2021
Distinct functions of POT1 proteins contribute to the regulation of telomerase recruitment to telomeres
Gu P, Jia S, Takasugi T, Tesmer VM, Nandakumar J, Chen Y, Chang S. Distinct functions of POT1 proteins contribute to the regulation of telomerase recruitment to telomeres. Nature Communications 2021, 12: 5514. PMID: 34535663, PMCID: PMC8448735, DOI: 10.1038/s41467-021-25799-7.Peer-Reviewed Original ResearchConceptsDNA damage responseTelomerase recruitmentPOT1 proteinsDamage responseATR-dependent DNA damage responseNon-homologous end-joining DNA repair pathwayRecruitment of telomeraseC-strand fillAmino acidsDNA repair pathwaysUnique amino acidsTEN1 (CST) complexTelomere extensionCTC1-STN1Stable heterodimerRepair pathwaysC-terminusDistinct functionsPOT1bPOT1aTelomeresC-strandG-strandTPP1Protein
2003
Expression of the Orphan Nuclear Receptor, Germ Cell Nuclear Factor, in Mouse Gonads and Preimplantation Embryos1
Lan ZJ, Gu P, Xu X, Cooney AJ. Expression of the Orphan Nuclear Receptor, Germ Cell Nuclear Factor, in Mouse Gonads and Preimplantation Embryos1. Biology Of Reproduction 2003, 68: 282-289. PMID: 12493724, DOI: 10.1095/biolreprod.102.008151.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAntibody SpecificityBase SequenceBlastocystDNADNA-Binding ProteinsFemaleGene Expression Regulation, DevelopmentalImmunohistochemistryIn Vitro TechniquesMaleMiceMice, Inbred C57BLMolecular Sequence DataNuclear Receptor Subfamily 6, Group A, Member 1OocytesOogenesisOvaryPregnancyReceptors, Cytoplasmic and NuclearSpermatogenesisSpermatozoaTestisConceptsGerm cell nuclear factorGCNF proteinMouse gonadsEmbryonic developmentZygotic gene expressionNormal mouse embryonic developmentNuclear receptorsMouse embryonic developmentPreimplantation embryonic developmentSpermatogenic cellsPostmeiotic spermatogenic cellsCytoplasm of oocytesOrphan nuclear receptorNuclear factorPreimplantation Embryos1Early embryosGene transcriptionMaternal proteinsOrphan memberMouse embryosGene expressionPreimplantation embryosGCNFProteinEmbryos