The antimalarial activity of the pantothenamide α-PanAm is via inhibition of pantothenate phosphorylation
Chiu JE, Thekkiniath J, Choi JY, Perrin BA, Lawres L, Plummer M, Virji AZ, Abraham A, Toh JY, Zandt MV, Aly ASI, Voelker DR, Mamoun CB. The antimalarial activity of the pantothenamide α-PanAm is via inhibition of pantothenate phosphorylation. Scientific Reports 2017, 7: 14234. PMID: 29079738, PMCID: PMC5660193, DOI: 10.1038/s41598-017-14074-9.Peer-Reviewed Original ResearchConceptsMode of actionBlood stage developmentPantothenate kinase activityYeast mutantsMass spectrometry analysisBlood-stage parasitesPA-dependent mannerKinase activityPantothenate phosphorylationCAB1Pantothenate kinaseStage parasitesYeast growthCoenzyme ABiochemical analysisBlood stagesDirect competitionPantothenic acidSpectrometry analysisResistant P. falciparum strainsPhosphorylationStage developmentPlasmodium falciparumCompetitive inhibitorP. berghei