2024
High burden of viruses and bacterial pathobionts drives heightened nasal innate immunity in children
Watkins T, Green A, Amat J, Cheemarla N, Hänsel K, Lozano R, Dudgeon S, Germain G, Landry M, Schulz W, Foxman E. High burden of viruses and bacterial pathobionts drives heightened nasal innate immunity in children. Journal Of Experimental Medicine 2024, 221: e20230911. PMID: 38949638, PMCID: PMC11215523, DOI: 10.1084/jem.20230911.Peer-Reviewed Original ResearchConceptsBacterial pathobiontsRespiratory virusesBurden of virusesSARS-CoV-2Innate immune activationSARS-CoV-2 viral loadDynamic host-pathogen interactionsInnate immune responseViral coinfectionCytokine profileViral loadNasal virusImmune activationProinflammatory responseIL-1BNasopharyngeal samplesHost-pathogen interactionsImmune responseInterferon responsePathobiontsInnate immunityPaired samplesCXCL10Healthy 1-year-oldVirus
2000
Respiratory Syncytial Virus Stimulation of Vascular Endothelial Cell Growth Factor/Vascular Permeability Factor
Lee C, Yoon H, Zhu Z, Link H, Wang Z, Gwaltney J, Landry M, Elias J. Respiratory Syncytial Virus Stimulation of Vascular Endothelial Cell Growth Factor/Vascular Permeability Factor. American Journal Of Respiratory Cell And Molecular Biology 2000, 23: 662-669. PMID: 11062145, DOI: 10.1165/ajrcmb.23.5.4188.Peer-Reviewed Original ResearchConceptsVascular endothelial cell growth factorVEGF/VPFRespiratory syncytial virus stimulationRespiratory syncytial virusAcid isoformNormal human bronchial epithelial cellsEndothelial cell growth factorHuman bronchial epithelial cellsUnstimulated A549 cellsVascular permeability factorBronchial epithelial cellsCell growth factorVEGF messenger RNARSV infectionSyncytial virusVirus stimulationNasal washingsVirus infectionSignificant cell cytotoxicityPotent stimulatorCell cytotoxicityGrowth factorElevated levelsPermeability factorA549 cells
1996
Interleukin-11: stimulation in vivo and in vitro by respiratory viruses and induction of airways hyperresponsiveness.
Einarsson O, Geba G, Zhu Z, Landry M, Elias J. Interleukin-11: stimulation in vivo and in vitro by respiratory viruses and induction of airways hyperresponsiveness. Journal Of Clinical Investigation 1996, 97: 915-924. PMID: 8613544, PMCID: PMC507136, DOI: 10.1172/jci118514.Peer-Reviewed Original ResearchConceptsRespiratory syncytial virusIL-11 productionParainfluenza virus type 3Airway hyperresponsivenessIL-11Viral upper respiratory tract infectionUpper respiratory tract infectionBALB/c miceSimplex virus type 2Viral-induced asthmaViral respiratory infectionsRespiratory tract infectionsNonspecific airway hyperresponsivenessVirus type 2Virus type 3Clinical bronchospasmAirway dysfunctionAirway physiologyTract infectionsRespiratory infectionsRespiratory virusesSyncytial virusC miceNasal aspiratesViral infectionRhinovirus stimulation of interleukin-6 in vivo and in vitro. Evidence for nuclear factor kappa B-dependent transcriptional activation.
Zhu Z, Tang W, Ray A, Wu Y, Einarsson O, Landry ML, Gwaltney J, Elias JA. Rhinovirus stimulation of interleukin-6 in vivo and in vitro. Evidence for nuclear factor kappa B-dependent transcriptional activation. Journal Of Clinical Investigation 1996, 97: 421-430. PMID: 8567963, PMCID: PMC507033, DOI: 10.1172/jci118431.Peer-Reviewed Original ResearchConceptsIL-6 productionIL-6RV infectionPotent stimulatorIL-6 protein productionIL-6 siteSymptomatic RV infectionsNuclear factor kappa BFactor kappa BIL-6 mRNA accumulationNF-kappa B activationNF-kappa B DNA binding activityPromoter-driven luciferase activityRhinovirus stimulationRV challengeNF-kappa BNF-kappa B siteInterleukin-6Nasal washingsKappa BSymptomatic volunteersRhinovirusStimulation pathwayNuclear factorB activation