1990
Direct carbon versus proton heteronuclear editing of 2‐13C ethanol in rabbit brain in vivo: A sensitivity comparison
Novotny E, Ogino T, Rothman D, Petroff O, Prichard J, Shulman R. Direct carbon versus proton heteronuclear editing of 2‐13C ethanol in rabbit brain in vivo: A sensitivity comparison. Magnetic Resonance In Medicine 1990, 16: 431-443. PMID: 2077334, DOI: 10.1002/mrm.1910160310.Peer-Reviewed Original ResearchNeonatal seizure: magnetic resonance spectroscopic findings.
Young R, Petroff O. Neonatal seizure: magnetic resonance spectroscopic findings. Seminars In Perinatology 1990, 14: 238-47. PMID: 2196682.Peer-Reviewed Original ResearchProton NMR Observation of Phenylalanine and an Aromatic Metabolite in the Rabbit Brain in Vivo
Avison M, Herschkowitz N, Novotny E, Petroff O, Rothman D, Colombo J, Bachmann C, Shulman R, Prichard J. Proton NMR Observation of Phenylalanine and an Aromatic Metabolite in the Rabbit Brain in Vivo. Pediatric Research 1990, 27: 566-570. PMID: 2162514, DOI: 10.1203/00006450-199006000-00005.Peer-Reviewed Original ResearchNeonatal Excitotoxic Brain Injury
Young R, Petroff O, Novotny E, Wong M. Neonatal Excitotoxic Brain Injury. Developmental Neuroscience 1990, 12: 210-220. PMID: 2142073, DOI: 10.1159/000111850.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainFemaleMagnetic Resonance SpectroscopyMaleNeurotoxinsPyridinesQuinolinic AcidQuinolinic AcidsRatsRats, Inbred StrainsSeizuresConceptsQuisqualic acidBrain injuryNeonatal excitotoxic brain injuryExcitotoxic brain injuryHypoxic-ischemic injuryNeonatal rat brainN-acetyl aspartateExcitotoxic damageNeuronal necrosisNeuropathologic examinationParoxysmal dischargesNeonatal ratsElectroencephalographic monitoringHilar areaRat brainMedial CA1Pathologic alterationsMetabolic alterationsParahippocampal regionPathological effectsGlutamate analogueInjuryPhysiologicUnique patternAlterationsIn Vivo Measurements of Ethanol Concentration in Rabbit Brain by 1H Magnetic Resonance Spectroscopy
Petroff O, Novotny E, Ogino T, Avison M, Prichard J. In Vivo Measurements of Ethanol Concentration in Rabbit Brain by 1H Magnetic Resonance Spectroscopy. Journal Of Neurochemistry 1990, 54: 1188-1195. PMID: 2313285, DOI: 10.1111/j.1471-4159.1990.tb01947.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainCatheterizationEthanolHydrogenInjections, Intra-ArterialKineticsMagnetic Resonance SpectroscopyModels, NeurologicalOsmolar ConcentrationRabbitsStomachConceptsMagnetic resonance spectroscopyResonance spectroscopyChemical Shift Selective Magnetic Resonance ImagingVivo 1H magnetic resonance spectroscopyCerebral blood flowBlood ethanol concentrationVivo 1H spectroscopyMagnetic resonance imagingIntragastric administrationBlood flowGas chromatographyRabbit brainResonance imagingSpectroscopyPerchloric acid extractsEthanol levelsAdministrationBrainAcid extractsVivo measurementsCerebralEthanol concentrationMeasurement of ethanol in the human brain using NMR spectroscopy.
Hanstock C, Rothman D, Shulman R, Novotny E, Petroff O, Prichard J. Measurement of ethanol in the human brain using NMR spectroscopy. Journal Of Studies On Alcohol And Drugs 1990, 51: 104-7. PMID: 2308346, DOI: 10.15288/jsa.1990.51.104.Peer-Reviewed Original ResearchAlcoholic IntoxicationBrainBrain ChemistryEthanolHumansMagnetic Resonance SpectroscopyMaleMiddle AgedTime Factors
1989
High-field proton magnetic resonance spectroscopy of human cerebrum obtained during surgery for epilepsy.
Petroff O, Spencer D, Alger J, Prichard J. High-field proton magnetic resonance spectroscopy of human cerebrum obtained during surgery for epilepsy. Neurology 1989, 39: 1197-202. PMID: 2771071, DOI: 10.1212/wnl.39.9.1197.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrainBrain ChemistryEpilepsyFrontal LobeHumansIntraoperative PeriodMagnetic Resonance SpectroscopyTemporal LobeTissue DistributionConceptsProton magnetic resonance spectroscopyGamma-aminobutyric acidWhite matterTemporal lobe cortexHuman cerebrumHigh-field proton magnetic resonance spectroscopyBeta-hydroxybutyric acidConcentrations of creatineRefractory epilepsyN-acetylaspartateTemporal lobeMagnetic resonance spectroscopyPerchloric acid extractsSignificant differencesSurgeryEpilepsyCerebrumCreatineAcid extractsResonance spectroscopyBeagle puppy model of perinatal asphyxia: Blockade of excitatory neurotransmitters
Ment L, Stewart W, Petroff O, Duncan C, Montoya D. Beagle puppy model of perinatal asphyxia: Blockade of excitatory neurotransmitters. Pediatric Neurology 1989, 5: 281-286. PMID: 2553028, DOI: 10.1016/0887-8994(89)90018-0.Peer-Reviewed Original ResearchConceptsN-methyl-D-aspartate receptor antagonist MK801Cerebral blood flowBlood flowPerinatal asphyxiaCerebral high-energy phosphatesN-methyl-D-aspartate receptorsSaline 15 minBeagle puppy modelModel of ischemiaNewborn beagle puppiesHigh-energy phosphatesNeuropathologic damageAsphyxial insultPuppy modelNeuronal changesCerebral lactateExcitatory neurotransmitterBrainstem structuresPhosphocreatine levelsDrug treatmentMetabolic insultsBeagle puppiesMK801InsultPuppiesThromboxane synthesis inhibitor in a beagle pup model of perinatal asphyxia.
Ment L, Stewart W, Petroff O, Duncan C. Thromboxane synthesis inhibitor in a beagle pup model of perinatal asphyxia. Stroke 1989, 20: 809-814. PMID: 2728050, DOI: 10.1161/01.str.20.6.809.Peer-Reviewed Original ResearchConceptsCerebral blood flowThromboxane synthesis inhibitorBlood flowPerinatal asphyxiaSynthesis inhibitorCGS 13080Intraventricular hemorrhageLactate levelsCerebral regionsHigh incidenceMetabolic alterationsWhite matterLactate concentrationAsphyxiaBrain extractsInsultPhosphocreatine concentrationPupsSalineInhibitorsHemorrhageProstaglandinsMedullaThe Effect of Diazepam on Neonatal Seizure: In Vivo 31P and 1H NMR Study
Young R, Chen B, Petroff O, Gore J, Cowan B, Novotny E, Wong M, Zuckerman K. The Effect of Diazepam on Neonatal Seizure: In Vivo 31P and 1H NMR Study. Pediatric Research 1989, 25: 27-31. PMID: 2919113, DOI: 10.1203/00006450-198901000-00006.Peer-Reviewed Original ResearchConceptsBrain lactateBrain high-energy phosphatesArrest of seizuresFlurothyl-induced seizuresCerebral blood flowNormalization of EEGEffects of diazepamVivo 31P nuclear magnetic resonance spectroscopyHigh-energy phosphatesElectrographic seizuresNeonatal seizuresNeonatal dogsPostictal periodBrain pHBaseline valuesBlood flowBrain phosphocreatineMetabolic recoveryProlonged elevationSeizuresSustained increaseVivo 31PRapid returnDiazepamEnergy phosphates
1988
Proton magnetic resonance spectroscopic studies of agonal carbohydrate metabolism in rabbit brain.
C. Petroff O, Prichard J, Ogino T, Shulman R. Proton magnetic resonance spectroscopic studies of agonal carbohydrate metabolism in rabbit brain. Neurology 1988, 38: 1569-74. PMID: 3419601, DOI: 10.1212/wnl.38.10.1569.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAspartic AcidBlood GlucoseBrainCarbohydrate MetabolismCerebrovascular CirculationCreatineElectroshockFemaleGlycolysisLactatesMagnetic Resonance SpectroscopyRabbitsConceptsBlood glucoseCerebral lactate accumulationLactate accumulationProton magnetic resonance spectroscopic studyWet weight/minCerebral metabolismCardiac arrestControl rabbitsRabbit brainGlycolytic rateMagnetic resonance spectroscopic measurementsCarbohydrate metabolismEquivalents/RabbitsMagnetic resonance spectroscopyMetabolismGlucoseCarbohydrate availabilityGlucose equivalent/High‐Resolution Proton Magnetic Resonance Spectroscopy of Rabbit Brain: Regional Metabolite Levels and Postmortem Changes
Petroff O, Ogino T, Alger J. High‐Resolution Proton Magnetic Resonance Spectroscopy of Rabbit Brain: Regional Metabolite Levels and Postmortem Changes. Journal Of Neurochemistry 1988, 51: 163-171. PMID: 3379399, DOI: 10.1111/j.1471-4159.1988.tb04850.x.Peer-Reviewed Original ResearchConceptsN-acetylaspartateWhite matterRabbit cerebral cortexCerebral white matterProton magnetic resonance spectroscopyGamma-aminobutyric acidRegional metabolite levelsTotal creatine poolCardiac arrestCerebral cortexCerebral metabolitesRabbit brainMagnetic resonance spectroscopyCreatine poolMetabolite levelsReference standardPostmortem changesCortexResonance spectroscopy1H nuclear magnetic resonance spectroscopy study of neonatal hypoglycemia
Petroff O, Young R, Cowan B, Novotny E. 1H nuclear magnetic resonance spectroscopy study of neonatal hypoglycemia. Pediatric Neurology 1988, 4: 31-34. PMID: 3233106, DOI: 10.1016/0887-8994(88)90021-5.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornDogsEnergy MetabolismHydrogenHypoglycemiaMagnetic Resonance SpectroscopyConceptsHigh-energy phosphatesBrain high-energy phosphatesBrain energy stateHypoglycemic brain damageInsulin-induced hypoglycemiaExcitatory amino acidsHypoglycemic brain injuryBrain tissue injuryMagnetic resonance spectroscopy studyAdult experimental animalsBrain glucose contentNeonatal hypoglycemiaExcitatory neurotransmitterInhibitory neurotransmitterMechanisms of resistanceNeonatal dogsBrain damageBrain injuryBrain glutamateTissue injuryEnergy failureNeonatal animalsGABA concentrationExperimental animalsHypoglycemiaBiological 1H NMR spectroscopy
Petroff O. Biological 1H NMR spectroscopy. Comparative Biochemistry And Physiology Part B Comparative Biochemistry 1988, 90: 249-260. PMID: 3044689, DOI: 10.1016/0305-0491(88)90069-7.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBody FluidsHumansHydrogenMagnetic Resonance SpectroscopyPharmaceutical PreparationsConceptsProton nuclear magnetic resonance spectroscopyNuclear magnetic resonance spectroscopyRecent biological applicationsPowerful analytical methodMagnetic resonance spectroscopyNMR spectroscopyNMR methodsRate of metabolismBiological applicationsMetabolic fluxResonance spectroscopyChemical compoundsComplex mixturesAbnormal physiological conditionsNMRCompoundsSpectroscopyAnalytical methodPhysiological conditionsExogenous compoundsIntracellular pHBody fluidsMetabolismMetabolic pathophysiologyMagnetization transfer
1987
Cerebral Lactate Elevation by Electroshock: A 1H Magnetic Resonance Studya
PRICHARD J, PETROFF O, OGINO T, SHULMAN R. Cerebral Lactate Elevation by Electroshock: A 1H Magnetic Resonance Studya. Annals Of The New York Academy Of Sciences 1987, 508: 54-63. PMID: 3439712, DOI: 10.1111/j.1749-6632.1987.tb32894.x.Peer-Reviewed Original ResearchAnimalsBrainElectroencephalographyElectroshockFemaleHydrogenKineticsLactatesMagnetic Resonance SpectroscopyRabbitsIn vivo 31P and in vitro 1H nuclear magnetic resonance study of hypoglycemia during neonatal seizure
Young R, Cowan B, Petroff O, Novotny E, Dunham S, Briggs R. In vivo 31P and in vitro 1H nuclear magnetic resonance study of hypoglycemia during neonatal seizure. Annals Of Neurology 1987, 22: 622-628. PMID: 3426168, DOI: 10.1002/ana.410220511.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornBicucullineBrainCerebrovascular CirculationDogsGlucoseHemodynamicsHydrogenHypoglycemiaIn Vitro TechniquesLactatesLactic AcidMagnetic Resonance SpectroscopyPhosphorusSeizuresConceptsNeonatal seizuresBrain energy stateBicuculline-induced seizuresBrain glucose concentrationsCerebral blood flowBeta-hydroxybutyrate levelsBrain metabolic stateVivo 31P nuclear magnetic resonance spectroscopyBrain alanineAdenosine triphosphate levelsNeonatal dogsPhosphocreatine levelsSignificant elevationBlood flowSeizuresMagnetic resonance spectroscopyBrain extractsVivo 31PHypoglycemiaAdverse effectsTriphosphate levelsGlucose concentrationGreater declineFurther deteriorationMetabolic state31P magnetization transfer studies of creatine kinase kinetics in living rabbit brain
Degani H, Alger J, Shulman R, Petroff O, Prichard J. 31P magnetization transfer studies of creatine kinase kinetics in living rabbit brain. Magnetic Resonance In Medicine 1987, 5: 1-12. PMID: 3657491, DOI: 10.1002/mrm.1910050102.Peer-Reviewed Original ResearchAdenosine TriphosphateAnimalsBrainCreatine KinaseFemaleKineticsMagnetic Resonance SpectroscopyPhosphocreatineRabbitsProton magnetic resonance spectroscopy of leech muscle and nervous system
Petroff O, Hogan E, Johansen J, Kleinhaus A. Proton magnetic resonance spectroscopy of leech muscle and nervous system. Comparative Biochemistry And Physiology Part B Comparative Biochemistry 1987, 87: 927-931. PMID: 3665438, DOI: 10.1016/0305-0491(87)90414-7.Peer-Reviewed Original ResearchMeSH Keywords3-Hydroxybutyric AcidAcetatesAmino AcidsAnimalsCholineHydroxybutyratesInositolLactatesLeechesMagnetic Resonance SpectroscopyMusclesNervous SystemConceptsMagnetic resonance spectroscopyProton nuclear magnetic resonance spectroscopyNuclear magnetic resonance spectroscopyResonance spectroscopyNMR spectroscopySpectroscopyMammalian cerebrumOrganic metabolitesIntracellular metabolitesNervous systemVentral cordPerchloric acid extractsMajor intracellular metaboliteSpectraNervous tissueAspartateAminobutyric acidRapid meansAcid extractsMetabolitesHirudonineInositolRabbit cerebrumAlanineDistinctive components
1986
Detection of metabolites in rabbit brain by 13C NMR spectroscopy following administration of [1‐13C]glucose
Behar K, Petroff O, Prichard J, Alger J, Shulman R. Detection of metabolites in rabbit brain by 13C NMR spectroscopy following administration of [1‐13C]glucose. Magnetic Resonance In Medicine 1986, 3: 911-920. PMID: 2881185, DOI: 10.1002/mrm.1910030611.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainGlucoseGlutamatesGlutamic AcidGlutamineHypoxia, BrainLactatesMagnetic Resonance SpectroscopyRabbitsRadionuclide ImagingSpectrum AnalysisHigh‐Resolution Proton Magnetic Resonance Analysis of Human Cerebrospinal Fluid
Petroff O, Yu R, Ogino T. High‐Resolution Proton Magnetic Resonance Analysis of Human Cerebrospinal Fluid. Journal Of Neurochemistry 1986, 47: 1270-1276. PMID: 3746301, DOI: 10.1111/j.1471-4159.1986.tb00750.x.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrainBrain InjuriesCerebrospinal FluidComaFemaleGlucoseHumansInfantMagnetic Resonance SpectroscopyMaleNervous System DiseasesPropylene GlycolPropylene GlycolsSeizures