2023
WICOX: Weight-Based Integrated Cox Model for Time-to-Event Data in Distributed Databases Without Data-Sharing
Park J, Kim T, Kim J, Park Y. WICOX: Weight-Based Integrated Cox Model for Time-to-Event Data in Distributed Databases Without Data-Sharing. IEEE Journal Of Biomedical And Health Informatics 2023, 27: 526-537. PMID: 36318551, DOI: 10.1109/jbhi.2022.3218585.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsComputer Communication NetworksHumansInformation DisseminationPrivacyProportional Hazards ModelsConceptsLarge-scale biomedical dataPrivacy-preserving mannerPrivacy-protecting methodsCommon data modelPrivacy issuesDistributed DatabaseBiomedical dataData modelData networksIterative communicationCentralized modelPatient-level informationEvent dataSimulation resultsNon-iterative methodPredictive performanceRobust characteristicsRobust resultsMultiple institutionsDatabaseIntegrated modelAlgorithmNetworkCommunicationModel
2021
Benchmarking blockchain-based gene-drug interaction data sharing methods: A case study from the iDASH 2019 secure genome analysis competition blockchain track
Kuo T, Bath T, Ma S, Pattengale N, Yang M, Cao Y, Hudson C, Kim J, Post K, Xiong L, Ohno-Machado L. Benchmarking blockchain-based gene-drug interaction data sharing methods: A case study from the iDASH 2019 secure genome analysis competition blockchain track. International Journal Of Medical Informatics 2021, 154: 104559. PMID: 34474309, PMCID: PMC9933142, DOI: 10.1016/j.ijmedinf.2021.104559.Peer-Reviewed Original ResearchConceptsSecure genome analysis competitionData retrieval queriesBlockchain-based methodData sharing methodReal-world problemsQuery indexType of sharingRetrieval queriesBlockchain technologyLedger technologySource codeBlockchain utilizationBlockchain strategyHealthcare applicationsInteraction recordsSharing methodTest datasetSharing recordsBiomedical research applicationsConsortium resourcesNew platformPatient recordsBlockchainQueriesTechnology
2019
Patient Perspectives About Decisions to Share Medical Data and Biospecimens for Research
Kim J, Kim H, Bell E, Bath T, Paul P, Pham A, Jiang X, Zheng K, Ohno-Machado L. Patient Perspectives About Decisions to Share Medical Data and Biospecimens for Research. JAMA Network Open 2019, 2: e199550. PMID: 31433479, PMCID: PMC6707015, DOI: 10.1001/jamanetworkopen.2019.9550.Peer-Reviewed Original Research
2016
iCONCUR: informed consent for clinical data and bio-sample use for research
Kim H, Bell E, Kim J, Sitapati A, Ramsdell J, Farcas C, Friedman D, Feupe S, Ohno-Machado L. iCONCUR: informed consent for clinical data and bio-sample use for research. Journal Of The American Medical Informatics Association 2016, 24: 380-387. PMID: 27589942, PMCID: PMC5391727, DOI: 10.1093/jamia/ocw115.Peer-Reviewed Original ResearchMeSH KeywordsBiomedical ResearchElectronic Health RecordsFeasibility StudiesFemaleHumansInformation DisseminationInformed ConsentMalePatient PreferenceSocioeconomic FactorsConceptsPatient preferencesClinical dataHuman immunodeficiency virus clinicInternal medicine clinicElectronic health record dataHealth record dataAcademic medical centerElectronic health recordsDe-identified dataOutpatient clinicMedicine clinicFamily historyMedical CenterInformed Consent ToolClinical settingClinicHealth recordsRecord dataInformed consent systemPatientsConsent toolRecipientsConsentE-consentParticipants
2012
Grid Binary LOgistic REgression (GLORE): building shared models without sharing data
Wu Y, Jiang X, Kim J, Ohno-Machado L. Grid Binary LOgistic REgression (GLORE): building shared models without sharing data. Journal Of The American Medical Informatics Association 2012, 19: 758-764. PMID: 22511014, PMCID: PMC3422844, DOI: 10.1136/amiajnl-2012-000862.Peer-Reviewed Original ResearchMeSH KeywordsArea Under CurveBiomedical ResearchComputer SimulationConfidentialityHumansInformation DisseminationLogistic ModelsPattern Recognition, AutomatedROC CurveConceptsIntegrity of communicationCentralized data sourcesTraditional LR modelCentral repositoryComputational costData sourcesData setsSame formatPatient dataComputationGenomic dataRare patternRelevant dataLR modelPrediction valueSetRepositoryPartial elementsFormatClassificationCommunicationModelDataPatient setPerformiDASH: integrating data for analysis, anonymization, and sharing
Ohno-Machado L, Bafna V, Boxwala A, Chapman B, Chapman W, Chaudhuri K, Day M, Farcas C, Heintzman N, Jiang X, Kim H, Kim J, Matheny M, Resnic F, Vinterbo S, team A. iDASH: integrating data for analysis, anonymization, and sharing. Journal Of The American Medical Informatics Association 2012, 19: 196-201. PMID: 22081224, PMCID: PMC3277627, DOI: 10.1136/amiajnl-2011-000538.Commentaries, Editorials and LettersConceptsHigh-performance computing environmentPrivacy-preserving mannerCollaborative tool developmentData-sharing capabilitiesData ownersComputing environmentData consumersBiomedical computingHealth Insurance PortabilityTechnology researchTool developmentAccountability ActBiological projectsBiological dataInsurance PortabilityAnonymizationComputingPortabilityBehavioral researchersAlgorithmSoftwareCloudNew National CenterDataCapability
2011
Full impact of laboratory information system requires direct use by clinical staff: cluster randomized controlled trial
Blaya J, Shin S, Contreras C, Yale G, Suarez C, Asencios L, Kim J, Rodriguez P, Cegielski P, Fraser H. Full impact of laboratory information system requires direct use by clinical staff: cluster randomized controlled trial. Journal Of The American Medical Informatics Association 2011, 18: 11-16. PMID: 21113076, PMCID: PMC3005868, DOI: 10.1136/jamia.2010.005280.Peer-Reviewed Original ResearchConceptsPeripheral health centresDrug susceptibility testHealth centersIntervention groupControl groupElectronic laboratory reportingE-ChasquiCare accessClinical staffCulture resultsLaboratory reportingHealth establishmentsSusceptibility testsLaboratory information systemBaseline dataTrialsLaboratory resultsMonthsLower proportionGroupPaper-based systemProportion