2024
Integrated longitudinal multiomics study identifies immune programs associated with acute COVID-19 severity and mortality
Gygi J, Maguire C, Patel R, Shinde P, Konstorum A, Shannon C, Xu L, Hoch A, Jayavelu N, Haddad E, Network I, Reed E, Kraft M, McComsey G, Metcalf J, Ozonoff A, Esserman D, Cairns C, Rouphael N, Bosinger S, Kim-Schulze S, Krammer F, Rosen L, van Bakel H, Wilson M, Eckalbar W, Maecker H, Langelier C, Steen H, Altman M, Montgomery R, Levy O, Melamed E, Pulendran B, Diray-Arce J, Smolen K, Fragiadakis G, Becker P, Sekaly R, Ehrlich L, Fourati S, Peters B, Kleinstein S, Guan L. Integrated longitudinal multiomics study identifies immune programs associated with acute COVID-19 severity and mortality. Journal Of Clinical Investigation 2024, 134: e176640. PMID: 38690733, PMCID: PMC11060740, DOI: 10.1172/jci176640.Peer-Reviewed Original ResearchConceptsClinical outcomesImmune cascadeElevated levels of inflammatory cytokinesDisease severityLevels of inflammatory cytokinesFormation of neutrophil extracellular trapsAcute COVID-19 severityCritically ill patientsNeutrophil extracellular trapsDevelopment of therapiesCOVID-19 cohortCOVID-19 severityViral clearanceImmunosuppressive metabolitesDeep immunophenotypingMultiomic modelIFN-stimulated genesImmunophenotypic assessmentB cellsDisease courseEarly upregulationInflammatory cytokinesDisease progressionIFN inhibitorsExtracellular traps
2019
Increased T Cell Differentiation and Cytolytic Function in Bangladeshi Compared to American Children
Wagar LE, Bolen CR, Sigal N, Angel C, Guan L, Kirkpatrick BD, Haque R, Tibshirani RJ, Parsonnet J, Petri WA, Davis MM. Increased T Cell Differentiation and Cytolytic Function in Bangladeshi Compared to American Children. Frontiers In Immunology 2019, 10: 2239. PMID: 31620139, PMCID: PMC6763580, DOI: 10.3389/fimmu.2019.02239.Peer-Reviewed Original ResearchConceptsPeripheral blood mononuclear cellsYears of ageIL-8Immune cellsPMA-ionomycinInfection-related morbidityIncidence of allergyBlood mononuclear cellsCytokine production profileT cell differentiationYears of lifeHygiene hypothesisImmune monitoringCytolytic functionMononuclear cellsHigh-income countriesImmune responseBangladeshi childrenMicrobial exposureAmerican childrenTGFβ expressionInfectious agentsImmune systemClinical healthAltered activation