2023
Parkinson’s disease kinase LRRK2 coordinates a cell-intrinsic itaconate-dependent defence pathway against intracellular Salmonella
Lian H, Park D, Chen M, Schueder F, Lara-Tejero M, Liu J, Galán J. Parkinson’s disease kinase LRRK2 coordinates a cell-intrinsic itaconate-dependent defence pathway against intracellular Salmonella. Nature Microbiology 2023, 8: 1880-1895. PMID: 37640963, PMCID: PMC10962312, DOI: 10.1038/s41564-023-01459-y.Peer-Reviewed Original ResearchConceptsLeucine-rich repeat kinase 2Loss of LRRK2Host defense mechanismsKinase leucine-rich repeat kinase 2Parkinson's disease-associated leucine-rich repeat kinase 2Host defense pathwaysBacterial pathogen SalmonellaRepeat kinase 2Salmonella infectionSalmonella-containing vacuolesCell-intrinsic defenseIntracellular pathogensIntracellular SalmonellaFirst lineSalmonella replicationSalmonella mutantsKinase 2Pathogen SalmonellaDefense mechanismsSalmonellaHost mitochondriaDefense pathwaysDeliveryDefense responsesCells
1993
Colonization and Invasion of the Intestinal Tract by Salmonella
Curtiss R, MacLeod D, Lockman H, Galan J, Kelly S, Mahairas G. Colonization and Invasion of the Intestinal Tract by Salmonella. NATO Science Series A: 1993, 191-198. DOI: 10.1007/978-1-4615-2854-8_22.Peer-Reviewed Original ResearchEnteric feverSalmonella infectionS. typhiMurine animal modelCause of gastroenteritisAnimal modelsMore serovarsIntestinal tractWater-borne illnessMajor causeDisease statesGastroenteritisSerotypes of SalmonellaSerotype TyphimuriumS. EnteritidisS. choleraesuisFeverInfectionDisease symptomologyPrincipal causeCauseTyphiMost studiesAnimal hostsSalmonella