2023
Integrated transcriptome and trajectory analysis of cutaneous T-cell lymphoma identifies putative precancer populations
Ren J, Qu R, Rahman N, Lewis J, King A, Liao X, Mirza F, Carlson K, Huang Y, Gigante S, Evans B, Rajendran B, Xu S, Wang G, Foss F, Damsky W, Kluger Y, Krishnaswamy S, Girardi M. Integrated transcriptome and trajectory analysis of cutaneous T-cell lymphoma identifies putative precancer populations. Blood Advances 2023, 7: 445-457. PMID: 35947128, PMCID: PMC9979716, DOI: 10.1182/bloodadvances.2022008168.Peer-Reviewed Original ResearchConceptsCutaneous T-cell lymphomaMalignant CTCL cellsDiverse transcriptomic profilesT cellsSingle-cell RNACTCL cellsDevelopment of CTCLIntegrated transcriptomeT-cell receptor sequencingT cell exhaustion phenotypeCommon antigenic stimulusPeripheral blood CD4Transcriptomic profilesGene expressionT-cell lymphomaIntegrative analysisPotential therapeutic targetProliferation advantageLimited diversityBlood CD4Blood involvementMutation levelsExhaustion phenotypeWorse prognosisAntigenic stimulus
2003
Anti‐inflammatory effects in the skin of thymosin‐β4 splice‐variants
Girardi M, Sherling MA, Filler RB, Shires J, Theodoridis E, Hayday AC, Tigelaar RE. Anti‐inflammatory effects in the skin of thymosin‐β4 splice‐variants. Immunology 2003, 109: 1-7. PMID: 12709011, PMCID: PMC1782938, DOI: 10.1046/j.1365-2567.2003.01616.x.Peer-Reviewed Original ResearchConceptsDendritic epidermal T cellsContact dermatitisAnti-inflammatory effectsEpidermal T cellsAnti-inflammatory propertiesIrritant contact dermatitisAllergic contact dermatitisAnti-inflammatory activityT cell receptorNeutrophil infiltrationNeutrophilic infiltrationCutaneous inflammationLocal inflammationLymphoid tissueT cellsMurine skinCellular activationInflammationDermatitisThymosin β4SkinIELInfiltrationUnknown bioactivitiesGene expression