2018
Efficacy and safety of a fatty acid amide hydrolase inhibitor (PF-04457845) in the treatment of cannabis withdrawal and dependence in men: a double-blind, placebo-controlled, parallel group, phase 2a single-site randomised controlled trial
D'Souza DC, Cortes-Briones J, Creatura G, Bluez G, Thurnauer H, Deaso E, Bielen K, Surti T, Radhakrishnan R, Gupta A, Gupta S, Cahill J, Sherif MA, Makriyannis A, Morgan PT, Ranganathan M, Skosnik PD. Efficacy and safety of a fatty acid amide hydrolase inhibitor (PF-04457845) in the treatment of cannabis withdrawal and dependence in men: a double-blind, placebo-controlled, parallel group, phase 2a single-site randomised controlled trial. The Lancet Psychiatry 2018, 6: 35-45. PMID: 30528676, DOI: 10.1016/s2215-0366(18)30427-9.Peer-Reviewed Original ResearchConceptsPF-04457845Cannabis withdrawal symptomsFatty acid amide hydrolaseCannabis withdrawalPlacebo groupAdverse eventsCannabis useWithdrawal symptomsFatty acid amide hydrolase inhibitorSerious adverse eventsPhase 2a trialWeeks of treatmentTreatment of cannabisCannabis use disorderSelf-reported cannabis useDSM-IV criteriaTreatment-related differencesTHC-COOH concentrationsAnandamide concentrationsTreat populationPrimary endpointPill countHospital admissionNovel FAAH inhibitorsSelf-reported cannabis
2015
Ketamine-Induced Hallucinations
Powers A, Gancsos MG, Finn ES, Morgan PT, Corlett PR. Ketamine-Induced Hallucinations. Psychopathology 2015, 48: 376-385. PMID: 26361209, PMCID: PMC4684980, DOI: 10.1159/000438675.Peer-Reviewed Original ResearchConceptsAuditory verbal hallucinationsPerceptual inputVerbal hallucinationsPredictive coding modelDelusion-like ideasPerceptual disruptionsPerceptual expectationsPerceptual environmentCoding modelPhenomenological experienceSensory stimuliStimulation environmentAuditory hallucinationsHealthy participantsHallmark symptomFirst-episode psychosisMusical hallucinationsMRI scannerHallucinationsParticipantsMagnetic resonance imaging (MRI) scannerPsychosisAmotivationPerceptVivid hallucinations
2014
N-Methyl-D-Aspartate Receptor Antagonist Effects on Prefrontal Cortical Connectivity Better Model Early Than Chronic Schizophrenia
Anticevic A, Corlett PR, Cole MW, Savic A, Gancsos M, Tang Y, Repovs G, Murray JD, Driesen NR, Morgan PT, Xu K, Wang F, Krystal JH. N-Methyl-D-Aspartate Receptor Antagonist Effects on Prefrontal Cortical Connectivity Better Model Early Than Chronic Schizophrenia. Biological Psychiatry 2014, 77: 569-580. PMID: 25281999, DOI: 10.1016/j.biopsych.2014.07.022.Peer-Reviewed Original ResearchConceptsHealthy volunteersFunctional connectivityKetamine effectsChronic schizophreniaIllness progressionChronic illnessHigh riskRecent pharmacologic studiesReceptor antagonist effectsAspartate glutamate receptorsStages of schizophreniaCourse of schizophreniaGlutamate dysfunctionPharmacologic modelsPrefrontal cortex functionIllness stageNMDAR antagonistsFunctional dysconnectivityGlutamate receptorsPharmacologic studiesHealthy subjectsSchizophrenia onsetFunctional alterationsDevelopment of therapeuticsAntagonist effects
2013
The Impact of NMDA Receptor Blockade on Human Working Memory-Related Prefrontal Function and Connectivity
Driesen NR, McCarthy G, Bhagwagar Z, Bloch MH, Calhoun VD, D'Souza DC, Gueorguieva R, He G, Leung HC, Ramani R, Anticevic A, Suckow RF, Morgan PT, Krystal JH. The Impact of NMDA Receptor Blockade on Human Working Memory-Related Prefrontal Function and Connectivity. Neuropsychopharmacology 2013, 38: 2613-2622. PMID: 23856634, PMCID: PMC3828532, DOI: 10.1038/npp.2013.170.Peer-Reviewed Original ResearchConceptsNMDA-Rs
2012
NMDA receptor function in large-scale anticorrelated neural systems with implications for cognition and schizophrenia
Anticevic A, Gancsos M, Murray JD, Repovs G, Driesen NR, Ennis DJ, Niciu MJ, Morgan PT, Surti TS, Bloch MH, Ramani R, Smith MA, Wang XJ, Krystal JH, Corlett PR. NMDA receptor function in large-scale anticorrelated neural systems with implications for cognition and schizophrenia. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109: 16720-16725. PMID: 23012427, PMCID: PMC3478611, DOI: 10.1073/pnas.1208494109.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlgorithmsBrainCognitionDouble-Blind MethodExcitatory Amino Acid AntagonistsFemaleHumansInfusions, IntravenousKetamineMagnetic Resonance ImagingMaleMemoryModels, NeurologicalPattern Recognition, VisualPsychomotor PerformanceReceptors, N-Methyl-D-AspartateSchizophreniaSynaptic TransmissionYoung AdultConceptsNeural systemsLarge-scale brain systemsTask-dependent activationN-methyl-D-aspartate receptorsRealistic computational modelingSevere neuropsychiatric illnessNMDA glutamate receptor antagonistGlutamate receptor antagonistsBrain systemsNMDA receptor functionTask performanceMultiple interacting regionsCognitionCortical disinhibitionGlutamatergic neurotransmissionReceptor antagonistCortical computationGlutamate's roleReciprocal relationshipNeuropsychiatric illnessLocal circuitsReceptor functionSchizophreniaPresent findingsComputational modelingNight eating in obese treatment‐seeking hispanic patients with and without binge eating disorder
Grilo CM, Milsom VA, Morgan PT, White MA. Night eating in obese treatment‐seeking hispanic patients with and without binge eating disorder. International Journal Of Eating Disorders 2012, 45: 787-791. PMID: 22407481, PMCID: PMC3378792, DOI: 10.1002/eat.22011.Peer-Reviewed Original ResearchConceptsEating-disorder psychopathologyHispanic patientsMetabolic variablesBed statusNon-NE groupNon-NE patientsFrequency of nightConsecutive seriesPatientsHispanic menSpanish-language versionDepression levelsDisorder psychopathologyMonolingual SpanishGroup differencesPsychopathologyDepressionGreater frequencyDisorders
2010
A multistudy analysis of the effects of early cocaine abstinence on sleep
Matuskey D, Pittman B, Forselius E, Malison RT, Morgan PT. A multistudy analysis of the effects of early cocaine abstinence on sleep. Drug And Alcohol Dependence 2010, 115: 62-66. PMID: 21144676, PMCID: PMC3081928, DOI: 10.1016/j.drugalcdep.2010.10.015.Peer-Reviewed Original Research
2009
Regulation of cocaine self-administration in humans: Lack of evidence for loading and maintenance phases
Angarita GA, Pittman B, Gueorguieva R, Kalayasiri R, Lynch WJ, Sughondhabirom A, Morgan PT, Malison RT. Regulation of cocaine self-administration in humans: Lack of evidence for loading and maintenance phases. Pharmacology Biochemistry And Behavior 2009, 95: 51-55. PMID: 20005893, PMCID: PMC2824073, DOI: 10.1016/j.pbb.2009.12.005.Peer-Reviewed Original ResearchSex differences in sleep and sleep-dependent learning in abstinent cocaine users
Morgan PT, Paliwal P, Malison RT, Sinha R. Sex differences in sleep and sleep-dependent learning in abstinent cocaine users. Pharmacology Biochemistry And Behavior 2009, 93: 54-58. PMID: 19379771, PMCID: PMC2699445, DOI: 10.1016/j.pbb.2009.04.006.Peer-Reviewed Original Research
2008
CLINICAL STUDY: Subjective responses and cardiovascular effects of self‐administered cocaine in cocaine‐abusing men and women
Lynch WJ, Kalayasiri R, Sughondhabirom A, Pittman B, Coric V, Morgan PT, Malison RT. CLINICAL STUDY: Subjective responses and cardiovascular effects of self‐administered cocaine in cocaine‐abusing men and women. Addiction Biology 2008, 13: 403-410. PMID: 18782384, PMCID: PMC3690939, DOI: 10.1111/j.1369-1600.2008.00115.x.Peer-Reviewed Original ResearchConceptsSelf-administer cocaineSelf-administered cocaine infusionsDiastolic blood pressureSubjective effect measuresCocaine-induced increasesCocaine self-administration sessionsFeelings of hungerFixed ratio 1Cocaine-abusing menSelf-administration sessionsTime-dependent increaseCardiovascular effectsBlood pressureCardiovascular responsesHormonal influencesCocaine abuseSecondary analysisCocaine infusionsHuman laboratoryCardiovascular measuresEffect measuresWomenCocaineMenSignificant main effectSleep architecture, cocaine and visual learning
Morgan PT, Pace‐Schott E, Sahul ZH, Coric V, Stickgold R, Malison RT. Sleep architecture, cocaine and visual learning. Addiction 2008, 103: 1344-1352. PMID: 18855824, PMCID: PMC3690941, DOI: 10.1111/j.1360-0443.2008.02233.x.Peer-Reviewed Original ResearchConceptsChronic cocaine usersVisual learningProgressive abstinenceVisual texture discrimination taskLate night REM sleepSlow wave activityAbstinence-related changesTexture discrimination taskCocaine usersSleep architectureCocaine useVisual performanceREM sleepOvernight enhancementDays of abstinenceDiscrimination taskCocaine self-administration sessionsSelf-administration sessionsCognitive functionChronic cocaine useLearning deficitsCognitive dysfunctionRapid eye movement (REM) sleepAbstinenceCocaine abstinence