2022
Urine Uromodulin as a Biomarker of Kidney Tubulointerstitial Fibrosis
Melchinger H, Calderon-Gutierrez F, Obeid W, Xu L, Shaw MM, Luciano RL, Kuperman M, Moeckel GW, Kashgarian M, Wilson FP, Parikh CR, Moledina DG. Urine Uromodulin as a Biomarker of Kidney Tubulointerstitial Fibrosis. Clinical Journal Of The American Society Of Nephrology 2022, 17: 1284-1292. PMID: 35948365, PMCID: PMC9625093, DOI: 10.2215/cjn.04360422.Peer-Reviewed Original ResearchMeSH KeywordsAlbuminsAnimalsAtrophyBiomarkersCreatinineFibrosisHumansKidneyKidney DiseasesMiceUromodulinConceptsInterstitial fibrosis/tubular atrophyUrine uromodulinTubular atrophyThick ascending limbUrine albuminSerum creatinineKidney biopsyTubulointerstitial fibrosisMultivariable linear regression modelsTime of biopsyKidney's thick ascending limbAcademic medical centerHuman kidney biopsiesKidney tubulointerstitial fibrosisTubular healthMultivariable analysisHistologic featuresHistologic findingsHistologic changesKidney fibrosisIndependent associationFibrotic modelMultivariable modelMedical CenterMurine model
2008
Disruption of Myosin 1e Promotes Podocyte Injury
Krendel M, Kim SV, Willinger T, Wang T, Kashgarian M, Flavell RA, Mooseker MS. Disruption of Myosin 1e Promotes Podocyte Injury. Journal Of The American Society Of Nephrology 2008, 20: 86-94. PMID: 19005011, PMCID: PMC2615733, DOI: 10.1681/asn.2007111172.Peer-Reviewed Original ResearchConceptsChronic renal injuryNormal glomerular filtrationGlomerular basement membraneRenal injuryKidney inflammationPodocyte foot processesGlomerular diseasePodocyte injuryGlomerular filtrationRenal tissueFoot processesPodocyte functionBasement membraneInjuryUltrastructural levelDiseaseMiceType IProteinuriaInflammationKidneyImportant rolePodocytes
1994
A granulocyte inhibitory protein overexpressed in chronic renal disease regulates expression of interleukin 6 and interleukin 8.
Ziesche R, Roth M, Papakonstantinou E, Nauck M, Hörl W, Kashgarian M, Block L. A granulocyte inhibitory protein overexpressed in chronic renal disease regulates expression of interleukin 6 and interleukin 8. Proceedings Of The National Academy Of Sciences Of The United States Of America 1994, 91: 301-305. PMID: 8278382, PMCID: PMC42935, DOI: 10.1073/pnas.91.1.301.Peer-Reviewed Original ResearchConceptsGranulocyte inhibitory proteinsInterleukin-6Chronic renal diseaseChronic renal failureProgression of glomerulosclerosisHuman mesangial cellsInhibitory proteinPluripotential effectsRenal failureRenal diseaseCytokine expressionIL-6IL-8Interleukin-8Inflammatory reactionGIP resultsGlomerular responseMesangial cellsC-jun mRNAC-fos geneC-JunDe novo synthesisNovo synthesisExpressionOverall effect
1993
Transport defects of rabbit medullary thick ascending limb cells in obstructive nephropathy.
Hwang S, Haas M, Harris H, Silva P, Yalla S, Sullivan M, Otuechere G, Kashgarian M, Zeidel M. Transport defects of rabbit medullary thick ascending limb cells in obstructive nephropathy. Journal Of Clinical Investigation 1993, 91: 21-28. PMID: 8380811, PMCID: PMC329990, DOI: 10.1172/jci116173.Peer-Reviewed Original ResearchConceptsMedullary thick ascending limbNa-K-ATPase activityNa-K-ATPaseBasolateral Na-K-ATPaseObstructed kidneysObstructive nephropathyUreteral obstructionLuminal NaRelease of obstructionThick ascending limbMajor sodium transportersUntreated kidneysTransport defectSpecific monoclonal antibodiesSodium transport defectsControl animalsAscending limbOuter medullaKidneyApical NaMarked reductionMonoclonal antibodiesMTAL cellsInhibitory effectObstruction
1981
Wegener's Granulomatosis — Clinical-Pathologic Correlations and Long-Term Course
Appel G, Gee B, Kashgarian M, Hayslett J. Wegener's Granulomatosis — Clinical-Pathologic Correlations and Long-Term Course. American Journal Of Kidney Diseases 1981, 1: 27-37. PMID: 7332000, DOI: 10.1016/s0272-6386(81)80008-x.Peer-Reviewed Original ResearchConceptsEnd-stage renal diseaseModern immunosuppressive therapyLong-term courseClinical-pathologic entityLong-term reportsImmunosuppressive therapyRenal involvementRenal manifestationsSerum creatinineWegener's granulomatosisRenal diseaseEventual prognosisSingle institutionLight microscopic morphologyPathologic correlationMedical CenterRenal tissueDisease processRespiratory tissuesSpecific diagnosisPotential diagnosisPatientsDiagnosisGranulomatosisBiopsy
1977
Renal disease.
Kashgarian M, Hayslett J, Spargo B. Renal disease. American Journal Of Pathology 1977, 89: 183-272. PMID: 143893, PMCID: PMC2032191.Peer-Reviewed Original Research
1975
Clinical Aspects of Bilateral Renal Dysplasia in Children
Gur A, Siegel N, Davis C, Kashgarian M, Hayslett J. Clinical Aspects of Bilateral Renal Dysplasia in Children. Nephron 1975, 15: 50-61. PMID: 236522, DOI: 10.1159/000180492.Peer-Reviewed Original ResearchConceptsBilateral renal dysplasiaRenal dysplasiaClinical featuresClinical aspectsProgressive renal deteriorationLong-term prognosisRenal deteriorationBilateral involvementClinical courseUrinary concentrationsLaurence-MoonBiedl syndromePathogenic mechanismsDysplasiaPaucity of informationPatientsChildrenLarge proportionPrognosisSyndromeImpairmentGlomerulonephropathy.
Hayslett J, Siegel N, Kashgarian M. Glomerulonephropathy. Advances In Internal Medicine 1975, 20: 215-48. PMID: 1090119.Peer-Reviewed Original ResearchAdolescentAdultAmyloidosisBasement MembraneBlood Coagulation DisordersChildChild, PreschoolDiabetic NephropathiesFemaleGlomerulonephritisGranulomatosis with PolyangiitisHematuriaHumansImmunoglobulin GImmunoglobulin MKidney DiseasesKidney GlomerulusLupus Erythematosus, SystemicMaleMiddle AgedNephrosis, LipoidProteinuriaStreptococcal InfectionsUremia
1973
CLINICOPATHOLOGICAL CORRELATIONS IN THE NEPHROTIC SYNDROME DUE TO PRIMARY RENAL DISEASE
HAYSLETT J, KASHGARIAN M, BENSCH K, SPARGO B, FREEDMAN L, EPSTEIN F. CLINICOPATHOLOGICAL CORRELATIONS IN THE NEPHROTIC SYNDROME DUE TO PRIMARY RENAL DISEASE. Medicine 1973, 52: 93-120. PMID: 4695844, DOI: 10.1097/00005792-197303000-00001.Peer-Reviewed Original ResearchAcute DiseaseAdolescentAdultAgedAutopsyAzathioprineBiopsyChildChild, PreschoolChronic DiseaseFemaleFollow-Up StudiesGlomerulonephritisHumansKidney DiseasesKidney Function TestsMaleMicroscopy, ElectronMiddle AgedNephrosis, LipoidNephrotic SyndromePrednisonePrognosisProteinuriaRemission, SpontaneousSerum AlbuminUrineAn Evaluation of Routine Electron Microscopy in the Examination of Renal Biopsies
Siegel N, Spargo B, Kashgarian M, Hayslett J. An Evaluation of Routine Electron Microscopy in the Examination of Renal Biopsies. Nephron 1973, 10: 209-215. PMID: 4701576, DOI: 10.1159/000180189.Peer-Reviewed Original ResearchConceptsRenal biopsyRoutine electron microscopyConsecutive renal biopsiesUltrastructural studyRenal biopsy materialConsequence of treatmentNatural coursePatient managementBiopsy materialDifferent diagnosesRelevant subclassificationBiopsyRenal pathologistsRoutine casesDiagnosisExaminationLight microscopy
1971
Mortality trends for chronic nephritis and infections of the kidney A clinical and statistical comparison between mortality in New Haven, Connecticut and the United States, 1950–1960
Du V. Florey C, Kessner D, Kashgarian M, Senter M. Mortality trends for chronic nephritis and infections of the kidney A clinical and statistical comparison between mortality in New Haven, Connecticut and the United States, 1950–1960. Journal Of Clinical Epidemiology 1971, 24: 71-77. PMID: 5568747, DOI: 10.1016/0021-9681(71)90060-9.Peer-Reviewed Original Research
1969
Physiologic studies in renal osteodystrophy treated by subtotal parathyroidectomy
Gill G, Pallotta J, Kashgarian M, Kessner D, Epstein F. Physiologic studies in renal osteodystrophy treated by subtotal parathyroidectomy. The American Journal Of Medicine 1969, 46: 930-940. PMID: 5797916, DOI: 10.1016/0002-9343(69)90095-3.Peer-Reviewed Original ResearchConceptsSubtotal parathyroidectomyParathyroid hormoneRenal osteodystrophyAbnormal renal handlingAdvanced renal insufficiencyOsteitis fibrosa cysticaRenal tubular reabsorptionRoentgenologic evidenceRenal insufficiencyFibrosa cysticaPreoperative levelsMetastatic calcificationUremic patientsTubular reabsorptionParathyroid tissueMedullary cystsRenal handlingPhysiologic studiesPatientsParathyroidectomyBone healingHormoneOsteodystrophyHypercalciuriaCystica
1961
Renal Tubular Acidosis and Renal Potassium Wasting Acquired as a Result of Hypercalcemic Nephropathy
Ferris T, Kashgarian M, Levitin H, Brandt I, Epstein F. Renal Tubular Acidosis and Renal Potassium Wasting Acquired as a Result of Hypercalcemic Nephropathy. New England Journal Of Medicine 1961, 265: 924-928. PMID: 13892591, DOI: 10.1056/nejm196111092651902.Peer-Reviewed Original Research