Featured Publications
Impact of genetic polymorphisms on the risk of epilepsy amongst patients with acute brain injury: A systematic review
Misra S, Quinn T, Falcone G, Sharma V, de Havenon A, Zhao Y, Eldem E, French J, Yasuda C, Dawson J, Liebeskind D, Kwan P, Mishra N. Impact of genetic polymorphisms on the risk of epilepsy amongst patients with acute brain injury: A systematic review. European Journal Of Neurology 2023, 30: 1791-1800. PMID: 36912749, DOI: 10.1111/ene.15777.Peer-Reviewed Original ResearchConceptsPost-traumatic epilepsyPost-stroke epilepsyTraumatic brain injuryRisk of epilepsySystematic reviewSingle nucleotide polymorphismsBrain injuryOdds ratioRisk of PSERisk of PTEAcute brain injuryGenetic polymorphismsConfidence intervalsAssociation of SNPsQ-Genie toolPSE patientsLate seizuresHazard ratioStroke patientsTBI patientsPrespecified protocolStudy qualityCurrent evidenceEpilepsyPatientsClinical characteristics and outcomes of patients with post-stroke epilepsy: protocol for an individual patient data meta-analysis from the International Post-stroke Epilepsy Research Repository (IPSERR)
Mishra N, Kwan P, Tanaka T, Sunnerhagen K, Dawson J, Zhao Y, Misra S, Wang S, Sharma V, Mazumder R, Funaro M, Ihara M, Nicolo J, Liebeskind D, Yasuda C, Cendes F, Quinn T, Ge Z, Scalzo F, Zelano J, Kasner S, Consortium I, Mishra N, Kwan P, Friedman A, Engel J. Clinical characteristics and outcomes of patients with post-stroke epilepsy: protocol for an individual patient data meta-analysis from the International Post-stroke Epilepsy Research Repository (IPSERR). BMJ Open 2023, 13: e078684. PMID: 37968000, PMCID: PMC10660442, DOI: 10.1136/bmjopen-2023-078684.Peer-Reviewed Original ResearchConceptsPost-stroke epilepsyPost-stroke seizuresIndividual patient dataClinical characteristicsLate post-stroke seizuresPatient dataOutcomes of patientsFuture clinical trialsPatient outcome measuresComprehensive search strategyAcute strokePeer-reviewed journalsStroke patientsPrognostic valueStroke mortalityBias assessmentClinical trialsObservational studyOutcome measuresLanguage of publicationEpileptic seizuresPatientsEthics approvalStudy authorsIPD-MAMortality and functional outcomes in patients with post-stroke epileptic seizures: a systematic review and meta-analysis (S45.006)
Misra S, Vazquez J, Eldem E, Silva L, Mohidat S, Hickman L, Khan E, Funaro M, Yasuda C, Liebeskind D, Kasner S, Mishra N. Mortality and functional outcomes in patients with post-stroke epileptic seizures: a systematic review and meta-analysis (S45.006). Neurology 2023, 100 DOI: 10.1212/wnl.0000000000203419.Peer-Reviewed Original Research
2022
Platelet FcγRIIa Expression in Ischemic Stroke: A Marker of Increased Platelet Reactivity
Schneider D, Honda T, Feldmann E, de Havenon A, Romano J, Nogueira R, Prabhakaran S, Mishra N, Beaman C, Hinman J, Commichau C, Callas P, Kaneko N, Morales J, Patel S, Sharma L, Kim S, Taatjes‐Sommer H, Liebeskind D. Platelet FcγRIIa Expression in Ischemic Stroke: A Marker of Increased Platelet Reactivity. Stroke Vascular And Interventional Neurology 2022, 2 DOI: 10.1161/svin.121.000201.Peer-Reviewed Original ResearchStroke/transient ischemic attackTransient ischemic attackRecent myocardial infarctionMyocardial infarctionPlatelet expressionFcγRIIa expressionNeurologic dysfunctionPlatelet reactivitySubsequent stroke/transient ischemic attacksSubsequent cardiovascular eventsEmbolic causesNonembolic causesPlatelet FcγRIIACardiovascular eventsIschemic attackIdentifies patientsIschemic strokeMethods PatientsDischarge diagnosisTreatment decisionsLower riskPatientsPlatelet activationFlow cytometryEmbolic
2016
Optimal Computed Tomographic Perfusion Scan Duration for Assessment of Acute Stroke Lesion Volumes
Kasasbeh AS, Christensen S, Straka M, Mishra N, Mlynash M, Bammer R, Albers GW, Lansberg MG. Optimal Computed Tomographic Perfusion Scan Duration for Assessment of Acute Stroke Lesion Volumes. Stroke 2016, 47: 2966-2971. PMID: 27895299, PMCID: PMC5134896, DOI: 10.1161/strokeaha.116.014177.Peer-Reviewed Original ResearchConceptsVenous output functionOptimal scan timeLesion volumePerfusion scanAcute stroke patientsIschemic lesion volumeStroke lesion volumeScan durationLesion volume measurementsMost patientsStroke patientsTomographic perfusionOptimal durationScan protocolTotal scan durationContrast bolusScansScan timePatientsSufficient durationDurationVolume measurementsShort scan durationPerfusionBolusComparison of stroke volume evolution on diffusion-weighted imaging and fluid-attenuated inversion recovery following endovascular thrombectomy
Federau C, Christensen S, Mlynash M, Tsai J, Kim S, Zaharchuk G, Inoue M, Straka M, Mishra NK, Kemp S, Lansberg MG, Albers GW. Comparison of stroke volume evolution on diffusion-weighted imaging and fluid-attenuated inversion recovery following endovascular thrombectomy. International Journal Of Stroke 2016, 12: 510-518. PMID: 27811306, DOI: 10.1177/1747493016677985.Peer-Reviewed Original ResearchConceptsInfarct lesion volumeFluid-attenuated inversion recoveryDiffusion-weighted imagingLesion volumeEndovascular thrombectomyInversion recoveryDay 5Fluid-attenuated inversion recovery lesionsPost-stroke onsetDegree of reperfusionStroke lesion volumeFluid-attenuated inversion recovery imagesInversion recovery imagesInfarct volumeInfarct growthStroke onsetSymptom onsetLesion growthPatientsRecovery imagesInterquartile rangeThrombectomyProcedure images
2015
Response to endovascular reperfusion is not time-dependent in patients with salvageable tissue
Lansberg MG, Cereda CW, Mlynash M, Mishra NK, Inoue M, Kemp S, Christensen S, Straka M, Zaharchuk G, Marks MP, Bammer R, Albers GW, Saver J, Fayad P, Howard G, Tomsick. T, Jovin T, Wechsler L, DeCesare S, Thai D, Sherr A, Wilder M, Tricot A, Lutsep H, McDaneld L, Larsen D, Czartoski T, Keogh B, Malik A, Brown A, Bernstein R, Muskovich K, Chang C, Stern T, Warach S, Davis L, Fazekas F, Seifert-Held T. Response to endovascular reperfusion is not time-dependent in patients with salvageable tissue. Neurology 2015, 85: 708-714. PMID: 26224727, PMCID: PMC4553034, DOI: 10.1212/wnl.0000000000001853.Peer-Reviewed Original ResearchConceptsGood functional outcomeEndovascular reperfusionFunctional outcomeSalvageable tissueLesion volumeLesion growthRandomized placebo-controlled trialModified Rankin Scale scorePerfusion Imaging EvaluationPerfusion lesion volumeTarget mismatch profilePlacebo-controlled trialRankin Scale scorePerfusion-diffusion mismatchSubgroup of patientsRadiologic outcomesCohort studyEndovascular therapyEarly followStroke patientsImaging evaluationReperfusionDay 90PatientsScale scoreReperfusion of Very Low Cerebral Blood Volume Lesion Predicts Parenchymal Hematoma After Endovascular Therapy
Mishra NK, Christensen S, Wouters A, Campbell BC, Straka M, Mlynash M, Kemp S, Cereda CW, Bammer R, Marks MP, Albers GW, Lansberg MG. Reperfusion of Very Low Cerebral Blood Volume Lesion Predicts Parenchymal Hematoma After Endovascular Therapy. Stroke 2015, 46: 1245-1249. PMID: 25828235, PMCID: PMC4414872, DOI: 10.1161/strokeaha.114.008171.Peer-Reviewed Original ResearchConceptsParenchymal hemorrhageIntravenous alteplaseEndovascular therapyBaseline imagingLesion volumeLow cerebral blood volumePerfusion Imaging EvaluationIschemic stroke patientsEndovascular reperfusion therapySingle independent predictorRoutine clinical practiceCerebral blood volumeMagnetic resonance imagingRegional reperfusionParenchymal hematomaReperfusion therapyIndependent predictorsEarly followRisk stratificationStroke patientsImaging evaluationNormal perfusionVLCBVBlood volumePatients
2013
Influence of racial differences on outcomes after thrombolytic therapy in acute ischemic stroke
Mishra NK, Mandava P, Chen C, Grotta J, Lees KR, Kent TA, collaboration V. Influence of racial differences on outcomes after thrombolytic therapy in acute ischemic stroke. International Journal Of Stroke 2013, 9: 613-617. PMID: 24148895, DOI: 10.1111/ijs.12162.Peer-Reviewed Original ResearchConceptsTissue plasminogen activatorBaseline National InstitutesHealth Stroke ScaleNon-Caucasian patientsPlasminogen activatorStroke ScaleNational InstituteRace-EthnicityNon-thrombolysed patientsStroke III TrialRace-ethnicity groupsNeuroprotection trialsIII trialsDiabetes statusFunctional outcomeImproved outcomesPatientsNeurological disordersCaucasian populationDifferential responseEthnicity groupsOutcomesCaucasiansOddsTrials
2011
Thrombolysis outcomes in acute ischemic stroke patients with prior stroke and diabetes mellitus
Mishra NK, Ahmed N, Davalos A, Iversen HK, Melo T, Soinne L, Wahlgren N, Lees KR. Thrombolysis outcomes in acute ischemic stroke patients with prior stroke and diabetes mellitus. Neurology 2011, 77: 1866-1872. PMID: 22094479, DOI: 10.1212/wnl.0b013e318238ee42.Peer-Reviewed Original ResearchConceptsNIH Stroke Scale scoreBaseline NIH Stroke Scale scoreConcomitant diabetes mellitusPrior strokeIschemic stroke patientsDiabetes mellitusThrombolytic therapyStroke patientsOdds ratioScale scoreAcute ischemic stroke patientsInfluence of DMOutcomes of patientsStroke Scale scoreRankin Scale scoreConfidence intervalsDistribution of mRSAlteplase treatmentProportional odds logistic regressionMRS outcomesThrombolysis outcomesPatientsHaenszel testEuropean approvalCochran-Mantel
2010
Thrombolysis in very elderly people: controlled comparison of SITS International Stroke Thrombolysis Registry and Virtual International Stroke Trials Archive
Mishra NK, Ahmed N, Andersen G, Egido JA, Lindsberg PJ, Ringleb PA, Wahlgren NG, Lees KR. Thrombolysis in very elderly people: controlled comparison of SITS International Stroke Thrombolysis Registry and Virtual International Stroke Trials Archive. The BMJ 2010, 341: c6046. PMID: 21098614, PMCID: PMC2990864, DOI: 10.1136/bmj.c6046.Peer-Reviewed Original ResearchConceptsVirtual International Stroke Trials ArchiveNon-randomised patientsAcute ischemic strokeProportional odds logistic regression analysisComparison of outcomesLogistic regression analysisNeuroprotection trialsSITS-ISTREffect of ageIschemic strokeHaenszel testCochran-MantelThrombolysisPatientsRegression analysisInfluence of Age on Outcome From Thrombolysis in Acute Stroke
Mishra NK, Diener HC, Lyden PD, Bluhmki E, Lees KR. Influence of Age on Outcome From Thrombolysis in Acute Stroke. Stroke 2010, 41: 2840-2848. PMID: 21030710, DOI: 10.1161/strokeaha.110.586206.Peer-Reviewed Original ResearchConceptsAcute ischemic strokeHealth scale scoresControl subjectsIschemic strokeInfluence of ageScale scoreBaseline National InstitutesRankin Scale scoreNational InstituteLimited trial dataNeuroprotection trialsRankin scoreThrombolysis treatmentAcute strokeYounger patientsAge decilesPoor outcomeBaseline severityImproved outcomesPatientsHaenszel testTrial dataCochran-MantelThrombolysisLogistic regressionComparison of Outcomes Following Thrombolytic Therapy Among Patients With Prior Stroke and Diabetes in the Virtual International Stroke Trials Archive (VISTA)
Mishra NK, Davis SM, Kaste M, Lees KR, . Comparison of Outcomes Following Thrombolytic Therapy Among Patients With Prior Stroke and Diabetes in the Virtual International Stroke Trials Archive (VISTA). Diabetes Care 2010, 33: 2531-2537. PMID: 20843977, PMCID: PMC2992183, DOI: 10.2337/dc10-1125.Peer-Reviewed Original ResearchConceptsVirtual International Stroke Trials ArchivePrior strokeUse of alteplaseBaseline National InstitutesHealth Stroke ScaleProportional odds logistic regression analysisInfluence of diabetesInteraction of diabetesComparison of outcomesLogistic regression analysisConcomitant diabetesEligible patientsNeurological outcomeStroke ScaleIschemic strokeThrombolytic treatmentThrombolytic therapyThrombolysed patientsFunctional outcomeControl subjectsOutcome measuresPatientsDiabetesHaenszel testCochran-MantelStroke program for India
Mishra NK, Khadilkar SV. Stroke program for India. Annals Of Indian Academy Of Neurology 2010, 13: 28-32. PMID: 20436743, PMCID: PMC2859584, DOI: 10.4103/0972-2327.61273.Peer-Reviewed Original ResearchStroke ProgramStroke medicineNon-neurologist physiciansStroke care modelCentral nervous systemStroke epidemicStroke patientsStroke cliniciansCare modelCardiovascular disordersNervous systemCare trainingClinical expertiseStrokeCliniciansMulti-disciplinary approachNational programUrgent needMedicinePatientsNeurologistsPhysiciansNeurology
2008
Recurrent Wernicke's Aphasia: Migraine and Not Stroke!
Mishra NK, Rossetti AO, Ménétrey A, Carota A. Recurrent Wernicke's Aphasia: Migraine and Not Stroke! Headache The Journal Of Head And Face Pain 2008, 49: 765-768. PMID: 19456883, DOI: 10.1111/j.1526-4610.2008.01255.x.Peer-Reviewed Original Research
2005
Abulia: no will, no way.
Hastak SM, Gorawara PS, Mishra NK. Abulia: no will, no way. Journal Of Association Of Physicians Of India 2005, 53: 814-8. PMID: 16334629.Peer-Reviewed Original Research