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Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths. Science Immunology 2021, 6: eabl4340. PMID: 34413139, PMCID: PMC8521484, DOI: 10.1126/sciimmunol.abl4340.Peer-Reviewed Original Research