Systematically identifying genetic signatures including novel SNP-clusters, nonsense variants, frame-shift INDELs, and long STR expansions that potentially link to unknown phenotypes existing in dog breeds
Li Z, Wang Z, Chen Z, Voegeli H, Lichtman J, Smith P, Liu J, DeWan A, Hoh J. Systematically identifying genetic signatures including novel SNP-clusters, nonsense variants, frame-shift INDELs, and long STR expansions that potentially link to unknown phenotypes existing in dog breeds. BMC Genomics 2023, 24: 302. PMID: 37277710, PMCID: PMC10240460, DOI: 10.1186/s12864-023-09390-6.Peer-Reviewed Original ResearchConceptsBreed-specific traitsGenetic signaturesShort tandem repeatsSingle nucleotide polymorphismsSNP clustersGenome-wide association studiesDog breedsNovel single nucleotide polymorphismsWhole-genome sequencing technologyFrame-shifting indelsNovel genetic signaturesNonsense variantGenomic structureUnknown phenotypeSTR expansionsGenomic regionsPhenotypic traitsSequencing technologiesGenetic insightsAssociation studiesTandem repeatsDisease predispositionSequence mapsNucleotide polymorphismsTraits