2024
Automated detection of early signs of irreversible ischemic change on CTA source images in patients with large vessel occlusion
Mak A, Matouk C, Avery E, Behland J, Haider S, Frey D, Madai V, Vajkoczy P, Griessenauer C, Zand R, Hendrix P, Abedi V, Sanelli P, Falcone G, Petersen N, Sansing L, Sheth K, Payabvash S, Malhotra A. Automated detection of early signs of irreversible ischemic change on CTA source images in patients with large vessel occlusion. PLOS ONE 2024, 19: e0304962. PMID: 38870240, PMCID: PMC11175522, DOI: 10.1371/journal.pone.0304962.Peer-Reviewed Original ResearchConceptsDiffusion-weighted imagingLarge vessel occlusionIrreversible ischemic changesPoor functional outcomeFunctional outcomesIschemic changesInfarct volumeAlberta Stroke Program Early CT ScorePredicting poor functional outcomeVessel occlusionFollow-up diffusion-weighted imagingAnterior circulation LVO strokeCTA source imagesReceiver operating characteristic curveExpert human readersPredicting final infarctionASPECTS regionsAdmission CTANon-inferior performanceBaseline CTACT scoreFinal infarctEndovascular therapyHU attenuationValidation cohortMapping the Ecological Terrain of Stroke Prehospital Delay: A Nationwide Registry Study
Dhand A, Reeves M, Mu Y, Rosner B, Rothfeld-Wehrwein Z, Nieves A, Dhongade V, Jarman M, Bergmark R, Semco R, Ader J, Marshall B, Goedel W, Fonarow G, Smith E, Saver J, Schwamm L, Sheth K. Mapping the Ecological Terrain of Stroke Prehospital Delay: A Nationwide Registry Study. Stroke 2024, 55: 1507-1516. PMID: 38787926, PMCID: PMC11299104, DOI: 10.1161/strokeaha.123.045521.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overEmergency Medical ServicesFemaleHumansIschemic StrokeMaleMiddle AgedRegistriesStrokeTime-to-TreatmentUnited StatesConceptsSocial Vulnerability IndexPrehospital delayHospital arrivalZIP Code Tabulation AreasEmergency medical servicesCommunity-level social vulnerabilityGuidelines-Stroke registryCommunity socioeconomic statusCommunity-level factorsPatient-level factorsNationwide registry studyAmerican Heart AssociationSocial vulnerabilityCox proportional hazards modelsSocially vulnerable areasAssociated with delaySocial determinantsProportional hazards modelAcute stroke treatmentGeospatial mappingSocioeconomic statusMedical servicesIncreased social vulnerabilityPrimary exposureQuartile 3
2023
Clinical implications of Peri-hematomal edema microperfusion fraction in intracerebral hemorrhage intravoxel incoherent motion imaging – A pilot study
Abou Karam G, Tharmaseelan H, Aboian M, Malhotra A, Gilmore E, Falcone G, de Havenon A, Sheth K, Payabvash S. Clinical implications of Peri-hematomal edema microperfusion fraction in intracerebral hemorrhage intravoxel incoherent motion imaging – A pilot study. Journal Of Stroke And Cerebrovascular Diseases 2023, 32: 107375. PMID: 37738914, PMCID: PMC10591892, DOI: 10.1016/j.jstrokecerebrovasdis.2023.107375.Peer-Reviewed Original ResearchConceptsModified Rankin ScaleSecondary brain injuryIntracerebral hemorrhagePerihematomal edemaSubacute intracerebral hemorrhageIntravoxel incoherent motion imagingAdmission NIHSSBrain injuryMedian baseline National InstitutesPilot studyBaseline National InstitutesHealth Stroke ScalePerfusion fractionSupratentorial intracerebral hemorrhageIVIM metricsIncoherent motion imagingStroke ScaleNeuroprotective therapiesParenchymal injuryRankin ScaleRisk patientsConsecutive patientsUnivariable analysisPoor outcomeICH volume
2021
Assessment of Discrepancies Between Follow-up Infarct Volume and 90-Day Outcomes Among Patients With Ischemic Stroke Who Received Endovascular Therapy
Ganesh A, Ospel J, Menon B, Demchuk A, McTaggart R, Nogueira R, Poppe A, Almekhlafi M, Hanel R, Thomalla G, Holmin S, Puetz V, van Adel B, Tarpley J, Tymianski M, Hill M, Goyal M, Barber P, Smith E, Bal S, Subramanian S, Peters S, Couillard P, Klein G, Stys P, Coutts S, Wong J, Mitha A, Eesa M, Morrish W, Alqatani S, Kashani N, Venkatesan P, Teleg E, Sitaram A, Graham B, Gaal S, Moussaddy A, Chakraborty D, Maraj N, Lockey A, Chen S, Singh R, Alsultan A, Asunsian R, Tse D, Doshi D, Volny O, Ojha P, Wadhwa A, Marko M, Singh N, Wasyliw S, Ryckborst K, Kenney C, Save S, Jambula A, Newcommon N, Hull G, Blackstock D, Kiszczak S, Zimmel L, Wright M, Jahraus C, Andersen L, Bohn S, Paul J, Buck B, Butcher K, Shuaib A, Jeerakathil T, Jickling G, Emery D, Rempel J, Ower R, Ashforth R, Yeo T, Kotylak T, O;Kelly C, Chow M, Siddiqui M, Saqqur M, D'Souza A, Lloret M, Butt A, Nomani A, Kalashyan H, Thirunavukkarasu S, Jabs J, Fairall P, Piquette L, Phillips S, Green A, Gubitz G, Heidenreich J, Huynh T, Shankar J, Maloney W, Vandorpe R, Schmidt M, Pickett G, Weeks A, Jarrett J, MacDonald D, Arsenault J, Kinnear R, Mandzia J, Mayich M, Boulton M, Bullrich M, Fridman S, Kiwan R, Lee D, Lownie S, Khaw A, Pandey S, Sharma M, Sposato L, Wade K, Beauchamp B, Lambourn L, Amato-Marziali B, Roy D, Deneault N, Deschaintre Y, Gioia L, Jacquin G, Odier C, Stapf C, Iancu D, Raymond J, Weill A, Lapierre M, Jadil N, Jolteus J, Teitelbaum J, Angle M, Hannouche M, Badawy M, Letourneau J, Cortes M, Linnell G, Tampieri D, Vieira L, Legault C, Durcan L, Moore A, Cole E, Magnussen C, Salmon K, Khalil S, Desloges I, Waxman L, Abdon W, Lai S, Dowlatshahi D, Shamy M, Stotts G, Blacquiere D, Lesiuk H, Quateen A, Drake B, Dewar B, Daham Z, Kelly M, Hunter G, Peeling L, Graham B, Whelan R, Garner A, Urroz L, Maley S, Silver F, Casaubon L, Pikula A, Campo M, Schaafsma J, Jaigobin C, Krings T, Pereira V, Agid R, Farb R, Kalman L, Cayley A, Williams J, Stewart T, Misquitta K, Bharatha A, Selchen D, Marotta T, Sarma D, Montanera W, Spears J, Saposnik G, Kostyrko P, Li Y, Parra-Farinas C, Diestro J, Camden M, Verreault S, Mackey A, Audet M, Milot G, Lavoie P, Gariépy J, Collard K, Haché A, Sahlas D, Alshanbari A, Baldwin J, Catanese L, Chen B, Sa Boasquevisque D, Deshmukh A, Knapman J, Lamers S, Larrazabal R, MacMillan S, Mai L, Mattai A, Nayar S, Ng K, Oczkowski W, Perera K, Shawawrah M, Shoamanesh A, Sobhi G, Syed N, Yaher N, Vandervelde C, Wang D, Field T, Van Gaal S, Teal P, Benavente O, Wilson L, Mann S, Yip S, Murphy C, Heran M, Rohr A, Settecase F, Redekop G, Haw C, Maclean G, Murray K, Chiu R, Flexman A, Strecha E, Gayton Y, Yip J, Swartz R, Boulos M, Gladstone D, Yu A, Hopyan J, Khosravani H, Manosalva Alzate H, Southwell A, Kamra M, Lopes K, Kapoor A, da Costa L, Yang V, Dyer E, Shah R, Knowles B, Nichols J, Patterson J, Cope K, Dickerson L, Barton K, Gray K, Massengale T, Miller M, Simpson C, Walker S, Tennyson-Yemm C, Frei D, Bellon R, Atchie B, Kaminsky I, Wilson D, Schraeder N, Arias E, Kodis L, Talley M, Edinger A, Talley T, Dempsey I, Williams L, Williams S, Kupniewski S, Fasbinder B, Snead J, Choe H, Mackenzie L, Weisman D, Kozak O, Shah Q, Gzesh D, Kulandaivel K, Khoury J, Klein B, Bussinger P, Griffin L, DePalmo A, Oliva C, Jadhav A, Jovin T, Kenmuir C, Jankowitz B, Gross B, Rocha M, Starr M, Brown M, Hawkes C, Shah K, Tememe D, Walker G, Patel P, Klein B, Ziayee H, Limaye K, Baxendell L, Glichrist V, Feineigle P, Toseki Haibach K, Van Every C, Desai S, Zulfiqar M, Gibson L, Barrett S, Turkel-Parrella D, Arcot K, DiCrescento S, Farkas J, Filipowski G, Frontera J, Joset D, Liff J, Scher E, McDougall C, Kelly C, Patel A, Monteith S, Starkman S, Atchaneeyasakul K, Burgos A, Anne Y. Chua J, Gaines N, Grunberg I, Guzy J, Liu Z, Maluste N, Ramirez L, Sharma L, Heck D, Brown M, McDonald C, Calderon M, Hargis M, Roels C, Emmady P, Alvi T, Jayaraman M, Cutting S, Smith W, Foley S, Paolucci G, Haas R, Quinn K, Fuller L, Brierley R, Watkins C, Demir N, Lopez G, Vargas A, Osteraas N, Holtz B, Sauvageau E, Aghaebrahim A, Chmayssani M, Naval N, Day J, Dellorso S, Ludwig B, Schemmel D, Ebreo N, Bell K, Lewis L, Delucia M, Haussen D, Frankel M, Bhatt N, Bianchi N, Anderson A, Belagaje S, Liberato B, Rangaraju S, Al-Bayati A, Grossber J, Craft L, Schindler K, Schaad E, Schultz M, Sutherly L, Doppelheuer S, Charlton J, Faggard J, Barbret Z, DukSoo Han E, Walters R, Dolia J, El-Jamal S, Eby B, Saleem Y, Pearl H, Patel K, Rahman H, Butt R, English S, Puri A, Howk M, Singh J, Massari F, DeMacedo Rodrigues K, Kuhn A, English J, Barazangi N, Telischak N, Kim W, Ross J, DeVole N, Redford J, Ferreira M, Ponting K, Shen H, Bedenk A, Patel S, Fernandess J, Ke M, Spokoyny I, Gao B, Tong D, Chen C, Wong C, Choe J, Martin C, Summers D, Boutwell C, Olds K, Crandall S, Eatman J, Akhtar N, Holloway W, Halpin J, Donegan B, Schindler J, Hwang D, Gilmore E, Petersen N, Sheth K, Brown S, Beekman R, George B, Kaddouh F, Falcone G, Wira C, Matouk C, Loomis C, Amin H, Stretz H, Narula R, Jasne A, Sansing L, Agarwal T, Jasak S, Fontaine B, King Z, Kouhn L, Orgass H, Leary M, Nye J, Halbert K, Nystrom K, Neuschatz K, Petrucci D, Coppola A, Joyce T, Hou S, Umekubo M, Nakamura C, Ovando R, Zuniga D, Nien Y, Basto F, Arch A, Jong L, Conrad W, Abbott T, Yao J, Caganap S, Jordan J, Teitelbaum G, Darflinger R, Kelly D, Gupta R, Budzik R, Czerniak J, Groezinger K, Hicks W, Kaskar O, Katz B, Loochtan A, Pema P, Rai V, Vora N, Brown A, Goodman D, Danenbergs B, Gossett M, Bang O, Chung J, Jeon P, Kim K, Lim Y, Hoe Heo J, Nam H, Kim Y, Park H, Hwang I, Ha W, Choi J, Jeong K, Rha J, Park H, Yoon C, Kim B, Sohn S, Kim C, Yoo J, Hong J, Park H, Kim S, Choi M, Bae H, Lee J, Lee J, Jun G, Jeon S, Campbell B, Mitchell P, Yassi N, Davis S, Donnan G, Parsons M, Yan B, Dowling R, Bush S, Wu T, Shan D, Zhao H, Salvaris P, Alemseged F, Ng F, Williams C, Balabanski A, dos Santos A, Ng J, McDonald A, Jackson D, Tsoleridis J, Pesavento L, Kleinig T, Drew R, Cranefield J, Scroop R, Cagi L, Harvey J, Waters M, Thornton J, Brennan R, O'Hare A, Power S, Williams D, Boyle K, Moynihan B, Liddy A, Large M, Cullen A, Walsh R, Martin E, Lynch J, McElroy S, Murphy S, Coveney S, Deegan C, Horgan G, Kelly P, Laffan A, Llamas-Osorio Y, Lynch C, Mac Mahon P, Marnane M, McCabe J, Burns P, Tauro S, Cuddy S, Rennie I, Smyth G, Flynn P, Wiggam I, Kerr E, Gordon P, Fearon P, Roberts G, Patterson C, Adams K, Wells B, McFarland M, Moreira T, Sjöstrand C, Mazya M, Almqvist H, Wahlgren N, Steinberg A, Cooray C, Eriksson E, Thorén M, Keselman B, Ahmed N, Holmberg Å, Axelsson M, Berglund A, Golsari A, Hoppe J, Deb-Chatterji M, Cheng B, Barow E, Schlemm E, Lettow I, Jensen M, Otto D, Jaramillo K, Appelbohm H, Fiehler J, Bester M, Schönfeld M, Brekenfeld C, Holst B, Wortmann G, Koch F, Gerber J, Abramyuk A, Kaiser D, Winzer S, Prakapenia A, Pallesen L, Siepmann T, Barlinn K, Haase K, Sauer A, Psychogios M, Liman J, Brehm A, Maus V, Hollstein N, Reinke A, Neitz G, Schnieder M, Schwarz M, Ibrahim A, Müller J, Meister S, Bäumle B, Chapot R, Pilgram-Pastor S, Wallocha M, Stauder M, Celik E, Stracke P, Müller N, Weber R, Veltkamp R, Nagel S, Ringleb P, Heyse M, Amiri H, Mundiyanapurath S, Chen M, Beyrle E, Beck P, Möhlenbruch M. Assessment of Discrepancies Between Follow-up Infarct Volume and 90-Day Outcomes Among Patients With Ischemic Stroke Who Received Endovascular Therapy. JAMA Network Open 2021, 4: e2132376. PMID: 34739060, PMCID: PMC8571657, DOI: 10.1001/jamanetworkopen.2021.32376.Peer-Reviewed Original ResearchConceptsSerious adverse eventsHigher mRS scoreLower mRS scoresMRS scoreInfarct volumeEndovascular therapyPretreatment factorsPosttreatment factorsBlood pressureHemoglobin levelsFunctional outcomeAnterior Circulation Proximal OcclusionDiscrepant casesHighest FIVTomography/magnetic resonance imagingHigher baseline hemoglobinRecanalization Times (ESCAPE) trialAbsence of diabetesStroke unit careSymptomatic intracerebral hemorrhageCongestive heart failureDiastolic blood pressureRankin Scale scoreMagnetic resonance imagingStepwise model
2020
Efficacy and safety of nerinetide for the treatment of acute ischaemic stroke (ESCAPE-NA1): a multicentre, double-blind, randomised controlled trial
Hill MD, Goyal M, Menon BK, Nogueira RG, McTaggart RA, Demchuk AM, Poppe AY, Buck BH, Field TS, Dowlatshahi D, van Adel BA, Swartz RH, Shah RA, Sauvageau E, Zerna C, Ospel JM, Joshi M, Almekhlafi MA, Ryckborst KJ, Lowerison MW, Heard K, Garman D, Haussen D, Cutting SM, Coutts SB, Roy D, Rempel JL, Rohr AC, Iancu D, Sahlas DJ, Yu AYX, Devlin TG, Hanel RA, Puetz V, Silver FL, Campbell BCV, Chapot R, Teitelbaum J, Mandzia JL, Kleinig TJ, Turkel-Parrella D, Heck D, Kelly ME, Bharatha A, Bang OY, Jadhav A, Gupta R, Frei DF, Tarpley JW, McDougall CG, Holmin S, Rha JH, Puri AS, Camden MC, Thomalla G, Choe H, Phillips SJ, Schindler JL, Thornton J, Nagel S, Heo JH, Sohn SI, Psychogios MN, Budzik RF, Starkman S, Martin CO, Burns PA, Murphy S, Lopez GA, English J, Tymianski M, Demchuk A, Barber P, Smith E, Bal S, Subramaniam S, Peters S, Couillard P, Klein G, Stys P, Menon B, Coutts S, Almekhlafi M, Hill M, Goyal M, Wong J, Mitha A, Eesa M, Morrish W, Alqatani S, Kashani N, Joshi M, Zerna C, Ospel J, Venkatesan P, Teleg E, Sitaram A, Graham B, Van Gaal S, Moussaddy A, Chakraborty D, Maraj N, Loockey A, Chen S, Singh R, Alsultan A, Asuncion R, Tse D, Doshi D, Volny O, Ojha P, Wadhwa A, Marko M, Singh N, Wasyliw S, Ryckborst K, Kenney C, Save S, Jambula A, Newcommon N, Hull G, Blackstock D, Kiszczak S, Zimmel L, Wright M, Jahraus C, Andersen L, Bohn S, Paul J, Zhang O, Doram C, Lowerison M, Hanley A, Campbell L, Ure A, Taylor F, Hul D, Wiebe S, Saluzzi M, Blenkin N, Frayne R, Buck B, Butcher K, Shuaib A, Jeerakathil T, Jickling G, Emery D, Rempel J, Owen R, Ashforth R, Yeo T, Kotylak T, O'Kelly C, Chow M, Siddiqui M, Saqqur M, D'Souza A, Lloret M, Butt A, Nomani A, Kalashyan H, Thirunavukkarasu S, Jabs J, Fairall P, Piquette L, Phillips S, Green A, Gubitz G, Heidenreich J, Huynh T, Shankar J, Maloney W, Vandorpe R, Schmidt M, Pickett G, Weeks A, Jarrett J, MacDonald D, Arsenault J, Kinnear R, Mandzia J, Mayich M, Boulton M, Bullrich M, Fridman S, Kiwan R, Lee D, Lownie S, Khaw A, Pandey S, Sharma M, Sposato L, Wade K, Beauchamp B, Lambourn L, Amato-Marziali B, Poppe A, Roy D, Daneault N, Deschaintre Y, Gioia L, Jacquin G, Odier C, Stapf C, Iancu D, Raymond J, Weill A, Lapierre M, Jadil N, Jolteus J, Teitelbaum J, Angle M, Hannouche M, Badawy M, Letourneau J, Cortes M, Linnell G, Tampieri D, Vieira L, Moussaddy A, Legault C, Durcan L, Moore A, Cole E, Magnussen C, Salmon K, Khalil S, Desloges I, Waxman L, Abdon W, Lai S, Dowlatshahi D, Iancu D, Shamy M, Stotts G, Blacquiere D, Lesiuk H, Quateen A, Drake B, Dewar B, Daham Z, Kelly M, Hunter G, Peeling L, Graham B, Whelan R, Garner A, Urroz L, Maley S, Silver F, Casaubon L, Pikula A, Del Campo M, Schaafsma J, Jaigobin C, Krings T, Pereira V, Agid R, Farb R, Kalman L, Cayley A, Williams J, Stewart T, Misquitta K, Bharatha A, Selchen D, Marotta T, Sarma D, Montanera W, Spears J, Saposnik G, Kostyrko P, Li Y, Parra-Farina C, Diestro J, Camden M, Verreault S, Mackey A, Audet M, Milot G, Lavoie P, Gariépy J, Collard K, Haché A, Van Adel B, Sahlas D, Alshanbari A, Baldwin J, Catanese L, Chen B, Boasquevisque D, Deshmukh A, Knapman J, Lamers S, Larrazabal R, MacMillan S, Mai L, Mattia A, Nayar S, Ng K, Oczkowski W, Perera K, Shawawrah M, Shoamanesh A, Sobhi G, Syed N, Taher N, Vandervelde C, Pharm D, Field T, Van Gaal S, Teal P, Benavente O, Wilson L, Mann S, Yip S, Murphy C, Heran M, Rohr A, Settecase F, Redekop G, Haw C, Maclean G, Murray K, Chiu R, Flexman A, Strecha E, Gayton Y, Yip J, Swartz R, Boulos M, Gladstone D, Yu A, Hopyan J, Khosravani H, Alzate H, Southwell A, Kamra M, Lopes K, Kapoor A, da Costa L, Yang V, Dyer E, Shah R, Knowles B, Nichols J, Patterson J, Cope K, Dickerson L, Barton K, Gray K, Massengale T, Miller M, Simpson C, Walker S, Tennyson-Yemm C, Devlin T, Frei D, Bellon R, Atchie B, Kaminsky I, Wilson D, Schraeder N, Arias E, Kodis L, Talley M, Edinger A, Talley T, Dempsey I, Williams L, Williams S, Kupniewski S, Fasbinder B, Snead J, Choe H, Mackenzie L, Weisman D, Kozak O, Shah Q, Gzesh D, Kulandaivel K, Khoury J, Klein B, Bussinger P, Griffin L, dePalmo A, Oliva C, Jadhav A, Jovin T, Kenmuir C, Jankowitz B, Gross B, Rocha M, Starr M, Brown M, Hawkes C, Shah K, Tememe D, Walker G, Patel P, Klein B, Ziayee H, Limaye K, Baxendell L, Gilchrist V, Feineigle P, Haibach K, Van Every C, Desai S, Zulfiqar M, Gibson L, Barrett S, Turkel-Parrella D, Arcot K, DiCrescento S, Farkas J, Filipowski G, Frontera J, Joset D, Liff J, Scher E, McDougall C, Kelly C, Patel A, Monteith S, Starkman S, Atchaneeyasakul K, Burgos A, Chua J, Gaines N, Grunberg I, Guzy J, Liu Z, Maluste N, Ramirez L, Sharma L, Heck D, Brown M, McDonald C, Calderon M, Hargis M, Roels C, Emmady P, Alvi T, McTaggart R, Jayaraman M, Cutting S, Smith W, Foley S, Paolucci G, Has R, Quinn K, Fuller L, Brierley R, Watkins C, Demir N, Lopez G, Vargas A, Osteraas N, Holtz B, Sauvageau E, Hanel R, Aghaebrahim A, Chmayssani M, Naval N, Day J, Dellorso S, Ludwig B, Schemmel D, Ebreo N, Bell K, Lewis L, Delucia M, Nogueira R, Haussen D, Frankel M, Bhatt N, Bianchi N, Anderson A, Belagaje S, Liberato B, Rangaraju S, Al-Bayati A, Grossberg J, Craft L, Schindler K, Schaad E, Schultz M, Southerly L, Doppelheuer S, Charlton J, Faggard J, Barbret Z, Han E, Walters R, Dolia J, El-Jamal S, Eby B, Saleem Y, Pearl H, Patel K, Rahman H, Butt R, English S, Puri A, Howk M, Singh J, Massari F, Rodrigues K, Kuhn A, English J, Barazangi N, Telischak N, Kim W, Ross J, DeVole N, Redford J, Ferreira M, Ponting K, Shen H, Bedenk A, Patel S, Fernandess J, Ke M, Spokoyny I, Gao B, Tong D, Chen C, Wong C, Choe J, Martin C, Summers D, Boutwell C, Olds K, Crandall S, Eatman J, Akhtar N, Holloway W, Halpin J, Donegan B, Schindler J, Hwang D, Gilmore E, Petersen N, Sheth K, Brown S, Beekman R, George B, Kaddouh F, Falcone G, Wira C, Matouk C, Loomis C, Amin H, Stretz H, Narula R, Jasne A, Sansing L, Agarwal T, Jasak S, Fontaine B, King Z, Kuohn L, Orgass H, Leary M, Nye J, Halbert K, Nystrom K, Neuschatz K, Petrucci D, Coppola A, Tarpley J, Joyce T, Hou S, Umekubo M, Nakamura C, Ovando R, Zuniga D, Nien Y, Basto F, Arch A, Jong L, Conrad W, Abbott T, Yao J, Caganap S, Jordan J, Teitelbaum G, Darflinger R, Gupta R, Bain M, Budzik R, Czerniak J, Groezinger K, Hicks W, Kaskar O, Katz B, Loochtan A, Pema P, Rai V, Vora N, Brown A, Goodman D, Danenbergs B, Gossett M, Bang O, Chung J, Jeon P, Kim K, Lim Y, Heo J, Nam H, Kim Y, Park H, Hwang I, Ha W, Choi J, Jeong K, Rha J, Park H, Yoon C, Kim B, Sohn S, Kim C, Yoo J, Hong J, Park H, Kim S, Choi M, Bae H, Lee J, Lee J, Jun G, Jeon S, Campbell B, Mitchell P, Yassi N, Davis S, Donnan G, Parsons M, Yan B, Dowling R, Bush S, Wu T, Shah D, Zhao H, Salvaris P, Alemseged F, Ng F, Williams C, Balabanski A, Dos Santos A, Ng J, McDonald A, Jackson D, Tsoleridis J, Pesavento L, Kleinig T, Nurs R, Cranefield J, Scroop R, Cagi L, Harvey J, Waters M, Thornton J, Brennan R, O'Hare A, Power S, Williams D, Boyle K, Moynihan B, Liddy A, Large M, Cullen A, Walsh R, Martin E, Lynch J, McElroy S, Murphy S, Coveney S, Deegan C, Horgan G, Kelly P, Laffan A, Llamas-Osorio Y, Lynch C, Mac Mahon P, Marnane M, McCabe J, Burns P, Tauro S, Cuddy S, Rennie I, Smyth G, Flynn P, Wiggam I, Kerr E, Gordon P, Fearon P, Roberts G, Patterson C, Adams K, Wells B, McFarland M, Holmin S, Moreira T, Sjöstrand C, Mazya M, Almqvist H, Wahlgren N, Steinberg A, Cooray C, Eriksson E, Thorén M, Keselman B, Ahmed N, Holmberg Å, Axelsson M, Berglund A, Thomalla G, Golsari A, Hoppe J, Deb-Chatterji M, Cheng B, Barrow E, Schlemm E, Lettow I, Jensen M, Otto D, Jaramillo K, Appelbohm H, Fiehler J, Bester M, Schönfeld M, Brekenfeld C, Holst B, Wortmann G, Koch F, Puetz V, Gerber J, Abramyuk A, Kaiser D, Winzer S, Prakapenia A, Pallesen L, Siepmann T, Barlinn K, Haase K, Sauer A, Psychogios M, Liman J, Brehm A, Maus V, Hollstein N, Reinke A, Neitz G, Schnieder M, Schwarz M, Ibrahim A, Müller J, Meister S, Bäumle B, Chapot R, Pilgram-Pastor S, Wallocha M, Stauder M, Celik E, Stracke P, Müller N, Weber R, Velktamp R, Nagel S, Ringleb P, Heyse M, Amiri H, Mundiyanapurath S, Chen M, Bevrle E, Beck P, Möhlenbruch M, Tymianski M, Potvin A, Harris C, Wang C, Adams C, Mayor D, Garman D, Chau D, Wu J, Lunn J, Heard K, Bermanis L, Teyes L, Constant M, Galsim M, Helbin M, Leroux M, Felix N, Bendre N, Cuthbert S, Brokx S, Zhang Y, Lingham T, Kohli Y, Salter M, Liebeschuetz J, Hofmann F, Constant J, Soeder T, Snoke K, Bologa M, Stahl K, Graziewicz M. Efficacy and safety of nerinetide for the treatment of acute ischaemic stroke (ESCAPE-NA1): a multicentre, double-blind, randomised controlled trial. The Lancet 2020, 395: 878-887. PMID: 32087818, DOI: 10.1016/s0140-6736(20)30258-0.Peer-Reviewed Original ResearchConceptsAlberta Stroke Program Early CT ScoreAcute ischemic strokeIschemic strokeEndovascular thrombectomySecondary outcomesScale scoreHealth Stroke Scale scoreModified Rankin Scale scorePost-synaptic density protein 95H treatment windowIntravenous alteplase treatmentBaseline National InstitutesPlacebo-controlled studySerious adverse eventsStroke Scale scoreExcellent functional outcomeProportion of patientsTime of randomisationLarge vessel occlusionPreclinical stroke modelsRankin Scale scoreBetter clinical outcomesMultiphase CT angiographyAcute care hospitalsGood collateral filling
2019
Global, regional, and national burden of neurological disorders, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016
Collaborators G, Feigin V, Nichols E, Alam T, Bannick M, Beghi E, Blake N, Culpepper W, Dorsey E, Elbaz A, Ellenbogen R, Fisher J, Fitzmaurice C, Giussani G, Glennie L, James S, Johnson C, Kassebaum N, Logroscino G, Marin B, Mountjoy-Venning W, Nguyen M, Ofori-Asenso R, Patel A, Piccininni M, Roth G, Steiner T, Stovner L, Szoeke C, Theadom A, Vollset S, Wallin M, Wright C, Zunt J, Abbasi N, Abd-Allah F, Abdelalim A, Abdollahpour I, Aboyans V, Abraha H, Acharya D, Adamu A, Adebayo O, Adeoye A, Adsuar J, Afarideh M, Agrawal S, Ahmadi A, Ahmed M, Aichour A, Aichour I, Aichour M, Akinyemi R, Akseer N, Al-Eyadhy A, Salman R, Alahdab F, Alene K, Aljunid S, Altirkawi K, Alvis-Guzman N, Anber N, Antonio C, Arabloo J, Aremu O, Ärnlöv J, Asayesh H, Asghar R, Atalay H, Awasthi A, Quintanilla B, Ayuk T, Badawi A, Banach M, Banoub J, Barboza M, Barker-Collo S, Bärnighausen T, Baune B, Bedi N, Behzadifar M, Behzadifar M, Béjot Y, Bekele B, Belachew A, Bennett D, Bensenor I, Berhane A, Beuran M, Bhattacharyya K, Bhutta Z, Biadgo B, Bijani A, Bililign N, Bin Sayeed M, Blazes C, Brayne C, Butt Z, Campos-Nonato I, Cantu-Brito C, Car M, Cárdenas R, Carrero J, Carvalho F, Castañeda-Orjuela C, Castro F, Catalá-López F, Cerin E, Chaiah Y, Chang J, Chatziralli I, Chiang P, Christensen H, Christopher D, Cooper C, Cortesi P, Costa V, Criqui M, Crowe C, Damasceno A, Daryani A, De la Cruz-Góngora V, De la Hoz F, De Leo D, Demoz G, Deribe K, Dharmaratne S, Diaz D, Dinberu M, Djalalinia S, Doku D, Dubey M, Dubljanin E, Duken E, Edvardsson D, El-Khatib Z, Endres M, Endries A, Eskandarieh S, Esteghamati A, Esteghamati S, Farhadi F, Faro A, Farzadfar F, Farzaei M, Fatima B, Fereshtehnejad S, Fernandes E, Feyissa G, Filip I, Fischer F, Fukumoto T, Ganji M, Gankpe F, Garcia-Gordillo M, Gebre A, Gebremichael T, Gelaw B, Geleijnse J, Geremew D, Gezae K, Ghasemi-Kasman M, Gidey M, Gill P, Gill T, Girma E, Gnedovskaya E, Goulart A, Grada A, Grosso G, Guo Y, Gupta R, Gupta R, Haagsma J, Hagos T, Haj-Mirzaian A, Haj-Mirzaian A, Hamadeh R, Hamidi S, Hankey G, Hao Y, Haro J, Hassankhani H, Hassen H, Havmoeller R, Hay S, Hegazy M, Heidari B, Henok A, Heydarpour F, Hoang C, Hole M, Rad E, Hosseini S, Hu G, Igumbor E, Ilesanmi O, Irvani S, Islam M, Jakovljevic M, Javanbakht M, Jha R, Jobanputra Y, Jonas J, Jozwiak J, Jürisson M, Kahsay A, Kalani R, Kalkonde Y, Kamil T, Kanchan T, Karami M, Karch A, Karimi N, Kasaeian A, Kassa T, Kassa Z, Kaul A, Kefale A, Keiyoro P, Khader Y, Khafaie M, Khalil I, Khan E, Khang Y, Khazaie H, Kiadaliri A, Kiirithio D, Kim A, Kim D, Kim Y, Kim Y, Kisa A, Kokubo Y, Koyanagi A, Krishnamurthi R, Defo B, Bicer B, Kumar M, Lacey B, Lafranconi A, Lansingh V, Latifi A, Leshargie C, Li S, Liao Y, Linn S, Lo W, Lopez J, Lorkowski S, Lotufo P, Lucas R, Lunevicius R, Mackay M, Mahotra N, Majdan M, Majdzadeh R, Majeed A, Malekzadeh R, Malta D, Manafi N, Mansournia M, Mantovani L, März W, Mashamba-Thompson T, Massenburg B, Mate K, McAlinden C, McGrath J, Mehta V, Meier T, Meles H, Melese A, Memiah P, Memish Z, Mendoza W, Mengistu D, Mengistu G, Meretoja A, Meretoja T, Mestrovic T, Miazgowski B, Miazgowski T, Miller T, Mini G, Mirrakhimov E, Moazen B, Mohajer B, Mezerji N, Mohammadi M, Mohammadi-Khanaposhtani M, Mohammadibakhsh R, Mohammadnia-Afrouzi M, Mohammed S, Mohebi F, Mokdad A, Monasta L, Mondello S, Moodley Y, Moosazadeh M, Moradi G, Moradi-Lakeh M, Moradinazar M, Moraga P, Velásquez I, Morrison S, Mousavi S, Muhammed O, Muruet W, Musa K, Mustafa G, Naderi M, Nagel G, Naheed A, Naik G, Najafi F, Nangia V, Negoi I, Negoi R, Newton C, Ngunjiri J, Nguyen C, Nguyen L, Ningrum D, Nirayo Y, Nixon M, Norrving B, Noubiap J, Shiadeh M, Nyasulu P, Ogah O, Oh I, Olagunju A, Olagunju T, Olivares P, Onwujekwe O, Oren E, Owolabi M, Mahesh P, Pakpour A, Pan W, Panda-Jonas S, Pandian J, Patel S, Pereira D, Petzold M, Pillay J, Piradov M, Polanczyk G, Polinder S, Postma M, Poulton R, Poustchi H, Prakash S, Prakash V, Qorbani M, Radfar A, Rafay A, Rafiei A, Rahim F, Rahimi-Movaghar V, Rahman M, Rahman M, Rahman M, Rajati F, Ram U, Ranta A, Rawaf D, Rawaf S, Reinig N, Reis C, Renzaho A, Resnikoff S, Rezaeian S, Rezai M, González C, Roberts N, Roever L, Ronfani L, Roro E, Roshandel G, Rostami A, Sabbagh P, Sacco R, Sachdev P, Saddik B, Safari H, Safari-Faramani R, Safi S, Safiri S, Sagar R, Sahathevan R, Sahebkar A, Sahraian M, Salamati P, Zahabi S, Salimi Y, Samy A, Sanabria J, Santos I, Milicevic M, Sarrafzadegan N, Sartorius B, Sarvi S, Sathian B, Satpathy M, Sawant A, Sawhney M, Schneider I, Schöttker B, Schwebel D, Seedat S, Sepanlou S, Shabaninejad H, Shafieesabet A, Shaikh M, Shakir R, Shams-Beyranvand M, Shamsizadeh M, Sharif M, Sharif-Alhoseini, She J, Sheikh A, Sheth K, Shigematsu M, Shiri R, Shirkoohi R, Shiue I, Siabani S, Siddiqi T, Sigfusdottir I, Sigurvinsdottir R, Silberberg D, Silva J, Silveira D, Singh J, Sinha D, Skiadaresi E, Smith M, Sobaih B, Sobhani S, Soofi M, Soyiri I, Sposato L, Stein D, Stein M, Stokes M, Sufiyan M, Sykes B, Sylaja P, Tabarés-Seisdedos R, Ao B, Tehrani-Banihashemi A, Temsah M, Temsah O, Thakur J, Thrift A, Topor-Madry R, Tortajada-Girbés M, Tovani-Palone M, Tran B, Tran K, Truelsen T, Tsadik A, Car L, Ukwaja K, Ullah I, Usman M, Uthman O, Valdez P, Vasankari T, Vasanthan R, Veisani Y, Venketasubramanian N, Violante F, Vlassov V, Vosoughi K, Vu G, Vujcic I, Wagnew F, Waheed Y, Wang Y, Weiderpass E, Weiss J, Whiteford H, Wijeratne T, Winkler A, Wiysonge C, Wolfe C, Xu G, Yadollahpour A, Yamada T, Yano Y, Yaseri M, Yatsuya H, Yimer E, Yip P, Yisma E, Yonemoto N, Yousefifard M, Yu C, Zaidi Z, Bin Zaman S, Zamani M, Zandian H, Zare Z, Zhang Y, Zodpey S, Naghavi M, Murray C, Vos T. Global, regional, and national burden of neurological disorders, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. The Lancet Neurology 2019, 18: 459-480. PMID: 30879893, PMCID: PMC6459001, DOI: 10.1016/s1474-4422(18)30499-x.Peer-Reviewed Original ResearchConceptsNeurological disordersNational burdenAbsolute numberGlobal burdenAge-standardised DALY ratesBayesian meta-regression toolRisk Factors Study 2016Disorder categoriesCauses of DALYsDisMod-MR 2.1Death Ensemble modelDisease Study 2016Age-standardised ratesTension-type headacheCause of deathComparative risk assessment approachDALY ratesDALY burdenModifiable riskMultiple sclerosisFemale ratioNeurological burdenRisk factorsIdiopathic epilepsyTreatment strategiesGlobal, regional, and national burden of stroke, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016
Collaborators G, Johnson C, Nguyen M, Roth G, Nichols E, Alam T, Abate D, Abd-Allah F, Abdelalim A, Abraha H, Abu-Rmeileh N, Adebayo O, Adeoye A, Agarwal G, Agrawal S, Aichour A, Aichour I, Aichour M, Alahdab F, Ali R, Alvis-Guzman N, Anber N, Anjomshoa M, Arabloo J, Arauz A, Ärnlöv J, Arora A, Awasthi A, Banach M, Barboza M, Barker-Collo S, Bärnighausen T, Basu S, Belachew A, Belayneh Y, Bennett D, Bensenor I, Bhattacharyya K, Biadgo B, Bijani A, Bikbov B, Bin Sayeed M, Butt Z, Cahuana-Hurtado L, Carrero J, Carvalho F, Castañeda-Orjuela C, Castro F, Catalá-López F, Chaiah Y, Chiang P, Choi J, Christensen H, Chu D, Cortinovis M, Damasceno A, Dandona L, Dandona R, Daryani A, Davletov K, de Courten B, De la Cruz-Góngora V, Degefa M, Dharmaratne S, Diaz D, Dubey M, Duken E, Edessa D, Endres M, FARAON E, Farzadfar F, Fernandes E, Fischer F, Flor L, Ganji M, Gebre A, Gebremichael T, Geta B, Gezae K, Gill P, Gnedovskaya E, Gómez-Dantés H, Goulart A, Grosso G, Guo Y, Gupta R, Haj-Mirzaian A, Haj-Mirzaian A, Hamidi S, Hankey G, Hassen H, Hay S, Hegazy M, Heidari B, Herial N, Hosseini M, Hostiuc S, Irvani S, Islam M, Jahanmehr N, Javanbakht M, Jha R, Jonas J, Jozwiak J, Jürisson M, Kahsay A, Kalani R, Kalkonde Y, Kamil T, Kanchan T, Karch A, Karimi N, Karimi-Sari H, Kasaeian A, Kassa T, Kazemeini H, Kefale A, Khader Y, Khalil I, Khan E, Khang Y, Khubchandani J, Kim D, Kim Y, Kisa A, Kivimäki M, Koyanagi A, Krishnamurthi R, Kumar G, Lafranconi A, Lewington S, Li S, Lo W, Lopez A, Lorkowski S, Lotufo P, Mackay M, Majdan M, Majdzadeh R, Majeed A, Malekzadeh R, Manafi N, Mansournia M, Mehndiratta M, Mehta V, Mengistu G, Meretoja A, Meretoja T, Miazgowski B, Miazgowski T, Miller T, Mirrakhimov E, Mohajer B, Mohammad Y, Mohammadoo-khorasani M, Mohammed S, Mohebi F, Mokdad A, Mokhayeri Y, Moradi G, Morawska L, Velásquez I, Mousavi S, Muhammed O, Muruet W, Naderi M, Naghavi M, Naik G, Nascimento B, Negoi R, Nguyen C, Nguyen L, Nirayo Y, Norrving B, Noubiap J, Ofori-Asenso R, Ogbo F, Olagunju A, Olagunju T, Owolabi M, Pandian J, Patel S, Perico N, Piradov M, Polinder S, Postma M, Poustchi H, Prakash V, Qorbani M, Rafiei A, Rahim F, Rahimi K, Rahimi-Movaghar V, Rahman M, Rahman M, Reis C, Remuzzi G, Renzaho A, Ricci S, Roberts N, Robinson S, Roever L, Roshandel G, Sabbagh P, Safari H, Safari S, Safiri S, Sahebkar A, Zahabi S, Samy A, Santalucia P, Santos I, Santos J, Milicevic M, Sartorius B, Sawant A, Schutte A, Sepanlou S, Shafieesabet A, Shaikh M, Shams-Beyranvand M, Sheikh A, Sheth K, Shibuya K, Shigematsu M, Shin M, Shiue I, Siabani S, Sobaih B, Sposato L, Sutradhar I, Sylaja P, Szoeke C, Ao B, Temsah M, Temsah O, Thrift A, Tonelli M, Topor-Madry R, Tran B, Tran K, Truelsen T, Tsadik A, Ullah I, Uthman O, Vaduganathan M, Valdez P, Vasankari T, Vasanthan R, Venketasubramanian N, Vosoughi K, Vu G, Waheed Y, Weiderpass E, Weldegwergs K, Westerman R, Wolfe C, Wondafrash D, Xu G, Yadollahpour A, Yamada T, Yatsuya H, Yimer E, Yonemoto N, Yousefifard M, Yu C, Zaidi Z, Zamani M, Zarghi A, Zhang Y, Zodpey S, Feigin V, Vos T, Murray C. Global, regional, and national burden of stroke, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. The Lancet Neurology 2019, 18: 439-458. PMID: 30871944, PMCID: PMC6494974, DOI: 10.1016/s1474-4422(19)30034-1.Peer-Reviewed Original ResearchConceptsAge-standardised mortality ratesAge-standardised incidenceSocio-demographic IndexSDI quintileGlobal burdenMortality rateAge-standardised DALY ratesTransient ischemic attackBurden of strokePost-stroke careDisease Study 2016Risk Factor StudyCause-specific mortalityNew stroke casesVerbal autopsy dataYears of lifeEstimates of burdenIschemic attackSDI groupCause of diseaseGBD 2016DALY ratesHaemorrhagic strokeIntracerebral hemorrhageAtrial fibrillation
2018
Global, Regional, and Country-Specific Lifetime Risks of Stroke, 1990 and 2016
Feigin V, Nguyen G, Cercy K, Johnson C, Alam T, Parmar P, Abajobir A, Abate K, Abd-Allah F, Abejie A, Abyu G, Ademi Z, Agarwal G, Ahmed M, Akinyemi R, Al-Raddadi R, Aminde L, Amlie-Lefond C, Ansari H, Asayesh H, Asgedom S, Atey T, Ayele H, Banach M, Banerjee A, Barac A, Barker-Collo S, Bärnighausen T, Barregard L, Basu S, Bedi N, Behzadifar M, Béjot Y, Bennett D, Bensenor I, Berhe D, Boneya D, Brainin M, Campos-Nonato I, Caso V, Castañeda-Orjuela C, Rivas J, Catalá-López F, Christensen H, Criqui M, Damasceno A, Dandona L, Dandona R, Davletov K, de Courten B, deVeber G, Dokova K, Edessa D, Endres M, Faraon E, Farvid M, Fischer F, Foreman K, Forouzanfar M, Gall S, Gebrehiwot T, Geleijnse J, Gillum R, Giroud M, Goulart A, Gupta R, Gupta R, Hachinski V, Hamadeh R, Hankey G, Hareri H, Havmoeller R, Hay S, Hegazy M, Hibstu D, James S, Jeemon P, John D, Jonas J, Jóźwiak J, Kalani R, Kandel A, Kasaeian A, Kengne A, Khader Y, Khan A, Khang Y, Khubchandani J, Kim D, Kim Y, Kivimaki M, Kokubo Y, Kolte D, Kopec J, Kosen S, Kravchenko M, Krishnamurthi R, Kumar G, Lafranconi A, Lavados P, Legesse Y, Li Y, Liang X, Lo W, Lorkowski S, Lotufo P, Loy C, Mackay M, Abd El Razek H, Mahdavi M, Majeed A, Malekzadeh R, Malta D, Mamun A, Mantovani L, Martins S, Mate K, Mazidi M, Mehata S, Meier T, Melaku Y, Mendoza W, Mensah G, Meretoja A, Mezgebe H, Miazgowski T, Miller T, Ibrahim N, Mohammed S, Mokdad A, Moosazadeh M, Moran A, Musa K, Negoi R, Nguyen M, Nguyen Q, Nguyen T, Tran T, Nguyen T, Anggraini Ningrum D, Norrving B, Noubiap J, O’Donnell M, Olagunju A, Onuma O, Owolabi M, Parsaeian M, Patton G, Piradov M, Pletcher M, Pourmalek F, Prakash V, Qorbani M, Rahman M, Rahman M, Rai R, Ranta A, Rawaf D, Rawaf S, Renzaho A, Robinson S, Sahathevan R, Sahebkar A, Salomon J, Santalucia P, Santos I, Sartorius B, Schutte A, Sepanlou S, Shafieesabet A, Shaikh M, Shamsizadeh M, Sheth K, Sisay M, Shin M, Shiue I, Silva D, Sobngwi E, Soljak M, Sorensen R, Sposato L, Stranges S, Suliankatchi R, Tabarés-Seisdedos R, Tanne D, Nguyen C, Thakur J, Thrift A, Tirschwell D, Topor-Madry R, Tran B, Nguyen L, Truelsen T, Tsilimparis N, Tyrovolas S, Ukwaja K, Uthman O, Varakin Y, Vasankari T, Venketasubramanian N, Vlassov V, Wang W, Werdecker A, Wolfe C, Xu G, Yano Y, Yonemoto N, Yu C, Zaidi Z, El Sayed Zaki M, Zhou M, Ziaeian B, Zipkin B, Vos T, Naghavi M, Murray C, Roth G. Global, Regional, and Country-Specific Lifetime Risks of Stroke, 1990 and 2016. New England Journal Of Medicine 2018, 379: 2429-2437. PMID: 30575491, PMCID: PMC6247346, DOI: 10.1056/nejmoa1804492.Peer-Reviewed Original ResearchGlobal, regional, and national burden of traumatic brain injury and spinal cord injury, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016
James S, Theadom A, Ellenbogen R, Bannick M, Montjoy-Venning W, Lucchesi L, Abbasi N, Abdulkader R, Abraha H, Adsuar J, Afarideh M, Agrawal S, Ahmadi A, Ahmed M, Aichour A, Aichour I, Aichour M, Akinyemi R, Akseer N, Alahdab F, Alebel A, Alghnam S, Ali B, Alsharif U, Altirkawi K, Andrei C, Anjomshoa M, Ansari H, Ansha M, Antonio C, Appiah S, Ariani F, Asefa N, Asgedom S, Atique S, Awasthi A, Ayala Quintanilla B, Ayuk T, Azzopardi P, Badali H, Badawi A, Balalla S, Banstola A, Barker-Collo S, Bärnighausen T, Bedi N, Behzadifar M, Behzadifar M, Bekele B, Belachew A, Belay Y, Bennett D, Bensenor I, Berhane A, Beuran M, Bhalla A, Bhaumik S, Bhutta Z, Biadgo B, Biffino M, Bijani A, Bililign N, Birungi C, Boufous S, Brazinova A, Brown A, Car M, Cárdenas R, Carrero J, Carvalho F, Castañeda-Orjuela C, Catalá-López F, Chaiah Y, Champs A, Chang J, Choi J, Christopher D, Cooper C, Crowe C, Dandona L, Dandona R, Daryani A, Davitoiu D, Degefa M, Demoz G, Deribe K, Djalalinia S, Do H, Doku D, Drake T, Dubey M, Dubljanin E, El-Khatib Z, Ofori-Asenso R, Eskandarieh S, Esteghamati A, Esteghamati S, Faro A, Farzadfar F, Farzaei M, Fereshtehnejad S, Fernandes E, Feyissa G, Filip I, Fischer F, Fukumoto T, Ganji M, Gankpe F, Gebre A, Gebrehiwot T, Gezae K, Gopalkrishna G, Goulart A, Haagsma J, Haj-Mirzaian A, Haj-Mirzaian A, Hamadeh R, Hamidi S, Haro J, Hassankhani H, Hassen H, Havmoeller R, Hawley C, Hay S, Hegazy M, Hendrie D, Henok A, Hibstu D, Hoffman H, Hole M, Homaie Rad E, Hosseini S, Hostiuc S, Hu G, Hussen M, Ilesanmi O, Irvani S, Jakovljevic M, Jayaraman S, Jha R, Jonas J, Jones K, Jorjoran Shushtari Z, Jozwiak J, Jürisson M, Kabir A, Kahsay A, Kahssay M, Kalani R, Karch A, Kasaeian A, Kassa G, Kassa T, Kassa Z, Kengne A, Khader Y, Khafaie M, Khalid N, Khalil I, Khan E, Khan M, Khang Y, Khazaie H, Khoja A, Khubchandani J, Kiadaliri A, Kim D, Kim Y, Kisa A, Koyanagi A, Krohn K, Kuate Defo B, Kucuk Bicer B, Kumar G, Kumar M, Lalloo R, Lami F, Lansingh V, Laryea D, Latifi A, Leshargie C, Levi M, Li S, Liben M, Lotufo P, Lunevicius R, Mahotra N, Majdan M, Majeed A, Malekzadeh R, Manda A, Mansournia M, Massenburg B, Mate K, Mehndiratta M, Mehta V, Meles H, Melese A, Memiah P, Mendoza W, Mengistu G, Meretoja A, Meretoja T, Mestrovic T, Miazgowski T, Miller T, Mini G, Mirica A, Mirrakhimov E, Moazen B, Mohammadi M, Mohammed S, Mokdad A, Molokhia M, Monasta L, Mondello S, Moosazadeh M, Moradi G, Moradi M, Moradi-Lakeh M, Moradinazar M, Morrison S, Moschos M, Mousavi S, Murthy S, Musa K, Mustafa G, Naghavi M, Naik G, Najafi F, Nangia V, Nascimento B, Negoi I, Nguyen T, Nichols E, Ningrum D, Nirayo Y, Nyasulu P, Ogbo F, Oh I, Okoro A, Olagunju A, Olagunju T, Olivares P, Otstavnov S, Owolabi M, P A M, Pakhale S, Pandey A, Pesudovs K, Pinilla-Monsalve G, Polinder S, Poustchi H, Prakash S, Qorbani M, Radfar A, Rafay A, Rafiei A, Rahimi-Movaghar A, Rahimi-Movaghar V, Rahman M, Rahman M, Rai R, Rajati F, Ram U, Rawaf D, Rawaf S, Reiner R, Reis C, Renzaho A, Resnikoff S, Rezaei S, Rezaeian S, Roever L, Ronfani L, Roshandel G, Roy N, Ruhago G, Saddik B, Safari H, Safiri S, Sahraian M, Salamati P, Saldanha R, Samy A, Sanabria J, Santos J, Santric Milicevic M, Sartorius B, Satpathy M, Savuon K, Schneider I, Schwebel D, Sepanlou S, Shabaninejad H, Shaikh M, Shams-Beyranvand M, Sharif M, Sharif-Alhoseini M, Shariful Islam S, She J, Sheikh A, Shen J, Sheth K, Shibuya K, Shiferaw M, Shigematsu M, Shiri R, Shiue I, Shoman H, Siabani S, Siddiqi T, Silva J, Silveira D, Sinha D, Smith M, Soares Filho A, Sobhani S, Soofi M, Soriano J, Soyiri I, Stein D, Stokes M, Sufiyan M, Sunguya B, Sunshine J, Sykes B, Szoeke C, Tabarés-Seisdedos R, Te Ao B, Tehrani-Banihashemi A, Tekle M, Temsah M, Temsah O, Topor-Madry R, Tortajada-Girbés M, Tran B, Tran K, Tudor Car L, Ukwaja K, Ullah I, Usman M, Uthman O, Valdez P, Vasankari T, Venketasubramanian N, Violante F, Wagnew F, Waheed Y, Wang Y, Weldegwergs K, Werdecker A, Wijeratne T, Winkler A, Wyper G, Yano Y, Yaseri M, Yasin Y, Ye P, Yimer E, Yip P, Yisma E, Yonemoto N, Yoon S, Yost M, Younis M, Yousefifard M, Yu C, Zaidi Z, Zaman S, Zamani M, Zenebe Z, Zodpey S, Feigin V, Vos T, Murray C. Global, regional, and national burden of traumatic brain injury and spinal cord injury, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. The Lancet Neurology 2018, 18: 56-87. PMID: 30497965, PMCID: PMC6291456, DOI: 10.1016/s1474-4422(18)30415-0.Peer-Reviewed Original ResearchConceptsSpinal cord injuryTraumatic brain injuryCause of injuryAge-standardised incidence ratesMedical careNew casesCord injuryNational burdenBrain injuryIncidence rateGlobal burdenProportion of TBIIncidence of TBIBayesian meta-regression toolGlobal injury burdenAge-standardised prevalenceDisease Study 2016Long-term disabilityCause-specific mortality ratesAge-standardised ratesStandardised mortality ratiosNature of injurySocio-demographic IndexGlobal health priorityRoad injuriesGlobal, regional, and national age-sex-specific mortality and life expectancy, 1950–2017: a systematic analysis for the Global Burden of Disease Study 2017
Collaborators G, Dicker D, Nguyen G, Abate D, Abate K, Abay S, Abbafati C, Abbasi N, Abbastabar H, Abd-Allah F, Abdela J, Abdelalim A, Abdel-Rahman O, Abdi A, Abdollahpour I, Abdulkader R, Abdurahman A, Abebe H, Abebe M, Abebe Z, Abebo T, Aboyans V, Abraha H, Abrham A, Abu-Raddad L, Abu-Rmeileh N, Accrombessi M, Acharya P, Adebayo O, Adedeji I, Adedoyin R, Adekanmbi V, Adetokunboh O, Adhena B, Adhikari T, Adib M, Adou A, Adsuar J, Afarideh M, Afshin A, Agarwal G, Aggarwal R, Aghayan S, Agrawal S, Agrawal A, Ahmadi M, Ahmadi A, Ahmadieh H, Ahmed M, Ahmed S, Ahmed M, Aichour A, Aichour I, Aichour M, Akanda A, Akbari M, Akibu M, Akinyemi R, Akinyemiju T, Akseer N, Alahdab F, Al-Aly Z, Alam K, Alebel A, Aleman A, Alene K, Al-Eyadhy A, Ali R, Alijanzadeh M, Alizadeh-Navaei R, Aljunid S, Alkerwi A, Alla F, Allebeck P, Allen C, Alonso J, Al-Raddadi R, Alsharif U, Altirkawi K, Alvis-Guzman N, Amare A, Amini E, Ammar W, Amoako Y, Anber N, Andrei C, Androudi S, Animut M, Anjomshoa M, Anlay D, Ansari H, Ansariadi A, Ansha M, Antonio C, Appiah S, Aremu O, Areri H, Ärnlöv J, Arora M, Artaman A, Aryal K, Asadi-Lari M, Asayesh H, Asfaw E, Asgedom S, Assadi R, Ataro Z, Atey T, Athari S, Atique S, Atre S, Atteraya M, Attia E, Ausloos M, Avila-Burgos L, Avokpaho E, Awasthi A, Awuah B, Quintanilla B, Ayele H, Ayele Y, Ayer R, Ayuk T, Azzopardi P, Azzopardi-Muscat N, Badali H, Badawi A, Balakrishnan K, Bali A, Banach M, Banstola A, Barac A, Barboza M, Barquera S, Barrero L, Basaleem H, Bassat Q, Basu A, Basu S, Baune B, Bazargan-Hejazi S, Bedi N, Beghi E, Behzadifar M, Behzadifar M, Béjot Y, Bekele B, Belachew A, Belay A, Belay E, Belay S, Belay Y, Bell M, Bello A, Bennett D, Bensenor I, Berhane A, Berman A, Bernabe E, Bernstein R, Bertolacci G, Beuran M, Beyranvand T, Bhala N, Bhatia E, Bhatt S, Bhattarai S, Bhaumik S, Bhutta Z, Biadgo B, Bijani A, Bikbov B, Bililign N, Bin Sayeed M, Birlik S, Birungi C, Bisanzio D, Biswas T, Bjørge T, Bleyer A, Basara B, Bose D, Bosetti C, Boufous S, Bourne R, Brady O, Bragazzi N, Brant L, Brazinova A, Breitborde N, Brenner H, Britton G, Brugha T, Burke K, Busse R, Butt Z, Cahuana-Hurtado L, Callender C, Campos-Nonato I, Rincon J, Cano J, Car M, Cárdenas R, Carreras G, Carrero J, Carter A, Carvalho F, Castañeda-Orjuela C, Rivas J, Castro F, Catalá-López F, Çavlin A, Cerin E, Chaiah Y, Champs A, Chang H, Chang J, Chattopadhyay A, Chaturvedi P, Chen W, Chiang P, Chimed-Ochir O, Chin K, Chisumpa V, Chitheer A, Choi J, Christensen H, Christopher D, Chung S, Cicuttini F, Ciobanu L, Cirillo M, Claro R, Cohen A, Collado-Mateo D, Constantin M, Conti S, Cooper C, Cooper L, Cortesi P, Cortinovis M, Cousin E, Criqui M, Cromwell E, Crowe C, Crump J, Cucu A, Cunningham M, Daba A, Dachew B, Dadi A, Dandona L, Dandona R, Dang A, Dargan P, Daryani A, Das S, Gupta R, Neves J, Dasa T, Dash A, Weaver N, Davitoiu D, Davletov K, Dayama A, de Courten B, De la Hoz F, De leo D, De Neve J, Degefa M, Degenhardt L, Degfie T, Deiparine S, Dellavalle R, Demoz G, Demtsu B, Denova-Gutiérrez E, Deribe K, Dervenis N, Jarlais D, Dessie G, Dey S, Dharmaratne S, Dhimal M, Ding E, Djalalinia S, Doku D, Dolan K, Donnelly C, Dorsey E, Douwes-Schultz D, Doyle K, Drake T, Driscoll T, Dubey M, Dubljanin E, Duken E, Duncan B, Duraes A, Ebrahimi H, Ebrahimpour S, Edessa D, Edvardsson D, Eggen A, Bcheraoui C, Zaki M, Elfaramawi M, El-Khatib Z, Ellingsen C, Elyazar I, Enayati A, Endries A, Er B, Ermakov S, Eshrati B, Eskandarieh S, Esmaeili R, Esteghamati A, Esteghamati S, Fakhar, Fakhim H, Farag T, Faramarzi M, Fareed M, Farhadi F, Farid T, Farinha C, Farioli A, Faro A, Farvid M, Farzadfar F, Farzaei M, Fazeli M, Feigin V, Feigl A, Feizy F, Fentahun N, Fereshtehnejad S, Fernandes E, Fernandes J, Feyissa G, Fijabi D, Filip I, Finegold S, Fischer F, Flor L, Foigt N, Ford J, Foreman K, Fornari C, Frank T, Franklin R, Fukumoto T, Fuller J, Fullman N, Fürst T, Furtado J, Futran N, Galan A, Gallus S, Gambashidze K, Gamkrelidze A, Gankpe F, Garcia-Basteiro A, Garcia-Gordillo M, Gebre T, Gebre A, Gebregergs G, Gebrehiwot T, Gebremedhin A, Gelano T, Gelaw Y, Geleijnse J, Genova-Maleras R, Gessner B, Getachew S, Gething P, Gezae K, Ghadami M, Ghadimi R, Falavarjani K, Ghasemi-Kasman M, Ghiasvand H, Ghimire M, Ghoshal A, Gill P, Gill T, Gillum R, Giussani G, Goenka S, Goli S, Gomez R, Gomez-Cabrera M, Gómez-Dantés H, Gona P, Goodridge A, Gopalani S, Goto A, Goulart A, Goulart B, Grada A, Grosso G, Gugnani H, Guimaraes A, Guo Y, Gupta P, Gupta R, Gupta R, Gupta T, Gyawali B, Haagsma J, Hachinski V, Hafezi-Nejad N, Hagos T, Hailegiyorgis T, Hailu G, Haj-Mirzaian A, Haj-Mirzaian A, Hamadeh R, Hamidi S, Handal A, Hankey G, Harb H, Harikrishnan S, Haririan H, Haro J, Hasan M, Hassankhani H, Hassen H, Havmoeller R, Hay R, Hay S, He Y, Hedayatizadeh-Omran A, Hegazy M, Heibati B, Heidari M, Hendrie D, Henok A, Henry N, Heredia-Pi I, Herteliu C, Heydarpour F, Heydarpour P, Heydarpour S, Hibstu D, Hoek H, Hole M, Rad E, Hoogar P, Horino M, Hosgood H, Hosseini S, Hosseinzadeh M, Hostiuc S, Hostiuc M, Hotez P, Hoy D, Hsairi M, Htet A, Hu G, Huang J, Husseini A, Hussen M, Hutfless S, Iburg K, Igumbor E, Ikeda C, Ilesanmi O, Iqbal U, Irvani S, Isehunwa O, Islam M, Islami F, Jahangiry L, Jahanmehr N, Jain R, Jain S, Jakovljevic M, James S, Javanbakht M, Jayaraman S, Jayatilleke A, Jee S, Jeemon P, Jha R, Jha V, Ji J, Johnson S, Jonas J, Joshi A, Jozwiak J, Jungari S, Jürisson M, Madhanraj K, Kabir Z, Kadel R, Kahsay A, Kahssay M, Kalani R, Kapil U, Karami M, Matin B, Karch A, Karema C, Karimi N, Karimi S, Karimi-Sari H, Kasaeian A, Kassa G, Kassa T, Kassa Z, Kassebaum N, Katibeh M, Katikireddi S, Kaul A, Kawakami N, Kazemeini H, Kazemi Z, Karyani A, Prakash K, Kebede S, Keiyoro P, Kemp G, Kengne A, Keren A, Kereselidze M, Khader Y, Khafaie M, Khajavi A, Khalid N, Khalil I, Khan E, Khan G, Khan M, Khan M, Khang Y, Khanna T, Khater M, Khatony A, Khazaie H, Khoja A, Khosravi A, Khosravi M, Khubchandani J, Kiadaliri A, Kibret G, Kim C, Kim D, Kim J, Kim Y, Kimokoti R, Kinfu Y, Kinra S, Kisa A, Kissimova-Skarbek K, Kissoon N, Kivimäki M, Kleber M, Knibbs L, Knudsen A, Kochhar S, Kokubo Y, Kolola T, Kopec J, Kosek M, Kosen S, Koul P, Koyanagi A, Kravchenko M, Krishan K, Krishnaswami S, Defo B, Bicer B, Kudom A, Kuipers E, Kulikoff X, Kumar G, Kumar M, Kumar P, Kumsa F, Kutz M, Lad S, Lafranconi A, Lal D, Lalloo R, Lam H, Lami F, Lan Q, Langan S, Lansingh V, Lansky S, Larson H, Laryea D, Lassi Z, Latifi A, Lavados P, Laxmaiah A, Lazarus J, Lebedev G, Lee P, Leigh J, Leshargie C, Leta S, Levi M, Li S, Li Y, Li X, Liang J, Liang X, Liben M, Lim L, Lim S, Limenih M, Linn S, Liu S, Liu Y, Lodha R, Logroscino G, Lonsdale C, Lorch S, Lorkowski S, Lotufo P, Lozano R, Lucas T, Lunevicius R, Lyons R, Ma S, Mabika C, Macarayan E, Mackay M, Maddison E, Maddison R, Madotto F, Razek H, Razek M, Maghavani D, Majdan M, Majdzadeh R, Majeed A, Malekzadeh R, Malik M, Malta D, Mamun A, Manamo W, Manda A, Mansournia M, Mantovani L, Mapoma C, Marami D, Maravilla J, Marcenes W, Marina S, Martinez-Raga J, Martins S, Martins-Melo F, März W, Marzan M, Mashamba-Thompson T, Masiye F, Massenburg B, Maulik P, Mazidi M, McGrath J, McKee M, Mehata S, Mehendale S, Mehndiratta M, Mehrotra R, Mehta K, Mehta V, Mekonen T, Mekonnen T, Meles H, Meles K, Melese A, Melku M, Memiah P, Memish Z, Mendoza W, Mengistu D, Mengistu G, Mensah G, Mereta S, Meretoja A, Meretoja T, Mestrovic T, Mezgebe H, Miangotar Y, Miazgowski B, Miazgowski T, Miller T, Mini G, Mirica A, Mirrakhimov E, Misganaw A, Moazen B, Moges N, Mohammad K, Mohammadi M, Mohammadifard N, Mohammadi-Khanaposhtani M, Mohammadnia-Afrouzi M, Mohammed S, Mohammed M, Mohan V, Mokdad A, Molokhia M, Monasta L, Moradi G, Moradi M, Moradi-Lakeh M, Moradinazar M, Moraga P, Morawska L, Velásquez I, Morgado-da-Costa J, Morrison S, Mosapour A, Moschos M, Mousavi S, Muche A, Muchie K, Mueller U, Mukhopadhyay S, Mullany E, Muller K, Murhekar M, Murphy T, Murthy G, Murthy S, Musa J, Musa K, Mustafa G, Muthupandian S, Nachega J, Nagel G, Naghavi M, Naheed A, Nahvijou A, Naik G, Nair S, Najafi F, Nangia V, Nansseu J, Nascimento B, Nawaz H, Ncama B, Neamati N, Negoi I, Negoi R, Neupane S, Newton C, Ngalesoni F, Ngunjiri J, Nguyen H, Nguyen H, Nguyen L, Nguyen M, Nguyen T, Ningrum D, Nirayo Y, Nisar M, Nixon M, Nolutshungu N, Nomura S, Norheim O, Noroozi M, Norrving B, Noubiap J, Nouri H, Shiadeh M, Nowroozi M, Nsoesie E, Nyasulu P, Ofori-Asenso R, Ogah O, Ogbo F, Oh I, Okoro A, Oladimeji O, Olagunju A, Olagunju T, Olivares P, Olusanya B, Olusanya J, Ong S, Opio J, Oren E, Ortiz J, Ortiz A, Ota E, Otstavnov S, Øverland S, Owolabi M, Oyekale A, Mahesh P, Pacella R, Pakhale S, Pakhare A, Pana A, Panda B, Panda-Jonas S, Pandey A, Pandian J, Parisi A, Park E, Parry C, Parsian H, Patel S, Patle A, Patten S, Patton G, Paudel D, Pearce N, Peprah E, Pereira A, Pereira D, Perez K, Perico N, Pervaiz A, Pesudovs K, Petri W, Petzold M, Phillips M, Pigott D, Pillay J, Pirsaheb M, Pishgar F, Plass D, Polinder S, Pond C, Popova S, Postma M, Pourmalek F, Pourshams A, Poustchi H, Prabhakaran D, Prakash V, Prakash S, Prasad N, Qorbani M, Quistberg D, Radfar A, Rafay A, Rafiei A, Rahim F, Rahimi K, Rahimi-Movaghar A, Rahimi-Movaghar V, Rahman M, Rahman M, Rahman M, Rahman S, Kumar R, Rajati F, Rajsic S, Raju S, Ram U, Ranabhat C, Ranjan P, Ranta A, Rasella D, Rawaf D, Rawaf S, Ray S, Razo-García C, Rego M, Rehm J, Reiner R, Reinig N, Reis C, Remuzzi G, Renzaho A, Resnikoff S, Rezaei S, Rezaeian S, Rezai M, Riahi S, Ribeiro A, Riojas H, Rios-Blancas M, Roba K, Robinson S, Roever L, Ronfani L, Roshandel G, Roshchin D, Rostami A, Rothenbacher D, Rubagotti E, Ruhago G, Saadat S, Sabde Y, Sachdev P, Saddik B, Sadeghi E, Moghaddam S, Safari H, Safari Y, Safari-Faramani R, Safdarian, Safi S, Safiri S, Sagar R, Sahebkar A, Sahraian M, Sajadi H, Salahshoor M, Salam N, Salama J, Salamati P, de Freitas Saldanha R, Salimi Y, Salimzadeh H, Salz I, Sambala E, Samy A, Sanabria J, Sanchez-Niño M, Santos I, Santos J, Milicevic M, Jose B, Sardana M, Sarker A, Sarrafzadegan N, Sartorius B, Sarvi S, Sathian B, Satpathy M, Savic M, Sawant A, Sawhney M, Saxena S, Sayyah M, Scaria V, Schaeffner E, Schelonka K, Schmidt M, Schneider I, Schöttker B, Schutte A, Schwebel D, Schwendicke F, Scott J, Sekerija M, Sepanlou S, Serván-Mori E, Shabaninejad H, Shackelford K, Shafieesabet A, Shaheen A, Shaikh M, Shakir R, Shams-Beyranvand M, Shamsi M, Shamsizadeh M, Sharafi H, Sharafi K, Sharif M, Sharif-Alhoseini, Sharma M, Sharma J, Sharma R, She J, Sheikh A, Sheth K, Shi P, Shibuya K, Shifa G, Shiferaw M, Shigematsu M, Shiri R, Shirkoohi R, Shiue I, Shokraneh F, Shrime M, Shukla S, Si S, Siabani S, Siddiqi T, Sigfusdottir I, Sigurvinsdottir R, Silpakit N, Silva D, Silva J, Silveira D, Singam N, Singh J, Singh V, Sinha A, Sinha D, Sitas F, Skirbekk V, Sliwa K, Filho A, Sobaih B, Sobhani S, Soofi M, Soriano J, Soyiri I, Sposato L, Sreeramareddy C, Srinivasan V, Srivastava R, Starodubov V, Stathopoulou V, Steel N, Stein D, Steiner C, Stewart L, Stokes M, Sudaryanto A, Sufiyan M, Sulo G, Sunguya B, Sur P, Sutradhar I, Sykes B, Sylaja P, Sylte D, Szoeke C, Tabarés-Seisdedos R, Tabuchi T, Tadakamadla S, Takahashi K, Tandon N, Tassew A, Tassew S, Tavakkoli M, Taveira N, Tawye N, Tehrani-Banihashemi A, Tekalign T, Tekle M, Temesgen H, Temsah M, Temsah O, Terkawi A, Teshale M, Tessema B, Teweldemedhin M, Thakur J, Thankappan K, Thirunavukkarasu S, Thomas L, Thomas N, Thrift A, Tilahun B, To Q, Tobe-Gai R, Tonelli M, Topor-Madry R, Topouzis F, Torre A, Tortajada-Girbés M, Tovani-Palone M, Towbin J, Tran B, Tran K, Tripathi S, Tripathy S, Truelsen T, Truong N, Tsadik A, Tsilimparis N, Car L, Tuzcu E, Tyrovolas S, Ukwaja K, Ullah I, Usman M, Uthman O, Uzun S, Vaduganathan M, Vaezi A, Vaidya G, Valdez P, Varavikova E, Varughese S, Vasankari T, Vasconcelos A, Venketasubramanian N, Vidavalur R, Villafaina S, Violante F, Vladimirov S, Vlassov V, Vollset S, Vos T, Vosoughi K, Vujcic I, Wagner G, Wagnew F, Waheed Y, Wang Y, Wang Y, Wassie M, Weiderpass E, Weintraub R, Weiss D, Weiss J, Weldegebreal F, Weldegwergs K, Werdecker A, Westerman R, Whiteford H, Widecka J, Widecka K, Wijeratne T, Winkler A, Wiysonge C, Wolfe C, Wondemagegn S, Wu S, Wyper G, Xu G, Yadav R, Yakob B, Yamada T, Yan L, Yano Y, Yaseri M, Yasin Y, Ye P, Yearwood J, Yentür G, Yeshaneh A, Yimer E, Yip P, Yisma E, Yonemoto N, Yoon S, York H, Yotebieng M, Younis M, Yousefifard M, Yu C, Zachariah G, Zadnik V, Zafar S, Zaidi Z, Bin Zaman S, Zamani M, Zare Z, Zeeb H, Zeleke M, Zenebe Z, Zerfu T, Zhang K, Zhang X, Zhou M, Zhu J, Zodpey S, Zucker I, Zuhlke L, Lopez A, Gakidou E, Murray C. Global, regional, and national age-sex-specific mortality and life expectancy, 1950–2017: a systematic analysis for the Global Burden of Disease Study 2017. The Lancet 2018, 392: 1684-1735. PMID: 30496102, PMCID: PMC6227504, DOI: 10.1016/s0140-6736(18)31891-9.Peer-Reviewed Original Research
2013
Pilot Study of Intravenous Glyburide in Patients With a Large Ischemic Stroke
Sheth KN, Kimberly WT, Elm JJ, Kent TA, Mandava P, Yoo AJ, Thomalla G, Campbell B, Donnan GA, Davis SM, Albers GW, Jacobson S, Simard JM, Stern BJ. Pilot Study of Intravenous Glyburide in Patients With a Large Ischemic Stroke. Stroke 2013, 45: 281-283. PMID: 24193798, PMCID: PMC4235339, DOI: 10.1161/strokeaha.113.003352.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overBlood GlucoseBrain EdemaBrain IschemiaComorbidityFemaleFibrinolytic AgentsGlyburideHumansHypoglycemiaHypoglycemic AgentsInjections, IntravenousMagnetic Resonance ImagingMaleMiddle AgedPatient SafetyPilot ProjectsProspective StudiesStrokeTissue Plasminogen ActivatorTreatment OutcomeWhite PeopleYoung AdultConceptsIschemic strokeLesion volumeIntravenous recombinant tissue-type plasminogen activatorRecombinant tissue-type plasminogen activatorIpsilateral hemisphere volumeLarge ischemic strokeSerious adverse eventsAcute ischemic strokeRetrospective clinical dataFeasibility of recruitingTissue-type plasminogen activatorIntravenous glyburideSevere strokeSymptomatic hypoglycemiaAdverse eventsFocal ischemiaMean ageClinical trialsHemisphere volumeClinical dataDose reductionAge 18PatientsSulfonylurea receptorPlasminogen activator
2012
Intracranial Pressure Dose and Outcome in Traumatic Brain Injury
Sheth KN, Stein DM, Aarabi B, Hu P, Kufera JA, Scalea TM, Hanley DF. Intracranial Pressure Dose and Outcome in Traumatic Brain Injury. Neurocritical Care 2012, 18: 26-32. PMID: 23055087, DOI: 10.1007/s12028-012-9780-3.Peer-Reviewed Original ResearchConceptsSevere traumatic brain injuryTraumatic brain injuryElevated intracranial pressureBrain injuryIntracranial pressureFunctional outcomeExtended Glasgow Outcome ScaleCenter observational studyCornerstone of managementGlasgow Outcome ScalePoor functional outcomeIntracranial pressure measurementClinical outcomesOutcome ScaleUniversity HospitalObservational studyProspective patientsCandidate biomarkersInjuryTime doseConclusionsThese resultsOutcomesPatientsMortalityDose