2024
A common polymorphism in the Intelectin-1 gene influences mucus plugging in severe asthma
Everman J, Sajuthi S, Liegeois M, Jackson N, Collet E, Peters M, Chioccioli M, Moore C, Patel B, Dyjack N, Powell R, Rios C, Montgomery M, Eng C, Elhawary J, Mak A, Hu D, Huntsman S, Salazar S, Feriani L, Fairbanks-Mahnke A, Zinnen G, Michel C, Gomez J, Zhang X, Medina V, Chu H, Cicuta P, Gordon E, Zeitlin P, Ortega V, Reisdorph N, Dunican E, Tang M, Elicker B, Henry T, Bleecker E, Castro M, Erzurum S, Israel E, Levy B, Mauger D, Meyers D, Sumino K, Gierada D, Hastie A, Moore W, Denlinger L, Jarjour N, Schiebler M, Wenzel S, Woodruff P, Rodriguez-Santana J, Pearson C, Burchard E, Fahy J, Seibold M. A common polymorphism in the Intelectin-1 gene influences mucus plugging in severe asthma. Nature Communications 2024, 15: 3900. PMID: 38724552, PMCID: PMC11082194, DOI: 10.1038/s41467-024-48034-5.Peer-Reviewed Original ResearchConceptsAirway epithelial cellsIntelectin-1Mucus pluggingGene expressionAirways of severe asthmaticsEpithelial cellsHuman airway epithelial cellsAirway epithelial brushingsMucus secretory cellsT2-high asthmaFormation of mucus plugsAssociated with protectionC-terminusGenetic variantsAirway mucus pluggingMolecular roleSecretory cellsSecreted componentsEpithelial brushingsT2-lowIL-13Mucus obstructionTarget pathwaysSevere asthmaticsClinical significance
2020
Intelectin-1 Affects Interleukin-13-Induced Mucociliary Airway Dysfunction and Its Expression Is Regulated by a Cis-eQTL Associated with Development of Asthma and IBD
Everman J, Jackson N, Sajuthi S, Saef B, Chioccioli M, Dyjack N, Powell R, Rios C, Montgomery M, Oh S, Eng C, Elhawary J, Feriani L, Armstrong M, Gomez J, Zhang X, Medina V, Chu H, Cicuta P, Rodriguez-Santana J, Reisdorph N, Burchard E, Seibold M. Intelectin-1 Affects Interleukin-13-Induced Mucociliary Airway Dysfunction and Its Expression Is Regulated by a Cis-eQTL Associated with Development of Asthma and IBD. 2020, a7400-a7400. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a7400.Peer-Reviewed Original Research