2024
Absence of Anti-Babesia microti antibody in commercial intravenous immunoglobulin (IVIG)
Kostka J, Maharjan A, Kumar S, Hackenyos D, Krause P, Dieckhaus K. Absence of Anti-Babesia microti antibody in commercial intravenous immunoglobulin (IVIG). PLOS Neglected Tropical Diseases 2024, 18: e0012035. PMID: 38484010, PMCID: PMC10965045, DOI: 10.1371/journal.pntd.0012035.Peer-Reviewed Original ResearchConceptsIntravenous immunoglobulinB. microti antibodiesBabesiosis patientsSpectrum of disease severityCommercial intravenous immunoglobulinEffective treatment strategiesSevere organ damageHost antibody responseImmunocompromised patientsAdjunctive therapyOrgan damageTreatment strategiesAcute andClinical trialsMicroti antibodiesAsymptomatic infectionAntibody responseTherapeutic benefitTherapeutic effectPatientsDisease severityAntibodiesImmunofluorescence assayProtozoan infectionsCommercial samples
2020
644. Borrelia miyamotoi and Borrelia burgdorferi Seroprevalence in New England
Johnston D, Kelly J, Ledizet M, Lavoie N, Krause P. 644. Borrelia miyamotoi and Borrelia burgdorferi Seroprevalence in New England. Open Forum Infectious Diseases 2020, 7: s381-s381. PMCID: PMC7777872, DOI: 10.1093/ofid/ofaa439.838.Peer-Reviewed Original ResearchSerum samplesB. burgdorferi antibodiesMethods Serum samplesNon-endemic areasResidential zip codeResidential countyBackground diseasesBurgdorferi antibodiesMultiplex LuminexStudy participantsLyme diseaseSpirochetal pathogensBorrelia miyamotoiB. miyamotoiBorrelia burgdorferiB. burgdorferiCausative agentZip codesHuman exposureDiseaseAntibodiesMiyamotoiBurgdorferiIxodes scapularisBorrelia burgdorferi and Borrelia miyamotoi seroprevalence in California blood donors
Brummitt SI, Kjemtrup AM, Harvey DJ, Petersen JM, Sexton C, Replogle A, Packham AE, Bloch EM, Barbour AG, Krause PJ, Green V, Smith WA. Borrelia burgdorferi and Borrelia miyamotoi seroprevalence in California blood donors. PLOS ONE 2020, 15: e0243950. PMID: 33370341, PMCID: PMC7769429, DOI: 10.1371/journal.pone.0243950.Peer-Reviewed Original ResearchConceptsLyme diseaseBlood donorsB. miyamotoiB. burgdorferiEndemic countiesWestern blotBorrelia miyamotoiB. burgdorferi antibodiesAdult blood donorsBorrelia burgdorferiIgG Western blotBlood donor seraRisk of infectionELISA test systemBurgdorferi antibodiesDonor seraC6 ELISAClinical casesEquivocal samplesHuman casesDiseaseAntibodiesI. pacificus ticksMiyamotoiBurgdorferi
2019
Adaptive Immunity: Antigen Recognition by T and B Lymphocytes
Kavathas P, Krause P, Ruddle N. Adaptive Immunity: Antigen Recognition by T and B Lymphocytes. 2019, 55-74. DOI: 10.1007/978-3-030-25553-4_4.ChaptersB cell receptorCell receptorMajor histocompatibility complexB lymphocytesKiller T cellsEffective immune responseVariety of antigensT cell receptors (TCRs) bindCentral toleranceT cellsImmune responseHLA proteinsAntigen recognitionHistocompatibility complexIntracellular pathogensCell surfaceReceptorsHLALymphocytesCorresponding antibodiesHost cellsAntibodiesIsotypesMHC systemDefense mechanisms
2018
Human Borrelia miyamotoi infection in California: Serodiagnosis is complicated by multiple endemic Borrelia species
Krause PJ, Carroll M, Fedorova N, Brancato J, Dumouchel C, Akosa F, Narasimhan S, Fikrig E, Lane RS. Human Borrelia miyamotoi infection in California: Serodiagnosis is complicated by multiple endemic Borrelia species. PLOS ONE 2018, 13: e0191725. PMID: 29420552, PMCID: PMC5805228, DOI: 10.1371/journal.pone.0191725.Peer-Reviewed Original ResearchConceptsBorrelia miyamotoi infectionMiyamotoi infectionB. miyamotoiB. miyamotoi diseaseB. miyamotoi infectionB. burgdorferi infectionHealth care professionalsWhole cell lysatesSeropositive subjectsSufficient serumClinical dataBurgdorferi infectionAntibody assaysSeropositive samplesCare professionalsBorrelia antigensInfectionSerumAntibodiesBorrelia burgdorferiAntigenI. pacificus ticksMiyamotoiTick infectionFever spirochetes
2017
Human seroprevalence of Borrelia miyamotoi in Manitoba, Canada, in 2011-2014: a cross-sectional study
Kadkhoda K, Dumouchel C, Brancato J, Gretchen A, Krause PJ. Human seroprevalence of Borrelia miyamotoi in Manitoba, Canada, in 2011-2014: a cross-sectional study. CMAJ Open 2017, 5: e690-e693. PMID: 28882852, PMCID: PMC5621960, DOI: 10.9778/cmajo.20170070.Peer-Reviewed Original ResearchEnzyme-linked immunosorbent assayWestern blotLyme diseasePeptide enzyme-linked immunosorbent assayCross-sectional studyResidents of ManitobaTick-borne relapsing feverHuman seroprevalenceResidents of areasResidual seraRelapsing feverImmunosorbent assayBorrelia miyamotoiInitial reportSerumFeverInfectionDiseaseAntibodiesBlotBorreliaParticipantsSeronegativeSeropositiveHumans
2006
Confirmation of Tick Bite by Detection of Antibody to Ixodes Calreticulin Salivary Protein▿
Alarcon-Chaidez F, Ryan R, Wikel S, Dardick K, Lawler C, Foppa IM, Tomas P, Cushman A, Hsieh A, Spielman A, Bouchard KR, Dias F, Aslanzadeh J, Krause PJ. Confirmation of Tick Bite by Detection of Antibody to Ixodes Calreticulin Salivary Protein▿. MSphere 2006, 13: 1217-1222. PMID: 16928887, PMCID: PMC1656538, DOI: 10.1128/cvi.00201-06.Peer-Reviewed Original ResearchConceptsEnzyme-linked immunosorbent assayImmune responseTick exposureBALB/c miceC3H/HeNTick-borne infectionsHuman granulocytic anaplasmosisDetection of antibodiesLaboratory markersAntibody responseC miceTick biteSalivary proteinsObjective evidenceLyme diseaseImmunosorbent assayGranulocytic anaplasmosisHuman babesiosisSalivary glandsIxodes ticksAntibodiesBlood mealSame assayMiceSerum
1999
Southern Extension of the Range of Human Babesiosis in the Eastern United States
Eskow E, Krause P, Spielman A, Freeman K, Aslanzadeh J. Southern Extension of the Range of Human Babesiosis in the Eastern United States. Journal Of Clinical Microbiology 1999, 37: 2051-2052. PMID: 10325378, PMCID: PMC85028, DOI: 10.1128/jcm.37.6.2051-2052.1999.Peer-Reviewed Original ResearchConceptsMicroti infectionBlood samplesB. microti antibodiesSerial blood samplesBabesia microti infectionB. microti infectionCollected blood samplesMicroti antibodiesAcute babesiosisImmunofluorescent antibodyHuman B. microti infectionBabesial antigensHuman babesiosisB. microtiInfectionBabesiosisAntibodiesPCR techniqueUnited StatesLocal acquisitionResidentsPatientsSymptomsAntigenBlood
1989
Enhancement of neutrophil function for treatment of neonatal infections
KRAUSE P, HERSON V, EISENFELD L, JOHNSON G. Enhancement of neutrophil function for treatment of neonatal infections. The Pediatric Infectious Disease Journal 1989, 8: 382-389. PMID: 2664694, DOI: 10.1097/00006454-198906000-00011.Peer-Reviewed Original ResearchConceptsNewborn infantsRisk of morbidityFresh frozen plasmaMaximum therapeutic benefitHost defense mechanismsNeonatal infectionImportant therapyNeutrophil functionFrozen plasmaPMN functionTherapeutic benefitAdult PMNInfectionFurther studiesInfantsNew antibioticsDefense mechanismsTransfusionMorbidityNeonatesTherapyMortalityAdministrationImpairmentAntibodiesCharacterization of Nonmotile Neutrophil Subpopulations in Neonates and Adults
Krause P, Kreutzer D, Eisenfeld L, Herson V, Weisman S, Bannon P, Greca N. Characterization of Nonmotile Neutrophil Subpopulations in Neonates and Adults. Pediatric Research 1989, 25: 519-524. PMID: 2717268, DOI: 10.1203/00006450-198905000-00019.Peer-Reviewed Original ResearchConceptsPMN subpopulationPolymorphonuclear leukocytesPMN motilityAdult polymorphonuclear leukocytesMost polymorphonuclear leukocytesMicropore filtersNeutrophil subpopulationsHomogeneous populationPhagocytic functionNeonatesChemotactic stimuliMAbsSubpopulationsAdultsPMN precursorsPresent studyHigh percentageMotilityCellsPrevious studiesPopulationLeukocytesAntibodies
1986
Polymorphonuclear Leukocyte Heterogeneity in Neonates and Adults
Krause P, Malech H, Kristie J, Kosciol C, Herson V, Eisenfeld L, Pastuszak W, Kraus A, Seligmann B. Polymorphonuclear Leukocyte Heterogeneity in Neonates and Adults. Blood 1986, 68: 200-204. DOI: 10.1182/blood.v68.1.200.200.Peer-Reviewed Original Research