2022
Rapid Screen for Antiviral T‐Cell Immunity with Nanowire Electrochemical Biosensors
Nami M, Han P, Hanlon D, Tatsuno K, Wei B, Sobolev O, Pitruzzello M, Vassall A, Yosinski S, Edelson R, Reed M. Rapid Screen for Antiviral T‐Cell Immunity with Nanowire Electrochemical Biosensors. Advanced Materials 2022, 34: e2109661. PMID: 35165959, DOI: 10.1002/adma.202109661.Peer-Reviewed Original ResearchConceptsT cell immunitySARS-CoV-2Immune responseHuman T cell immune responseAntiviral T cell immunityPathogen-specific T cellsT cell immune responsesT cell analysisPatient's immune responseT cell responsesAntibody-based protectionPandemic SARS-CoV-2Protective immunityT cellsVaccine formulationsB cellsVaccine designBroad protectionDisease riskInfectious diseasesCare toolsTranslational platformImmunityEmergent variantsPandemic coronavirus
2019
Ex vivo dendritic cell generation—A critical comparison of current approaches
Han P, Hanlon D, Sobolev O, Chaudhury R, Edelson RL. Ex vivo dendritic cell generation—A critical comparison of current approaches. International Review Of Cytology 2019, 349: 251-307. PMID: 31759433, DOI: 10.1016/bs.ircmb.2019.10.003.Peer-Reviewed Original ResearchConceptsDendritic cellsDiscovery of DCsMemory T cell responsesProfessional antigen-presenting cellsAntigen-specific immune responsesDendritic cell generationAntigen-specific immunityT cell responsesAntigen-presenting cellsEx vivo productionMononuclear cell fractionRalph SteinmanDC therapyAutoimmune disordersImmunologic functionDC functionPoor survivalImmunologic roleImmune responsePeripheral tissuesPhysiologic productionAdaptive immunityClinical utilityTherapeutic modulationImmune system
2016
Induction of anti-tumor CD8 T cell responses by experimental ECP-induced human dendritic antigen presenting cells
Kibbi N, Sobolev O, Girardi M, Edelson RL. Induction of anti-tumor CD8 T cell responses by experimental ECP-induced human dendritic antigen presenting cells. Transfusion And Apheresis Science 2016, 55: 146-152. PMID: 27317354, DOI: 10.1016/j.transci.2016.06.001.Peer-Reviewed Original ResearchConceptsCD8 T cell responsesCutaneous T-cell lymphomaT cell responsesCell responsesCD8 T cell populationsMonocyte-derived DCsAnti-tumor immunityT cell populationsT-cell lymphomaAntigen presenting cellsClass I major histocompatibilityCentral mechanistic roleMelanoma-associated proteinImmunotherapeutic managementHost diseaseAllograft rejectionPresenting cellsDendritic antigenImmunologic reactionsCell lymphomaMalignant cloneMajor histocompatibilityPathogenic clonesCell populationsAntigen