Featured Publications
Public Health Impacts of Vaccines for COVID-19 and Beyond: Opportunities to Overcome Technical and Regulatory Barriers for Randomized Trials.
Kennedy-Shaffer L. Public Health Impacts of Vaccines for COVID-19 and Beyond: Opportunities to Overcome Technical and Regulatory Barriers for Randomized Trials. American Journal Of Public Health 2023, 113: 778-785. PMID: 37104734, PMCID: PMC10262256, DOI: 10.2105/ajph.2023.307302.Peer-Reviewed Original ResearchConceptsPublic health impactCOVID-19 pandemicPopulation healthEvidence baseCOVID-19Health impactsInfectious disease outbreaksCommunity levelRandomized trialsIndividual levelRegulatory barriersPivotal trialsClinical benefitTrialsClinical trialsVaccine trialsPrevent infectionStrategic deploymentVaccineHealthThe required size of cluster randomized trials of nonpharmaceutical interventions in epidemic settings
Sheen J, Haushofer J, Metcalf C, Kennedy‐Shaffer L. The required size of cluster randomized trials of nonpharmaceutical interventions in epidemic settings. Statistics In Medicine 2022, 41: 2466-2482. PMID: 35257398, PMCID: PMC9111156, DOI: 10.1002/sim.9365.Peer-Reviewed Original ResearchConceptsCluster randomized trialEffectiveness of interventionsSample sizeRandomized trialsPlanning such trialsApproximate sample size formulaeReduce transmissionEffect sizeNonpharmaceutical interventionsInfectious disease outbreaksObservational studyInterventionEpidemic settingsSample size methodsAdequate powerSARS-CoV-2 pandemicSARS-CoV-2 transmissionSample size formulaTested individualsSimulated bankTreatment effectsTrialsCommunity transmissionOutbreak settingsSize formulaEstimating Vaccine Efficacy Against Transmission via Effect on Viral Load
Kennedy-Shaffer L, Kahn R, Lipsitch M. Estimating Vaccine Efficacy Against Transmission via Effect on Viral Load. Epidemiology 2021, 32: 820-828. PMID: 34469363, PMCID: PMC8478108, DOI: 10.1097/ede.0000000000001415.Peer-Reviewed Original ResearchConceptsViral load measurementsVaccine efficacyViral loadMeasure of vaccine efficacyRandomized controlled trialsEstimates of vaccine efficacyVirological testingAsymptomatic infectionVaccine effectivenessSevere diseaseControlled trialsViral variantsSARS-CoV-2Estimate efficacyEfficacySARS-CoV-2 pandemicVaccineLoad measurementsInfectionVirus transmissionEstimating epidemiologic dynamics from cross-sectional viral load distributions
Hay J, Kennedy-Shaffer L, Kanjilal S, Lennon N, Gabriel S, Lipsitch M, Mina M. Estimating epidemiologic dynamics from cross-sectional viral load distributions. Science 2021, 373: eabh0635. PMID: 34083451, PMCID: PMC8527857, DOI: 10.1126/science.abh0635.Peer-Reviewed Original ResearchSnowball Sampling Study Design for Serosurveys Early in Disease Outbreaks
Kennedy-Shaffer L, Qiu X, Hanage W. Snowball Sampling Study Design for Serosurveys Early in Disease Outbreaks. American Journal Of Epidemiology 2021, 190: 1918-1927. PMID: 33831177, PMCID: PMC8083564, DOI: 10.1093/aje/kwab098.Peer-Reviewed Original ResearchPerfect as the enemy of good: tracing transmissions with low-sensitivity tests to mitigate SARS-CoV-2 outbreaks
Kennedy-Shaffer L, Baym M, Hanage W. Perfect as the enemy of good: tracing transmissions with low-sensitivity tests to mitigate SARS-CoV-2 outbreaks. The Lancet Microbe 2021, 2: e219-e224. PMID: 33748803, PMCID: PMC7954468, DOI: 10.1016/s2666-5247(21)00004-5.Peer-Reviewed Original Research
2023
Comparative performance of between-population vaccine allocation strategies with applications for emerging pandemics
Joshi K, Rumpler E, Kennedy-Shaffer L, Bosan R, Lipsitch M. Comparative performance of between-population vaccine allocation strategies with applications for emerging pandemics. Vaccine 2023, 41: 1864-1874. PMID: 36697312, PMCID: PMC10075509, DOI: 10.1016/j.vaccine.2022.12.053.Peer-Reviewed Original Research