2024
Protective mechanical ventilation in critically ill patients after surgery
Zorrilla-Vaca A, Arevalo J, Grant M. Protective mechanical ventilation in critically ill patients after surgery. Current Opinion In Critical Care 2024 DOI: 10.1097/mcc.0000000000001215.Peer-Reviewed Original ResearchIntensive care unitVentilator-induced lung injuryLung protective strategyCritically ill patientsMechanical ventilationCare unitLung injurySurgical patientsFast-track extubation protocolOpen-lung ventilation strategyIll patientsRisk of ventilator-induced lung injuryHigh-flow nasal cannulaHigh-risk surgical patientsOpen lung ventilationOperating roomNoninvasive ventilation supportProtective mechanical ventilationPositive-end expiratory pressureAcute lung injuryMechanically ventilated patientsStandard of careThoracic surgeryNasal cannulaRetrospective studyERAS® Cardiac Turnkey Order Set for Perioperative Pain Management in Cardiac Surgery: Proceedings from the AATS ERAS Conclave 2023
Gregory A, Arora R, Chatterjee S, Crisafi C, Morton-Bailey V, Rea A, Salenger R, Engelman D, Grant M, Group E, Cangut B, Crotwell S, Lobdell K, McConnell G, Reddy S. ERAS® Cardiac Turnkey Order Set for Perioperative Pain Management in Cardiac Surgery: Proceedings from the AATS ERAS Conclave 2023. JTCVS Open 2024 DOI: 10.1016/j.xjon.2024.08.018.Peer-Reviewed Original ResearchPerioperative pain managementCardiac surgeryPain managementOpioid administrationOptimal perioperative pain managementOpioid-related adverse eventsClass IShort-acting synthetic opioidLong-acting opioidsCardiac surgical patientsControl post-operativelyNon-steroidal anti-inflammatory drugsAssociated with delayed recoveryLong-term adverse effectsOpioid-based analgesiaEvidence-based order setsOpioid-sparing medicationsAnti-inflammatory drugsComprehensive multimodal approachExpert consensus documentRate of postoperative recoveryOpioid reductionInadequate analgesiaIntravenous analgesicsPost-operativelyExtubation After Cardiac Surgery: It’s Better Early, If Often
Grant M. Extubation After Cardiac Surgery: It’s Better Early, If Often. The Annals Of Thoracic Surgery 2024, 118: 699-700. PMID: 39182952, DOI: 10.1016/j.athoracsur.2024.06.026.Peer-Reviewed Original ResearchCardiac Surgical Bleeding, Transfusion and Quality Metrics: Joint Consensus Statement by the Enhanced Recovery After Surgery Cardiac Society and Society for the Advancement of Patient Blood Management
Salenger R, Arora R, Bracey A, D'Oria M, Engelman D, Evans C, Grant M, Gunaydin S, Morton V, Ozawa S, Patel P, Raphael J, Rosengart T, Shore-Lesserson L, Tibi P, Shander A. Cardiac Surgical Bleeding, Transfusion and Quality Metrics: Joint Consensus Statement by the Enhanced Recovery After Surgery Cardiac Society and Society for the Advancement of Patient Blood Management. The Annals Of Thoracic Surgery 2024 PMID: 39222899, DOI: 10.1016/j.athoracsur.2024.06.039.Peer-Reviewed Original ResearchCardiac surgical bleedingRe-exploration rateControl of bleedingRe-explorationCardiac surgeryConsensus statementSurgical bleedingExcessive bleedingCessation of antithrombotic agentsRisk of excessive bleedingAssociated with major complicationsExcessive perioperative bleedingAdvancement of Patient Blood ManagementPreoperative risk scoreManagement of bleedingPatient blood managementBlood management strategiesJoint consensus statementManagement of transfusionPerioperative bleedingMajor complicationsBlood lossInternational expert panelImprove patient outcomesBleeding scaleMaximizing Minimally Invasive Cardiac Surgery With Enhanced Recovery (ERAS).
Salenger R, Ad N, Grant M, Bakaeen F, Balkhy H, Mick S, Sardari Nia P, Kempfert J, Bonaros N, Bapat V, Wyler von Ballmoos M, Gerdisch M, Johnston D, Engelman D. Maximizing Minimally Invasive Cardiac Surgery With Enhanced Recovery (ERAS). Innovations Technology And Techniques In Cardiothoracic And Vascular Surgery 2024, 15569845241264565. PMID: 39205530, DOI: 10.1177/15569845241264565.Peer-Reviewed Original ResearchMinimally invasive cardiac surgeryInvasive cardiac surgeryCardiac surgeryPerioperative carePreservation of cardiac functionManagement of hemodynamicsGroup of cardiac surgeonsEnhanced recoveryComprehensive perioperative careCardiac surgeonsCardiac functionSurgical incisionERAS programSurgical goalsMyocardial managementSurgeryTissue invasionIncisionPatientsTyrosine Kinase Inhibitors With and Without Up-Front Stereotactic Radiosurgery for Brain Metastases From EGFR and ALK Oncogene-Driven Non-Small Cell Lung Cancer (TURBO-NSCLC).
Pike L, Miao E, Boe L, Patil T, Imber B, Myall N, Pollom E, Hui C, Qu V, Langston J, Chiang V, Grant M, Goldberg S, Palmer J, Prasad R, Wang T, Lee A, Shu C, Chen L, Thomas N, Braunstein S, Kavanagh B, Camidge D, Rusthoven C. Tyrosine Kinase Inhibitors With and Without Up-Front Stereotactic Radiosurgery for Brain Metastases From EGFR and ALK Oncogene-Driven Non-Small Cell Lung Cancer (TURBO-NSCLC). Journal Of Clinical Oncology 2024, jco2302668. PMID: 39047224, DOI: 10.1200/jco.23.02668.Peer-Reviewed Original ResearchNon-small cell lung cancerUp-front stereotactic radiosurgeryTyrosine kinase inhibitorsALK-driven NSCLCStereotactic radiosurgeryBrain metastasesCell lung cancerOverall survivalCNS controlLung cancerOncogene-driven non-small cell lung cancerKinase inhibitorsCNS progression-free survivalStereotactic radiosurgery groupTKI-naive patientsProgression-free survivalAnaplastic lymphoma kinaseEpidermal growth factor receptorCox proportional hazards modelsGrowth factor receptorClinically relevant factorsProportional hazards modelMedian OSNo significant differenceNeurological symptomsERAS/STS 2024 Expert Consensus Statement on Perioperative Care in Cardiac Surgery: Continuing the Evolution of Optimized Patient Care and Recovery
Gregory A, Ender J, Shaw A, Denault A, Ibekwe S, Stoppe C, Alli A, Manning M, Brodt J, Galhardo C, Sander M, Zarbock A, Fletcher N, Ghadimi K, Grant M. ERAS/STS 2024 Expert Consensus Statement on Perioperative Care in Cardiac Surgery: Continuing the Evolution of Optimized Patient Care and Recovery. Journal Of Cardiothoracic And Vascular Anesthesia 2024, 38: 2155-2162. PMID: 39004570, DOI: 10.1053/j.jvca.2024.06.025.Peer-Reviewed Original ResearchPreoperative Medication Management Turnkey Order Set for Nonemergent Adult Cardiac Surgery
Rea A, Salenger R, Grant M, Yeh J, Damas B, Crisalfi C, Arora R, Gregory A, Morton-Bailey V, Engelman D, Group E, Cangut B, Chatterjee S, Lobdell K, McConnell G, Crotwell S, Reddy S. Preoperative Medication Management Turnkey Order Set for Nonemergent Adult Cardiac Surgery. JTCVS Open 2024 DOI: 10.1016/j.xjon.2024.06.009.Peer-Reviewed Original ResearchSodium-glucose co-transporter-2Adult cardiac surgeryPreoperative medical managementGlucagon-like peptide-1Cardiac surgeryConsensus manuscriptNon-emergent cardiac surgeryMedical managementClass ICardiac surgical patientsCardiac surgical proceduresRisk of bleedingExpert consensus documentPreoperative managementPreoperative medicationsAnticoagulant medicationSurgical patientsSurgical proceduresSurgeryAnti-plateletPeptide-1Perioperative careConsensus documentCardiac SocietyManagement of patients' medicationTyrosine kinase inhibitors with and without upfront CNS radiation for brain metastases in oncogene-driven non-small cell lung cancer (TURBO-NSCLC).
Miao E, Pike L, Boe L, Patil T, Myall N, Hui C, Pollom E, Qu V, Langston J, Grant M, Goldberg S, Palmer J, Prasad R, Wang T, Lee A, Shu C, Chen L, Thomas N, Camidge D, Rusthoven C. Tyrosine kinase inhibitors with and without upfront CNS radiation for brain metastases in oncogene-driven non-small cell lung cancer (TURBO-NSCLC). Journal Of Clinical Oncology 2024, 42: 2019-2019. DOI: 10.1200/jco.2024.42.16_suppl.2019.Peer-Reviewed Original ResearchTyrosine kinase inhibitorsUpfront stereotactic radiosurgeryCentral nervous systemTKI-naive patientsStereotactic radiosurgeryOverall survivalMultivariable adjustmentCNS controlNeurological symptomsCNS objective response rateOncogene-driven non-small cell lung cancerFirst-generation TKIsKinase inhibitorsUpfront tyrosine kinase inhibitorNon-small cell lung cancerCentral nervous system radiationGeneration tyrosine kinase inhibitorsEGFR-mutant NSCLCMulti-institutional seriesObjective response rateInferior overall survivalMedian follow-upTreatment of BMCell lung cancerCox proportional hazards modelsComprehensive characterization of ERBB2 genomic alterations inlung cancer.
El Zarif T, Stockhammer P, Schillo J, Goldberg S, Politi K, Grant M. Comprehensive characterization of ERBB2 genomic alterations inlung cancer. Journal Of Clinical Oncology 2024, 42: 3148-3148. DOI: 10.1200/jco.2024.42.16_suppl.3148.Peer-Reviewed Original ResearchNon-small cell lung cancerProgression-free survivalShorter progression-free survivalTyrosine kinase domainSystemic therapyCo-mutationsClinical characteristics of non-small cell lung cancerCharacteristics of non-small cell lung cancerFirst-line platinum-based chemotherapyMedian tumor mutation burdenNon-small cell lung cancer tumorsFirst-line systemic therapyTP53 co-mutationsPlatinum-based chemotherapyTumor mutational burdenKaplan-Meier methodCell lung cancerLog-rank testOptimal treatment strategyHistory of smokingCopy number profilesTumor profile dataJuxtamembrane domainSquamous histologyTrastuzumab deruxtecanERAS® Cardiac Society Turnkey Order Set for Surgical Site Infection Prevention: Proceedings from the AATS ERAS Conclave 2023
Crisafi C, Grant M, Rea A, Morton-Bailey V, Gregory A, Arora R, Chatterjee S, Lother S, Cangut B, Engelman D, Group E, Salenger R, Lobdell K, McConnell G, Crotwell S, Reddy S, Lazar H. ERAS® Cardiac Society Turnkey Order Set for Surgical Site Infection Prevention: Proceedings from the AATS ERAS Conclave 2023. Journal Of Thoracic And Cardiovascular Surgery 2024 PMID: 38574802, DOI: 10.1016/j.jtcvs.2024.03.027.Peer-Reviewed Original ResearchSurgical site infectionCardiac surgeryManagement of surgical site infectionsHigher risk of surgical site infectionImplementation of evidence-based best practicesCardiac surgery increases morbidityRisk of surgical site infectionClass IConsume healthcare resourcesCardiac surgical populationSurgical site infection reductionEvidence-based best practicesProphylactic intravenous antibioticsManaging surgical site infectionsMultidisciplinary care pathwaySurgical site infection preventionPatients' quality of lifeExpert consensus documentQuality of lifeNasal carriageIntravenous antibioticsBlood glucose levelsPatient engagementSSI riskPreoperative identificationEnhanced Recovery After Surgery Cardiac Society turnkey order set for prevention and management of postoperative atrial fibrillation after cardiac surgery: Proceedings from the American Association for Thoracic Surgery ERAS Conclave 2023
Chatterjee S, Cangut B, Rea A, Salenger R, Arora R, Grant M, Morton-Bailey V, Hirji S, Engelman D, Group E, Gregory A, Lobdell K, Hui D, Puskas J, Gaudino M, Crisafi C, Reddy V. Enhanced Recovery After Surgery Cardiac Society turnkey order set for prevention and management of postoperative atrial fibrillation after cardiac surgery: Proceedings from the American Association for Thoracic Surgery ERAS Conclave 2023. JTCVS Open 2024, 18: 118-122. PMID: 38690434, PMCID: PMC11056439, DOI: 10.1016/j.xjon.2024.02.008.Peer-Reviewed Original ResearchPostoperative atrial fibrillationManagement of postoperative atrial fibrillationCardiac surgeryAtrial fibrillationDevelopment of postoperative atrial fibrillationOccurrence of postoperative atrial fibrillationAssociated with increased adverse eventsAdministration of beta-blockersClass IChronic atrial fibrillationPatient-specific risk profilesInitiate appropriate treatmentIndividual risk stratificationExpert consensus documentMultidisciplinary care pathwayElectrolyte normalizationPosterior pericardiotomyRhythm controlAdoption of evidence-based practicesBeta-blockersSurgical interventionRisk stratificationAdverse eventsAnticoagulation managementConsensus manuscriptPerioperative Care in Cardiac Surgery: A Joint Consensus Statement by the Enhanced Recovery After Surgery (ERAS) Cardiac Society, ERAS International Society, and The Society of Thoracic Surgeons (STS)
Grant M, Crisafi C, Alvarez A, Arora R, Brindle M, Chatterjee S, Ender J, Fletcher N, Gregory A, Gunaydin S, Jahangiri M, Ljungqvist O, Lobdell K, Morton V, Reddy V, Salenger R, Sander M, Zarbock A, Engelman D. Perioperative Care in Cardiac Surgery: A Joint Consensus Statement by the Enhanced Recovery After Surgery (ERAS) Cardiac Society, ERAS International Society, and The Society of Thoracic Surgeons (STS). The Annals Of Thoracic Surgery 2024, 117: 669-689. PMID: 38284956, DOI: 10.1016/j.athoracsur.2023.12.006.Peer-Reviewed Original ResearchSociety of Thoracic SurgeonsCardiac surgeryImproved postoperative clinical outcomesConsensus statementPostoperative clinical outcomesEnhanced recoveryMultidisciplinary expert panelJoint consensus statementSurgical insultThoracic surgeonsAdult patientsClinical outcomesPerioperative interventionsSurgeryERAS principlesPerioperative careRelevant interventionsCardiac SocietyClinical practiceSpecialty operationsExpert panelPromote recoveryCardiacInternational SocietyProgram elementsTelehealth and Outcomes in Patients With Cancer
Grant M, Chiang A. Telehealth and Outcomes in Patients With Cancer. The Cancer Journal 2024, 30: 16-21. PMID: 38265921, DOI: 10.1097/ppo.0000000000000697.Peer-Reviewed Original ResearchConceptsCost-effective care deliveryDelivery of oncology careCare delivery mechanismsIn-person careEffectiveness of telehealthPatient-centered outcomesQuality of lifeCare deliveryCancer abstractsCancer careOncology careReduce disparitiesFinancial toxicityIn-personTelehealthPatient satisfactionCareCOVID-19 pandemicOutcomesCancerEfficacy endpointPatientsDeliveryCOVID-19Disparities
2023
Dexmedetomidine improves pulmonary outcomes in thoracic surgery under one-lung ventilation: A meta-analysis
Zorrilla-Vaca A, Grant M, Law M, Messinger C, Pelosi P, Varelmann D. Dexmedetomidine improves pulmonary outcomes in thoracic surgery under one-lung ventilation: A meta-analysis. Journal Of Clinical Anesthesia 2023, 93: 111345. PMID: 37988813, PMCID: PMC11034816, DOI: 10.1016/j.jclinane.2023.111345.Peer-Reviewed Original ResearchAcute respiratory distress syndromePostoperative pulmonary complicationsOne-lung ventilationThoracic surgeryDexmedetomidine groupPlacebo groupPostoperative atelectasisRandomized trialsOdds ratioIncidence of PPCsImpact of dexmedetomidineIntraoperative respiratory mechanicsPostoperative lung functionRespiratory distress syndromeML/cmHRandom-effects modelPostoperative pneumoniaPulmonary complicationsPulmonary outcomesIntrapulmonary shuntPostoperative FEV1Secondary outcomesDistress syndromeLung functionPrimary outcomePerioperative hemodynamic monitoring in cardiac surgery
Grant M, Salenger R, Lobdell K. Perioperative hemodynamic monitoring in cardiac surgery. Current Opinion In Anaesthesiology 2023, 37: 1-9. PMID: 38085877, DOI: 10.1097/aco.0000000000001327.Peer-Reviewed Original ResearchConceptsPulmonary artery catheterCardiac surgeryArtery catheterHemodynamic monitoringInvasive alternativeLow-risk cardiac surgeryInvasive hemodynamic monitoringLow-risk patientsPerioperative hemodynamic monitoringPulse contour analysisPatient's hemodynamicsResuscitation therapyBedside cliniciansInvasive approachInvasive monitoringRecent studiesSurgeryMonitoring modalitiesQuestionable benefitCatheterRegular useBroader indicationsPatientsSelective useUseful alternativeIn Response
Makkad B, Heinke T, Sheriffdeen R, Khatib D, Brodt J, Meng M, Grant M, Kachulis B, Popescu W, Wu C, Bollen B. In Response. Anesthesia & Analgesia 2023, 137: e52-e53. PMID: 37973139, DOI: 10.1213/ane.0000000000006708.Peer-Reviewed Original ResearchExtubation After Cardiac Surgery: It’s Not the Destination, It’s the Journey
Grant M. Extubation After Cardiac Surgery: It’s Not the Destination, It’s the Journey. The Annals Of Thoracic Surgery 2023, 117: 94-95. PMID: 37839538, DOI: 10.1016/j.athoracsur.2023.09.047.Peer-Reviewed Original ResearchCo-Occurring Alterations in Multiple Tumor Suppressor Genes Are Associated With Worse Outcomes in Patients With EGFR-Mutant Lung Cancer
Stockhammer P, Grant M, Wurtz A, Foggetti G, Expósito F, Gu J, Zhao H, Choi J, Chung S, Li F, Walther Z, Dietz J, Duffield E, Gettinger S, Politi K, Goldberg S. Co-Occurring Alterations in Multiple Tumor Suppressor Genes Are Associated With Worse Outcomes in Patients With EGFR-Mutant Lung Cancer. Journal Of Thoracic Oncology 2023, 19: 240-251. PMID: 37806385, PMCID: PMC11364167, DOI: 10.1016/j.jtho.2023.10.001.Peer-Reviewed Original ResearchProgression-free survivalEGFR-mutant NSCLCTP53 mutationsOverall survivalClinical outcomesEGFR-TKIInferior outcomesWorse outcomesYale cohortMetastatic EGFR-mutant NSCLCShorter progression-free survivalEGFR-mutant lung cancerTyrosine kinase inhibitor therapyFirst-line TKIYale Cancer CenterSecond-line therapyInferior clinical outcomesSubset of patientsKinase inhibitor therapyAdditional therapeutic interventionsAggressive disease phenotypeCo-occurring alterationsTumor suppressor gene alterationsTumor genomic profilingMultiple tumor suppressor genesGood Old-Fashioned Lasix: An Early Novel Kidney Biomarker
Grant M. Good Old-Fashioned Lasix: An Early Novel Kidney Biomarker. The Annals Of Thoracic Surgery 2023, 117: 438-439. PMID: 37582427, DOI: 10.1016/j.athoracsur.2023.07.045.Peer-Reviewed Original Research