Featured Publications
Neurons for infant social behaviors in the mouse zona incerta
Li Y, Liu Z, Santana G, Capaz A, Doumazane E, Gao X, Renier N, Dietrich M. Neurons for infant social behaviors in the mouse zona incerta. Science 2024, 385: 409-416. PMID: 39052814, DOI: 10.1126/science.adk7411.Peer-Reviewed Original ResearchConceptsInfant social behaviorSocial behaviorZona incertaSomatostatin-expressing neuronsNeural basisInfant behaviorBehavioral distressEmotional developmentMaternal presenceNeural activity manipulationFacilitation of learningBrain centersSocial interactionPopulations of neuronsInfant mouse brainPreweaning miceMouse brainNeuronsInfantsMiceActive manipulationBehaviorMothersDistressIncerta
2012
Limitations in anti-obesity drug development: the critical role of hunger-promoting neurons
Dietrich MO, Horvath TL. Limitations in anti-obesity drug development: the critical role of hunger-promoting neurons. Nature Reviews Drug Discovery 2012, 11: 675-691. PMID: 22858652, DOI: 10.1038/nrd3739.Peer-Reviewed Original ResearchConceptsNPY/AgRP neuronsNegative energy balanceSevere side effectsAgRP neuronsPOMC neuronsPositive energy balanceChronic disordersPeripheral tissuesReactive oxygen speciesSide effectsLong-term positive energy balanceCalorie restrictionAnti-obesity drug developmentBehavioral interventionsIntense behavioral interventionsPro-opiomelanocortin (POMC) neuronsChronic metabolic disorderLong-term treatmentWhite adipose tissueAlternative therapeutic approachAnti-obesity therapiesPromotion of satietyNew drug therapiesPopulations of neuronsHigher brain functions