2015
Dimethadione embryotoxicity in the rat is neither correlated with maternal systemic drug concentrations nor embryonic tissue levels
Ozolinš TR, Weston AD, Perretta A, Thomson JJ, Brown NA. Dimethadione embryotoxicity in the rat is neither correlated with maternal systemic drug concentrations nor embryonic tissue levels. Toxicology And Applied Pharmacology 2015, 289: 89-97. PMID: 26375719, DOI: 10.1016/j.taap.2015.09.005.Peer-Reviewed Original ResearchConceptsGD 11Tissue concentrationsSystemic concentrationsWhole embryo cultureTissue levelsMaternal serum levelsIncidence of CHDSystemic drug concentrationsGestational day 8Embryonic concentrationsCHD incidenceMaternal serumSerum levelsPregnant ratsSeparate cohortAnticonvulsant trimethadioneDay 8Embryonic outcomeCongenital heartDrug concentrationsDimethadioneDMO concentrationIncidenceDevelopmental outcomesRats
2011
Noninvasive High‐Resolution Ultrasound Reveals Structural and Functional Deficits in Dimethadione‐Exposed Fetal Rat Hearts In Utero
Purssell E, Weston AD, Thomson JJ, Swanson TA, Brown NA, Ozolinš TR. Noninvasive High‐Resolution Ultrasound Reveals Structural and Functional Deficits in Dimethadione‐Exposed Fetal Rat Hearts In Utero. Birth Defects Research Part B Developmental And Reproductive Toxicology 2011, 95: 35-46. PMID: 22127902, DOI: 10.1002/bdrb.20339.Peer-Reviewed Original ResearchNot a walk in the park: the ECVAM whole embryo culture model challenged with pharmaceuticals and attempted improvements with random forest design
Thomson J, Johnson K, Chapin R, Stedman D, Kumpf S, Ozolinš TR. Not a walk in the park: the ECVAM whole embryo culture model challenged with pharmaceuticals and attempted improvements with random forest design. Birth Defects Research Part B Developmental And Reproductive Toxicology 2011, 92: 111-121. PMID: 21370399, DOI: 10.1002/bdrb.20289.Peer-Reviewed Original Research
2008
Assessment of the Embryonic Stem Cell Test and application and use in the pharmaceutical industry
Paquette JA, Kumpf SW, Streck RD, Thomson JJ, Chapin RE, Stedman DB. Assessment of the Embryonic Stem Cell Test and application and use in the pharmaceutical industry. Birth Defects Research Part B Developmental And Reproductive Toxicology 2008, 83: 104-111. PMID: 18361453, DOI: 10.1002/bdrb.20148.Peer-Reviewed Original Research