conjugate VaccineRoutine vaccinationReactive vaccinationVaccination strategiesOutbreak settingsMultidrug-resistant Salmonella typhiQueen Elizabeth Central HospitalTyphoid fever epidemicYears of ageMonths of ageCost-effectiveness analysisWorld Health OrganizationConjugate vaccineCentral HospitalRoutine immunizationVaccine deploymentPreventive vaccinationVaccinationTyphoid feverCost-effective strategyAge 15Health OrganizationFever epidemicAntimicrobial resistanceOutbreak definitionsThe Estimated Lifetime Quality-Adjusted Life-Years Lost Due to Chlamydia, Gonorrhea, and Trichomoniasis in the United States in 2018
Li Y, You S, Lee K, Yaesoubi R, Hsu K, Gift T, Chesson H, Berruti A, Salomon J, Rönn M. The Estimated Lifetime Quality-Adjusted Life-Years Lost Due to Chlamydia, Gonorrhea, and Trichomoniasis in the United States in 2018. The Journal Of Infectious Diseases 2023, 227: 1007-1018. PMID: 36806950, PMCID: PMC10112678, DOI: 10.1093/infdis/jiad047.Peer-Reviewed Original ResearchConceptsLifetime QALYsSubstantial health lossesDuration of infectionCost-effectiveness analysisGenital chlamydiaInfection interventionTotal QALYsIncident infectionsChronic sequelaeInfection helpGonorrheaAge groupsChlamydiaInfectionMultivariate sensitivity analysisHealth lossTrichomoniasisQALYWomenSequelaeUnited StatesPrevention policiesQALYsPopulation levelLifetime qualityGenerating simple classification rules to predict local surges in COVID-19 hospitalizations
Yaesoubi R, You S, Xi Q, Menzies N, Tuite A, Grad Y, Salomon J. Generating simple classification rules to predict local surges in COVID-19 hospitalizations. Health Care Management Science 2023, 26: 301-312. PMID: 36692583, PMCID: PMC9872755, DOI: 10.1007/s10729-023-09629-4.Peer-Reviewed Original Research
2022
Yield of Head Computed Tomography Examinations for Common Psychiatric Presentations and Implications for Medical Clearance From a 6-Year Analysis of Acute Hospital Visits
Tu LH, Malhotra A, Sheth KN, Yaesoubi R, Forman HP, Venkatesh AK. Yield of Head Computed Tomography Examinations for Common Psychiatric Presentations and Implications for Medical Clearance From a 6-Year Analysis of Acute Hospital Visits. JAMA Internal Medicine 2022, 182: 879-881. PMID: 35727595, PMCID: PMC9214629, DOI: 10.1001/jamainternmed.2022.2198.Peer-Reviewed Original ResearchEstimation of the Lifetime Quality-Adjusted Life Years (QALYs) Lost Due to Syphilis Acquired in the United States in 2018
Lee K, You S, Li Y, Chesson H, Gift TL, Berruti AA, Hsu K, Yaesoubi R, Salomon JA, Rönn M. Estimation of the Lifetime Quality-Adjusted Life Years (QALYs) Lost Due to Syphilis Acquired in the United States in 2018. Clinical Infectious Diseases 2022, 76: e810-e819. PMID: 35684943, PMCID: PMC9907519, DOI: 10.1093/cid/ciac427.Peer-Reviewed Original ResearchConceptsQuality-adjusted life yearsCongenital syphilisHealth lossLife yearsNumber of QALYsTerms of QALYsLifetime numberBurden of syphilisSubstantial health lossesManagement of syphilisLifetime quality-adjusted life yearsAverage lifetime numberCost-effectiveness analysisPrimary infectionOverall burdenSyphilisNatural historyInfectionHealth impactsMSMChildrenMothersUnited StatesBurdenDecision tree modelEvaluating spatially adaptive guidelines for the treatment of gonorrhea to reduce the incidence of gonococcal infection and increase the effective lifespan of antibiotics
Yaesoubi R, Cohen T, Hsu K, Gift TL, St. Cyr SB, Salomon JA, Grad YH. Evaluating spatially adaptive guidelines for the treatment of gonorrhea to reduce the incidence of gonococcal infection and increase the effective lifespan of antibiotics. PLOS Computational Biology 2022, 18: e1009842. PMID: 35139073, PMCID: PMC8863219, DOI: 10.1371/journal.pcbi.1009842.Peer-Reviewed Original ResearchConceptsIncidence of gonorrhoeaTreatment guidelinesResistance prevalenceGonorrhea casesTreatment of gonorrheaNational surveillance systemPrevalence of resistanceTransmission dynamic modelGonococcal infectionGonorrhea treatmentMSM populationAntibiotic susceptibilityGonorrheaStandardized guidelinesSurveillance dataPrevalenceIncidenceAntibioticsPotential strategySurveillance systemAbsence of pointsGuidelinesCurrent strategiesEffective lifespanMenSpatially targeted digital chest radiography to reduce tuberculosis in high-burden settings: A study of adaptive decision making
de Villiers AK, Dye C, Yaesoubi R, Cohen T, Marx FM. Spatially targeted digital chest radiography to reduce tuberculosis in high-burden settings: A study of adaptive decision making. Epidemics 2022, 38: 100540. PMID: 35093849, PMCID: PMC8983993, DOI: 10.1016/j.epidem.2022.100540.Peer-Reviewed Original ResearchConceptsHigh-burden settingsTB casesTB prevalenceChest radiographyAdditional TB casesCase-finding yieldTB prevalence estimatesHigh-burden populationsCommunity-randomized trialNumber of screeningsTB controlXpert UltraScreening roundNotification ratesPrevalence estimatesTuberculosisPrevalenceDigital chest radiographyScreeningTrialsInterventionRadiography
2021
Scenarios to improve CT head utilization in the emergency department delineated by critical results reporting
Tu LH, Venkatesh AK, Malhotra A, Taylor RA, Sheth KN, Forman HP, Yaesoubi R. Scenarios to improve CT head utilization in the emergency department delineated by critical results reporting. Emergency Radiology 2021, 29: 81-88. PMID: 34617133, DOI: 10.1007/s10140-021-01947-w.Peer-Reviewed Original ResearchConceptsAdult ED encountersCommon chief complaintChief complaintEmergency departmentED encountersPatient selectionHead examsLoss of consciousnessAcademic medical centerChest painBlood sugarRetrospective studyHead injuryMental statusNew headacheMedical CenterPsychiatric evaluationConclusionOur studyBetter outcomesAdvanced imagingAlcohol intoxicationTotal encountersComplaintsHeadacheSignificant differencesHead and Neck CTA Utilization: Analysis of Ordering Frequency and Nonroutine Results Communication, With Focus on the 50 Most Common Emergency Department Clinical Presentations.
Tu LH, Malhotra A, Venkatesh AK, Taylor RA, Sheth KN, Forman HP, Yaesoubi R. Head and Neck CTA Utilization: Analysis of Ordering Frequency and Nonroutine Results Communication, With Focus on the 50 Most Common Emergency Department Clinical Presentations. American Journal Of Roentgenology 2021, 218: 544-551. PMID: 34585611, DOI: 10.2214/ajr.21.26543.Peer-Reviewed Original ResearchConceptsNeck CTAED visitsEmergency departmentNonroutine communicationSingle health care systemAdult ED visitsSubset of reportsRadiologist communicationResult communicationPatient's chief concernHealth care systemFrequency of headCTA utilizationAcute findingsClinical presentationED settingPatient selectionIncidental findingClinical impactCTA examinationsCare systemCTAVisitsHigher numberNegative resultsReducing the Prevalence of Alcohol-Exposed Pregnancies in the United States: A Simulation Modeling Study
Yaesoubi R, Mahin M, Martin G, Paltiel AD, Sharifi M. Reducing the Prevalence of Alcohol-Exposed Pregnancies in the United States: A Simulation Modeling Study. Medical Decision Making 2021, 42: 217-227. PMID: 34166146, PMCID: PMC8702569, DOI: 10.1177/0272989x211023203.Peer-Reviewed Original ResearchConceptsAlcohol-exposed pregnancyUnintended pregnancyPublic health effortsAlcohol abstinenceHealth effortsDifferent public health strategiesPublic health strategiesPrevalence of alcoholFamily Growth dataAwareness of pregnancyReproductive ageEffective contraceptionLive birthsContraceptive useUS womenHealth strategiesPregnancyWoman's riskPrevalenceDrinking patternsSexual activityWomenAbstinenceAlcoholic drinksNational surveyAdaptive Policies to Balance Health Benefits and Economic Costs of Physical Distancing Interventions during the COVID-19 Pandemic
Yaesoubi R, Havumaki J, Chitwood MH, Menzies NA, Gonsalves G, Salomon JA, Paltiel AD, Cohen T. Adaptive Policies to Balance Health Benefits and Economic Costs of Physical Distancing Interventions during the COVID-19 Pandemic. Medical Decision Making 2021, 41: 386-392. PMID: 33504258, PMCID: PMC8084913, DOI: 10.1177/0272989x21990371.Peer-Reviewed Original ResearchConceptsAdaptive policiesClear decision rulesSocial costsEconomic costsPolicy makersPhysical distancing policiesDecision toolPolicyPhysical distancing interventionsDistancing policiesModel-based experimentsDecision rulesReal-time surveillance dataCostCOVID-19 pandemicMakersShorter overall durationMore complex modelsHealth benefitsComplex modelsPandemicCurrent pandemicCOVID-19BenefitsRules
2020
Evaluation of 6-Month Versus Continuous Isoniazid Preventive Therapy for Mycobacterium tuberculosis in Adults Living With HIV/AIDS in Malawi.
Hsieh YL, Jahn A, Menzies NA, Yaesoubi R, Salomon JA, Girma B, Gunde L, Eaton JW, Auld A, Odo M, Kiyiika CN, Kalua T, Chiwandira B, Mpunga JU, Mbendra K, Corbett L, Hosseinipour MC, Cohen T, Kunkel A. Evaluation of 6-Month Versus Continuous Isoniazid Preventive Therapy for Mycobacterium tuberculosis in Adults Living With HIV/AIDS in Malawi. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2020, 85: 643-650. PMID: 33177475, PMCID: PMC8564780, DOI: 10.1097/qai.0000000000002497.Peer-Reviewed Original ResearchConceptsIsoniazid preventive therapyIPT programIPT strategyPreventive therapyContinuous isoniazid preventive therapyMore TB casesHIV-positive adultsCases of tuberculosisAnticipated health effectsComparable health benefitsHIV/AIDSCause deathAntiretroviral therapyTB casesTB controlTB incidenceDrug costsMalawi MinistryMean reductionTuberculosisMycobacterium tuberculosisTherapyAnticipated health impactsHealth effectsHealth benefitsTracking and predicting U.S. influenza activity with a real-time surveillance network
Leuba SI, Yaesoubi R, Antillon M, Cohen T, Zimmer C. Tracking and predicting U.S. influenza activity with a real-time surveillance network. PLOS Computational Biology 2020, 16: e1008180. PMID: 33137088, PMCID: PMC7707518, DOI: 10.1371/journal.pcbi.1008180.Peer-Reviewed Original ResearchConceptsInfluenza test resultsInfluenza activityU.S. influenza activityPhysician visitsInfluenza trendsInfluenza-like illness activityNational surveillance networkSurveillance networkInfluenza seasonCurrent burdenU.S. CentersIllness activityDisease controlUnited StatesLinear logistic modelVisitsLogistic modelValid estimatesProportionCost-effectiveness of post-treatment follow-up examinations and secondary prevention of tuberculosis in a high-incidence setting: a model-based analysis
Marx FM, Cohen T, Menzies NA, Salomon JA, Theron G, Yaesoubi R. Cost-effectiveness of post-treatment follow-up examinations and secondary prevention of tuberculosis in a high-incidence setting: a model-based analysis. The Lancet Global Health 2020, 8: e1223-e1233. PMID: 32827484, PMCID: PMC7549318, DOI: 10.1016/s2214-109x(20)30227-8.Peer-Reviewed Original ResearchConceptsIsoniazid preventive therapySecondary preventive therapyHigh-incidence settingsPost-treatment followPreventive therapyTuberculosis controlTuberculosis incidenceTreatment completionTuberculosis case findingOverall disease burdenHigh tuberculosis incidenceTuberculosis-endemic settingHigh-incidence communityFirst yearHealth system costsRecurrent tuberculosisSecondary preventionAnnual followTuberculosis treatmentDisease burdenHigh riskCase findingSingle followSuburban Cape TownPreventive interventionsAdaptive guidelines for the treatment of gonorrhea to increase the effective life span of antibiotics among men who have sex with men in the United States: A mathematical modeling study
Yaesoubi R, Cohen T, Hsu K, Gift TL, Chesson H, Salomon JA, Grad YH. Adaptive guidelines for the treatment of gonorrhea to increase the effective life span of antibiotics among men who have sex with men in the United States: A mathematical modeling study. PLOS Medicine 2020, 17: e1003077. PMID: 32243443, PMCID: PMC7122693, DOI: 10.1371/journal.pmed.1003077.Peer-Reviewed Original ResearchConceptsFirst-line antibioticsPrevalence of resistanceMSM populationGonorrhea casesPrevalence of gonorrheaTreatment of gonorrheaTransmission of gonorrheaIncidence of gonorrhoeaGonococcal antimicrobial resistanceProportion of casesAlternative surveillance strategiesBurden of gonorrheaEffective surveillance systemTreatment guidelinesGonorrhea treatmentGonorrhoea transmissionClinical effectivenessOverall burdenSurveillance estimatesLife spanGonorrheaDrug susceptibilitySurveillance findingsSurveillance strategiesSurveillance program