2023
Association of Neighborhood-Level Socioeconomic Factors With Delay to Hospital Arrival in Patients With Acute Stroke
Forman R, Okumu R, Mageid R, Baker A, Neu D, Parker R, Peyravi R, Schindler J, Sansing L, Sheth K, de Havenon A, Jasne A, Narula R, Wira C, Warren J, Sharma R. Association of Neighborhood-Level Socioeconomic Factors With Delay to Hospital Arrival in Patients With Acute Stroke. Neurology 2023, 102: e207764. PMID: 38165368, PMCID: PMC10834135, DOI: 10.1212/wnl.0000000000207764.Peer-Reviewed Original ResearchConceptsEmergency department arrival timesEmergency medical servicesLate presentationAcute ischemic stroke therapyYale-New Haven HospitalGuidelines-Stroke registryNeighborhood-level socioeconomic factorsPatient-level factorsRetrospective observational studyIschemic stroke therapyMixed-effects logistic regression modelNon-white patientsNon-white raceUnivariate logistic regressionNew Haven HospitalLogistic regression modelsHospital presentationTreatment ineligibilityStroke RegistryAcute strokeHospital arrivalStroke therapyUnivariate analysisObservational studyPatients
2021
Drip-and-ship versus mothership for endovascular treatment of acute stroke: A comparative effectiveness analysis
Wu X, Wira C, Matouk C, Forman H, Gandhi D, Sanelli P, Schindler J, Malhotra A. Drip-and-ship versus mothership for endovascular treatment of acute stroke: A comparative effectiveness analysis. International Journal Of Stroke 2021, 17: 315-322. PMID: 33759645, DOI: 10.1177/17474930211008701.Peer-Reviewed Original ResearchConceptsComprehensive stroke centerPrimary stroke centerAcute stroke patientsNearest comprehensive stroke centerAcute strokeMothership strategyStroke centersStroke patientsPlace of onsetHealth benefitsMarkov decision-analytic modelComparative effectiveness analysisRecent medical literatureMultiple sensitivity analysesDecision analytic modelMothership modelPrimary outcomeEndovascular treatmentPrehospital triageSudden onsetPatientsMedical literatureStrokeShip strategyTarget population
2020
Cost-effectiveness of endovascular thrombectomy in patients with acute stroke and M2 occlusion
Khunte M, Wu X, Payabvash S, Zhu C, Matouk C, Schindler J, Sanelli P, Gandhi D, Malhotra A. Cost-effectiveness of endovascular thrombectomy in patients with acute stroke and M2 occlusion. Journal Of NeuroInterventional Surgery 2020, 13: 784-789. PMID: 33077578, DOI: 10.1136/neurintsurg-2020-016765.Peer-Reviewed Original ResearchConceptsEndovascular thrombectomyMedical managementProbabilistic sensitivity analysesM2 occlusionsAcute strokeBranch occlusionEVT-treated patientsAcute ischemic strokeQuality-adjusted life yearsLifetime quality-adjusted life yearsDecision analytic modelDecision analytic studyIschemic strokeReperfusion techniquesLifetime horizonBetter outcomesPatientsLife yearsAge groupsPerfect healthSocietal perspectiveCost-effective strategyStrokeHealth benefitsOcclusionSpecial Populations
Amin H, Schindler J. Special Populations. 2020, 135-155. DOI: 10.1007/978-3-030-52552-1_11.ChaptersPharmacology
Amin H, Schindler J. Pharmacology. 2020, 235-241. DOI: 10.1007/978-3-030-52552-1_19.ChaptersConcomitant medical comorbiditiesManagement of patientsStroke therapeuticsMedical comorbiditiesAcute strokeSecondary preventionCerebrovascular diseaseVascular neurologistsClinical indicationsPharmacological basisNeurologistsTherapeuticsHypertensionComorbiditiesHyperlipidemiaThrombosisOutpatientsPatientsInternistsCardiologistsStrokeDiseaseSeverityPreventionPharmacologyStroke Syndromes
Amin H, Schindler J. Stroke Syndromes. 2020, 31-47. DOI: 10.1007/978-3-030-52552-1_4.ChaptersStroke Treatment, Early Management, and Secondary Prevention
Amin H, Schindler J. Stroke Treatment, Early Management, and Secondary Prevention. 2020, 85-105. DOI: 10.1007/978-3-030-52552-1_8.Peer-Reviewed Original ResearchSecondary preventionStroke treatmentAcute ischemic patientsMost stroke patientsStent retrieval deviceAcute stroke treatmentModifiable risk factorsOnset of symptomsAmerican Heart AssociationStroke neurologistsAcute strokeSelect patientsMost strokesStroke patientsAcute interventionCerebrovascular diseaseStroke managementTherapeutic optionsHeart AssociationIschemic patientsEarly managementRisk factorsTreatment windowPatientsManagement guidelines
2019
Comparative Effectiveness of Endovascular Thrombectomy in Elderly Stroke Patients
Malhotra A, Wu X, Payabvash S, Matouk CC, Forman HP, Gandhi D, Sanelli P, Schindler J. Comparative Effectiveness of Endovascular Thrombectomy in Elderly Stroke Patients. Stroke 2019, 50: 963-969. PMID: 30908156, DOI: 10.1161/strokeaha.119.025031.Peer-Reviewed Original ResearchConceptsQuality-adjusted life yearsIntravenous thrombolysisEndovascular thrombectomyLarge vessel occlusionAge 80 yearsEVT strategyVessel occlusionModified Rankin Scale scorePoststroke functional outcomeAcute ischemic strokeRankin Scale scoreElderly stroke patientsMarkov decision-analytic modelYears of ageDecision analytic modelMultiple sensitivity analysesPurpose- StrokeAcute strokeBaseline disabilityElderly patientsIschemic strokeStroke patientsFunctional outcomeHealthy patientsAdvanced age
2016
Stroke Treatment and Management
Amin H, Schindler J. Stroke Treatment and Management. 2016, 63-80. DOI: 10.1007/978-3-319-39605-7_8.ChaptersStroke treatmentAcute ischemic patientsMost stroke patientsStent retrieval deviceAcute stroke treatmentModifiable risk factorsOnset of symptomsAmerican Heart AssociationStroke neurologistsAcute strokeSecondary preventionSelect patientsMost strokesStroke patientsAcute interventionCerebrovascular diseaseStroke managementTherapeutic optionsHeart AssociationIschemic patientsRisk factorsPatientsT-PAManagement guidelinesStrokeSpecial Populations
Amin H, Schindler J. Special Populations. 2016, 103-120. DOI: 10.1007/978-3-319-39605-7_11.ChaptersPharmacology
Amin H, Schindler J. Pharmacology. 2016, 177-183. DOI: 10.1007/978-3-319-39605-7_19.ChaptersConcomitant medical comorbiditiesManagement of patientsStroke therapeuticsMedical comorbiditiesAcute strokeSecondary preventionCerebrovascular diseaseVascular neurologistsClinical indicationsPharmacological basisNeurologistsTherapeuticsHypertensionComorbiditiesHyperlipidemiaThrombosisOutpatientsPatientsInternistsCardiologistsStrokeDiseaseSeverityPreventionPharmacologyStroke Syndromes
Amin H, Schindler J. Stroke Syndromes. 2016, 23-35. DOI: 10.1007/978-3-319-39605-7_4.Chapters
2015
On- versus Off-Hour Patient Cohorts at a Primary Stroke Center: Onset-to-Treatment Duration and Clinical Outcomes after IV Thrombolysis
Asuzu D, Nystrӧm K, Amin H, Schindler J, Wira C, Greer D, Chi NF, Halliday J, Sheth KN. On- versus Off-Hour Patient Cohorts at a Primary Stroke Center: Onset-to-Treatment Duration and Clinical Outcomes after IV Thrombolysis. Journal Of Stroke And Cerebrovascular Diseases 2015, 25: 447-451. PMID: 26654664, DOI: 10.1016/j.jstrokecerebrovasdis.2015.10.017.Peer-Reviewed Original ResearchConceptsSymptomatic intracerebral hemorrhagePrimary stroke centerClinical outcomesStroke centersStroke severitySymptom onsetStroke careStroke patientsPatient cohortIntravenous recombinant tissue plasminogen activator (rt-PA) therapyTreatment durationRecombinant tissue plasminogen activator therapyHealth Stroke Scale scoreTissue plasminogen activator therapyConsistent quality careBaseline National InstitutesStroke Scale scoreAcute stroke careIschemic stroke patientsPlasminogen activator therapyMann-Whitney testSICH rateAcute strokeIschemic strokeConsecutive patients