2018
CRISPR/Cas9 F0 Screening of Congenital Heart Disease Genes in Xenopus tropicalis
Deniz E, Mis EK, Lane M, Khokha MK. CRISPR/Cas9 F0 Screening of Congenital Heart Disease Genes in Xenopus tropicalis. Methods In Molecular Biology 2018, 1865: 163-174. PMID: 30151766, DOI: 10.1007/978-1-4939-8784-9_12.Peer-Reviewed Original ResearchConceptsCardiac developmentCRISPR/Candidate genesHigh-density SNP arrayCRISPR/Cas9 systemGenome editing technologyCongenital heart disease genesNew genomic technologiesHeart disease genesCopy number variationsRapid functional assayXenopus tropicalisCas9 systemGenetic basisDevelopmental systemsEditing technologyGenomic technologiesSequence variationDisease genesDifferent genesGenetic analysisSNP arrayDevelopmental mechanismsMolecular mechanismsWhole-exome sequencing
2005
Identification of mutants in inbred Xenopus tropicalis
Grammer TC, Khokha MK, Lane MA, Lam K, Harland RM. Identification of mutants in inbred Xenopus tropicalis. Cells And Development 2005, 122: 263-272. PMID: 15763207, DOI: 10.1016/j.mod.2004.11.003.Peer-Reviewed Original ResearchConceptsXenopus tropicalisRecessive embryonic lethalsGenetic model organismEarly vertebrate developmentIdentification of mutantsFuture mutagenesisVertebrate developmentMutant analysisModel organismsX. tropicalisEmbryonic lethalGenetic analysisGenetic backgroundFrogsMutationsTropicalisAmphibiansMutantsMutagenesisLethalGeneticsOrganismsStrainsCrossHybrids