2016
Multipoint genome-wide linkage scan for nonword repetition in a multigenerational family further supports chromosome 13q as a locus for verbal trait disorders
Truong DT, Shriberg LD, Smith SD, Chapman KL, Scheer-Cohen AR, DeMille MM, Adams AK, Nato AQ, Wijsman EM, Eicher JD, Gruen JR. Multipoint genome-wide linkage scan for nonword repetition in a multigenerational family further supports chromosome 13q as a locus for verbal trait disorders. Human Genetics 2016, 135: 1329-1341. PMID: 27535846, PMCID: PMC5065602, DOI: 10.1007/s00439-016-1717-z.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overChildChild, PreschoolChromosome MappingChromosomes, Human, Pair 13Drosophila ProteinsDyslexiaFemaleGenetic LinkageGenetic Predisposition to DiseaseGenotypeHumansLanguage DisordersLod ScoreMaleMembrane ProteinsMiddle AgedNuclear ProteinsPedigreeQuantitative Trait LociReadingSpeech DisordersWritingConceptsNonword repetitionSpecific language impairmentCognitive processesLanguage impairmentAuditory processingVerbal developmentMotor planningPerson's abilityRobust endophenotypesMultigenerational familiesLanguage traitsRepetitionDisordersGenome-wide linkage scanSpellingVariance component linkage analysisCausal genetic factorsMultipoint variance component linkage analysisMemoryEndophenotypesSpeechChromosome 13qFuture studiesPresent studyDeficits
2010
A Dyslexia-Associated Variant in DCDC2 Changes Gene Expression
Meng H, Powers NR, Tang L, Cope NA, Zhang PX, Fuleihan R, Gibson C, Page GP, Gruen JR. A Dyslexia-Associated Variant in DCDC2 Changes Gene Expression. Behavior Genetics 2010, 41: 58-66. PMID: 21042874, PMCID: PMC3053575, DOI: 10.1007/s10519-010-9408-3.Peer-Reviewed Original Research
2007
Genetic approaches to complications of prematurity.
Meng H, Gruen JR. Genetic approaches to complications of prematurity. Frontiers In Bioscience-Landmark 2007, 12: 2344-51. PMID: 17127244, DOI: 10.2741/2236.Peer-Reviewed Original ResearchConceptsNeonatal morbidityLow birth weight babiesBirth weight babiesComplications of prematurityGestational age groupsVLBW babiesWeight babiesBronchopulmonary dysplasiaIntraventricular hemorrhageSpecific therapyTherapeutic advancesClinical trialsAnimal modelsAge groupsGenetic componentMorbidityDizygotic twinsSignificant genetic componentBabiesMortalityComplex genetic diseasesTimely implementationRecent studiesGenetic diseasesEnterocolitis
2001
Peaks of Linkage Are Localized by a BAC/PAC Contig of the 6p Reading Disability Locus
Ahn J, Won T, Zia A, Reutter H, Kaplan D, Sparks R, Gruen J. Peaks of Linkage Are Localized by a BAC/PAC Contig of the 6p Reading Disability Locus. Genomics 2001, 78: 19-29. PMID: 11707069, DOI: 10.1006/geno.2001.6645.Peer-Reviewed Original ResearchConceptsBacterial artificial chromosomeBAC/PAC contigHigh-resolution genetic studiesEntire chromosome 6Intermarker distanceArtificial chromosome contigPhysical mapping dataPeak of linkageSuccinic semialdehyde dehydrogenaseUncharacterized genesGenetic boundariesSequence tagsShort tandem repeatsArtificial chromosomesMarker orderClone contigNew contigPhysical mapGenetic lociLinkage peakCandidate genesPAC contigSemialdehyde dehydrogenaseContigsChromosome 6
1992
Physical and genetic mapping of the telomeric major histocompatibility complex region in man and relevance to the primary hemochromatosis gene (HFE)
Gruen J, Goei V, Summers K, Capossela A, Powell L, Halliday J, Zoghbi H, Shukla H, Weissman S. Physical and genetic mapping of the telomeric major histocompatibility complex region in man and relevance to the primary hemochromatosis gene (HFE). Genomics 1992, 14: 232-240. PMID: 1427838, DOI: 10.1016/s0888-7543(05)80211-3.Peer-Reviewed Original ResearchConceptsPhysical mapGenomic DNACell linesRadiation hybrid cell linesHigh-resolution physical mapLong-range physical mapGenetic mapping studiesHuman genomic DNAPulsed-field gel electrophoresisHybrid cell linesRestriction fragment banding patternsMajor histocompatibility complex regionGenetic mappingMajor histocompatibility complex (MHC) class I regionHuman genomeHLA-F geneBanding patternsClass I regionGenesDisequilibrium analysisGel electrophoresisMapping studiesDNAI regionClass I