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INFORMATION FOR

Preston C. Sprenkle, MD

Associate Professor of Urology
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Additional Titles

Director, Urology Research Fellowship, Urology

Co-Chair, Cancer Liaison Committee, Oncology, VA Connecticut Healthcare System

Co-Chair, NCCN Guidelines Committee on Prostate Cancer Early Detection, National Comprehensive Cancer Network (NCCN)

Division Chief, Division of Urology at VA Connecticut Healthcare System, Urology, VA Connecticut Healthcare System

About

Titles

Associate Professor of Urology

Director, Urology Research Fellowship, Urology

Positions outside Yale

Co-Chair, Cancer Liaison Committee, Oncology, VA Connecticut Healthcare System; Co-Chair, NCCN Guidelines Committee on Prostate Cancer Early Detection, National Comprehensive Cancer Network (NCCN); Division Chief, Division of Urology at VA Connecticut Healthcare System, Urology, VA Connecticut Healthcare System

Biography

Dr. Preston C. Sprenkle specializes in the treatment of urologic cancers, primarily prostate cancer, but also including kidney cancer, bladder cancer, and testicular cancer.

Dr. Sprenkle has dedicated his career to using the latest technologies to improve prostate cancer diagnosis and treatment that minimizes the impact on a man's quality of life.

He was one of the first physicians nationwide to implement the use of the Artemis Device. This machine, introduced in 2009, allows a surgeon to use 3D ultrasound technology and merge it with even more precise magnetic resonance imaging (MRI) to accurately identify cancerous tumors.

“Skilled and experienced radiologists are rare for this relatively new technique,” Dr. Sprenkle explains. “At Yale, we are fortunate to have some of the world leaders in prostate MRI.”

Dr. Sprenkle is also a pioneer in “focal therapy,” which allows a surgeon to treat tiny prostate lesions, rather than the whole organ. This avoids many of the side effects—such as erectile dysfunction and incontinence—that may follow the removal of the whole prostate.

“Exciting technological advances are revolutionizing urology. Prostate cancer is very common and current treatments can majorly impact a man's sexual and urinary function,” Dr. Sprenkle says. “Developing ways to minimize the impact of prostate cancer diagnosis and treatment on a man's health and quality of life is tremendously rewarding.”

Dr. Sprenkle believes in working with patients to come up with individualized treatment plans. “I want my patients to feel that I hear their concerns and treat them like a person. I am pleased at the end of a long consultation when they feel like they understand their disease and their options.”

Appointments

  • Urology

    Associate Professor on Term
    Primary
    Urology

Other Departments & Organizations

Education & Training

Non Degree Program
Yale School of Management, Emerging Leaders Program (2018)
Fellowship
Memorial Sloan Kettering Cancer Center (2011)
Residency
New York Presbyterian Hospital (2009)
Internship
New York Presbyterian Hospital (2005)
MD
Columbia University (2004)
BA
Stanford University, Human Biology (1998)

Research

Overview

Improving accuracy of prostate cancer diagnosis, staging, and treatment through enhanced imaging techniques with Prostate MRI and targeted prostate biopsies using our clinical outcomes database.

Clinical trial interventions on patients with high risk prostate cancer as well as utilizing new techniques and technologies for ablation (destruction) of prostate cancer using such technologies as cryoablation, irreversible electroporation, TULSA, laser ablation, and others.

Medical Subject Headings (MeSH)

Ablation Techniques; Genomics; High-Intensity Focused Ultrasound Ablation; Machine Learning; Magnetic Resonance Imaging; Prostatectomy; Urology

Research at a Glance

Yale Co-Authors

Frequent collaborators of Preston C. Sprenkle's published research.

Publications

2024

See All Publications

Clinical Trials

Current Trials

Academic Achievements & Community Involvement

  • activity

    NCCN Prostate Cancer Early Detection Guideline Panel

    Peer Review Groups and Grant Study SectionsVice Chair
  • activity

    Scientific Advisory Board

    Advisory BoardsAdvisor
  • activity

    Frontiers

    Journal ServiceAssociate Editor
  • activity

    Urologic Oncology

    Journal ServiceReviewer
  • activity

    Oncotarget

    Journal ServiceReviewer
See All Achievements

Clinical Care

Overview

Preston C. Sprenkle, MD, specializes in the treatment of urologic cancers, including prostate cancer, kidney cancer, bladder cancer, testicular cancer and sarcoma—a rare kind of cancer that grows in cells that connect or support other parts of the body, like bone or muscle.

Dr. Sprenkle has dedicated his career to using the latest imaging technologies to improve diagnosis. He was one of the first physicians nationwide to implement the use of the Artemis Device. This machine, introduced in 2009, allows a surgeon to use 3D ultrasound technology and merge it with even more precise magnetic resonance imaging (MRI) to accurately identify cancerous tumors.

“Skilled and experienced radiologists are rare for this relatively new technique,” Dr. Sprenkle explains. “At Yale, we are fortunate to have some of the world leaders in prostate MRI.”

Dr. Sprenkle is also a pioneer in “focal therapy,” which allows a surgeon to treat tiny prostate lesions, rather than the whole organ. This avoids many of the side effects—such as erectile dysfunction and incontinence—that may follow the removal of the whole prostate.

“Exciting technological advances are revolutionizing urology. Prostate cancer is very common and current treatments can majorly impact a man's sexual and urinary function,” Dr. Sprenkle says. “Developing ways to minimize the impact of prostate cancer diagnosis and treatment on a man's health and quality of life is tremendously rewarding.”

Dr. Sprenkle believes in working with patients to come up with individualized treatment plans. “I want my patients to feel that I hear their concerns and treat them like a person. I am pleased at the end of a long consultation when they feel like they understand their disease and their options.”

Clinical Specialties

Urology; Urologic Oncology

Fact Sheets

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Yale Medicine News

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Are You a Patient?

View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.

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Get In Touch

Contacts

Email
Appointment Number
Clinic Fax Number
Mailing Address

Urology

PO Box 208058

New Haven, CT 06520-8058

United States

Locations

  • Patient Care Locations

    Are You a Patient? View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.

    See Patient Care Locations

Events

Nov 20242All Day
  • Everyone
    All Day
    Isaac Y. Kim, MD, PhD, MBA - Jill C. Buckley, MD, MBA - Chester J. Koh, MD, MBA - Curtis A. Pettaway, MD - Landon W. Trost, MD - Angela Arlen, MD - Eric Bortnick, MD - Jaime A. Cavallo, MD, MPHS - Fed Ghali, MD - Adam Benjamin Hittelman, MD, PhD - Stanton Honig, MD - Patrick A. Kenney, MD - Thomas V. Martin, MD - Katherine Rotker, MD - Dinesh Singh, MD - Preston C. Sprenkle, MD - Joshua Sterling, MD, MSc - Yi An, MD

    Yale Urology CME Symposium

    2nd Annual "Bulldog Debates"

    Yale Club of New York City
    Add event to Calendar