2021
Deletion of Cdh16 Ksp-cadherin leads to a developmental delay in the ability to maximally concentrate urine in mouse
Thomson R, Dynia DW, Burlein S, Thomson BR, Booth C, Knauf F, Wang T, Aronson P. Deletion of Cdh16 Ksp-cadherin leads to a developmental delay in the ability to maximally concentrate urine in mouse. American Journal Of Physiology. Renal Physiology 2021, 320: f1106-f1122. PMID: 33938239, PMCID: PMC8285649, DOI: 10.1152/ajprenal.00556.2020.Peer-Reviewed Original ResearchConceptsKsp-cadherinCell adhesion moleculeAtypical memberKidney developmentMammalian kidneyAdult mammalian kidneyBasolateral membraneNormal kidney developmentEpithelial cellsAdhesion moleculesMutant animalsExpression analysisSpecific expressionE-cadherin expressionWestern blot analysisEpithelial phenotypePrincipal proteinE-cadherinBlot analysisMouse linesAquaporin-2CadherinCritical roleDevelopmental delayKnockout mice
1998
cDNA Cloning and Chromosomal Localization of the Human and Mouse Isoforms of Ksp-Cadherin
Thomson RB, Ward DC, Quaggin SE, Igarashi P, Muckler ZE, Aronson PS. cDNA Cloning and Chromosomal Localization of the Human and Mouse Isoforms of Ksp-Cadherin. Genomics 1998, 51: 445-451. PMID: 9721215, DOI: 10.1006/geno.1998.5402.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsCadherinsCell Adhesion MoleculesChromosome MappingChromosomes, Human, Pair 16Cloning, MolecularHumansIn Situ Hybridization, FluorescenceKidneyMiceMice, Inbred StrainsMolecular Sequence DataMultigene FamilyRNA, MessengerSequence Analysis, DNASequence Homology, Amino AcidConceptsMouse isoformsKsp-cadherinPutative N-glycosylation sitesInferred amino acid sequenceSingle ancestral geneCharacteristic protein domainsCadherin family membersKidney-specific memberN-glycosylation sitesAmino acid sequenceMammalian genomesAncestral geneGene duplicationSyntenic regionsChromosomal localizationComplete cDNAGene mapsProtein domainsSequence motifsGene sequencesCDNA cloningCell adhesion moleculeAcid sequenceNorthern analysisChromosome 8