2019
Modeling defibrillation benefit for survival among cardiac resynchronization therapy defibrillator recipients
Bilchick KC, Wang Y, Curtis JP, Cheng A, Dharmarajan K, Shadman R, Dardas TF, Anand I, Lund LH, Dahlström U, Sartipy U, Maggioni A, O'Connor C, Levy WC. Modeling defibrillation benefit for survival among cardiac resynchronization therapy defibrillator recipients. American Heart Journal 2019, 222: 93-104. PMID: 32032927, PMCID: PMC7814502, DOI: 10.1016/j.ahj.2019.12.017.Peer-Reviewed Original ResearchConceptsCRT-D patientsImplantable cardioverter defibrillatorSurvival benefitCRT-DsCardiac resynchronization therapy defibrillator recipientsCardiac resynchronization therapy candidatesSeattle Heart Failure ModelSeattle Proportional Risk ModelCox proportional hazards regressionNational Cardiovascular Data RegistryHeart Failure TrialHeart failure patientsProportional hazards regressionHeart failure modelProportional risk modelFailure patientsCRT candidatesHeart failureCRT pacemakerFailure TrialArrhythmic deathHazards regressionDefibrillator recipientsCRT deviceCardioverter defibrillatorTrends in Performance and Opportunities for Improvement on a Composite Measure of Acute Myocardial Infarction Care
Desai NR, Udell JA, Wang Y, Spatz ES, Dharmarajan K, Ahmad T, Julien HM, Annapureddy A, Goyal A, de Lemos JA, Masoudi FA, Bhatt DL, Minges KE, Krumholz HM, Curtis JP. Trends in Performance and Opportunities for Improvement on a Composite Measure of Acute Myocardial Infarction Care. Circulation Cardiovascular Quality And Outcomes 2019, 12: e004983. PMID: 30871375, DOI: 10.1161/circoutcomes.118.004983.Peer-Reviewed Original ResearchMeSH KeywordsAgedCardiology Service, HospitalFemaleGuideline AdherenceHealthcare DisparitiesHumansMaleMiddle AgedMyocardial InfarctionOutcome and Process Assessment, Health CarePractice Guidelines as TopicQuality ImprovementQuality Indicators, Health CareRacial GroupsRegistriesSex FactorsSocioeconomic FactorsTreatment OutcomeUnited StatesConceptsProportion of patientsAcute myocardial infarctionDefect-free careHispanic patientsAMI careOlder patientsCare measuresNational Cardiovascular Data Registry Acute Coronary TreatmentIntervention Outcomes Network RegistryAcute myocardial infarction careGuideline-recommended pharmacotherapyMedicaid insurance coverageSociodemographic groupsMyocardial infarction careSafety-net statusGreatest absolute improvementComposite measureQuality of careHospital-level performanceCessation counselingEvidence-based processReperfusion therapyCardiac rehabilitationCoronary TreatmentVentricular function
2017
Quality of Care in Chinese Hospitals: Processes and Outcomes After ST‐segment Elevation Myocardial Infarction
Downing NS, Wang Y, Dharmarajan K, Nuti SV, Murugiah K, Du X, Zheng X, Li X, Li J, Masoudi FA, Spertus JA, Jiang L, Krumholz HM. Quality of Care in Chinese Hospitals: Processes and Outcomes After ST‐segment Elevation Myocardial Infarction. Journal Of The American Heart Association 2017, 6: e005040. PMID: 28645937, PMCID: PMC5669155, DOI: 10.1161/jaha.116.005040.Peer-Reviewed Original ResearchConceptsST-elevation myocardial infarctionRisk-standardized mortality ratesQuality of careGuideline-recommended careGuideline-recommended treatmentMyocardial infarctionMortality rateST-segment elevation myocardial infarctionChina PEACE-Retrospective AMI StudyComposite rateMedian risk-standardized mortality rateProportion of patientsElevation myocardial infarctionQuality improvement initiativesProportion of opportunitiesDefect-free rateHospital levelInfarctionHospitalChinese hospitalsPatientsCareAMI studyImprovement initiativesHigh rate
2016
Outcomes 1 Year After Implantable Cardioverter–Defibrillator Lead Abandonment Versus Explantation for Unused or Malfunctioning Leads
Zeitler EP, Wang Y, Dharmarajan K, Anstrom KJ, Peterson ED, Daubert JP, Curtis JP, Al-Khatib SM. Outcomes 1 Year After Implantable Cardioverter–Defibrillator Lead Abandonment Versus Explantation for Unused or Malfunctioning Leads. Circulation Arrhythmia And Electrophysiology 2016, 9: e003953. PMID: 27406605, PMCID: PMC4973616, DOI: 10.1161/circep.116.003953.Peer-Reviewed Original ResearchConceptsNational Cardiovascular Data Registry ICD RegistryLead explantationUpper extremity thrombosisProcedure-related complicationsImplantable cardioverter-defibrillator leadsOutcomes 1 yearLong-term safetyCardioverter-defibrillator leadsHospital complicationsHospital deathUrgent surgeryPulmonary embolismICD RegistryHospital eventsPostprocedure complicationsMortality riskPatientsICD leadPropensity scoreComplicationsExplantationLead abandonmentMalfunctioning leadsHigh rateComparative acute
2015
Hospital Variability in Use of Anticoagulant Strategies During Acute Myocardial Infarction Treated With an Early Invasive Strategy
Arnold SV, Li SX, Alexander KP, Spertus JA, Nallamothu BK, Curtis JP, Kosiborod M, Gupta A, Wang TY, Lin H, Dharmarajan K, Strait KM, Lowe TJ, Krumholz HM. Hospital Variability in Use of Anticoagulant Strategies During Acute Myocardial Infarction Treated With an Early Invasive Strategy. Journal Of The American Heart Association 2015, 4: e002009. PMID: 26077589, PMCID: PMC4599539, DOI: 10.1161/jaha.115.002009.Peer-Reviewed Original ResearchConceptsEarly invasive strategyAnticoagulant strategiesMyocardial infarctionBleeding rateInvasive strategyAcute myocardial infarction patientsOptimal anticoagulant strategyHalf of patientsPercutaneous coronary interventionAcute myocardial infarctionMyocardial infarction patientsHospital use patternsComparative effectiveness studiesRisk-standardized mortalityChoice of anticoagulantsMedian odds ratioCoronary interventionPatient factorsSystemic anticoagulationHospital variabilityInfarction patientsPrincipal diagnosisOdds ratioMultivariate regression modelPatterns of useReadmissions After Carotid Artery Revascularization in the Medicare Population
Al-Damluji MS, Dharmarajan K, Zhang W, Geary LL, Stilp E, Dardik A, Mena-Hurtado C, Curtis JP. Readmissions After Carotid Artery Revascularization in the Medicare Population. Journal Of The American College Of Cardiology 2015, 65: 1398-1408. PMID: 25857904, PMCID: PMC4403264, DOI: 10.1016/j.jacc.2015.01.048.Peer-Reviewed Original ResearchConceptsRisk-standardized readmission ratesCarotid artery stentingHospital risk-standardized readmission ratesCarotid revascularizationCarotid endarterectomyReadmission ratesHospital variationReadmission riskService administrative claims dataKaplan-Meier survival curvesLogistic regressionCarotid artery revascularizationPrior clinical researchAcute care hospitalizationDays of dischargeHospital-level variationSevere carotid stenosisCause hospital readmissionAdministrative claims dataMixed-effects logistic regressionChoice of procedureArtery revascularizationIschemic strokeArtery stentingHospital readmission
2013
Most Important Outcomes Research Papers on Hypertension
Chen R, Dharmarajan K, Kulkarni VT, Punnanithinont N, Gupta A, Bikdeli B, Mody PS, Ranasinghe I. Most Important Outcomes Research Papers on Hypertension. Circulation Cardiovascular Quality And Outcomes 2013, 6: e26-e35. PMID: 23838106, PMCID: PMC8152105, DOI: 10.1161/circoutcomes.113.000424.Peer-Reviewed Original ResearchMost Important Outcomes Research Papers on Treatment of Stable Coronary Artery Disease
Bikdeli B, Ranasinghe I, Chen R, Gupta A, Lampropulos JF, Kulkarni VT, Mody PS, Dharmarajan K. Most Important Outcomes Research Papers on Treatment of Stable Coronary Artery Disease. Circulation Cardiovascular Quality And Outcomes 2013, 6: e17-e25. PMID: 23674308, DOI: 10.1161/circoutcomes.113.000310.Peer-Reviewed Original ResearchDominance of Furosemide for Loop Diuretic Therapy in Heart Failure Time to Revisit the Alternatives?
Bikdeli B, Strait KM, Dharmarajan K, Partovian C, Coca SG, Kim N, Li SX, Testani JM, Khan U, Krumholz HM. Dominance of Furosemide for Loop Diuretic Therapy in Heart Failure Time to Revisit the Alternatives? Journal Of The American College Of Cardiology 2013, 61: 1549-1550. PMID: 23500272, PMCID: PMC4038646, DOI: 10.1016/j.jacc.2012.12.043.Peer-Reviewed Original ResearchMost Important Outcomes Research Papers on Variation in Cardiovascular Disease
Lampropulos JF, Gupta A, Kulkarni VT, Mody P, Chen R, Bikdeli B, Dharmarajan K. Most Important Outcomes Research Papers on Variation in Cardiovascular Disease. Circulation Cardiovascular Quality And Outcomes 2013, 6: e9-e16. PMID: 23481532, DOI: 10.1161/circoutcomes.113.000185.Peer-Reviewed Original ResearchAge FactorsCardiovascular DiseasesGuideline AdherenceHealth Services ResearchHealthcare DisparitiesHumansOutcome and Process Assessment, Health CarePractice Guidelines as TopicPractice Patterns, Physicians'Quality Indicators, Health CareResidence CharacteristicsRisk AssessmentRisk FactorsTreatment Outcome
2012
Most Important Outcomes Research Papers on Valvular Heart Disease
Lampropulos JF, Bikdeli B, Gupta A, Mody P, Kulkarni VT, Chen R, Dharmarajan K. Most Important Outcomes Research Papers on Valvular Heart Disease. Circulation Cardiovascular Quality And Outcomes 2012, 5: e95-e103. PMID: 23170009, DOI: 10.1161/circoutcomes.112.969766.Peer-Reviewed Original ResearchMost Important Outcomes Research Papers on Anticoagulation for Cardiovascular Disease
Bikdeli B, Gupta A, Mody P, Lampropulos JF, Dharmarajan K. Most Important Outcomes Research Papers on Anticoagulation for Cardiovascular Disease. Circulation Cardiovascular Quality And Outcomes 2012, 5: e65-e74. PMID: 22991352, DOI: 10.1161/circoutcomes.112.968701.Peer-Reviewed Original ResearchMost Important Articles on Cardiovascular Disease Among Racial and Ethnic Minorities
Mody P, Gupta A, Bikdeli B, Lampropulos JF, Dharmarajan K. Most Important Articles on Cardiovascular Disease Among Racial and Ethnic Minorities. Circulation Cardiovascular Quality And Outcomes 2012, 5: e33-e41. PMID: 22811508, DOI: 10.1161/circoutcomes.112.967638.Peer-Reviewed Original ResearchProcedure Intensity and the Cost of Care
Chen SI, Dharmarajan K, Kim N, Strait KM, Li SX, Safavi KC, Lindenauer PK, Krumholz HM, Lagu T. Procedure Intensity and the Cost of Care. Circulation Cardiovascular Quality And Outcomes 2012, 5: 308-313. PMID: 22576844, PMCID: PMC3415230, DOI: 10.1161/circoutcomes.112.966069.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overCosts and Cost AnalysisCross-Sectional StudiesFemaleHeart FailureHospital Bed CapacityHospital CostsHospital MortalityHospitalizationHospitals, RuralHospitals, TeachingHospitals, UrbanHumansLength of StayLinear ModelsMaleMiddle AgedModels, EconomicOutcome and Process Assessment, Health CareResidence CharacteristicsRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeUnited StatesYoung AdultConceptsHF hospitalizationHeart failureInvasive proceduresHospital groupRisk-standardized mortality ratesProportion of patientsLength of stayCost of careWilcoxon rank sum testHigher procedure ratesRank sum testPatient demographicsPerspective databaseMedian lengthSurgical proceduresProcedure ratesHospitalizationOutcome differencesMortality rateHospitalPatientsPractice styleProcedure useSum testOverall useMost Important Outcomes Research Papers in Cardiovascular Disease in the Elderly
Gupta A, Mody P, Bikdeli B, Lampropulos JF, Dharmarajan K. Most Important Outcomes Research Papers in Cardiovascular Disease in the Elderly. Circulation Cardiovascular Quality And Outcomes 2012, 5: e17-e26. PMID: 22592757, DOI: 10.1161/circoutcomes.112.966531.Peer-Reviewed Original Research