2024
High ambient temperature in pregnancy and risk of childhood acute lymphoblastic leukaemia: an observational study
Rogne T, Wang R, Wang P, Deziel N, Metayer C, Wiemels J, Chen K, Warren J, Ma X. High ambient temperature in pregnancy and risk of childhood acute lymphoblastic leukaemia: an observational study. The Lancet Planetary Health 2024, 8: e506-e514. PMID: 38969477, PMCID: PMC11260908, DOI: 10.1016/s2542-5196(24)00121-9.Peer-Reviewed Original ResearchConceptsRisk of childhood acute lymphoblastic leukemiaChildhood acute lymphoblastic leukemiaAcute lymphoblastic leukemiaLymphoblastic leukemiaLatino childrenNon-Latino white childrenAssociated with risk of adverse pregnancy outcomesCalifornia Cancer RegistryRisk of acute lymphoblastic leukemiaCalifornia birth recordsRisk of adverse pregnancy outcomesPre-pregnancy periodAssociated with riskBayesian meta-regressionNational Institutes of HealthCancer RegistryCases of childhood acute lymphoblastic leukemiaNational Center for Advancing Translational SciencesAdverse pregnancy outcomesAcute lymphoblastic leukemia casesInstitutes of HealthInvestigation of mechanistic pathwaysBirth recordsGestational weeks 8Pre-pregnancy
2023
Outdoor artificial light at night, air pollution, and risk of childhood acute lymphoblastic leukemia in the California Linkage Study of Early-Onset Cancers
Zhong C, Wang R, Morimoto L, Longcore T, Franklin M, Rogne T, Metayer C, Wiemels J, Ma X. Outdoor artificial light at night, air pollution, and risk of childhood acute lymphoblastic leukemia in the California Linkage Study of Early-Onset Cancers. Scientific Reports 2023, 13: 583. PMID: 36631468, PMCID: PMC9834257, DOI: 10.1038/s41598-022-23682-z.Peer-Reviewed Original ResearchConceptsAcute lymphoblastic leukemiaRisk of childhoodEarly-onset cancersLymphoblastic leukemiaBirth recordsChildhood acute lymphoblastic leukemiaNon-Hispanic white childrenHispanic childrenCalifornia Cancer RegistryEtiology of childhoodOutdoor artificial lightOutdoor ALANHighest tertileCancer RegistryLinkage studiesRisk factorsBorderline associationElevated riskCancer diagnosisCancerEnvironmental exposuresWhite childrenCommon typeAir pollutionRisk
2021
Cytokine Levels at Birth in Children Who Developed Acute Lymphoblastic Leukemia
Whitehead TP, Wiemels JL, Zhou M, Kang AY, McCoy LS, Wang R, Fitch B, Petrick LM, Yano Y, Imani P, Rappaport SM, Dahl GV, Kogan SC, Ma X, Metayer C. Cytokine Levels at Birth in Children Who Developed Acute Lymphoblastic Leukemia. Cancer Epidemiology Biomarkers & Prevention 2021, 30: 1526-1535. PMID: 34078642, PMCID: PMC8338848, DOI: 10.1158/1055-9965.epi-20-1704.Peer-Reviewed Original ResearchConceptsAcute lymphoblastic leukemiaCytokine levelsLymphoblastic leukemiaChildhood acute lymphoblastic leukemiaAberrant immune reactionsPrenatal immune developmentRisk of childhoodInterquartile range incrementAltered cytokine levelsCalifornia Childhood Leukemia StudyChildhood Leukemia StudyBirth characteristicsNeonatal levelsPrenatal exposureImmunomodulatory cytokinesImmune developmentHigh hyperdiploidyImmune reactionsCytokinesGM-CSFBlood spotsLogistic regressionLeukemia StudyEndogenous metabolitesConfidence intervals
2020
Spatial-Temporal Cluster Analysis of Childhood Cancer in California.
Francis SS, Enders C, Hyde R, Gao X, Wang R, Ma X, Wiemels JL, Selvin S, Metayer C. Spatial-Temporal Cluster Analysis of Childhood Cancer in California. Epidemiology 2020, 31: 214-223. PMID: 31596791, PMCID: PMC9005107, DOI: 10.1097/ede.0000000000001121.Peer-Reviewed Original ResearchConceptsMalignant gonadal germ cell tumorsGonadal germ cell tumorsGerm cell tumorsAcute lymphoblastic leukemiaChildhood cancerCell tumorsChildhood acute lymphoblastic leukemiaYears of ageRace/ethnicity-matched controlsEthnicity-matched controlsSpace-time cluster analysisEpidemiologic featuresHodgkin's lymphomaLymphoblastic leukemiaBirth addressHealth professionalsCancerSpace-time clustersTumorsAgeSaTScanTemporal cluster analysisFurther researchEvidenceLymphoma
2019
Increased neonatal level of arginase 2 in cases of childhood acute lymphoblastic leukemia implicates immunosuppression in the etiology
Nielsen AB, Zhou M, de Smith AJ, Wang R, McCoy L, Hansen H, Morimoto L, Grønbæk K, Johansen C, Kogan SC, Metayer C, Bracci PM, Ma X, Wiemels JL. Increased neonatal level of arginase 2 in cases of childhood acute lymphoblastic leukemia implicates immunosuppression in the etiology. Haematologica 2019, 104: e514-e516. PMID: 30923090, PMCID: PMC6821599, DOI: 10.3324/haematol.2019.216465.Peer-Reviewed Original ResearchConceptsChildhood acute lymphoblastic leukemiaAcute lymphoblastic leukemiaLymphoblastic leukemiaNeonatal levelsArginase-2ImmunosuppressionEtiologyLeukemia
2016
Cesarean Section and Risk of Childhood Acute Lymphoblastic Leukemia in a Population-Based, Record-Linkage Study in California
Wang R, Wiemels JL, Metayer C, Morimoto L, Francis SS, Kadan-Lottick N, DeWan AT, Zhang Y, Ma X. Cesarean Section and Risk of Childhood Acute Lymphoblastic Leukemia in a Population-Based, Record-Linkage Study in California. American Journal Of Epidemiology 2016, 185: 96-105. PMID: 27986703, PMCID: PMC5253971, DOI: 10.1093/aje/kww153.Peer-Reviewed Original ResearchConceptsElective C-sectionAcute lymphoblastic leukemiaChildhood acute lymphoblastic leukemiaC-sectionCesarean sectionLymphoblastic leukemiaHigh riskPopulation-based case-control studyPeak ageEmergency C-sectionRecord linkage studyCancer registry dataCase-control studyPotential risk factorsEtiology of childhoodRelationship of modeVaginal deliveryRisk factorsRole of deliveryRegistry dataElevated riskBirth recordsInaccurate recallChildhoodRisk