2022
Typhoid toxin sorting and exocytic transport from Salmonella Typhi-infected cells
Chang SJ, Hsu YT, Chen Y, Lin YY, Lara-Tejero M, Galan JE. Typhoid toxin sorting and exocytic transport from Salmonella Typhi-infected cells. ELife 2022, 11: e78561. PMID: 35579416, PMCID: PMC9142146, DOI: 10.7554/elife.78561.Peer-Reviewed Original ResearchConceptsCellular machineryType III protein secretion systemSpecific cellular machineryVesicle carriersProtein secretion systemExtracellular spaceTyphoid toxinEssential virulence factorExocytic transportGTPase Sar1Syntaxin 4Unusual biologySecretion systemPlasma membraneIntracellular transportRemarkable adaptationSpecific effectorsHost cellsIntracellular pathogensVirulence factorsMachineryCooptionVacuolesToxinSpecific environment
2015
9 Typhoid toxin
Galan J. 9 Typhoid toxin. 2015, 261-266. DOI: 10.1016/b978-0-12-800188-2.00009-4.Peer-Reviewed Original ResearchTyphoid feverTyphoid toxinLife-threatening systemic diseaseUnique virulence factorsSalmonella enterica serovar TyphiPentameric B subunitEnterica serovar TyphiSystemic diseaseExperimental animalsFeverUnique receptorSerovar TyphiVirulence factorsToxinDiseaseB subunitSalmonella entericaPathogenesisSymptomsSpecificityHuman glycansImportant diseaseReceptors
2001
Structural mimicry in bacterial virulence
Stebbins C, Galán J. Structural mimicry in bacterial virulence. Nature 2001, 412: 701-705. PMID: 11507631, DOI: 10.1038/35089000.Peer-Reviewed Original ResearchConceptsAmino acid sequence similarityConvergent evolutionCellular functionsSequence similarityDirect homologuesBacterial virulenceHost proteinsNew effectorsMicrobial pathogensFunctional mimicryStructural mimicryMolecular levelVirulence factorsMimicryStructural studiesHost factorsImportant mechanismHost activityHomologuesVirulenceEffectorsProteinPathogensSimilarity