2024
Novel physiologic predictors of positive airway pressure effectiveness (NICEPAP) study: rationale, design and methods
Anwar A, Byrne S, Sharma A, Sands S, Wellman A, Redeker N, Yaggi H, Zinchuk A. Novel physiologic predictors of positive airway pressure effectiveness (NICEPAP) study: rationale, design and methods. Sleep And Breathing 2024, 28: 2005-2015. PMID: 38995327, DOI: 10.1007/s11325-024-03099-w.Peer-Reviewed Original ResearchObstructive sleep apneaPositive airway pressure effectObstructive sleep apnea traitsCPAP effectsCPAP adherencePrimary outcomePurposeContinuous positive airway pressureFunctional Outcomes of Sleep QuestionnaireEffects of CPAPPositive airway pressureAcademic sleep centerObservational cohort studyPrecision medicine approachCPAP dataCPAP efficacyBaseline polysomnographySleep apneaPrimary therapyAirway pressureSleep centerArousal thresholdPatient-centered outcomesPharyngeal collapseSleep qualityCPAPLinks Between Obstructive Sleep Apnea and Myocardial Blood Flow Changes Impacting Adverse Cardiovascular Disease-related Outcomes
Aneni E, Sinusas A, Emokpae M, Thorn S, Yaggi H, Miller E. Links Between Obstructive Sleep Apnea and Myocardial Blood Flow Changes Impacting Adverse Cardiovascular Disease-related Outcomes. Current Cardiology Reports 2024, 26: 723-734. PMID: 38806976, DOI: 10.1007/s11886-024-02072-z.Peer-Reviewed Original ResearchObstructive sleep apneaCoronary microvascular dysfunctionAbnormal myocardial blood flowSevere obstructive sleep apneaMyocardial flow reserveMyocardial blood flowSleep apneaModerate to severe obstructive sleep apneaAbnormal myocardial flow reserveRecent FindingsRecent studiesDisease-related outcomesBlood flow changesMyocardial blood flow changesCardiovascular disease-related outcomesMicrovascular dysfunctionClinical impactCPAPReviewRecent studiesStructural abnormalitiesCoronary microcirculationFindingsRecent studiesFlow reserveCardiac workBlood flowApnea0488 Exploring Study Recruitment Trends in the Acute Post-Stroke Setting
Schwarz J, Masroor K, Radulescu R, Tsang S, Sheth K, Redeker N, Yaggi H, Geer J. 0488 Exploring Study Recruitment Trends in the Acute Post-Stroke Setting. Sleep 2024, 47: a210-a210. DOI: 10.1093/sleep/zsae067.0488.Peer-Reviewed Original ResearchContinuous positive airway pressureObstructive sleep apneaPositive airway pressureAcute ischemic strokeAirway pressureUpper airway closureSleep-disordered breathingYale-New Haven HospitalCerebral blood flowOSA screeningOSA treatmentSleep apneaImpact cerebral blood flowAcademic medical centerSympathetic activityClinical trialsPatient populationHemodynamic changesRisk factorsPatientsFunctional recoveryExclusion criteriaAirway closureCardiovascular diseaseBlood flow0486 Performing Polysomnography in the Acute Post-stroke Setting
Masroor K, Schwarz J, Radulescu R, Tsang S, Sheth K, Redeker N, Yaggi H, Geer J. 0486 Performing Polysomnography in the Acute Post-stroke Setting. Sleep 2024, 47: a209-a209. DOI: 10.1093/sleep/zsae067.0486.Peer-Reviewed Original ResearchObstructive sleep apneaSleep apneaRates of obstructive sleep apneaSymptoms of obstructive sleep apneaSevere obstructive sleep apneaObstructive sleep apnea diagnosisAcute settingSleep-disordered breathingPercentage of patientsProportion of patientsYale-New Haven HospitalAHI cutoffOSA prevalenceOSA diagnosisPreventing recurrent strokeImprove stroke recoveryPolysomnography testNew Haven HospitalPolysomnographyScreening patientsTherapeutic windowApneaPatientsRisk factorsMedical recordsAssociation of Periodic Limb Movements and Obstructive Sleep Apnea With Risk of Cardiovascular Disease and Mortality
Zinchuk A, Srivali N, Qin L, Jeon S, Ibrahim A, Sands S, Koo B, Yaggi H. Association of Periodic Limb Movements and Obstructive Sleep Apnea With Risk of Cardiovascular Disease and Mortality. Journal Of The American Heart Association 2024, 13: e031630. PMID: 38240208, PMCID: PMC11056155, DOI: 10.1161/jaha.123.031630.Peer-Reviewed Original ResearchConceptsPeriodic limb movement indexApnea-hypopnea indexObstructive sleep apneaPeriodic limb movementsSleep apneaIncident cardiovascular diseasePrimary outcomeCardiovascular diseaseAssociation of apnea-hypopnea indexIncreased risk of primary outcomeIncreased riskRisk factorsRisk of primary outcomeAssociated with primary outcomeMedian follow-upBaseline risk of mortalityCox proportional hazards regressionRisk of cardiovascular diseaseLimb movement indexCharlson Comorbidity IndexFramingham risk scoreProportional hazards regressionRisk of mortalityCardiovascular disease eventsFollow-up
2023
Insomnia and Early Incident Atrial Fibrillation: A 16‐Year Cohort Study of Younger Men and Women Veterans
Gaffey A, Rosman L, Lampert R, Yaggi H, Haskell S, Brandt C, Enriquez A, Mazzella A, Skanderson M, Burg M. Insomnia and Early Incident Atrial Fibrillation: A 16‐Year Cohort Study of Younger Men and Women Veterans. Journal Of The American Heart Association 2023, 12: e030331. PMID: 37791503, PMCID: PMC10757545, DOI: 10.1161/jaha.123.030331.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaIncident atrial fibrillationAtrial fibrillationHealth care utilizationSleep apneaAF onsetCohort studyCare utilizationAF riskMultivariate Cox proportional hazards modelVeterans Health Administration (VHA) careRisk of AFCox proportional hazards modelCases of AFEarly cardiovascular riskIncident AF riskAssociation of insomniaProportional hazards modelCommon sleep disorderPost-9/11 veteransElectronic health recordsAF incidenceCardiovascular riskClinical comorbiditiesLifestyle factorsEXCESSIVE DAYTIME SLEEPINESS IS ASSOCIATED WITH INCIDENT HEART FAILURE IN A CLINICAL POPULATION WITH OBSTRUCTIVE SLEEP APNEA
SAEED G, OGUNMOLA I, OTITE F, LAMIKANRA O, OSONDU C, MEZUE K, FEHER A, YAGGI H, ANENI E. EXCESSIVE DAYTIME SLEEPINESS IS ASSOCIATED WITH INCIDENT HEART FAILURE IN A CLINICAL POPULATION WITH OBSTRUCTIVE SLEEP APNEA. CHEST Journal 2023, 164: a6312. DOI: 10.1016/j.chest.2023.07.4065.Peer-Reviewed Original ResearchMorning Chronotype Is Associated with Improved Adherence to Continuous Positive Airway Pressure among Individuals with Obstructive Sleep Apnea.
Knauert M, Adekolu O, Xu Z, Deng A, Chu J, Baldassarri S, Kushida C, Yaggi H, Zinchuk A. Morning Chronotype Is Associated with Improved Adherence to Continuous Positive Airway Pressure among Individuals with Obstructive Sleep Apnea. Annals Of The American Thoracic Society 2023, 20: 1182-1191. PMID: 36917194, PMCID: PMC10405611, DOI: 10.1513/annalsats.202210-885oc.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaCPAP adherenceMorning chronotypeCPAP useSleep apneaClinical trialsMorningness-Eveningness QuestionnaireSleep durationContinuous positive airway pressure therapyPositive airway pressure therapyContinuous positive airway pressureSevere obstructive sleep apneaChronotype of patientsDaily CPAP useAirway pressure therapyPositive airway pressureShort sleep durationCPAP armAirway pressureObese menPressure therapyPoor adherenceWeekend catchAdherence dataEvening chronotypeSleep-related predictors of cognition among adults with chronic insomnia and heart failure enrolled in a randomized controlled trial of cognitive behavioral therapy for insomnia.
Redeker N, Conley S, O'Connell M, Geer J, Yaggi H, Jeon S. Sleep-related predictors of cognition among adults with chronic insomnia and heart failure enrolled in a randomized controlled trial of cognitive behavioral therapy for insomnia. Journal Of Clinical Sleep Medicine 2023, 19: 1073-1081. PMID: 36740924, PMCID: PMC10235706, DOI: 10.5664/jcsm.10498.Peer-Reviewed Original ResearchConceptsChronic heart failureCognitive behavioral therapyHeart failureGroup time effectsRest-activity rhythmBehavioral therapyChronic insomniaCBT-I groupSelf-reported cognitive functionProportion of participantsTrial of CBTQuality of lifeSelf-management strategiesGroup-based CBTWalk distanceSleep apneaChronic illnessWrist actigraphyCognitive impairmentInsomniaTherapyCognitive functionMinute walkSelf-reported cognitive abilitiesBaseline cognitionNicotine, alcohol, and caffeine use among individuals with untreated obstructive sleep apnea
Baldassarri S, Chu J, Deng A, Xu Z, Blohowiak R, Byrne S, Kushida C, Yaggi H, Zinchuk A. Nicotine, alcohol, and caffeine use among individuals with untreated obstructive sleep apnea. Sleep And Breathing 2023, 27: 2479-2490. PMID: 37058215, PMCID: PMC10576010, DOI: 10.1007/s11325-023-02830-3.Peer-Reviewed Original ResearchConceptsUntreated obstructive sleep apneaObstructive sleep apneaApnea Positive Pressure Long-term Efficacy StudySubstance useDaytime symptomsSleep characteristicsSleep durationCaffeine useModerate caffeine useLong-term Efficacy StudyCurrent cigarette smokersHeavy caffeine usersObjective sleep characteristicsShort sleep durationModerate alcohol useMore REM sleepLower sleep durationHeavy alcohol usersCross-sectional analysisPsychoactive substance useCurrent smokersCurrent smokingComorbid conditionsMedian BMISleep apneaThe Association Between Obstructive Sleep Apnea and Abnormal 82Rubidium Cardiac PET Perfusion Myocardial Flow Reserve
Aneni E, Thorn S, Feher A, Hong Chen J, Sinusas A, Yaggi H, Miller E. The Association Between Obstructive Sleep Apnea and Abnormal 82Rubidium Cardiac PET Perfusion Myocardial Flow Reserve. JACC Cardiovascular Imaging 2023, 16: 856-858. PMID: 36881426, PMCID: PMC10718199, DOI: 10.1016/j.jcmg.2022.11.024.Peer-Reviewed Original ResearchSleep apnea and stroke
Geer J, Karagoz E, Yaggi H. Sleep apnea and stroke. 2023, 271-277. DOI: 10.1016/b978-0-12-822963-7.00325-x.Peer-Reviewed Original ResearchObstructive sleep apneaCerebrovascular diseaseRisk factorsImportant public health issueIndependent risk factorModifiable risk factorsMechanism of strokeSleep-disordered breathingPotential treatment modalityPublic health issueParadoxical embolismSystemic inflammationIntermittent hypoxiaSleep apneaSympathetic activationTreatment modalitiesLeading causeMetabolic dysfunctionStrokeHealth issuesApneaCurrent literatureDiseaseEmbolismAtherosclerosis
2021
Polysomnographic Phenotypes of Obstructive Sleep Apnea and Incident Type 2 Diabetes: Results from the DREAM Study.
Ding Q, Qin L, Wojeck B, Inzucchi SE, Ibrahim A, Bravata DM, Strohl KP, Yaggi HK, Zinchuk AV. Polysomnographic Phenotypes of Obstructive Sleep Apnea and Incident Type 2 Diabetes: Results from the DREAM Study. Annals Of The American Thoracic Society 2021, 18: 2067-2078. PMID: 34185617, PMCID: PMC8641817, DOI: 10.1513/annalsats.202012-1556oc.Peer-Reviewed Original ResearchConceptsApnea-hypopnea indexObstructive sleep apneaPolysomnographic phenotypeIncident T2DMRisk of T2DMPredictive valueSleep apneaBlood glucoseRisk factorsCardiovascular diseaseMild obstructive sleep apneaIncident type 2 diabetesMultivariable-adjusted regression modelsCox proportional hazards regressionNew physician diagnosisT2DM risk predictionIncident cardiovascular diseaseIncident type 2Body mass indexProportional hazards regressionT2DM risk factorsBehavioral risk factorsType 2 diabetesMale veteran populationRisk regression modelsPrevalence of Obstructive Sleep Apnea in a Cohort of Veterans with Chronic Pain and Active Smoking History
Kunitomo Y, Lee M, DeRycke E, Yaggi H, Bastian L. Prevalence of Obstructive Sleep Apnea in a Cohort of Veterans with Chronic Pain and Active Smoking History. 2021, a1564-a1564. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a1564.Peer-Reviewed Original Research342 CBT-I Has Sustained Effects on Insomnia Versus Heart-Failure Self-Management Education among Adults with Chronic Heart Failure
Redeker N, Bessette A, Breazeale S, Conley S, Hollenbeak C, Hwang Y, Iannacco J, Jacoby D, Kelly-Hauser J, Linsky S, Moemeka L, Nwanaji-Enwerem U, O’Connell M, Yaggi H, Jeon S. 342 CBT-I Has Sustained Effects on Insomnia Versus Heart-Failure Self-Management Education among Adults with Chronic Heart Failure. Sleep 2021, 44: a136-a137. DOI: 10.1093/sleep/zsab072.341.Peer-Reviewed Original ResearchChronic heart failurePittsburgh Sleep Quality IndexHeart failureSleep apneaSleep disturbance questionnaireHS groupInsomnia severityStable chronic heart failureContinuous positive airway pressureSelf-reported sleep durationCBT-I interventionPoor daytime functionMild sleep apneaPositive airway pressureSleep-related cognitionsSleep Quality IndexModerate-severe insomniaCognitive behavioral therapyAirway pressureDaytime symptomsDaytime functionClinical insomniaSleep ScaleMild insomniaSleep qualityAssociations Between Polysomnographic Phenotypes of Obstructive Sleep Apnea and Incident Type 2 Diabetes
Ding Q, Qin L, Wojeck B, Inzucchi S, Ibrahim A, Bravata D, Strohl K, Yaggi H, Zinchuk A. Associations Between Polysomnographic Phenotypes of Obstructive Sleep Apnea and Incident Type 2 Diabetes. 2021, a4679-a4679. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4679.Peer-Reviewed Original ResearchTreatment-Emergent Central Sleep Apnea
Zinchuk A, Yaggi H. Treatment-Emergent Central Sleep Apnea. 2021, 85-102. DOI: 10.1007/978-3-030-57942-5_8.ChaptersTreatment-emergent central sleep apneaContinuous positive airway pressureCentral sleep apneaObstructive sleep apneaSleep apneaPositive airway pressureUpper airway collapsibilityUpper airway patencyMulti-modality therapyVentilatory control systemAirway collapsibilityAirway pressureOpioid useOSA patientsAirway patencyHeart failureAtrial fibrillationCarbonic anhydrase inhibitorsCentral sleepPoor adherenceOptimal treatmentSedative hypnoticsClinical careApneaMultifactorial nature
2020
1128-P: Empagliflozin and Obstructive Sleep Apnea (OSA): Exploratory Analysis from the EMPA-REG OUTCOME Trial
NEELAND I, ELIASSON B, KASAI T, MARX N, ZINMAN B, INZUCCHI S, WANNER C, ZWIENER I, WOJECK B, YAGGI H, JOHANSEN O. 1128-P: Empagliflozin and Obstructive Sleep Apnea (OSA): Exploratory Analysis from the EMPA-REG OUTCOME Trial. Diabetes 2020, 69 DOI: 10.2337/db20-1128-p.Peer-Reviewed Original ResearchObstructive sleep apneaNew-onset obstructive sleep apneaCardiovascular diseaseDohme Corp.Novo Nordisk A/SMundipharma InternationalMerck SharpEli LillyEMPA-REG OUTCOMEIncident obstructive sleep apneaFavorable metabolic effectsSanofi-AventisSystolic blood pressureCoronary artery diseaseType 2 diabetesAdvisory PanelEMPA-REGOSA statusPhilips RespironicsSanofi GenzymeSevere obesityArtery diseaseBlood pressureWaist circumferenceSleep apnea
2019
0138 Physiological Effects of Respiratory Events that Terminate Without Arousals During Sleep
Liu J, Qin L, Yaggi H. 0138 Physiological Effects of Respiratory Events that Terminate Without Arousals During Sleep. Sleep 2019, 42: a56-a57. DOI: 10.1093/sleep/zsz067.137.Peer-Reviewed Original ResearchHigh-frequency EEG powerRespiratory eventsHeart rateTest-retest reliabilityCortical neural activityZ-scoreREM sleepRespiratory arousalsEEG powerCommunity-dwelling elderly menPoor cardiovascular outcomesObstructive sleep apneaNeural activityMean z-scoreStage 2 sleepExcellent test-retest reliabilityNon-REM sleepSignificant increaseCardiovascular outcomesCardiac effectsSympathetic surgeSleep apneaElderly menMrOS StudyFrequent arousals0494 Associations of Obstructive Sleep Apnea with Renal Function Decline in a Cohort of Veterans
Liu J, Qin L, McConaughey C, Yaggi H. 0494 Associations of Obstructive Sleep Apnea with Renal Function Decline in a Cohort of Veterans. Sleep 2019, 42: a198-a198. DOI: 10.1093/sleep/zsz067.492.Peer-Reviewed Original ResearchObstructive sleep apneaRenal function declineApnea-hypopnea indexChronic kidney diseaseSevere obstructive sleep apneaDiabetes statusFunction declineSleep apneaSleep medicine clinicHypertension statusAssociation of OSAMild-moderate obstructive sleep apneaSlower renal function declineClinic-based cohortCohort of patientsGlomerular filtration rateCommunity-based cohortCohort of veteransMultivariable regression analysisEnd of observationRenal functionBaseline prevalenceKidney diseaseMedicine clinicFiltration rate