Non-psychotropic phytocannabinoid interactions with voltage-gated sodium channels: An update on cannabidiol and cannabigerol
Ghovanloo M, Dib-Hajj S, Goodchild S, Ruben P, Waxman S. Non-psychotropic phytocannabinoid interactions with voltage-gated sodium channels: An update on cannabidiol and cannabigerol. Frontiers In Physiology 2022, 13: 1066455. PMID: 36439273, PMCID: PMC9691960, DOI: 10.3389/fphys.2022.1066455.Peer-Reviewed Original ResearchLate sodium current: incomplete inactivation triggers seizures, myotonias, arrhythmias, and pain syndromes
Fouda MA, Ghovanloo M, Ruben PC. Late sodium current: incomplete inactivation triggers seizures, myotonias, arrhythmias, and pain syndromes. The Journal Of Physiology 2022, 600: 2835-2851. PMID: 35436004, DOI: 10.1113/jp282768.Peer-Reviewed Original ResearchConceptsLate sodium currentSodium currentSkeletal muscleAction potential durationRepetitive action potentialsVoltage-gated sodium channelsSeizure disorderTrigger seizuresPeripheral nervesPotential durationSodium channelopathiesAction potentialsSodium channelsChannel inactivationPainDysfunctionMyotoniaMuscleHeartGating propertiesNerveSeizuresArrhythmiasChannelopathiesDisease