2015
Neuropathology of Traumatic Brain Injury: Comparison of Penetrating, Nonpenetrating Direct Impact and Explosive Blast Etiologies
de Lanerolle NC, Kim JH, Bandak FA. Neuropathology of Traumatic Brain Injury: Comparison of Penetrating, Nonpenetrating Direct Impact and Explosive Blast Etiologies. Seminars In Neurology 2015, 35: 012-019. PMID: 25714863, DOI: 10.1055/s-0035-1544240.Peer-Reviewed Original ResearchConceptsClosed head injuryTraumatic brain injuryDiffuse axonal injuryAxonal injuryMild TBIHead injuryBrain injurySevere closed head injuryModerate traumatic brain injuryModerate closed head injuryMild traumatic brain injuryAnimal TBI modelsMicroglial activationNeuronal injuryTBI modelCerebral vasculatureInjuryNeuropathologyGross disruptionHuman brainBlunt impactUnique patternHumansActivationAstrocytes
2010
Astrocytes and Epilepsy
de Lanerolle NC, Lee TS, Spencer DD. Astrocytes and Epilepsy. Neurotherapeutics 2010, 7: 424-438. PMID: 20880506, PMCID: PMC5084304, DOI: 10.1016/j.nurt.2010.08.002.Peer-Reviewed Original ResearchConceptsSeizure focusReactive astrocytesCausation of seizuresGlial fibrillary acidic proteinHippocampal seizure focusRole of astrocytesTemporal lobe epilepsyFibrillary acidic proteinPositive reactive astrocytesNonsclerotic hippocampiHippocampal sclerosisSclerotic hippocampusSubicular neuronsLobe epilepsyEpileptiform activityInflammatory functionsAstrocytesAction potentialsAcidic proteinPotassium ion channelsVascular interfaceEpilepsyHippocampusPrecise roleHuman brain