2024
External Disruption of Ocular Development in Utero
Kim H, Sarrafpour S, Teng C, Liu J. External Disruption of Ocular Development in Utero. The Yale Journal Of Biology And Medicine 2024, 97: 41-48. PMID: 38559457, PMCID: PMC10964818, DOI: 10.59249/rrmm8911.Peer-Reviewed Original ResearchConceptsOcular developmentOcular embryologyEnglish-language articlesIntrauterine infectionMaternal nutritionClinical significanceGenetic signaling pathwaysWeb of ScienceAnimal modelsHormonal factorsHuman studiesMultifactorial naturePregnancySignaling pathwayGoogle ScholarReviewIntrauterineEmbryologyLimited resourcesGestationUteroPathophysiologyFactorsInfectionPubMed
2017
Epigenetics and Signaling Pathways in Glaucoma
Gauthier AC, Liu J. Epigenetics and Signaling Pathways in Glaucoma. BioMed Research International 2017, 2017: 5712341. PMID: 28210622, PMCID: PMC5292191, DOI: 10.1155/2017/5712341.Peer-Reviewed Original ResearchConceptsPotential new therapeutic targetGeneration of fibrosisNovel therapeutic agentsNew therapeutic targetsAqueous humor drainageProapoptotic gene expressionRetinal neuronsIrreversible blindnessCommon causeHuman trialsTherapeutic targetAnimal modelsTrabecular meshworkTherapeutic agentsNeurodegenerative diseasesProsurvival factorBcl-2Rho-kinaseGlaucomaSignaling pathwaysPathway membersMAP kinaseGene expressionPathwayPreliminary success
2016
Neurodegeneration and Neuroprotection in Glaucoma.
Gauthier AC, Liu J. Neurodegeneration and Neuroprotection in Glaucoma. The Yale Journal Of Biology And Medicine 2016, 89: 73-9. PMID: 27505018, PMCID: PMC4797839.Peer-Reviewed Original ResearchConceptsCentral nervous system degenerative disorderOptic nerve degenerationRetinal ganglion cellsLateral geniculate nucleusAdenosine receptor antagonistIntraocular pressureNerve degenerationNeurotrophic factorReceptor antagonistGanglion cellsGlaucoma progressionDisease progressionIrreversible blindnessGeniculate nucleusNew therapiesVisual cortexDegenerative disordersAxonal transportCell therapyGlaucomaOxidative stressTherapyDiseaseNeuroprotectionNeurodegeneration
2013
Ultrasound-Enhanced Delivery of Antibiotics and Anti-Inflammatory Drugs Into the Eye
Nabili M, Patel H, Mahesh SP, Liu J, Geist C, Zderic V. Ultrasound-Enhanced Delivery of Antibiotics and Anti-Inflammatory Drugs Into the Eye. Ultrasound In Medicine & Biology 2013, 39: 638-646. PMID: 23415283, PMCID: PMC3770302, DOI: 10.1016/j.ultrasmedbio.2012.11.010.Peer-Reviewed Original ResearchConceptsOphthalmic drugsLong-term survival studiesSodium fluoresceinAnti-inflammatory drugsTreatment parameter combinationUltrasound-enhanced deliveryTopical administrationHistologic analysisSurvival studiesCorneaCorneal permeabilityDexamethasoneEpithelial layerTherapeutic drugsRabbit corneaStatistical significanceDrug dexamethasoneDrugsTobramycinUltrasoundEyesDeliveryFuture investigationsAdministrationDrug delivery
2012
Focused ultrasound facilitated thermo-chemotherapy for targeted retinoblastoma treatment: A modeling study
Wang S, Mahesh SP, Liu J, Geist C, Zderic V. Focused ultrasound facilitated thermo-chemotherapy for targeted retinoblastoma treatment: A modeling study. Experimental Eye Research 2012, 100: 17-25. PMID: 22564972, DOI: 10.1016/j.exer.2012.04.009.Peer-Reviewed Original ResearchConceptsFocused ultrasoundType of treatmentVision preservationRetinoblastoma treatmentIntraocular tumorsTreatment paradigmRabbit eyesTumor areaEarly detectionTumorsVivo studiesRetinoblastomaHyperthermic temperature rangeCommon typeTreatmentDrug deliveryFUS parametersUltrasoundEye structuresHyperthermiaViable optionThermo-chemotherapyDeliveryTherapy