2024
Automated detection of early signs of irreversible ischemic change on CTA source images in patients with large vessel occlusion
Mak A, Matouk C, Avery E, Behland J, Haider S, Frey D, Madai V, Vajkoczy P, Griessenauer C, Zand R, Hendrix P, Abedi V, Sanelli P, Falcone G, Petersen N, Sansing L, Sheth K, Payabvash S, Malhotra A. Automated detection of early signs of irreversible ischemic change on CTA source images in patients with large vessel occlusion. PLOS ONE 2024, 19: e0304962. PMID: 38870240, PMCID: PMC11175522, DOI: 10.1371/journal.pone.0304962.Peer-Reviewed Original ResearchConceptsDiffusion-weighted imagingLarge vessel occlusionIrreversible ischemic changesPoor functional outcomeFunctional outcomesIschemic changesInfarct volumeAlberta Stroke Program Early CT ScorePredicting poor functional outcomeVessel occlusionFollow-up diffusion-weighted imagingAnterior circulation LVO strokeCTA source imagesReceiver operating characteristic curveExpert human readersPredicting final infarctionASPECTS regionsAdmission CTANon-inferior performanceBaseline CTACT scoreFinal infarctEndovascular therapyHU attenuationValidation cohort
2023
Racial and Ethnic Differences in the Risk of Ischemic Stroke After Nontraumatic Intracerebral Hemorrhage
Simonetto M, Sheth K, Ziai W, Iadecola C, Zhang C, Murthy S. Racial and Ethnic Differences in the Risk of Ischemic Stroke After Nontraumatic Intracerebral Hemorrhage. Stroke 2023, 54: 2401-2408. PMID: 37462054, PMCID: PMC10529487, DOI: 10.1161/strokeaha.123.043160.Peer-Reviewed Original ResearchMeSH KeywordsAtrial FibrillationCerebral HemorrhageEthnicityHumansIschemic StrokeRetrospective StudiesRisk FactorsStrokeConceptsNon-Hispanic white patientsNon-Hispanic blacksIschemic strokeIntracerebral hemorrhageHispanic patientsWhite patientsAtrial fibrillationICH patientsHigh riskNon-Hispanic black patientsCox proportional hazards modelIncident ischemic strokeRetrospective cohort studyNontraumatic intracerebral hemorrhageValvular heart diseaseTime of dischargeLarge heterogeneous cohortProportional hazards modelNon-Hispanic whitesICH hospitalizationsCardiovascular comorbiditiesMedian followCohort studyVascular comorbiditiesConcomitant diagnosisCT With CTA Versus MRI in Patients Presenting to the Emergency Department With Dizziness: Analysis Using Propensity Score Matching.
Tu L, Navaratnam D, Melnick E, Forman H, Venkatesh A, Malhotra A, Yaesoubi R, Sureshanand S, Sheth K, Mahajan A. CT With CTA Versus MRI in Patients Presenting to the Emergency Department With Dizziness: Analysis Using Propensity Score Matching. American Journal Of Roentgenology 2023, 221: 836-845. PMID: 37404082, DOI: 10.2214/ajr.23.29617.Peer-Reviewed Original ResearchConceptsSecondary stroke prevention medicationsStroke prevention medicationsEmergency departmentPrevention medicationsEchocardiography evaluationPosterior circulation strokeProportion of patientsGroup of patientsPhysical examination findingsNeuroimaging resultsUse of MRIReview of systemsGreater frequencyPropensity-score matchingExamination findingsRetrospective studyED readmissionMedical historyHead CTClinical impactMRI examinationsBrain MRINeck CTADizzinessPatientsPortable MRI to assess optic chiasm decompression after endoscopic endonasal resection of sellar and suprasellar lesions.
Hong C, Lamsam L, Yadlapalli V, Parasuram N, Mazurek M, Chavva I, Lalwani D, Zabinska J, Schiff S, Manes R, Vining E, Rimmer R, Kimberly W, Sheth K, Omay S. Portable MRI to assess optic chiasm decompression after endoscopic endonasal resection of sellar and suprasellar lesions. Journal Of Neurosurgery 2023, 139: 1664-1670. PMID: 37347618, DOI: 10.3171/2023.5.jns23174.Peer-Reviewed Original ResearchMeSH KeywordsDecompressionHumansMagnetic Resonance ImagingOptic ChiasmPituitary NeoplasmsReproducibility of ResultsRetrospective StudiesConceptsEndoscopic endonasal surgeryOptic nerve decompressionEndonasal surgerySuprasellar lesionsNerve decompressionOptic chiasmThird ventricleConventional MRIOptic chiasm compressionEndoscopic endonasal resectionChiasm compressionPreoperative imagingSingle institutionEndonasal resectionMRI availabilityRoutine MRISignificant interrater reliabilitySuprasellar pathologiesSurgeryNeurosurgical oncologyLinear mixed-effects modelsPortable MRIPatientsMRIMixed-effects modelsIdentification of White Matter Hyperintensities in Routine Emergency Department Visits Using Portable Bedside Magnetic Resonance Imaging
de Havenon A, Parasuram N, Crawford A, Mazurek M, Chavva I, Yadlapalli V, Iglesias J, Rosen M, Falcone G, Payabvash S, Sze G, Sharma R, Schiff S, Safdar B, Wira C, Kimberly W, Sheth K. Identification of White Matter Hyperintensities in Routine Emergency Department Visits Using Portable Bedside Magnetic Resonance Imaging. Journal Of The American Heart Association 2023, 12: e029242. PMID: 37218590, PMCID: PMC10381997, DOI: 10.1161/jaha.122.029242.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrainFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedProspective StudiesRetrospective StudiesWhite MatterConceptsWhite matter hyperintensitiesMagnetic resonance imagingSevere white matter hyperintensitiesConventional magnetic resonance imagingResonance imagingRetrospective cohortEmergency departmentMatter hyperintensitiesVascular risk factorsProspective observational studyVascular cognitive impairmentTesla magnetic resonance imagingArea Deprivation IndexProspective cohortAdult patientsAcute careRisk factorsCardiovascular diseaseObservational studyCognitive impairmentPatientsCare magnetic resonance imagingIntermodality agreementCohortDeprivation indexHigher Hospital Frailty Risk Score Is Associated With Increased Risk of Stroke: Observational and Genetic Analyses
Renedo D, Acosta J, Koo A, Rivier C, Sujijantarat N, de Havenon A, Sharma R, Gill T, Sheth K, Falcone G, Matouk C. Higher Hospital Frailty Risk Score Is Associated With Increased Risk of Stroke: Observational and Genetic Analyses. Stroke 2023, 54: 1538-1547. PMID: 37216451, PMCID: PMC10212531, DOI: 10.1161/strokeaha.122.041891.Peer-Reviewed Original ResearchMeSH KeywordsHemorrhagic StrokeHospitalsHumansPopulation HealthRetrospective StudiesRisk FactorsStrokeConceptsHospital Frailty Risk ScoreRisk of strokeHighest Hospital Frailty Risk ScoresDate of consentFrailty Risk ScoreMendelian randomization analysisStroke riskRisk scoreRandomization analysisTime of enrollmentAvailable electronic health recordsMendelian randomizationElectronic health recordsLook-back periodIncident strokeDose-response wayFrailty statusHemorrhagic strokeMultivariable analysisStroke eventsObservational studyHigh riskFrailtySignificant associationSimilar associationEffect of COVID-19 on Acute Ischemic Stroke Severity and Mortality in 2020: Results From the 2020 National Inpatient Sample
de Havenon A, Zhou L, Yaghi S, Frontera J, Sheth K. Effect of COVID-19 on Acute Ischemic Stroke Severity and Mortality in 2020: Results From the 2020 National Inpatient Sample. Stroke 2023, 54: e194-e198. PMID: 37021563, PMCID: PMC10121243, DOI: 10.1161/strokeaha.122.041929.Peer-Reviewed Original ResearchConceptsHealth Stroke ScaleStroke ScaleStroke severityLowest quartileCOVID-19Acute ischemic stroke outcomesAcute ischemic stroke severityHigher stroke severityHospital stroke mortalityIschemic stroke outcomeHigher National InstitutesNational Inpatient SampleCross-sectional cohortIschemic stroke severityCOVID-19 statusNational InstituteHospital mortalityAdjusted riskHospital dischargeIschemic strokeStroke outcomeStroke mortalityAIS severityInpatient SampleExposure statusEmergent external ventricular drain placement in patients with factor Xa inhibitor-associated intracerebral hemorrhage after reversal with andexanet alfa
Ammar A, Elsamadicy A, Ammar M, Reeves B, Koo A, Falcone G, Hwang D, Petersen N, Kim J, Beekman R, Prust M, Magid-Bernstein J, Acosta J, Herbert R, Sheth K, Matouk C, Gilmore E. Emergent external ventricular drain placement in patients with factor Xa inhibitor-associated intracerebral hemorrhage after reversal with andexanet alfa. Clinical Neurology And Neurosurgery 2023, 226: 107621. PMID: 36791588, DOI: 10.1016/j.clineuro.2023.107621.Peer-Reviewed Original ResearchMeSH KeywordsAdultCerebral HemorrhageDrainageFactor XaFactor Xa InhibitorsFibrinolytic AgentsHumansProspective StudiesRecombinant ProteinsRetrospective StudiesThrombosisConceptsAndexanet alfaExtra-axial hemorrhageEVD placementThrombotic eventsNew hemorrhagePrimary safety outcomeExternal ventricular drain placementLarge prospective studiesIntensive care unitIntracerebral hemorrhage patientsVentricular drain placementBolus patientsHospital lengthHospital LOSICU LOSTract hemorrhageRankin scoreSecondary outcomesAdult patientsBolus groupPrimary outcomeCare unitIntracerebral hemorrhageLong administration timeHemorrhage patients
2022
Association of Soluble ST2 With Functional Outcome, Perihematomal Edema, and Immune Response After Intraparenchymal Hemorrhage
Bevers M, Booraem C, Li K, Sreekrishnan A, Sastre C, Falcone G, Sheth K, Sansing L, Kimberly W. Association of Soluble ST2 With Functional Outcome, Perihematomal Edema, and Immune Response After Intraparenchymal Hemorrhage. Neurology 2022, 100: e1329-e1338. PMID: 36549913, PMCID: PMC10065211, DOI: 10.1212/wnl.0000000000206764.Peer-Reviewed Original ResearchMeSH KeywordsBrain EdemaCerebral HemorrhageEdemaHematomaHumansImmunityInterleukin-1 Receptor-Like 1 ProteinRetrospective StudiesConceptsSoluble ST2Deep intraparenchymal hemorrhageIntraparenchymal hemorrhagePerihematomal edemaImmune responseHematoma volumePoor outcomeFunctional outcomeMedian admission Glasgow Coma Scale scoreScale scoreAdmission Glasgow Coma Scale scorePeripheral innate immune responseModified Rankin Scale scoreGlasgow Coma Scale scoreHours of ictusPeripheral immune responseSecondary brain injuryRankin Scale scoreInnate immune cellsImmune cell populationsIntracerebral Hemorrhage ScoreSerial CT scansInnate immune responseHuman brain tissueSST2 levelsAssociation of Renin Angiotensin Aldosterone System Inhibitors and Outcomes of Hospitalized Patients With COVID-19
Gupta N, Settle L, Brown B, Armaignac D, Baram M, Perkins N, Kaufman M, Melamed R, Christie A, Danesh V, Denson J, Cheruku S, Boman K, Bansal V, Kumar V, Walkey A, Domecq J, Kashyap R, Aston C, Mesland J, Henin P, Petre H, Buelens I, Gerard A, Clevenbergh P, Granado R, Mercado J, Vega-Terrazas E, Iturricha-Caceres M, Garza R, Chu E, Chan V, Gavidia O, Pachon F, Sanchez Y, knežević D, Kassas M, Badr M, Tawheed A, Tawheed A, Yahia H, Kantas D, Koulouras V, Pineda E, Guillen G, Soto H, Lizardo A, Kopitkó C, Bencze Á, Méhész I, Gerendai Z, Doddaga P, Chandra N, Segu S, Chakraborty T, Joyce E, Vadgaonkar G, Ediga R, Basety S, Dammareddy S, Kasumalla P, Raju U, Manduva J, Kolakani N, Sripathi S, Chaitanya S, Cherian A, Parameswaran S, Parthiban M, A. M, Prabhu M, Jakati V, Rijhwani P, Jain A, Gupta A, Jaiswal R, Tyagi A, Mathur N, Daga M, Agarwal M, Rohtagi I, Papani S, Kamuram M, Agrawal K, Baghel V, Patel K, Mohan S, Jyothisree E, Petrolwala M, Ladva B, Dalili N, Nafa M, Matsuda W, Suzuki R, Tahara S, Suzuki R, Sanui M, Horikita S, Itagaki Y, Kodate A, Suzuki R, Kodate A, Takahashi Y, Moriki K, Shiga T, Iwasaki Y, Shigemitsu H, Mishima Y, Nosaka N, Nagashima M, Al-Fares A, Ulloa M, Rodriguez-Gutierrez R, Gonzalez-Gonzalez J, Salcido-Montenegro A, Camacho-Ortiz A, Hassan-Hanga F, Galadanci H, Gezawa A, Kabara H, Amole T, Kabir H, Haliru D, Ibrahim A, Asghar M, Syed M, Naqvi S, Zabolotskikh I, Zybin K, Sinkov S, Musaeva T, Alamoudi R, AlSharif H, Almazwaghi S, Elsakran M, Aid M, Darwich M, Hagag O, Ali S, rocacorba A, Supeña K, Juane E, Medina J, Baduria J, Amer M, Bawazeer M, Dahhan T, Kseibi E, Butt A, Khurshid S, Rabee M, Abujazar M, Alghunaim R, Abualkhair M, AlFirm A, Kseibi E, Khurshid S, Rabee M, Abujazar M, Alghunaim R, Arabi Y, Abdukahil S, Almazyad M, Alarifi M, Macarambon J, Bukhari A, Albahrani H, Asfina K, Aldossary K, Zdravkovic M, Todorovic Z, Popadic V, Klasnja S, Andrijevic A, Gavrilovic S, Carapic V, Kovacevic B, Bojicic J, Kovacevic P, Predrag S, Stojakov D, Ignjatovic D, Bojic S, Bobos M, Nenadic I, Zaric M, Djuric M, Djukic V, Teruel S, Martin B, Teruel S, Sili U, Bilgin H, Ay P, Gharpure V, Raheemi U, Dodd K, Goodmanson N, Hesse K, Bird P, Weinert C, Schoenrade N, Altaher A, Mayar E, Aronson M, Cooper T, Logan M, Miner B, Papo G, Siegal E, Runningen P, Barry S, Woll C, Wu G, Carrole E, Burke K, Mohammed M, Melamed R, Tierney D, Patel L, Raj V, Dawud B, Mazumder N, Sidebottom A, Guenther A, Krehbiel B, Schmitz N, Jepsen S, Sipsey L, Schulte A, Wunderlich W, Hoyt C, Raval A, Franks A, Irby K, Sanders R, Hefley G, Jarvis J, Kharbanda A, Jhajhria S, Fyffe Z, Capizzi S, Alicie B, Green M, Crockarell L, Drennan A, Dubuque K, Fambrough T, Gasaway N, Krantz B, Nebi P, Orga J, Serfass M, Simion A, Warren K, Wheeler C, Woolman C, Christie A, Ashley D, Adiga R, Moyer A, Verghese G, Newsome A, Forehand C, Bruning R, Jones T, Sabov M, Zaidi F, Tissavirasingham F, Malipeddi D, Mosier J, Lutrick K, Campbell B, Wilson C, Rivers P, Brinks J, Mongoh M, Gilson B, Armaignac D, Parris D, Zuniga M, Vargas I, Boronat V, Hutton A, Kaur N, Neupane P, Sadule-Rios N, Rojas L, Neupane A, Rivera P, Carlos C, Vincent G, Amin M, Schelle M, Steadham A, Howard C, McBride C, Abraham J, Garner O, Richards K, Collins K, Antony P, Mathew S, Danesh V, Dubrocq G, Davis A, Hammers M, McGahey J, Farris A, Priest E, Korsmo R, Fares L, Skiles K, Shor S, Burns K, Dowell C, Flores M, Newman L, Wilk D, Ettlinger J, Bomar J, Darji H, Arroliga A, Arroliga A, Dowell C, Conzales G, Flores M, Newman L, Wilk D, Ettlinger J, Darji H, Bomar J, Khandhar P, Kring E, Banner-Goodspeed V, Bose S, Kelly L, Joseph M, McGourty M, Capers K, Hoenig B, Karamourtopoulos M, Law A, Kassis E, Walkey A, Waikar S, Garcia M, Colona M, Kibbelaar Z, Leong M, Wallman D, Soni K, Maccarone J, Gilman J, Devis Y, Chung J, Paracha M, Lumelsky D, DiLorenzo M, Abdurrahman N, Johnson S, Hersh A, Wachs S, Swigger B, Wachs S, Sattler L, Moulton M, Zammit K, McGrath P, Loeffler W, Chilbert M, Miller A, Anderson E, Nagy R, Inja R, Nawathe P, Pedraza I, Tsing J, Carr K, Chaudhary A, Guglielmino K, Tirupathi R, Tang A, Safi A, Green C, Newell J, Maguire F, Roach K, Short J, Mullins J, Roumain A, Ihle R, Martin S, Davis E, Gist K, Sayed I, Brinton J, Strom L, Chiotos K, Blatz A, Lee G, Burnett R, Sydney G, Traynor D, Nauert K, Gonzalez A, Bagley M, Santpurkar A, Surani S, White J, Khan A, Dhahwal R, Cheruku S, Ahmed F, Deonarine C, Jones A, Shaikh M, Preston D, Chin J, Vachharajani V, Duggal A, Rajendram P, Mehkri O, Dugar S, Biehl M, Sacha G, Houltham S, King A, Ashok K, Poynter B, Beukemann M, Rice R, Gole S, Shaner V, Conjeevaram A, Ferrari M, Alappan N, Minear S, Hernandez-Montfort J, Nasim S, Sunderkrishnan R, Milligan P, Gupta S, Koglin J, Gibson R, Johnson L, Preston F, Scott C, Nungester B, Byrne D, Schorr C, Grant K, Doktor K, Porto M, Kaplan O, Siegler J, Schonewald B, Woodford A, Tsai A, Reid S, Bhowmick K, Daneshpooy S, Mowdawalla C, Dave T, Crudeli W, Ferry C, Nguyen L, Modi S, Padala N, Patel P, Lin B, Chatterjee L, Qiuyun J, Liu F, Kota R, Banerjee A, Daugherty S, Atkinson S, Shrimpton K, Ontai S, Contreras B, Obinwanko U, Amamasi N, Sharafi A, Lee S, Esber Z, Jinjvadia C, Bartz R, Krishnamoorthy V, Kraft B, Pulsipher A, Friedman E, Mehta S, Kaufman M, Lobel G, Gandhi N, Abdelaty A, Shaji E, Lim K, Marte J, Sosa D, Yamane D, Benjenk I, Prasanna N, Perkins N, Roth P, Sivaraj B, Fulton H, Herin M, Crum M, Fretwell M, Zhou E, Waller C, Kallies K, Waller C, Thorsen J, Fitzsimmons A, Olsen H, Dapul H, Verma S, Salas A, Daube A, Korn M, Ramirez M, Rajagopalan L, Santos L, Santiago H, Hernandez R, Smalls N, Bercow A, Shlomovich M, Crandall C, Stojanovski S, Johnson K, Michienzi K, Davis S, Jovic V, Jovic V, Masuda M, Hayes A, Nault K, Smith M, Snow W, Liptak R, Durant H, Pendleton V, Nanavati A, Mrozowsk R, Nag N, Brauer J, Dharmadhikari A, Singh S, Laghi F, Naeem G, Wang A, Bliden K, Rout A, Barnes J, Gesheff M, Thomas A, Thomas M, Liendo A, Milosavljevic J, Abbasi K, Burley N, Rapista N, Amankwah S, Poudel S, Timilsina S, Sarkar S, Akinyosoye O, Yalamanchili S, Moorthy S, Sugumar S, Ford J, Taylor M, Dunderdale C, Henshaw A, Brunk M, Hagy J, Masood S, Sridhar S, Gupta M, Oulds F, Nandavar A, Liu Y, Zavala S, Zavala S, Shim E, Reilkoff R, Heneghan J, Eichen S, Goertzen L, Rajala S, Feussom G, Tang B, Junia C, Lichtenberg R, Sidhu H, Espinoza D, Rodrigues S, Zabala M, Goyes D, Susheela A, Hatharaliyadda B, Rameshkumar N, Kasireddy A, Maldonado G, Beltran L, Chaugule A, Khan H, Patil N, Patil R, Cartin-Ceba R, Sen A, Talaei F, Kashyap R, Domecq J, Gajic O, Bansal V, Tekin A, Lal A, O’Horo J, Deo N, Sharma M, Qamar S, Singh R, Morales D, La Nou A, Bogojevic M, Zec S, Sanghavi D, Guru P, Franco P, Gnanapandithan K, Saunders H, Fleissner Z, Garcia J, Mateus A, Yarrarapu S, Kaur N, Giri A, Hasan M, Donepudi A, Khan S, Jain N, Koritala T, Bastidas A, Orellana G, Bierwirth A, Milazzo E, Sierra J, Dang T, Nanchal R, Bergl P, Peterson J, Timmer J, Welker K, Yamanaka T, Barreras N, Markos M, Fareeduddin A, Mehta R, Venkata C, Engemann M, Mantese A, Tarabichi Y, Perzynski A, Wang C, Kotekal D, Bierwirth A, Orellana G, Catalasan G, Ahmed S, Matute C, Hamdan A, Salinas I, Del Nogal G, Tejada A, Eschler A, Hejna M, Lewandowski E, Kusmierski K, Martin C, Chen J, Hope A, Tsagaris Z, Ruen E, Hambardzumyan A, Siddiqi N, Jurado L, Tincher L, Brown C, Sendi P, Nadiger M, Totapally B, Aulakh B, Tripathi S, Bandy J, Kreps L, Bollinger D, Bandy J, Gupta N, Brown B, Jones T, Malone K, Sinko L, Harrell A, Ayers S, Settle L, Sears T, Stienecker R, Melendez A, Brunner T, Budzon S, Heffernan J, Souder J, Miller T, Maisonneuve A, Redfern R, Shoemaker J, Micham J, Kenney L, Naimy G, Schauf V, Utley S, Balcer H, Pulver K, Yehle J, Weeks A, Inman T, Hamarshi M, Ploetz J, Bennett N, Klindworth K, Younis M, Mohamed A, Delmonaco B, Franklin A, Heath M, Barkas D, Vilella A, Kutner S, Clark K, Moore D, Menon S, McGuire J, Rich D, Anderson H, Rajkumar D, Abunayla A, Heiter J, Zaren H, Smith S, Lewis G, Seames L, Farlow C, Miller J, Broadstreet G, Lin J, Terrill C, Montgomery B, Reyes S, Reyes S, Plattner A, Martinez A, Allison M, Mittal A, Ruiz R, Skaanland A, Ross R, Patel U, Hodge J, Patel K, Dalal S, Kavani H, Joseph S, Bernstein M, Goff I, Naftilan M, Mathew A, Williams D, Murdock S, Ducey M, Nelson K, Mohabir P, O’Brien C, Dasani K, Marx W, Amzuta I, Choudhry A, Azam M, Carter K, Olmos M, Parker B, Quintanilla J, Craig T, Clough B, Jameson J, Gupta N, Jones T, Ayers S, Harrell A, Brown B, Bhalala U, Kuehne J, Garcia M, Beebe M, Herrera H, Fiack C, Guo S, Vawer M, Blackburn B, Darby C, Page K, Brown A, McAbee J, Belden K, Baram M, Weber D, DePaola R, Xia Y, Carter H, Tolley A, Ferranti M, Steele M, Kemble L, Denson J, Gillet A, Brown M, Stevens R, Wetherbie A, Tea K, Moore M, Husain A, Malhotra A, Zawaydeh Q, Sines B, Bice T, Markotić D, Bošnjak I, Vail E, Nicholson S, Jonas R, Dement A, Tang W, DeRosa M, Villarreal R, Dy R, Iardino A, Sharma J, Czieki R, Christopher J, Lacey R, Mashina M, Patel K, Bjornstad E, Tofil N, House S, Aldana I, Meena N, Caceres J, Meena N, Epps S, Goraya H, Besett K, James R, Abusalem L, Patel A, Hasan L, Gomaa D, Goodman M, Wakefield D, Spuzzillo A, Shinn J, MacLaren R, Bihorac A, Baslanti T, Omalay G, Hashemighouchani H, Cupka J, Ruppert M, McGonagill P, Galet C, Hubbard J, Wang D, Allan L, Badheka A, Chegondi M, Nazir U, Rampon G, Riggle J, Dismang N, Montgomery V, Sullivan J, Morris S, Nason J, Akca O, Lenhardt R, Cavallazzi R, Jerde A, Black A, Polidori A, Griffey H, Winkler J, Brenzel T, Alvarez R, Alarcon-Calderon A, Sosa M, Mahabir S, Patel M, Park P, Admon A, Hanna S, Chanderraj R, Pliakas M, Wolski A, Cirino J, Dandachi D, Regunath H, Camazine M, Geiger G, Njai A, Saad B, Shah F, Chuan B, Rawal S, Piracha M, Tonna J, Levin N, Suslavich K, Tsolinas R, Fica Z, Skidmore C, Stapleton R, Dixon A, Johnson O, Ardren S, Burns S, Raymond A, Gonyaw E, Hodgdon K, Housenger C, Lin B, McQuesten K, Pecott-Grimm H, Sweet J, Ventrone S, Khandelwal N, West T, Caldwell E, Lovelace-Macon L, Garimella N, Dow D, Cheruku S, Chen C, Ahmed F, Deonarine C, Jones A, Preston D, Shaikh M, Chin J, Akhter M, Rahman R, Mulrow M, Wilfong E, Vela K, Khanna A, Harris L, Cusson B, Fowler J, Vaneenenaam D, McKinney G, Udoh I, Johnson K, Lyons P, Michelson A, Haluf S, Lynch L, Nguyen N, Steinberg A, Braus N, Pattan V, Papke J, Jimada I, Mhid N, Chakola S, Sheth K, Ammar A, Ammar M, Lopez V, Dela Cruz C, Khosla A, Gautam S. Association of Renin Angiotensin Aldosterone System Inhibitors and Outcomes of Hospitalized Patients With COVID-19. Critical Care Medicine 2022, 50: e744-e758. PMID: 35894609, PMCID: PMC9469914, DOI: 10.1097/ccm.0000000000005627.Peer-Reviewed Original ResearchConceptsHospitalized COVID-19 patientsAldosterone system inhibitorsAntihypertensive agentsCOVID-19 patientsHigh mortalityHospital mortalitySystem inhibitorsRenin-angiotensin-aldosterone system inhibitorsPrior useCOVID-19Retrospective observational studyCOVID-19 registryHospitalized patientsRAASIsObservational studyPatientsLower mortalityMortalityACEIsHospitalizationARBsMedicationsOutcomesInhibitorsAssociation
2021
Sex Differences in Ablation Strategy, Lesion Sets, and Complications of Catheter Ablation for Atrial Fibrillation: An Analysis From the GWTG-AFIB Registry
Yunus F, Perino A, Holmes D, Matsouaka R, Curtis A, Ellenbogen K, Frankel D, Knight B, Russo A, Lewis W, Piccini J, Turakhia M, Day J, Desai N, Feld G, Fonarow G, Hurwitz J, Joglar J, Sheth K, Sidhu M. Sex Differences in Ablation Strategy, Lesion Sets, and Complications of Catheter Ablation for Atrial Fibrillation: An Analysis From the GWTG-AFIB Registry. Circulation Arrhythmia And Electrophysiology 2021, 14: e009790. PMID: 34719235, DOI: 10.1161/circep.121.009790.Peer-Reviewed Original ResearchConceptsAblation strategyNonparoxysmal AFLesion setsPatient sexInitial AF ablation procedureAdvanced atrial diseaseAtrial linear ablationNonpulmonary vein triggersQuality improvement registryAF ablation proceduresAtrial fibrillation ablationOptimal ablation strategyAF ablation strategiesAF ablationPatient demographicsCatheter ablationFibrillation ablationMultivariable analysisAtrial diseaseAtrial fibrillationLinear ablationAF typeAblation proceduresComplicationsPatients
2016
Predicting survival after acute civilian penetrating brain injuries
Muehlschlegel S, Ayturk D, Ahlawat A, Izzy S, Scalea TM, Stein DM, Emhoff T, Sheth KN. Predicting survival after acute civilian penetrating brain injuries. Neurology 2016, 87: 2244-2253. PMID: 27784772, PMCID: PMC5123553, DOI: 10.1212/wnl.0000000000003355.Peer-Reviewed Original ResearchConceptsRadiologic factorsBrain injuryMotor Glasgow Coma ScaleLower Injury Severity ScoreLevel 1 trauma centerLower international normalized ratioUS level 1 trauma centersSurvival prediction scoreInjury Severity ScoreGlasgow Coma ScaleInternational normalized ratioMultivariable logistic regressionTraumatic brain injurySelf-inflicted injurySurvival prediction toolHospital dischargeComa ScaleLocal traumaPenetrating injuryTrauma centerMean ageNormalized ratioFemale sexSeverity scorePupillary reactivity
2013
Glyburide is Associated with Attenuated Vasogenic Edema in Stroke Patients
Kimberly WT, Battey TW, Pham L, Wu O, Yoo AJ, Furie KL, Singhal AB, Elm JJ, Stern BJ, Sheth KN. Glyburide is Associated with Attenuated Vasogenic Edema in Stroke Patients. Neurocritical Care 2013, 20: 193-201. PMID: 24072459, PMCID: PMC5198519, DOI: 10.1007/s12028-013-9917-z.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBiomarkersBrain EdemaBrain IschemiaCase-Control StudiesClinical Trials as TopicCohort StudiesDouble-Blind MethodFemaleGlyburideHumansHypoglycemic AgentsMagnetic Resonance ImagingMaleMatrix Metalloproteinase 9Middle AgedPilot ProjectsRandom AllocationRetrospective StudiesStrokeTreatment OutcomeConceptsVasogenic edemaIschemic strokeStroke patientsMagnetic resonance imagesMatrix metalloproteinase-9 plasma levelsSerial brain magnetic resonance imagesTransient receptor potential cation channelM member 4Secondary neurological deteriorationPlacebo-controlled trialMMP-9 levelsLarge hemispheric strokeBrain magnetic resonance imagesPreclinical rodent modelsSulfonylurea receptor 1Case-control designBrain swellingCerebral edemaNeurological deteriorationHuman strokeSerious complicationsGlyburide treatmentHemispheric strokeBlood biomarkersBlood markers
2005
Sirolimus may not cause neurotoxicity in kidney and liver transplant recipients
Kasner S, Sheth K, Wu G, Messe S, Wolf R. Sirolimus may not cause neurotoxicity in kidney and liver transplant recipients. Neurology 2005, 65: 337-338. PMID: 16043820, DOI: 10.1212/wnl.65.2.337-a.Peer-Reviewed Original Research