2022
Podocyte VEGF-A Knockdown Induces Diffuse Glomerulosclerosis in Diabetic and in eNOS Knockout Mice
Veron D, Aggarwal PK, Li Q, Moeckel G, Kashgarian M, Tufro A. Podocyte VEGF-A Knockdown Induces Diffuse Glomerulosclerosis in Diabetic and in eNOS Knockout Mice. Frontiers In Pharmacology 2022, 12: 788886. PMID: 35280251, PMCID: PMC8906751, DOI: 10.3389/fphar.2021.788886.Peer-Reviewed Original ResearchDiabetic kidney diseaseGlomerular filtration rateDiffuse glomerulosclerosisDiabetic miceRenal failureNitric oxideMassive proteinuriaKnockout miceEndothelial nitric oxide synthase knockout miceNitric oxide synthase knockout miceNormal glomerular filtration rateAbsence of diabetesENOS knockout miceSynthase knockout miceVascular endothelial growth factorTargetable molecular mechanismsFoot process effacementEndothelial growth factorAbnormal S-nitrosylationArteriolar hyalinosisGFR lossMild proteinuriaSevere proteinuriaKidney diseaseUrinary excretion
2012
AS160: a new Na,K‐ATPase partner that regulates the trafficking of the sodium pump in response to energy depletion and renal ischemia
Alves D, Thulin G, Loffing J, Kashgarian M, Caplan M. AS160: a new Na,K‐ATPase partner that regulates the trafficking of the sodium pump in response to energy depletion and renal ischemia. The FASEB Journal 2012, 26: lb808-lb808. DOI: 10.1096/fasebj.26.1_supplement.lb808.Peer-Reviewed Original ResearchPlasma membraneRenal epithelial cellsK-ATPaseEpithelial cellsCytoplasmic vesicular compartmentsDifferent cellular poolsCultured epithelial cellsVesicular compartmentsWild typeCellular poolAS160Cytoplasmic accumulationKnockout micePhysiological roleWild-type controlsEnergy depletionRenal ischemiaPhysiological stimuliType controlsCellular NaK-ATPase activityIntracellular accumulationMembraneIschemic kidney injuryCells