Featured Publications
Cerebral Hemorrhage: Pathophysiology, Treatment, and Future Directions
Magid-Bernstein J, Girard R, Polster S, Srinath A, Romanos S, Awad IA, Sansing LH. Cerebral Hemorrhage: Pathophysiology, Treatment, and Future Directions. Circulation Research 2022, 130: 1204-1229. PMID: 35420918, PMCID: PMC10032582, DOI: 10.1161/circresaha.121.319949.Peer-Reviewed Original ResearchConceptsMechanism of injuryIntracerebral hemorrhageUltra-early hemostatic therapyInflammatory brain injuryCurrent treatment strategiesIron-induced injuryAnticoagulant useHemostatic therapyHemorrhagic strokeHypertension managementICH therapySurgical managementHigh morbidityPrimary preventionFunctional outcomeICH managementBrain injuryClinical trialsTreatment strategiesPrognostic biomarkerDevastating formDisease pathobiologyInjuryInvasive surgeryOxidative stressImpacts of ABO-incompatible platelet transfusions on platelet recovery and outcomes after intracerebral hemorrhage
Magid-Bernstein J, Beaman CB, Carvalho-Poyraz F, Boehme A, Hod EA, Francis RO, Elkind MSV, Agarwal S, Park S, Claassen J, Connolly ES, Roh D. Impacts of ABO-incompatible platelet transfusions on platelet recovery and outcomes after intracerebral hemorrhage. Blood 2021, 137: 2699-2703. PMID: 33649761, PMCID: PMC9635530, DOI: 10.1182/blood.2020008381.Peer-Reviewed Original ResearchConceptsABO-incompatible platelet transfusionsIntracerebral hemorrhagePlatelet transfusionsPlatelet recoveryABO-compatible transfusionsSingle-center cohortOdds of mortalityABO-incompatible transfusionLow platelet recoveryNeurological outcomeOngoing bleedingABO compatibilityICH outcomeMedication effectsTransfusionPoor mRSPatientsHemorrhageOutcomesUnderlying mechanismFurther investigationBleedingCohortMortalityRecoveryCerebral Microbleeds and Acute Hematoma Characteristics in the ATACH-2 and MISTIE III Trials
Magid-Bernstein JR, Li Y, Cho SM, Piran PJ, Roh DJ, Gupta A, Shoamanesh A, Merkler A, Zhang C, Avadhani R, Montano N, Iadecola C, Falcone G, Sheth K, Qureshi AI, Rosand J, Goldstein J, Awad I, Hanley D, Kamel H, Ziai WC, Murthy SB. Cerebral Microbleeds and Acute Hematoma Characteristics in the ATACH-2 and MISTIE III Trials. Neurology 2021, 98: e1013-e1020. PMID: 34937780, PMCID: PMC8967392, DOI: 10.1212/wnl.0000000000013247.Peer-Reviewed Original ResearchConceptsSmaller ICH volumeCerebral microbleedsSmall vessel diseaseIntracerebral hemorrhageHematoma expansionHematoma characteristicsICH volumeVessel diseaseNumber of CMBsSmaller baseline hematoma volumesUnderlying small vessel diseasePresence of CMBsCerebral small vessel diseaseAdmission ICH volumeMISTIE III trialPresence of microbleedsClass II evidencePhase 3 trialSeverity of leukoaraiosisPrimary intracerebral hemorrhageBaseline hematoma volumeIndividual patient dataBrain MRI scansLogistic regression modelsAntihypertensive treatment
2024
Exploring the Relationship Between Cerebrospinal Fluid Interleukin-6 and Cerebral Autoregulation After Subarachnoid Hemorrhage (S23.004)
Olexa M, Begunova Y, Gilmore E, Kim J, Herman A, Beekman R, Magid-Bernstein J, Matouk C, Sheth K, Miller E, Gutierrez S, De Havenon A, Sansing L, Petersen N. Exploring the Relationship Between Cerebrospinal Fluid Interleukin-6 and Cerebral Autoregulation After Subarachnoid Hemorrhage (S23.004). Neurology 2024, 102 DOI: 10.1212/wnl.0000000000205692.Peer-Reviewed Original ResearchPrognostication of Outcomes in Stroke Patients Using Inflammatory Biomarkers: Findings from the Yale Post-stroke Epilepsy Research Group (P3-5.010)
Wang E, Misra S, Yan J, Chook P, Kawamura Y, Kitagawa R, Kim J, Gilmore E, De Havenon A, Sivaraju A, Hirsch L, Falcone G, Sansing L, Magid-Bernstein J, Mishra N. Prognostication of Outcomes in Stroke Patients Using Inflammatory Biomarkers: Findings from the Yale Post-stroke Epilepsy Research Group (P3-5.010). Neurology 2024, 102 DOI: 10.1212/wnl.0000000000204783.Peer-Reviewed Original ResearchAssessing Effects of Intrathecal Nicardipine on Cerebral Autoregulation and Cortical Activity in Aneurysmal Subarachnoid Hemorrhage (P10-5.019)
Jayasundara S, Kim J, Choi R, Rapuano A, Barnes E, Parasram M, Moura M, Uppal P, Chen Y, Top I, Olexa M, Maarek R, Yan J, Beekman R, Magid-Bernstein J, Hebert R, Bahrassa F, Matouk C, Sheth K, Gilmore E, Petersen N. Assessing Effects of Intrathecal Nicardipine on Cerebral Autoregulation and Cortical Activity in Aneurysmal Subarachnoid Hemorrhage (P10-5.019). Neurology 2024, 102 DOI: 10.1212/wnl.0000000000206285.Peer-Reviewed Original Research
2023
ABO-Incompatible Platelet Transfusion Is Associated with Ischemic Lesions on Brain MRI in Patients with Intracerebral Hemorrhage
Poyraz F, Ridha M, Simonetto M, Kumar A, Hess E, Magid-Bernstein J, Connolly E, Ghoshal S, Agarwal S, Park S, Claassen J, Hod E, Roh D. ABO-Incompatible Platelet Transfusion Is Associated with Ischemic Lesions on Brain MRI in Patients with Intracerebral Hemorrhage. Blood 2023, 142: 1288. DOI: 10.1182/blood-2023-186171.Peer-Reviewed Original ResearchABO-incompatible platelet transfusionsAcute ischemic brain lesionsIschemic brain lesionsIschemic lesionsPlatelet transfusionsICH patientsBrain MRIPlatelet unitsICH hospitalizationsICH severityBrain lesionsICH symptom onsetIncompatible platelet transfusionsProspective cohort studyAcute ischemic lesionsSpontaneous ICH patientsIntracerebral hemorrhage outcomesConsecutive spontaneous ICH patientsPatient's blood typeCerebral microthrombosisCohort studySymptom onsetRegression modelsClinical outcomesImpaired hemostasisGuidelines in Action: Management of Acute and Chronic Hydrocephalus Following Aneurysmal Subarachnoid Hemorrhage
Parasram M, Park J, Al-Dulaimi M, Magid-Bernstein J. Guidelines in Action: Management of Acute and Chronic Hydrocephalus Following Aneurysmal Subarachnoid Hemorrhage. Stroke 2023, 54: e508-e511. PMID: 37842781, DOI: 10.1161/strokeaha.123.044793.Peer-Reviewed Original ResearchAcute and subacute neurovascular impact of cryptogenic air emboli
Gummerson C, Parasram M, Peng T, Picard J, Kahn P, Angelus E, Bhatt S, de Havenon A, Jasne A, Magid-Bernstein J. Acute and subacute neurovascular impact of cryptogenic air emboli. Surgical Neurology International 2023, 14: 285. PMID: 37680929, PMCID: PMC10481802, DOI: 10.25259/sni_382_2023.Peer-Reviewed Case Reports and Technical NotesMagnetic resonance imagingCortical diffusion restrictionAir emboliMiddle cerebral artery territoryRight anterior cerebral arterySubsequent magnetic resonance imagingDiffusion restrictionClose neurologic monitoringNeurocritical care managementCerebral air embolismAcute ischemic strokeAnterior cerebral arteryInitial radiographic findingsCerebral air emboliType of injuryComputerized tomography scanCourse of careArtery territoryCerebral edemaIschemic strokeNeurologic monitoringCerebral arteryCortical veinsInitial imagingMechanical ventilationEmergent external ventricular drain placement in patients with factor Xa inhibitor-associated intracerebral hemorrhage after reversal with andexanet alfa
Ammar A, Elsamadicy A, Ammar M, Reeves B, Koo A, Falcone G, Hwang D, Petersen N, Kim J, Beekman R, Prust M, Magid-Bernstein J, Acosta J, Herbert R, Sheth K, Matouk C, Gilmore E. Emergent external ventricular drain placement in patients with factor Xa inhibitor-associated intracerebral hemorrhage after reversal with andexanet alfa. Clinical Neurology And Neurosurgery 2023, 226: 107621. PMID: 36791588, DOI: 10.1016/j.clineuro.2023.107621.Peer-Reviewed Original ResearchConceptsAndexanet alfaExtra-axial hemorrhageEVD placementThrombotic eventsNew hemorrhagePrimary safety outcomeExternal ventricular drain placementLarge prospective studiesIntensive care unitIntracerebral hemorrhage patientsVentricular drain placementBolus patientsHospital lengthHospital LOSICU LOSTract hemorrhageRankin scoreSecondary outcomesAdult patientsBolus groupPrimary outcomeCare unitIntracerebral hemorrhageLong administration timeHemorrhage patients
2022
Intraventricular Hemorrhage Expansion in the CLEAR III Trial: A Post Hoc Exploratory Analysis
Roh DJ, Asonye IS, Poyraz F, Magid-Bernstein JR, Joiner EF, Avadhani R, Awad I, Hanley DF, Ziai WC, Murthy SB. Intraventricular Hemorrhage Expansion in the CLEAR III Trial: A Post Hoc Exploratory Analysis. Stroke 2022, 53: 1847-1853. PMID: 35086362, PMCID: PMC9133068, DOI: 10.1161/strokeaha.121.037438.Peer-Reviewed Original ResearchConceptsCLEAR III trialVentriculoperitoneal shunt placementIntraventricular hemorrhage expansionIII trialsIVH patientsShunt placementICH locationHematoma expansionIVH expansionHemorrhage expansionSubsequent ventriculoperitoneal shunt placementGlasgow Coma Scale scoreBaseline ICH volumeClinical trial cohortComposite of deathLong-term outcomesMultivariable logistic regressionPoor functional outcomePost-hoc exploratory analysisMultivariable regression modelsIntracerebral hemorrhage volumeRandomization armAnticoagulant useTrial cohortClinical outcomes
2021
Reversible Cerebral Vasoconstriction Syndrome
Magid-Bernstein J, Omran S, Parikh NS, Merkler AE, Navi B, Kamel H. Reversible Cerebral Vasoconstriction Syndrome. Neurology 2021, 97: e248-e253. PMID: 34050007, PMCID: PMC8302148, DOI: 10.1212/wnl.0000000000012223.Peer-Reviewed Original ResearchReversible cerebral vasoconstriction syndromeSex-standardized incidenceCerebral vasoconstriction syndromeHospital admissionNeurologic diagnosisPregnancy-related diagnosesIncidence of hospitalizationEmergency department visitsAdministrative dataIndex admissionED visitsIschemic strokeDepartment visitsIntracerebral hemorrhageCerebrovascular diseaseDischarge diagnosisSubarachnoid hemorrhagePopulation-wide dataCommunity hospitalAnnual ageUS adultsHealthcare costsPatientsAdmissionUtilization ProjectRed Blood Cell Transfusions and Associations with Outcome after Intracerebral Hemorrhage (2565)
Poyraz F, Magid-Bernstein J, Elkind M, Agarwal S, Park S, Claassen J, Hod E, Roh D, Connolly E. Red Blood Cell Transfusions and Associations with Outcome after Intracerebral Hemorrhage (2565). Neurology 2021, 96 DOI: 10.1212/wnl.96.15_supplement.2565.Peer-Reviewed Original Research
2020
Red Blood Cell Transfusions and Outcomes After Intracerebral Hemorrhage
Roh DJ, Carvalho Poyraz F, Magid-Bernstein J, Elkind MSV, Agarwal S, Park S, Claassen J, Connolly ES, Hod E, Murthy SB. Red Blood Cell Transfusions and Outcomes After Intracerebral Hemorrhage. Journal Of Stroke And Cerebrovascular Diseases 2020, 29: 105317. PMID: 32992186, PMCID: PMC7686150, DOI: 10.1016/j.jstrokecerebrovasdis.2020.105317.Peer-Reviewed Original ResearchConceptsRBC transfusionICH outcomeDisease severityComorbidity burdenICH hospitalizationsPoor outcomeRed blood cell transfusionICD-9-CM codesBlood cell transfusionAdditional prospective studiesRed blood cell levelsIntracerebral hemorrhage outcomesNationwide Inpatient SampleLower red blood cell levelsBlood cell levelsBaseline comorbiditiesHospital mortalityTransfusion exposureVentriculostomy drainsCell transfusionLow comorbidityIntracerebral hemorrhageMechanical ventilationProspective studyInpatient SampleA rare case of HIV CNS escape in a patient previously considered a viral controller
Magid-Bernstein J, Guo CY, Chow FC, Thakur KT. A rare case of HIV CNS escape in a patient previously considered a viral controller. International Journal Of STD & AIDS 2020, 31: 694-698. PMID: 32538333, DOI: 10.1177/0956462420922452.Peer-Reviewed Original ResearchConceptsViral controllersViral suppressionFungal CNS infectionsNon-HIV infectionsPerinatal HIV infectionHuman immunodeficiency virus ribonucleic acid levelsCentral nervous systemRibonucleic acid levelsCNS infectionsHIV RNAHIV infectionRare caseCerebrospinal fluidNervous systemAcid levelsInfectionYoung menIndependent replicationHIVPatientsSuppressionSetting
2019
Low hemoglobin and hematoma expansion after intracerebral hemorrhage.
Roh DJ, Albers DJ, Magid-Bernstein J, Doyle K, Hod E, Eisenberger A, Murthy S, Witsch J, Park S, Agarwal S, Connolly ES, Elkind MSV, Claassen J. Low hemoglobin and hematoma expansion after intracerebral hemorrhage. Neurology 2019, 93: e372-e380. PMID: 31209179, PMCID: PMC6669932, DOI: 10.1212/wnl.0000000000007820.Peer-Reviewed Original ResearchConceptsAdmission hemoglobin levelsLower admission hemoglobin levelsLower hemoglobin levelsHemoglobin levelsHematoma expansionLower hemoglobinWorse outcomesMultivariable logistic regression modelSeparate multivariable logistic regression modelsPoor clinical outcomeMeeting inclusion criteriaIntracerebral hemorrhage volumeLogistic regression modelsAdmission hemoglobinRankin ScaleCohort studyConsecutive patientsClinical outcomesIntracerebral hemorrhagePoor outcomeICH outcomeICH scoreHemorrhage volumeModifiable targetsInclusion criteriaAdmission Hemoglobin Level is Associated with Hematoma Expansion and Poor Outcome after Intracerebral Hemorrhage (S2.001)
Magid-Bernstein J, Albers D, Doyle K, Hod E, Eisenberger A, Murthy S, Park S, Agarwal S, Connolly E, Elkind M, Claassen J, Roh D. Admission Hemoglobin Level is Associated with Hematoma Expansion and Poor Outcome after Intracerebral Hemorrhage (S2.001). Neurology 2019, 92 DOI: 10.1212/wnl.92.15_supplement.s2.001.Peer-Reviewed Original Research
2017
Prognostic Value of the Neurological Examination in Cardiac Arrest Patients After Therapeutic Hypothermia
Matthews EA, Magid-Bernstein J, Sobczak E, Velazquez A, Falo CM, Park S, Claassen J, Agarwal S. Prognostic Value of the Neurological Examination in Cardiac Arrest Patients After Therapeutic Hypothermia. The Neurohospitalist 2017, 8: 66-73. PMID: 29623156, PMCID: PMC5882011, DOI: 10.1177/1941874417733217.Peer-Reviewed Original ResearchPositive predictive valuePupillary light responseTherapeutic hypothermiaNeurological examinationCorneal reflexPredictive valueDay 3Poor outcomePrognostic valueDay 5Cerebral Performance Category scoreUniversity intensive care unitTime pointsCardiac arrest patientsCardiac arrest survivorsIntensive care unitLife-sustaining therapyNegative predictive valueLeast day 5False positive rateHospital dischargeArrest patientsArrest survivorsCare unitIdeal timingCategorization of survival and death after cardiac arrest
Matthews EA, Magid-Bernstein J, Presciutti A, Rodriguez A, Roh D, Park S, Claassen J, Agarwal S. Categorization of survival and death after cardiac arrest. Resuscitation 2017, 114: 79-82. PMID: 28279695, PMCID: PMC5548414, DOI: 10.1016/j.resuscitation.2017.03.005.Peer-Reviewed Original ResearchConceptsCerebral Performance CategoryPoor neurological prognosisNeurological prognosisFamily's wishesPoor outcomeMost cardiac arrest patientsFavorable recoveryOne-yearEarly recovery groupUnfavorable neurological prognosisCardiac arrest patientsLife-sustaining therapyHemodynamic instabilityFavorable prognosisArrest patientsCardiac arrestGOC discussionsWorse outcomesPatient outcomesBrain deathCommon causeEarly recoveryCare conversationsRecovery groupMost survivorsHuman CD39+ Treg Cells Express Th17-Associated Surface Markers and Suppress IL-17 via a Stat3-Dependent Mechanism
Magid-Bernstein JR, Rohowsky-Kochan CM. Human CD39+ Treg Cells Express Th17-Associated Surface Markers and Suppress IL-17 via a Stat3-Dependent Mechanism. Journal Of Interferon & Cytokine Research 2017, 37: 153-164. PMID: 28387597, PMCID: PMC6435349, DOI: 10.1089/jir.2016.0071.Peer-Reviewed Original ResearchConceptsIL-17STAT3-dependent mechanismIL-23RHuman CD4T effector cellsIFN-γ productionEctonucleotidase CD39Autologous CD4Regulatory cellsAutoimmune responseEffector cellsAutoimmune diseasesTranscription factor STAT3Immune responseProliferative responseCD25CD4CD39Human CD39Surface markersSTAT3 activationCCR6STAT3CellsFirst evidence