Modifying the Backbone Chemistry of PEG‐Based Bottlebrush Block Copolymers for the Formation of Long‐Circulating Nanoparticles
Grundler J, Whang C, Shin K, Savan N, Zhong M, Saltzman W. Modifying the Backbone Chemistry of PEG‐Based Bottlebrush Block Copolymers for the Formation of Long‐Circulating Nanoparticles. Advanced Healthcare Materials 2024, 13: e2304040. PMID: 38734871, PMCID: PMC11368614, DOI: 10.1002/adhm.202304040.Peer-Reviewed Original ResearchBottlebrush block copolymersPerformance of nanoparticlesBottlebrush polymersBlock copolymersBiomedical applicationsLinear hydrophilic polymersBackbone chemistryLocation of functional groupsPoly(lactic acidBottlebrush backboneNanoparticle shellHydrophilic polymersPolymer backboneSurface functionalizationHeterobifunctional poly(ethylene glycolPoly(ethylene glycolHierarchical controlBlood circulation half-livesEnhanced tumor accumulationNanoparticlesPolymerReduced cellular uptakeNanoparticle physicochemical propertiesBottlebrushConventional nanoparticlesEnhancing in vivo cell and tissue targeting by modulation of polymer nanoparticles and macrophage decoys
Piotrowski-Daspit A, Bracaglia L, Eaton D, Richfield O, Binns T, Albert C, Gould J, Mortlock R, Egan M, Pober J, Saltzman W. Enhancing in vivo cell and tissue targeting by modulation of polymer nanoparticles and macrophage decoys. Nature Communications 2024, 15: 4247. PMID: 38762483, PMCID: PMC11102454, DOI: 10.1038/s41467-024-48442-7.Peer-Reviewed Original ResearchConceptsPoly(amine-co-esterPolymer nanoparticlesDelivery of nucleic acid therapeuticsCell-type tropismTissue tropismNucleic acid delivery vehiclesIn vivo deliveryIn vivo efficacyCirculation half-lifeNucleic acid therapeuticsVehicle characteristicsTunable propertiesBiodistribution assessmentPhysiological fatePolymer chemistrySurface propertiesPharmacokinetic modelTissue targetingNanoparticlesDistribution modifiersPolymeric nanoparticlesTropismPolymerDelivery vehiclesHalf-lifeNanoscale Surface Topography of Polyethylene Glycol-Coated Nanoparticles Composed of Bottlebrush Block Copolymers Prolongs Systemic Circulation and Enhances Tumor Uptake
Grundler J, Shin K, Suh H, Whang C, Fulgoni G, Pierce R, Saltzman W. Nanoscale Surface Topography of Polyethylene Glycol-Coated Nanoparticles Composed of Bottlebrush Block Copolymers Prolongs Systemic Circulation and Enhances Tumor Uptake. ACS Nano 2024, 18: 2815-2827. PMID: 38227820, DOI: 10.1021/acsnano.3c05921.Peer-Reviewed Original ResearchConceptsBottlebrush block copolymersSurface topographyBlock copolymersPoly(ethylene glycolClinical translation of nanomedicinePEGylated nanoparticlesEnhanced tumor uptakeNanoscale surface topographyTranslation of nanomedicinesRough surface topographyLinear block copolymersProlonged systemic circulationPerformance of nanocarriersPolymer coatingNanoparticle coatingSmooth surfaced nanoparticlesTumor uptakeTumor accumulationBiomedical applicationsNanoparticle formulationSystemic circulationClinical translationTumor extravasationNanoparticlesCoating